-
1
-
-
82755186505
-
Year in review 2010: Critical Care-Multiple organ dysfunction and sepsis
-
de Montmollin E, Annane D: Year in review 2010: Critical Care-Multiple organ dysfunction and sepsis. Crit Care 2011; 15:236
-
(2011)
Crit Care
, vol.15
, pp. 236
-
-
De Montmollin, E.1
Annane, D.2
-
2
-
-
79953090085
-
Multiple organ failure in sepsis: Prognosis and role of systemic inflammatory response
-
Gustot T: Multiple organ failure in sepsis: Prognosis and role of systemic inflammatory response. Curr Opin Crit Care 2011; 17:153-159
-
(2011)
Curr Opin Crit Care
, vol.17
, pp. 153-159
-
-
Gustot, T.1
-
4
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
-
(2001)
Crit Care Med
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
-
5
-
-
75149172745
-
The acute inflammatory response in trauma/hemorrhage and traumatic brain injury: Current state and emerging prospects
-
Namas R, Ghuma A, Hermus L, et al: The acute inflammatory response in trauma/hemorrhage and traumatic brain injury: Current state and emerging prospects. Libyan J Med 2009; 4:97-103
-
(2009)
Libyan J Med
, vol.4
, pp. 97-103
-
-
Namas, R.1
Ghuma, A.2
Hermus, L.3
-
6
-
-
69949086750
-
Global patterns of mortality in young people: A systematic analysis of population health data
-
Patton GC, Coffey C, Sawyer SM, et al: Global patterns of mortality in young people: A systematic analysis of population health data. Lancet 2009; 374:881-892
-
(2009)
Lancet
, vol.374
, pp. 881-892
-
-
Patton, G.C.1
Coffey, C.2
Sawyer, S.M.3
-
8
-
-
57749172576
-
Mechanistic simulations of inflammation: Current state and future prospects
-
Vodovotz Y, Constantine G, Rubin J, et al: Mechanistic simulations of inflammation: Current state and future prospects. Math Biosci 2009; 217:1-10
-
(2009)
Math Biosci
, vol.217
, pp. 1-10
-
-
Vodovotz, Y.1
Constantine, G.2
Rubin, J.3
-
9
-
-
80053574934
-
Systems biology and inflammation
-
Yan Q (Ed). Totowa, NJ, Springer Science & Business Media
-
Vodovotz Y, An G: Systems biology and inflammation. In: Systems Biology in Drug Discovery and Development: Methods and Protocols. Yan Q (Ed). Totowa, NJ, Springer Science & Business Media, 2009, pp 181-201
-
(2009)
Systems Biology in Drug Discovery and Development: Methods and Protocols
, pp. 181-201
-
-
Vodovotz, Y.1
An, G.2
-
10
-
-
74549170381
-
Translational systems biology of inflammation and healing
-
Vodovotz Y: Translational systems biology of inflammation and healing. Wound Repair Regen 2010; 18:3-7
-
(2010)
Wound Repair Regen
, vol.18
, pp. 3-7
-
-
Vodovotz, Y.1
-
11
-
-
0031942649
-
Ventilator-induced lung injury: Lessons from experimental studies
-
Dreyfuss D, Saumon G: Ventilator-induced lung injury: Lessons from experimental studies. Am J Respir Crit Care Med 1998; 157:294-323
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 294-323
-
-
Dreyfuss, D.1
Saumon, G.2
-
12
-
-
0031834452
-
Multiple system organ failure. Is mechanical ventilation a contributing factor?
-
Slutsky AS, Tremblay LN: Multiple system organ failure. Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 1998; 157:1721-1725
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 1721-1725
-
-
Slutsky, A.S.1
Tremblay, L.N.2
-
13
-
-
84864247996
-
Computational and systems biology in trauma and sepsis: Current state and future perspectives
-
An G, Nieman G, Vodovotz Y: Computational and systems biology in trauma and sepsis: Current state and future perspectives. Int J Burns Trauma 2012; 2:1-10
-
(2012)
Int J Burns Trauma
, vol.2
, pp. 1-10
-
-
An, G.1
Nieman, G.2
Vodovotz, Y.3
-
14
-
-
0029893535
-
Uncoupling of biological oscillators: A complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome
-
Godin PJ, Buchman TG: Uncoupling of biological oscillators: A complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 1996; 24:1107-1116
-
(1996)
Crit Care Med
, vol.24
, pp. 1107-1116
-
-
Godin, P.J.1
Buchman, T.G.2
-
15
-
-
0035486687
-
Complexity and non-linearity in shock research: Reductionism or synthesis?
