Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO

American Journal of Clinical Nutrition

Volumn 90, Issue 5, 2009, Pages 1426-1432

  Den Hoed, Marcel ^a   Westerterp Plantenga, Margriet S ^a   Bouwman, Freek G ^a   Mariman, Edwin C M ^a   Westerterp, Klaas R ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3B; LEPTIN; LEPTIN RECEPTOR;

ADULT; APPETITE; ARTICLE; BODY MASS; CONTROLLED STUDY; DNA METHYLATION; ENERGY BALANCE; FAT MASS AND OBESITY ASSOCIATED GENE; FEMALE; GENE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC EPISTASIS; GENOTYPE; HETEROZYGOTE; HUMAN; HUNGER; MALE; OBESITY; POSTPRANDIAL STATE; SATIETY; SINGLE NUCLEOTIDE POLYMORPHISM; VISUAL ANALOG SCALE;

ADOLESCENT; ADULT; BODY MASS INDEX; CARRIER STATE; CUES; DNA METHYLATION; EATING; ENERGY INTAKE; EPISTASIS, GENETIC; FEMALE; GENOTYPE; HUMANS; HUNGER; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTPRANDIAL PERIOD; PROTEINS; SATIETY RESPONSE; YOUNG ADULT;

EID: 70350647201     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2009.28053     Document Type: Article

References (46)

1. Bell CG, Walley AJ, Froguel P. The genetics of human obesity. Nat Rev Genet 2005;6:221-234
2. Faith MS, Pietrobelli A, Nunez C, Heo M, Heymsfield SB, Allison DB. Evidence for independent genetic influences on fat mass and body mass index in a pediatric twin sample. Pediatrics 1999;104:61-67 (Pubitemid 29315848)
3. Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. JAMA 1986;256:51-54
4. Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724-726 (Pubitemid 46848595)
5. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894
6. Hinney A, Nguyen TT, Scherag A, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One 2007;2: e1361. (Pubitemid 351753322)
7. Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007;3:e115. (Pubitemid 47203970)
8. Loos RJ, Lindgren CM, Li S, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008;40: 768-775 (Pubitemid 351748863)
9. Meyre D, Delplanque J, Chevre JC, et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 2009;41:157-159
10. Thorleifsson G, Walters GB, Gudbjartsson DF, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009;41:18-24.
11. Willer CJ, Speliotes EK, Loos RJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34.
12. Lindgren CM, Heid IM, Randall JC, et al. Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genet 2009;5:e1000508.
13. Fredriksson R, Hagglund M, Olszewski PK, et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 2008;149:2062-2071 (Pubitemid 351574484)
14. Gerken T, Girard CA, Tung YC, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007;318:1469-1472 (Pubitemid 350208961)
15. Stratigopoulos G, Padilla SL, Leduc CA, et al. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol 2008;294:R1185-96.
16. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 2008;359:2558-2566
17. Timpson NJ, Emmett PM, Frayling TM, et al. The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr 2008;88: 971-978
18. Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, Plomin R. Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 2008;93:3640-3643
19. Wardle J, Llewellyn C, Sanderson S, Plomin R. The FTO gene and measured food intake in children. Int J Obes (Lond) 2009;33:42-45
20. Schachter S. Obesity and eating. Internal and external cues differentially affect the eating behavior of obese and normal subjects. Science 1968; 161:751-756
21. Qi L, Kang K, Zhang C, et al. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes 2008;57:3145-3151
22. Diepvens K, Häberer D, Westerterp-Plantenga M. Different proteins and biopeptides differently affect satiety and anorexigenic/orexigenic hormones in healthy humans. Int J Obes (Lond) 2008;32:510-518
23. Lejeune MP, Westerterp KR, Adam TC, Luscombe-Marsh ND, Westerterp- Plantenga MS. Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber. Am J Clin Nutr 2006;83:89-94.
24. Smeets AJ, Soenen S, Luscombe-Marsh ND, Ueland O, Westerterp- Plantenga MS. Energy expenditure, satiety, and plasma ghrelin, glucagon-like peptide 1, and peptide tyrosine-tyrosine concentrations following a single high-protein lunch. J Nutr 2008;138:698-702.
25. Veldhorst M, Smeets A, Soenen S, et al. Protein-induced satiety: effects and mechanisms of different proteins. Physiol Behav 2008;94:300-307 (Pubitemid 351615432)
26. Harris JA, Benedict FG. A biometric study of basal metabolism in man. Washington, DC: Carnegie Institution of Washington, 1919:279.
27. Lee SJ, Jeon HS, Jang JS, et al. DNMT3B polymorphisms and risk of primary lung cancer. Carcinogenesis 2005;26:403-409 (Pubitemid 40246562)
28. Shen H, Wang L, Spitz MR, Hong WK, Mao L, Wei Q. A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. Cancer Res 2002;62:4992-4995 (Pubitemid 34984424)
29. Hoffstedt J, Eriksson P, Mottagui-Tabar S, Arner P. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res 2002;34:355-359 (Pubitemid 34912628)
30. Mammes O, Betoulle D, Aubert R, Herbeth B, Siest G, Fumeron F. Association of the G-2548A polymorphism in the 5′ region of the LEP gene with overweight. Ann Hum Genet 2000;64:391-394 (Pubitemid 32055730)
31. Chagnon YC, Chung WK, Perusse L, Chagnon M, Leibel RL, Bouchard C. Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Quebec Family Study. Int J Obes Relat Metab Disord 1999;23:278-286 (Pubitemid 29118858)
32. Mattevi VS, Zembrzuski VM, Hutz MH. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord 2002;26:1179-1185
33. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D, Mantzoros CS. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab 2001;86:4434-4439 (Pubitemid 32848571)
34. Heidema AG, Feskens EJ, Doevendans PA, et al. Analysis of multiple SNPs in genetic association studies: comparison of three multi-locus methods to prioritize and select SNPs. Genet Epidemiol 2007;31:910-921
35. den Hoed M, Smeets AJ, Veldhorst MA, et al. SNP analyses of postprandial responses in (an)orexigenic hormones and feelings of hunger reveal long-term physiological adaptations to facilitate homeostasis. Int J Obes (Lond) 2008;32:1790-1798
36. Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat Rev Genet 2000;1:11-19
37. Wang J, BhutaniM, PathakAK, et al.DeltaDNMT3Bvariants regulateDNA methylation in a promoter-specific manner. Cancer Res 2007;67:10647-10652 (Pubitemid 350145888)
38. Kangaspeska S, Stride B, Metivier R, et al. Transient cyclical methylation of promoter DNA. Nature 2008;452:112-115 (Pubitemid 351355094)
39. Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyl-transferase gene results in embryonic lethality. Cell 1992;69:915-926
40. Waterland RA, Travisano M, Tahiliani KG, Rached MT, Mirza S. Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes (Lond) 2008;32:1373-1379
41. Fischer J, Koch L, Emmerling C, et al. Inactivation of the Fto gene protects from obesity. Nature 2009;458:894-898
42. Speakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 2008;16:1961-1965
43. Clément K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392:398-401. (Pubitemid 28168737)
44. Lahlou N, Clement K, Carel JC, et al. Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass. Diabetes 2000;49:1347-1352 (Pubitemid 30624236)
45. Westerterp-Plantenga MS, Saris WH, Hukshorn CJ, Campfield LA. Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men. Am J Clin Nutr 2001;74:426-434
46. Do R, Bailey SD, Desbiens K, et al. Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes 2008;57:1147-1150