Nutritional state affects the expression of the obesity-associated genes Etv5, faim2, Fto, and negr1

Obesity

Volumn 20, Issue 12, 2012, Pages 2420-2425

  Boender, Arjen J ^a   Van Rozen, Andrea J ^a   Adan, Roger A H ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FAS APOPTOTIC INHIBITING MOLECULE 2; NEURAL GROWTH REGULATOR 1; NEURONAL APOPTOSIS INHIBITORY PROTEIN; PROTEIN SH2; PROTEIN SH2B1; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR ETS 5; UNCLASSIFIED DRUG;

ANATOMICAL VARIATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; ETV5 GENE; FAIM2 GENE; FEEDING BEHAVIOR; FTO GENE; GENE; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; MALE; MOUSE; NEGR1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUTRITIONAL STATUS; OBESITY; PATHOGENESIS; SH2B1 GENE; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL ADHESION MOLECULES, NEURONAL; DNA-BINDING PROTEINS; ENERGY INTAKE; ENERGY METABOLISM; FEEDING BEHAVIOR; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GPI-LINKED PROTEINS; MALE; NERVE TISSUE PROTEINS; NUTRITIONAL STATUS; OBESITY; PROTEINS; RATS; RATS, WISTAR; TRANSCRIPTION FACTORS;

EID: 84870301814     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2012.128     Document Type: Article

References (31)

1. Lewis CE, McTigue KM, Burke LE et al. Mortality, health outcomes, and body mass index in the overweight range: a science advisory from the American Heart Association. Circulation 2009;119:3263-3271.
2. Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 1997;27:325-351.
3. Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. JAMA 1986;256:51-54.
4. Thorleifsson G, Walters GB, Gudbjartsson DF et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009;41:18-24.
5. Willer CJ, Speliotes EK, Loos RJ et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34.
6. Bauer F, Elbers CC, Adan RA et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr 2009;90:951-959.
7. Hagan MM, Rushing PA, Schwartz MW et al. Role of the CNS melanocortin system in the response to overfeeding. J Neurosci 1999;19:2362-2367.
8. Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 2007;27:14265-14274.
9. Gutierrez-Aguilar R, Kim DH, Woods SC, Seeley RJ. Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Obesity (Silver Spring) 2012;20:306-312.
10. Olszewski PK, Fredriksson R, Olszewska AM et al. Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci 2009;10:129.
11. Tung YC, Ayuso E, Shan X et al. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS ONE 2010;5:e8771.
12. Fredriksson R, Hägglund M, Olszewski PK et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 2008;149:2062-2071.
13. Garfield AS, Lam DD, Marston OJ, Przydzial MJ, Heisler LK. Role of central melanocortin pathways in energy homeostasis. Trends Endocrinol Metab 2009;20:203-215.
14. Zhou QY, Palmiter RD. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 1995;83:1197-1209.
15. la Fleur SE, van Rozen AJ, Luijendijk MC, Groeneweg F, Adan RA. A freechoice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia. Int J Obes (Lond) 2010;34:537-546.
16. Schlesser HN, Simon L, Hofmann MC et al. Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice. Biol Reprod 2008;78:483-489.
17. Reich A, Spering C, Gertz K et al. Fas/CD95 regulatory protein Faim2 is neuroprotective after transient brain ischemia. J Neurosci 2011;31:225-233.
18. Reich A, Spering C, Schulz JB. Death receptor Fas (CD95) signaling in the central nervous system: tuning neuroplasticity? Trends Neurosci 2008;31:478-486.
19. Hashimoto T, Yamada M, Maekawa S, Nakashima T, Miyata S. IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons. Brain Res 2008;1224:1-11.
20. Hashimoto T, Maekawa S, Miyata S. IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neurons. Cell Biochem Funct 2009;27:496-498.
21. Pinto S, Roseberry AG, Liu H et al. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 2004;304:110-115.
22. Gerken T, Girard CA, Tung YC et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007;318:1469-1472.
23. Jia G, Yang CG, Yang S et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett 2008;582:3313-3319.
24. Fischer J, Koch L, Emmerling C et al. Inactivation of the Fto gene protects from obesity. Nature 2009;458:894-898.
25. Church C, Moir L, McMurray F et al. Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 2010;42:1086-1092.
26. Ren D, Li M, Duan C, Rui L. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab 2005;2:95-104.
27. Walters RG, Jacquemont S, Valsesia A et al. A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature 2010;463:671-675.
28. Ren D, Zhou Y, Morris D et al. Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest 2007;117:397-406.
29. Tiesjema B, Adan RA, Luijendijk MC, Kalsbeek A, la Fleur SE. Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior. J Neurosci 2007;27:14139-14146.
30. Stratigopoulos G, Padilla SL, LeDuc CA et al. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol 2008;294:R1185-R1196.
31. Münzberg H, Flier JS, Bjørbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004;145:4880-4889.