-
Neugebauer EA, Willy C, Sauerland S: Complexity and non-linearity in shock research: Reductionism or synthesis? Shock 2001; 16:252-258
-
(2001)
Shock
, vol.16
, pp. 252-258
-
-
Neugebauer, E.A.1
Willy, C.2
Sauerland, S.3
-
16
-
-
33750351769
-
Data-driven modelling of signal-transduction networks
-
Janes KA, Yaffe MB: Data-driven modelling of signal-transduction networks. Nat Rev Mol Cell Biol 2006; 7:820-828
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 820-828
-
-
Janes, K.A.1
Yaffe, M.B.2
-
17
-
-
0035501370
-
Microarrays: Handling the deluge of data and extracting reliable information
-
Hess KR, Zhang W, Baggerly KA, et al: Microarrays: Handling the deluge of data and extracting reliable information. Trends Biotechnol 2001; 19:463-468
-
(2001)
Trends Biotechnol
, vol.19
, pp. 463-468
-
-
Hess, K.R.1
Zhang, W.2
Baggerly, K.A.3
-
18
-
-
58049203835
-
Systems biology of innate immunity
-
Zak DE, Aderem A: Systems biology of innate immunity. Immunol Rev 2009; 227:264-282
-
(2009)
Immunol Rev
, vol.227
, pp. 264-282
-
-
Zak, D.E.1
Aderem, A.2
-
19
-
-
79955904927
-
A dynamic view of trauma/hemorrhage-induced inflammation in mice: Principal drivers and networks
-
Mi Q, Constantine G, Ziraldo C, et al: A dynamic view of trauma/hemorrhage-induced inflammation in mice: Principal drivers and networks. PLoS One 2011; 6:e19424
-
(2011)
PLoS One
, vol.6
-
-
Mi, Q.1
Constantine, G.2
Ziraldo, C.3
-
20
-
-
0029962716
-
Sepsis/SIRS, physiologic classification, severity stratification, relation to cytokine elaboration and outcome prediction in posttrauma critical illness
-
Rixen D, Siegel JH, Friedman HP: "Sepsis/SIRS," physiologic classification, severity stratification, relation to cytokine elaboration and outcome prediction in posttrauma critical illness. J Trauma 1996; 41:581-598
-
(1996)
J Trauma
, vol.41
, pp. 581-598
-
-
Rixen, D.1
Siegel, J.H.2
Friedman, H.P.3
-
21
-
-
36249024081
-
Early versus late onset of multiple organ failure is associated with differing patterns of plasma cytokine biomarker expression and outcome after severe trauma
-
Maier B, Lefering R, Lehnert M, et al: Early versus late onset of multiple organ failure is associated with differing patterns of plasma cytokine biomarker expression and outcome after severe trauma. Shock 2007; 28:668-674
-
(2007)
Shock
, vol.28
, pp. 668-674
-
-
Maier, B.1
Lefering, R.2
Lehnert, M.3
-
22
-
-
80054798414
-
Transcriptomic response of murine liver to severe injury and hemorrhagic shock: A dual-platform microarray analysis
-
Edmonds RD, Vodovotz Y, Lagoa C, et al: Transcriptomic response of murine liver to severe injury and hemorrhagic shock: A dual-platform microarray analysis. Physiol Genomics 2011; 43:1170-1183
-
(2011)
Physiol Genomics
, vol.43
, pp. 1170-1183
-
-
Edmonds, R.D.1
Vodovotz, Y.2
Lagoa, C.3
-
23
-
-
27144509163
-
A network-based analysis of systemic inflammation in humans
-
Inflamm and Host Response to Injury Large Scale Collab. Res. Program
-
Calvano SE, Xiao W, Richards DR, et al; Inflamm and Host Response to Injury Large Scale Collab. Res. Program: A network-based analysis of systemic inflammation in humans. Nature 2005; 437:1032-1037
-
(2005)
Nature
, vol.437
, pp. 1032-1037
-
-
Calvano, S.E.1
Xiao, W.2
Richards, D.R.3
-
24
-
-
84863338100
-
A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine
-
Nieman G, Brown D, Sarkar J, et al: A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Crit Care Med 2012; 40:1052-1063
-
(2012)
Crit Care Med
, vol.40
, pp. 1052-1063
-
-
Nieman, G.1
Brown, D.2
Sarkar, J.3
-
25
-
-
28844441230
-
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis
-
Janes KA, Albeck JG, Gaudet S, et al: A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science 2005; 310:1646-1653
-
(2005)
Science
, vol.310
, pp. 1646-1653
-
-
Janes, K.A.1
Albeck, J.G.2
Gaudet, S.3
-
26
-
-
41849114552
-
Translational systems biology: Introduction of an engineering approach to the pathophysiology of the burn patient
-
