Network topologies and dynamics leading to endotoxin tolerance and priming in innate immune cells

PLoS Computational Biology

Volumn 8, Issue 5, 2012, Pages

  Fu, Yan ^a   Glaros, Trevor ^a   Zhu, Meng ^b   Wang, Ping ^a   Wu, Zhanghan ^a   Tyson, John J ^a   Li, Liwu ^a   Xing, Jianhua ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b AMRL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SIGNALING; COMPLEX NETWORKS; NETWORK TOPOLOGY; SIGNALING;

BACTERIAL ENDOTOXINS; HOST DEFENSE; IMMUNE CELLS; INNATE IMMUNE SYSTEMS; INNATE IMMUNES; INTERCELLULAR SIGNALLING; INTRACELLULAR SIGNALING; NETWORK DYNAMICS; NETWORK TOPOLOGY; SIGNALING NETWORKS;

MACROPHAGES;

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE;

ALGORITHM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS PRESENTATION; CYTOKINE PRODUCTION; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; IMMUNOREGULATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MACROPHAGE ACTIVATION; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEMORY CELL; MOLECULAR DYNAMICS; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PROTEIN EXPRESSION; SYSTEMS BIOLOGY; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; DRUG EFFECT; DRUG TOLERANCE; HUMAN; IMMUNOLOGY; MACROPHAGE; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS);

ANIMALS; COMPUTER SIMULATION; DRUG TOLERANCE; ENDOTOXINS; HUMANS; IMMUNITY, INNATE; LIPOPOLYSACCHARIDES; MACROPHAGES; MODELS, IMMUNOLOGICAL; SIGNAL TRANSDUCTION;

EID: 84863654528     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002526     Document Type: Article

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