Visceral fat mass is a strong predictor of circulating ghrelin levels in premenopausal women

European Journal of Endocrinology

Volumn 160, Issue 3, 2009, Pages 375-379

  Sondergaard, E ^a   Gormsem, L C ^a   Nellemann, B ^a   Vestergaard, E T ^a   Christiansen, J S ^a   Nielsen, S ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; INSULIN;

ADULT; ARTICLE; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY MASS; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INTRAABDOMINAL FAT; OBESITY; PHENOTYPE; PREMENOPAUSE; PRIORITY JOURNAL; WAIST HIP RATIO; BLOOD; GLUCOSE CLAMP TECHNIQUE; METABOLISM; MIDDLE AGED; PREDICTION AND FORECASTING;

ADULT; BODY FAT DISTRIBUTION; FEMALE; GHRELIN; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN; INTRA-ABDOMINAL FAT; MIDDLE AGED; OBESITY; PREDICTIVE VALUE OF TESTS; PREMENOPAUSE; WAIST-HIP RATIO;

EID: 62649150785     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-08-0735     Document Type: Article

References (22)

1. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA & Bloom SR. Ghrelin enhances appetite and increases food intake in humans. Journal of Clinical Endocrinology and Metabolism 2001 86 5992.
2. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E & Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001 50 707-709.
3. Katsuki A, Urakawa H, Gabazza EC, Murashima S, Nakatani K, Togashi K, Yano Y, Adachi Y & Sumida Y. Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus. European Journal of Endocrinology 2004 151 573-577.
4. Flanagan DE, Evans ML, Monsod TP, Rife F, Heptulla RA, Tamborlane WV & Sherwin RS. The influence of insulin on circulating ghrelin. American Journal of Physiology. Endocrinology and Metabolism 2003 284 E313-E316.
5. Gormsen LC, Nielsen C, Gjedsted J, Gjedde S, Vestergaard ET, Christiansen JS, Jorgensen JO & Moller N. Effects of free fatty acids, growth hormone and growth hormone receptor blockade on serum ghrelin levels in humans. Clinical Endocrinology 2007 66 641-645.
6. Nielsen S & Jensen MD. Obesity and cardiovascular disease: is body structure a factor? Current Opinion in Lipidology 1997 8 200-204.
7. Yildiz BO, Suchard MA, Wong ML, McCann SM & Licinio J. Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. PNAS 2004 101 10434-10439.
8. Jensen MD, Haymond MW, Rizza RA, Cryer PE & Miles JM. Influence of body fat distribution on free fatty acid metabolism in obesity. Journal of Clinical Investigation 1989 83 1168-1173.
9. Ritland L, Alekel D, Matvienko O, Hanson K, Stewart J, Hanson L, Reddy M, Van Loan M & Genschel U. Centrally-located body fat is related to appetitive hormones in healthy postmenopausal women. European Journal of Endocrinology 2008 158 889-897.
10. Lindeman JH, Pijl H, Van Dielen FM, Lentjes EG, Van LC & Kooistra T. Ghrelin and the hyposomatotropism of obesity. Obesity Research 2002 10 1161-1166.
11. Purnell JQ, Weigle DS, Breen P & Cummings DE. Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans. Journal of Clinical Endocrinology and Metabolism 2003 88 5747-5752.
12. Jensen MD, Kanaley JA, Reed JE & Sheedy PF. Measurement of abdominal and visceral fat with computed tomography and dual-energy X-ray absorptiometry. American Journal of Clinical Nutrition 1995 61 274-278.
13. English PJ, Ghatei MA, Malik IA, Bloom SR & Wilding JPH. Food fails to suppress ghrelin levels in obese humans. Journal of Clinical Endocrinology and Metabolism 2002 87 2984.
14. Choi SC. Tests of equality of dependent correlation coefficients. Biometrika 1977 64 645-647.
15. Beaumont NJ, Skinner VO, Tan TMM, Ramesh BS, Byrne DJ, MacColl GS, Keen JN, Bouloux PM, Mikhailidis DP, Bruckdorfer KR, Vanderpump MP & Srai KS. Ghrelin can bind to a species of high density lipoprotein associated with paraoxonase. Journal of Biological Chemistry 2003 278 8877-8880.
16. Schutte AE, Huisman HW, Schutte R, van Rooyen JM, Malan L & Malan NT. Aging influences the level and functions of fasting plasma ghrelin levels: the POWIRS-study. Regulatory Peptides 2007 139 65-71.
17. Krsek M, Rosicka M, Haluzik M, Svobodova J, Kotrlikova E, Justova V, Lacinova Z & Jarkovska Z. Plasma ghrelin levels in patients with short bowel syndrome. Endocrine Research 2002 28 27-33.
18. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K & Nakao K. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. Journal of Clinical Endocrinology and Metabolism 2001 86 4753-4758.
19. Marin P, Andersson B, Ottosson M, Olbe L, Chowdhury B, Kvist H, Holm G, Sjostrom L & Bjorntorp P. The morphology and metabolism of intraabdominal adipose tissue in men. Metabolism 1992 41 1242-1248.
20. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H & Oikawa S. Effects of insulin, leptin, and glucagon on ghrelin secretion from isolated perfused rat stomach. Regulatory Peptides 2004 119 77-81.
21. St-Pierre DH, Bastard JP, Coderre L, Brochu M, Karelis AD, Lavoie ME, Malita F, Fontaine J, Mignault D, Cianflone K, Imbeault P, Doucet E & Rabasa-Lhoret R. Association of acylated ghrelin profiles with chronic inflammatory markers in overweight and obese postmenopausal women: a MONET study. European Journal of Endocrinology 2007 157 419-426.
22. Barazzoni R, Zanetti M, Ferreira C, Vinci P, Pirulli A, Mucci M, Dore F, Fonda M, Ciocchi B, Cattin L & Guarnieri G. Relationships between desacylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome. Journal of Clinical Endocrinology and Metabolism 2007 92 3935-3940.