An G, Faeder J, Vodovotz Y: Translational systems biology: Introduction of an engineering approach to the pathophysiology of the burn patient. J Burn Care Res 2008; 29:277-285
-
(2008)
J Burn Care Res
, vol.29
, pp. 277-285
-
-
An, G.1
Faeder, J.2
Vodovotz, Y.3
-
29
-
-
80054099633
-
Toward a comprehensive language for biological systems
-
Faeder JR: Toward a comprehensive language for biological systems. BMC Biol 2011; 9:68
-
(2011)
BMC Biol
, vol.9
, pp. 68
-
-
Faeder, J.R.1
-
31
-
-
4043056616
-
In silico design of clinical trials: A method coming of age
-
Clermont G, Bartels J, Kumar R, et al: In silico design of clinical trials: A method coming of age. Crit Care Med 2004; 32:2061-2070
-
(2004)
Crit Care Med
, vol.32
, pp. 2061-2070
-
-
Clermont, G.1
Bartels, J.2
Kumar, R.3
-
32
-
-
21744440089
-
The acute inflammatory response in diverse shock states
-
Chow CC, Clermont G, Kumar R, et al: The acute inflammatory response in diverse shock states. Shock 2005; 24:74-84
-
(2005)
Shock
, vol.24
, pp. 74-84
-
-
Chow, C.C.1
Clermont, G.2
Kumar, R.3
-
33
-
-
57749186048
-
A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior
-
Rivière B, Epshteyn Y, Swigon D, et al: A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior. Math Biosci 2009; 217:19-26
-
(2009)
Math Biosci
, vol.217
, pp. 19-26
-
-
Rivière, B.1
Epshteyn, Y.2
Swigon, D.3
-
34
-
-
0023151749
-
Transient behavior of a chemotaxis system modelling certain types of tissue inflammation
-
Alt W, Lauffenburger DA: Transient behavior of a chemotaxis system modelling certain types of tissue inflammation. J Math Biol 1987; 24:691-722
-
(1987)
J Math Biol
, vol.24
, pp. 691-722
-
-
Alt, W.1
Lauffenburger, D.A.2
-
35
-
-
0035491584
-
Agent-based computer simulation and SIRS: Building a bridge between basic science and clinical trials
-
An G: Agent-based computer simulation and SIRS: Building a bridge between basic science and clinical trials. Shock 2001; 16:266-273
-
(2001)
Shock
, vol.16
, pp. 266-273
-
-
An, G.1
-
36
-
-
4744344132
-
In silico experiments of existing and hypothetical cytokinedirected clinical trials using agent-based modeling
-
An G: In silico experiments of existing and hypothetical cytokinedirected clinical trials using agent-based modeling. Crit Care Med 2004; 32:2050-2060
-
(2004)
Crit Care Med
, vol.32
, pp. 2050-2060
-
-
An, G.1
-
37
-
-
57849103868
-
A model of TLR4 signaling and tolerance using a qualitative, particle-event-based method: Introduction of spatially configured stochastic reaction chambers (SCSRC)
-
An G: A model of TLR4 signaling and tolerance using a qualitative, particle-event-based method: Introduction of spatially configured stochastic reaction chambers (SCSRC). Math Biosci 2009; 217:43-52
-
(2009)
Math Biosci
, vol.217
, pp. 43-52
-
-
An, G.1
-
38
-
-
57849158644
-
Detailed qualitative dynamic knowledge representation using a BioNetGen model of TLR-4 signaling and preconditioning
-
An GC, Faeder JR: Detailed qualitative dynamic knowledge representation using a BioNetGen model of TLR-4 signaling and preconditioning. Math Biosci 2009; 217:53-63
-
(2009)
Math Biosci
, vol.217
, pp. 53-63
-
-
An, G.C.1
Faeder, J.R.2
-
39
-
-
77957900134
-
Analysis and verification of the HMGB1 signaling pathway
-
Gong H, Zuliani P, Komuravelli A, et al: Analysis and verification of the HMGB1 signaling pathway. BMC Bioinformatics 2010; 11(Suppl 7):S10
-
(2010)
BMC Bioinformatics
, vol.11
, Issue.SUPPL. 7
-
-
Gong, H.1
Zuliani, P.2
Komuravelli, A.3
-
40
-
-
32044469862
-
A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity
-
Blinov ML, Faeder JR, Goldstein B, et al: A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity. Biosystems 2006; 83:136-151
-
(2006)
Biosystems
, vol.83
, pp. 136-151
-
-
Blinov, M.L.1
Faeder, J.R.2
Goldstein, B.3
-
41
-
-
0034790629
-
Molecular signatures of sepsis: Multiorgan gene expression profiles of systemic inflammation
-
Chinnaiyan AM, Huber-Lang M, Kumar-Sinha C, et al: Molecular signatures of sepsis: Multiorgan gene expression profiles of systemic inflammation. Am J Pathol 2001; 159:1199-1209
