GOAT induced ghrelin acylation regulates hedonic feeding

Hormones and Behavior

Volumn 62, Issue 5, 2012, Pages 598-604

  Davis, J F ^a   Perello, M ^b   Choi, D L ^a   Magrisso, I J ^a   Kirchner, H ^a   Pfluger, P T ^a   Tschoep, M ^a   Zigman, J M ^b   Benoit, S C ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Ghrelin; GOAT; Hedonic feeding; Operant responding; Orexin; Reward

Indexed keywords

ACYLTRANSFERASE; GHRELIN; GHRELIN O ACYLTRANSFERASE; GHRELIN RECEPTOR; OREXIN 1 RECEPTOR; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BRAIN REGION; CONTROLLED STUDY; ENZYME ACTIVITY; FEEDING; FEEDING BEHAVIOR; FOOD; GLUCOSE BLOOD LEVEL; HEDONIC FEEDING; HORMONE BLOOD LEVEL; LIPID DIET; MALE; MOTIVATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REWARD; SIGNAL TRANSDUCTION;

ACYLATION; ACYLTRANSFERASES; ANIMALS; APPETITE REGULATION; BLOOD GLUCOSE; BODY WEIGHT; FEEDING BEHAVIOR; GHRELIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTIVATION; NEUROPEPTIDES;

EID: 84868210192     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2012.08.009     Document Type: Article

References (32)

1. Abizaid A., Liu Z.W., et al. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 2006, 116(12):3229-3239.
2. Alhadeff A.L., Rupprecht L.E., Hayes M.R. GLP neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control food intake. Endocrinology 2012, 153(2):647-658.
3. Borgland S.L., Chang S.J., et al. Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. J. Neurosci. 2009, 29(36):11215-11225.
4. Carroll M.E., Meisch R.A. The effects of feeding conditions on drug-reinforced behavior: maintenance at reduced body weight versus availability of food. Psychopharmacology (Berl) 1980, 68(2):121-124.
5. Carroll M.E., France C.P., et al. Food deprivation increases oral and intravenous drug intake in rats. Science 1979, 205(4403):319-321.
6. Choi D.L., Davis J.F., Magrisso I.J., Fitzgerald M.E., Lipton J.W., Benoit S.C. Neuroscience 2012, 210:243-248. (Electronic publication 2012 Mar 2, May 17).
7. Choi D.L., Davis J.F., et al. The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats. Neuroscience 2010, 167(1):11-20.
8. Gonzalez C.R., Vazquez M.J., et al. Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa. J. Mol. Endocrinol. 2008, 41(6):415-421.
9. Gutierrez J.A., Solenberg P.J., et al. Ghrelin octanoylation mediated by an orphan lipid transferase. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(17):6320-6325.
10. Holst B., Schwartz T. Constitutive ghrelin receptor activity as a signaling set point in appetite regulation. Trends Pharmacol. Sci. 2004, 25(3):113-117.
11. Jerlhag E., Egecioglu E., et al. Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward. Addict. Biol. 2006, 11(1):45-54.
12. Jerlhag E., Egecioglu E., et al. Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addict. Biol. 2007, 12(1):6-16.
13. Jerlhag E., Egecioglu E., Landgren S., Salome N., Heilig M., et al. Requirement of central ghrelin signaling for alcohol reward. PNAS 2009, 106(27):11318-11323.
14. Jerlhag E., Egecioglu E., Dikson S., Engel J. Ghrelin receptor antagonism attenuates cocaine and amphetamine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference. Psychopharmacology 2010, 211(4):415-422.
15. Kirchner H., Gutierrez J.A., et al. GOAT links dietary lipids with the endocrine control of energy balance. Nat. Med. 2009, 15(7):741-745.
16. Kojima M., Hosoda H., et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402(6762):656-660.
17. Kojima M., Hosoda H., Matsuo H., Kangawa K. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol. Metab. 2001, 12(3):118-122.
18. Malik S., McGlone F., Bedrossian D., Dagher A. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab. 2008, 7:400-409.
19. Matsumoto M., Hosoda H., Kitajima Y., Morozumi N., Minamitake Y., et al. Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides. Biochem. Biophys. Res. Commun. 2001, 287(1):142-146.
20. McCallum S.E., Taraschenko O.D., Hathaway E.R., Vincent M.Y., Glick S.D. Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats. Psychopharmacology (Berl) 2011, 215:247-256.
21. Mukai K., Kim J., et al. Electrophysiological effects of orexin/hypocretin on nucleus accumbens shell neurons in rats: an in vitro study. Peptides 2009, 30(8):1487-1496.
22. Perello M., Zigman J.M. The role of ghrelin in reward-based eating. Biol. Psychiatry 2012, Electronic publication ahead of print.
23. Perello M., Sakata I., et al. Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. Biol. Psychiatry 2010, 67(9):880-886.
24. Sakata I., Yang J., Lee C.E., Osborne-Lawrence S., Rovinsky S.A., Elmquist J.K., Zigman J.M. Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am. J. Physiol. Endocrinol. Metab. 2009, 29(1):E134-E141. (Jul).
25. Skibicka K.P., Hansson C., Alvarez-Crespo M., Friberg P.A., Dickson S.L. Ghrelin directly targets the ventral tegmental area to increase food motivation. Neuroscience 2011, 180:129-137.
26. Skibicka K.P., Hansson C., Egecioglu E., Dickson S.L. Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression. Addict. Biol. 2012, 17:95-107.
27. Toshinai K., Yamaguchi H., Sun Y., Smith R., Yamanaka A., et al. Des-acyl ghrelin stimulates food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology 2006, 147(5):2306-2314.
28. Tschop M., Smiley D.L., et al. Ghrelin induces adiposity in rodents. Nature 2000, 407(6806):908-913.
29. Yang J., Brown M.S., Liang G., Grishin N.V., Goldstein J.L. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008, 132(3):387-396. (Feb 8).
30. Zhao T.J., Liang G., et al. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(16):7467-7472.
31. Zheng H., Patterson L.M., et al. Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J. Neurosci. 2007, 27(41):11075-11082.
32. Zigman J.M., Nakano Y., et al. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J. Clin. Invest. 2005, 115(12):3564-3572.