Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1733-1736

  Gomez, Cindy ^a   Bai, Longchuan ^a,b   Zhang, Jian ^a,b   Nikolovska Coleska, Zaneta ^a,b   Chen, Jianyong ^a,b   Yi, Han ^a,b   Wang, Shaomeng ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Freidinger lactams; Peptidomimetics; Small molecule inhibitors; STAT3

Indexed keywords

ANTINEOPLASTIC AGENT; FREIDINGER LACTAM DERIVATIVE; LACTAM DERIVATIVE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS;

ANTINEOPLASTIC AGENTS; BIOMIMETICS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KINETICS; LACTAMS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHOSPHOPEPTIDES; PHOSPHORYLATION; PROTEIN CONFORMATION; STAT3 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 61349138340     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.091     Document Type: Article

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