-
(2001)
Am J Pathol
, vol.159
, pp. 1199-1209
-
-
Chinnaiyan, A.M.1
Huber-Lang, M.2
Kumar-Sinha, C.3
-
44
-
-
2942678943
-
Injury research in the genomic era
-
Cobb JP, O'Keefe GE: Injury research in the genomic era. Lancet 2004; 363:2076-2083
-
(2004)
Lancet
, vol.363
, pp. 2076-2083
-
-
Cobb, J.P.1
O'Keefe, G.E.2
-
45
-
-
2442587841
-
Differential gene expression in gram-negative and gram-positive sepsis
-
Yu SL, Chen HW, Yang PC, et al: Differential gene expression in gram-negative and gram-positive sepsis. Am J Respir Crit Care Med 2004; 169:1135-1143
-
(2004)
Am J Respir Crit Care Med
, vol.169
, pp. 1135-1143
-
-
Yu, S.L.1
Chen, H.W.2
Yang, P.C.3
-
46
-
-
33846069325
-
Microarray-based analysis of ventilator-induced lung injury
-
Wurfel MM: Microarray-based analysis of ventilator-induced lung injury. Proc Am Thorac Soc 2007; 4:77-84
-
(2007)
Proc Am Thorac Soc
, vol.4
, pp. 77-84
-
-
Wurfel, M.M.1
-
47
-
-
84856707802
-
Clinical review: Sepsis and septic shock-The potential of gene arrays
-
Wong HR: Clinical review: Sepsis and septic shock-The potential of gene arrays. Crit Care 2012; 16:204
-
(2012)
Crit Care
, vol.16
, pp. 204
-
-
Wong, H.R.1
-
48
-
-
84862908403
-
A genomic storm in critically injured humans
-
Inflammation and Host Response to Injury Large-Scale Collaborative Research Program
-
Xiao W, Mindrinos MN, Seok J, et al; Inflammation and Host Response to Injury Large-Scale Collaborative Research Program: A genomic storm in critically injured humans. J Exp Med 2011; 208:2581-2590
-
(2011)
J Exp Med
, vol.208
, pp. 2581-2590
-
-
Xiao, W.1
Mindrinos, M.N.2
Seok, J.3
-
49
-
-
77952163906
-
Translational systems approaches to the biology of inflammation and healing
-
Vodovotz Y, Constantine G, Faeder J, et al: Translational systems approaches to the biology of inflammation and healing. Immunopharmacol Immunotoxicol 2010; 32:181-195
-
(2010)
Immunopharmacol Immunotoxicol
, vol.32
, pp. 181-195
-
-
Vodovotz, Y.1
Constantine, G.2
Faeder, J.3
-
50
-
-
77957580213
-
Translational systems biology of inflammation: Potential applications to personalized medicine
-
Mi Q, Li NY, Ziraldo C, et al: Translational systems biology of inflammation: Potential applications to personalized medicine. Per Med 2010; 7:549-559
-
(2010)
Per Med
, vol.7
, pp. 549-559
-
-
Mi, Q.1
Li, N.Y.2
Ziraldo, C.3
-
51
-
-
0034033118
-
Scoring systems for assessing organ dysfunction and survival
-
Vincent JL, Ferreira F, Moreno R: Scoring systems for assessing organ dysfunction and survival. Crit Care Clin 2000; 16:353-366
-
(2000)
Crit Care Clin
, vol.16
, pp. 353-366
-
-
Vincent, J.L.1
Ferreira, F.2
Moreno, R.3
-
52
-
-
0029334924
-
Physiologic state severity classification as an indicator of posttrauma cytokine response
-
Rixen D, Siegel JH, Abu-Salih A, et al: Physiologic state severity classification as an indicator of posttrauma cytokine response. Shock 1995; 4:27-38
-
(1995)
Shock
, vol.4
, pp. 27-38
-
-
Rixen, D.1
Siegel, J.H.2
Abu-Salih, A.3
-
53
-
-
0030640878
-
Plasma nitric oxide in posttrauma critical illness: A function of "sepsis" and the physiologic state severity classification quantifying the probability of death
-
Rixen D, Siegel JH, Espina N, et al: Plasma nitric oxide in posttrauma critical illness: A function of "sepsis" and the physiologic state severity classification quantifying the probability of death. Shock 1997; 7:17-28
-
(1997)
Shock
, vol.7
, pp. 17-28
-
-
Rixen, D.1
Siegel, J.H.2
Espina, N.3
-
54
-
-
79951927866
-
Focus issue: Conquering the data mountain
-
Gough NR, Yaffe MB: Focus issue: Conquering the data mountain. Sci Signal 2011; 4:eg2
-
(2011)
Sci Signal
, vol.4
-
-
Gough, N.R.1
Yaffe, M.B.2
-
55
-
-
0037251105
-
Proteomics and systems biology approaches to signal transduction in sepsis
-
Nguyen A, Yaffe MB: Proteomics and systems biology approaches to signal transduction in sepsis. Crit Care Med 2003; 31(1 Suppl):S1-S6
-
(2003)
Crit Care Med
, vol.31
, Issue.1 SUPPL.
-
-
Nguyen, A.1
Yaffe, M.B.2
-
56
-
-
45349102367
-
Plasticity of the systemic inflammatory response to acute infection during critical illness: Development of the riboleukogram
-
McDunn JE, Husain KD, Polpitiya AD, et al: Plasticity of the systemic inflammatory response to acute infection during critical illness: Development of the riboleukogram. PLoS One 2008; 3:e1564
-
(2008)
PLoS One
, vol.3
-
-
McDunn, J.E.1
Husain, K.D.2
Polpitiya, A.D.3
-
57
-
-
70349239233
-
Identification of pediatric septic shock subclasses based on genome-wide expression profiling
-
Wong HR, Cvijanovich N, Lin R, et al: Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med 2009; 7:34
-
(2009)
BMC Med
, vol.7
, pp. 34
-
-
Wong, H.R.1
Cvijanovich, N.2
Lin, R.3
-
58
-
-
77953426735
-
Analysis of factorial time-course microarrays with application to a clinical study of burn injury
-
Inflammation and Host Response to Injury Program
-
Zhou B, Xu W, Herndon D, et al; Inflammation and Host Response to Injury Program: Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A 2010; 107:9923-9928
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 9923-9928
-
-
Zhou, B.1
Xu, W.2
Herndon, D.3
-
59
-
-
79958809160
-
Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis
-
Sutherland A, Thomas M, Brandon RA, et al: Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis. Crit Care 2011; 15:R149
-
(2011)
Crit Care
, vol.15
-
-
Sutherland, A.1
Thomas, M.2
Brandon, R.A.3
-
60
-
-
33750629023
-
High dynamic range characterization of the trauma patient plasma proteome
-
Inflammation and the Host Response to Injury Large Scale Collaborative Research Program
-
Liu T, Qian WJ, Gritsenko MA, et al; Inflammation and the Host Response to Injury Large Scale Collaborative Research Program: High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics 2006; 5:1899-1913
-
(2006)
Mol Cell Proteomics
, vol.5
, pp. 1899-1913
-
-
Liu, T.1
Qian, W.J.2
Gritsenko, M.A.3
-
61
-
-
77956330708
-
Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics
-
Inflammation and the Host Response to Injury Large Scale Collaborative Research Program
-
Qian WJ, Petritis BO, Kaushal A, et al; Inflammation and the Host Response to Injury Large Scale Collaborative Research Program: Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics. J Proteome Res 2010; 9:4779-4789
-
(2010)
J Proteome Res
, vol.9
, pp. 4779-4789
-
-
Qian, W.J.1
Petritis, B.O.2
Kaushal, A.3
-
62
-
-
0036790111
-
Heart rate variability in critical care medicine
-
Gang Y, Malik M: Heart rate variability in critical care medicine. Curr Opin Crit Care 2002; 8:371-375
-
(2002)
Curr Opin Crit Care
, vol.8
, pp. 371-375
-
-
Gang, Y.1
Malik, M.2
-
63
-
-
11344256331
-
Complex systems and the technology of variability analysis
-
Seely AJ, Macklem PT: Complex systems and the technology of variability analysis. Crit Care 2004; 8:R367-R384
-
(2004)
Crit Care
, vol.8
-
-
Seely, A.J.1
MacKlem, P.T.2
-
64
-
-
67650609140
-
Heart-rate complexity for prediction of prehospital lifesaving interventions in trauma patients
-
Cancio LC, Batchinsky AI, Salinas J, et al: Heart-rate complexity for prediction of prehospital lifesaving interventions in trauma patients. J Trauma 2008; 65:813-819
-
(2008)
J Trauma
, vol.65
, pp. 813-819
-
-
Cancio, L.C.1
Batchinsky, A.I.2
Salinas, J.3
-
65
-
-
77956642489
-
Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis
-
Cohen MJ, Grossman AD, Morabito D, et al: Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care 2010; 14:R10
-
(2010)
Crit Care
, vol.14
-
-
Cohen, M.J.1
Grossman, A.D.2
Morabito, D.3
-
66
-
-
79960393129
-
Use of advanced machine-learning techniques for noninvasive monitoring of hemorrhage
-
Convertino VA, Moulton SL, Grudic GZ, et al: Use of advanced machine-learning techniques for noninvasive monitoring of hemorrhage. J Trauma 2011; 71(1 Suppl):S25-S32
-
(2011)
J Trauma
, vol.71
, Issue.1 SUPPL.
-
-
Convertino, V.A.1
Moulton, S.L.2
Grudic, G.Z.3
-
67
-
-
0036884232
-
Sepsis gene expression profiling: Murine splenic compared with hepatic responses determined by using complementary DNA microarrays
-
Cobb JP, Laramie JM, Stormo GD, et al: Sepsis gene expression profiling: Murine splenic compared with hepatic responses determined by using complementary DNA microarrays. Crit Care Med 2002; 30:2711-2721
-
(2002)
Crit Care Med
, vol.30
, pp. 2711-2721
-
-
Cobb, J.P.1
Laramie, J.M.2
Stormo, G.D.3
-
68
-
-
0442292208
-
Gene expression profiles of livers from thermally injured rats
-
Dasu MR, Cobb JP, Laramie JM, et al: Gene expression profiles of livers from thermally injured rats. Gene 2004; 327:51-60
-
(2004)
Gene
, vol.327
, pp. 51-60
-
-
Dasu, M.R.1
Cobb, J.P.2
Laramie, J.M.3
-
69
-
-
84868357677
-
Toward computational identification of multiscale "tipping points" in acute inflammation and multiple organ failure
-
An G, Nieman G, Vodovotz Y: Toward computational identification of multiscale "tipping points" in acute inflammation and multiple organ failure. Ann Biomed Eng 2012; 40:2414-2424
-
(2012)
Ann Biomed Eng
, vol.40
, pp. 2414-2424
-
-
An, G.1
Nieman, G.2
Vodovotz, Y.3
-
70
-
-
33645957683
-
Concepts for developing a collaborative in silico model of the acute inflammatory response using agent-based modeling
-
discussion 110-111
-
An G: Concepts for developing a collaborative in silico model of the acute inflammatory response using agent-based modeling. J Crit Care 2006; 21:105-110; discussion 110-111
-
(2006)
J Crit Care
, vol.21
, pp. 105-110
-
-
An, G.1
-
71
-
-
84866733126
-
From artificial life to in silico medicine: Net Logo as a means of translational knowledge representation in biomedical research
-
Adamatsky A, Komosinski M (Eds). London, Springer-Verlag
-
An G, Wilensky U: From artificial life to in silico medicine: Net Logo as a means of translational knowledge representation in biomedical research. In: Artificial Life in Software. Adamatsky A, Komosinski M (Eds). London, Springer-Verlag, 2009, pp 183-209
-
(2009)
Artificial Life in Software
, pp. 183-209
-
-
An, G.1
Wilensky, U.2
-
72
-
-
65649091733
-
Dynamic knowledge representation using agent-based modeling: Ontology instantiation and verification of conceptual models
-
An G: Dynamic knowledge representation using agent-based modeling: Ontology instantiation and verification of conceptual models. Methods Mol Biol 2009; 500:445-468
-
(2009)
Methods Mol Biol
, vol.500
, pp. 445-468
-
-
An, G.1
-
73
-
-
74549209507
-
Translational systems biology using an agent-based approach for dynamic knowledge representation: An evolutionary paradigm for biomedical research
-
An GC: Translational systems biology using an agent-based approach for dynamic knowledge representation: An evolutionary paradigm for biomedical research. Wound Repair Regen 2010; 18:8-12
-
(2010)
Wound Repair Regen
, vol.18
, pp. 8-12
-
-
An, G.C.1
-
74
-
-
77955634106
-
Closing the scientific loop: Bridging correlation and causality in the petaflop age
-
An G: Closing the scientific loop: Bridging correlation and causality in the petaflop age. Sci Transl Med 2010; 2:41ps34
-
(2010)
Sci Transl Med
, vol.2
-
-
An, G.1
-
75
-
-
61449164943
-
Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin
-
Bailey AM, Lawrence MB, Shang H, et al: Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin. PLoS Comput Biol 2009; 5:e1000294
-
(2009)
PLoS Comput Biol
, vol.5
-
-
Bailey, A.M.1
Lawrence, M.B.2
Shang, H.3
-
76
-
-
0036500993
-
Systems biology: A brief overview
-
Kitano H: Systems biology: A brief overview. Science 2002; 295:1662-1664
-
(2002)
Science
, vol.295
, pp. 1662-1664
-
-
Kitano, H.1
-
77
-
-
38049150027
-
Complexity, emergence and pathophysiology: Using agent based computer simulation to characterize the non-adaptive inflammatory response
-
Manuscript 344. Accessed December 1, 2000
-
An G, Lee I: Complexity, emergence and pathophysiology: Using agent based computer simulation to characterize the non-adaptive inflammatory response. InterJournal Complex Syst 2000; Manuscript 344. Available at: http://www.interjournal.org Accessed December 1, 2000
-
(2000)
InterJournal Complex Syst
-
-
An, G.1
Lee, I.2
-
78
-
-
33747341838
-
In silico models of acute inflammation in animals
-
Vodovotz Y, Chow CC, Bartels J, et al: In silico models of acute inflammation in animals. Shock 2006; 26:235-244
-
(2006)
Shock
, vol.26
, pp. 235-244
-
-
Vodovotz, Y.1
Chow, C.C.2
Bartels, J.3
-
79
-
-
33747106908
-
A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation
-
Reynolds A, Rubin J, Clermont G, et al: A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation. J Theor Biol 2006; 242:220-236
-
(2006)
J Theor Biol
, vol.242
, pp. 220-236
-
-
Reynolds, A.1
Rubin, J.2
Clermont, G.3
-
80
-
-
33747094446
-
A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration
-
Day J, Rubin J, Vodovotz Y, et al: A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration. J Theor Biol 2006; 242:237-256
-
(2006)
J Theor Biol
, vol.242
, pp. 237-256
-
-
Day, J.1
Rubin, J.2
Vodovotz, Y.3
-
81
-
-
33749022785
-
In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice
-
Prince JM, Levy RM, Bartels J, et al: In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol Med 2006; 12:88-96
-
(2006)
Mol Med
, vol.12
, pp. 88-96
-
-
Prince, J.M.1
Levy, R.M.2
Bartels, J.3
-
82
-
-
33751222859
-
The role of initial trauma in the host's response to injury and hemorrhage: Insights from a correlation of mathematical simulations and hepatic transcriptomic analysis
-
Lagoa CE, Bartels J, Baratt A, et al: The role of initial trauma in the host's response to injury and hemorrhage: Insights from a correlation of mathematical simulations and hepatic transcriptomic analysis. Shock 2006; 26:592-600
-
(2006)
Shock
, vol.26
, pp. 592-600
-
-
Lagoa, C.E.1
Bartels, J.2
Baratt, A.3
-
83
-
-
27644466709
-
Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration
-
Ben-David I, Price SE, Bortz DM, et al: Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration. Am J Respir Cell Mol Biol 2005; 33:476-482
-
(2005)
Am J Respir Cell Mol Biol
, vol.33
, pp. 476-482
-
-
Ben-David, I.1
Price, S.E.2
Bortz, D.M.3
-
84
-
-
20144385752
-
Rule-based modeling of biochemical networks
-
Faeder JR, Blinov ML, Goldstein B, et al: Rule-based modeling of biochemical networks. Complexity 2005; 10:22-41
-
(2005)
Complexity
, vol.10
, pp. 22-41
-
-
Faeder, J.R.1
Blinov, M.L.2
Goldstein, B.3
-
85
-
-
49049088099
-
Stochastic effects and bistability in T cell receptor signaling
-
Lipniacki T, Hat B, Faeder JR, et al: Stochastic effects and bistability in T cell receptor signaling. J Theor Biol 2008; 254:110-122
-
(2008)
J Theor Biol
, vol.254
, pp. 110-122
-
-
Lipniacki, T.1
Hat, B.2
Faeder, J.R.3
-
86
-
-
82955222826
-
The interplay of double phosphorylation and scaffolding in MAPK pathways
-
Kocieniewski P, Faeder JR, Lipniacki T: The interplay of double phosphorylation and scaffolding in MAPK pathways. J Theor Biol 2012; 295:116-124
-
(2012)
J Theor Biol
, vol.295
, pp. 116-124
-
-
Kocieniewski, P.1
Faeder, J.R.2
Lipniacki, T.3
-
87
-
-
4744342992
-
Mathematical models of the acute inflammatory response
-
Vodovotz Y, Clermont G, Chow C, et al: Mathematical models of the acute inflammatory response. Curr Opin Crit Care 2004; 10:383-390
-
(2004)
Curr Opin Crit Care
, vol.10
, pp. 383-390
-
-
Vodovotz, Y.1
Clermont, G.2
Chow, C.3
-
88
-
-
34249826054
-
Challenges and rewards on the road to translational systems biology in acute illness: Four case reports from interdisciplinary teams
-
An G, Hunt CA, Clermont G, et al: Challenges and rewards on the road to translational systems biology in acute illness: Four case reports from interdisciplinary teams. J Crit Care 2007; 22:169-175
-
(2007)
J Crit Care
, vol.22
, pp. 169-175
-
-
An, G.1
Hunt, C.A.2
Clermont, G.3
-
89
-
-
79953894415
-
In silico augmentation of the drug development pipeline: Examples from the study of acute inflammation
-
An G, Bartels J, Vodovotz Y: In silico augmentation of the drug development pipeline: Examples from the study of acute inflammation. Drug Dev Res 2010; 72:187-200
-
(2010)
Drug Dev Res
, vol.72
, pp. 187-200
-
-
An, G.1
Bartels, J.2
Vodovotz, Y.3
-
90
-
-
84861199459
-
Sepsis: Something old, something new, and a systems view
-
Namas R, Zamora R, Namas R, et al: Sepsis: Something old, something new, and a systems view. J Crit Care 2012; 27:314.e1-314.e11
-
(2012)
J Crit Care
, vol.27
-
-
Namas, R.1
Zamora, R.2
Namas, R.3
-
91
-
-
57849104348
-
Modeling endotoxininduced systemic inflammation using an indirect response approach
-
Foteinou PT, Calvano SE, Lowry SF, et al: Modeling endotoxininduced systemic inflammation using an indirect response approach. Math Biosci 2009; 217:27-42
-
(2009)
Math Biosci
, vol.217
, pp. 27-42
-
-
Foteinou, P.T.1
Calvano, S.E.2
Lowry, S.F.3
-
92
-
-
62849112761
-
In silico simulation of corticosteroids effect on an NFkB-dependent physicochemical model of systemic inflammation
-
Foteinou PT, Calvano SE, Lowry SF, et al: In silico simulation of corticosteroids effect on an NFkB-dependent physicochemical model of systemic inflammation. PLoS One 2009; 4:e4706
-
(2009)
PLoS One
, vol.4
-
-
Foteinou, P.T.1
Calvano, S.E.2
Lowry, S.F.3
-
93
-
-
77949496645
-
Agent-based modeling of endotoxin-induced acute inflammatory response in human blood leukocytes
-
Dong X, Foteinou PT, Calvano SE, et al: Agent-based modeling of endotoxin-induced acute inflammatory response in human blood leukocytes. PLoS One 2010; 5:e9249
-
(2010)
PLoS One
, vol.5
-
-
Dong, X.1
Foteinou, P.T.2
Calvano, S.E.3
-
94
-
-
77952597821
-
Modeling the influence of circadian rhythms on the acute inflammatory response
-
Scheff JD, Calvano SE, Lowry SF, et al: Modeling the influence of circadian rhythms on the acute inflammatory response. J Theor Biol 2010; 264:1068-1076
-
(2010)
J Theor Biol
, vol.264
, pp. 1068-1076
-
-
Scheff, J.D.1
Calvano, S.E.2
Lowry, S.F.3
-
95
-
-
79952163506
-
A physiological model for autonomic heart rate regulation in human endotoxemia
-
Foteinou PT, Calvano SE, Lowry SF, et al: A physiological model for autonomic heart rate regulation in human endotoxemia. Shock 2011; 35:229-239
-
(2011)
Shock
, vol.35
, pp. 229-239
-
-
Foteinou, P.T.1
Calvano, S.E.2
Lowry, S.F.3
-
96
-
-
80052072238
-
Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia
-
Scheff JD, Mavroudis PD, Calvano SE, et al: Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia. Physiol Genomics 2011; 43:951-964
-
(2011)
Physiol Genomics
, vol.43
, pp. 951-964
-
-
Scheff, J.D.1
Mavroudis, P.D.2
Calvano, S.E.3
-
97
-
-
84866465712
-
Linking inflammation, cardiorespiratory variability, and neural control in acute inflammation via computational modeling
-
Dick TE, Molkov YI, Nieman G, et al: Linking inflammation, cardiorespiratory variability, and neural control in acute inflammation via computational modeling. Front Physiol 2012; 3:222
-
(2012)
Front Physiol
, vol.3
, pp. 222
-
-
Dick, T.E.1
Molkov, Y.I.2
Nieman, G.3
-
98
-
-
48149096398
-
HMGB1: Endogenous danger signaling
-
Klune JR, Dhupar R, Cardinal J, et al: HMGB1: Endogenous danger signaling. Mol Med 2008; 14:476-484
-
(2008)
Mol Med
, vol.14
, pp. 476-484
-
-
Klune, J.R.1
Dhupar, R.2
Cardinal, J.3
-
99
-
-
43349094278
-
Early events in the recognition of danger signals after tissue injury
-
Kaczorowski DJ, Mollen KP, Edmonds R, et al: Early events in the recognition of danger signals after tissue injury. J Leukoc Biol 2008; 83:546-552
-
(2008)
J Leukoc Biol
, vol.83
, pp. 546-552
-
-
Kaczorowski, D.J.1
Mollen, K.P.2
Edmonds, R.3
-
100
-
-
0036159842
-
Endotoxin tolerance: A review
-
West MA, Heagy W: Endotoxin tolerance: A review. Crit Care Med 2002; 30(1 Suppl):S64-S73
-
(2002)
Crit Care Med
, vol.30
, Issue.1 SUPPL.
-
-
West, M.A.1
Heagy, W.2
-
101
-
-
0037951567
-
Endotoxin tolerance: Is there a clinical relevance?
-
Cavaillon JM, Adrie C, Fitting C, et al: Endotoxin tolerance: Is there a clinical relevance? J Endotoxin Res 2003; 9:101-107
-
(2003)
J Endotoxin Res
, vol.9
, pp. 101-107
-
-
Cavaillon, J.M.1
Adrie, C.2
Fitting, C.3
-
102
-
-
79960132229
-
A dual negative regulation model of Toll-like receptor 4 signaling for endotoxin preconditioning in human endotoxemia
-
Yang Q, Calvano SE, Lowry SF, et al: A dual negative regulation model of Toll-like receptor 4 signaling for endotoxin preconditioning in human endotoxemia. Math Biosci 2011; 232:151-163
-
(2011)
Math Biosci
, vol.232
, pp. 151-163
-
-
Yang, Q.1
Calvano, S.E.2
Lowry, S.F.3
-
103
-
-
84863654528
-
Network topologies and dynamics leading to endotoxin tolerance and priming in innate immune cells
-
Fu Y, Glaros T, Zhu M, et al: Network topologies and dynamics leading to endotoxin tolerance and priming in innate immune cells. PLoS Comput Biol 2012; 8:e1002526
-
(2012)
PLoS Comput Biol
, vol.8
-
-
Fu, Y.1
Glaros, T.2
Zhu, M.3
-
104
-
-
50949091234
-
A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury
-
Li NY, Verdolini K, Clermont G, et al: A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS One 2008; 3:e2789
-
(2008)
PLoS One
, vol.3
-
-
Li, N.Y.1
Verdolini, K.2
Clermont, G.3
-
105
-
-
84878487132
-
Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury
-
Solovyev A, Mi Q, Tzen Y-T, et al: Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury. PLoS Comput Biol 2013; 9:e1003070
-
(2013)
PLoS Comput Biol
, vol.9
-
-
Solovyev, A.1
Mi, Q.2
Tzen, Y.-T.3
-
106
-
-
0031436960
-
Infections in patients with spinal cord injuries
-
Montgomerie JZ: Infections in patients with spinal cord injuries. Clin Infect Dis 1997; 25:1285-1290
-
(1997)
Clin Infect Dis
, vol.25
, pp. 1285-1290
-
-
Montgomerie, J.Z.1
-
107
-
-
84861154162
-
Ensemble models of neutrophil trafficking in severe sepsis
-
Song SO, Hogg J, Peng ZY, et al: Ensemble models of neutrophil trafficking in severe sepsis. PLoS Comput Biol 2012; 8:e1002422
-
(2012)
PLoS Comput Biol
, vol.8
-
-
Song, S.O.1
Hogg, J.2
Peng, Z.Y.3
-
108
-
-
84870827578
-
Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: Insights from in vivo and in silico studies
-
Namas RA, Namas R, Lagoa C, et al: Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: Insights from in vivo and in silico studies. Mol Med 2012; 18:1366-1374
-
(2012)
Mol Med
, vol.18
, pp. 1366-1374
-
-
Namas, R.A.1
Namas, R.2
Lagoa, C.3
-
109
-
-
0036500834
-
Reverse engineering of biological complexity
-
Csete ME, Doyle JC: Reverse engineering of biological complexity. Science 2002; 295:1664-1669
-
(2002)
Science
, vol.295
, pp. 1664-1669
-
-
Csete, M.E.1
Doyle, J.C.2
|