In silico simulation of corticosteroids effect on an NFkB-dependent physicochemical model of systemic inflammation

PLoS ONE

Volumn 4, Issue 3, 2009, Pages

  Foteinou, Panagiota T ^a   Calvano, Steve E ^b   Lowry, Stephen F ^b   Androulakis, Ioannis P ^a  

^a RUTGERS UNIVERSITY   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOINFORMATICS; COMPUTER MODEL; COMPUTER PREDICTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; HYPERCORTISOLISM; IMMUNE RESPONSE; PHYSICOCHEMICAL MODEL; SYMPTOMATOLOGY; SYSTEM ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; BIOLOGICAL MODEL; COMPUTER SIMULATION; INFLAMMATION; KINETICS; PHARMACOKINETICS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADRENAL CORTEX HORMONES; COMPUTER SIMULATION; HUMANS; INFLAMMATION; KINETICS; MODELS, BIOLOGICAL; NF-KAPPA B; PHARMACOKINETICS; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 62849112761     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004706     Document Type: Article

References (75)

1. Nystrom PO (1998) The systemic inflammatory response syndrome: definitions and aetiology. J Antimicrob Chemother 41 Suppl A: 1-7.
2. Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348: 138-150.
3. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101: 1644-1655.
4. Tetta C, Fonsato V, Ronco C, Camussi G (2005) Recent insights into the pathogenesis of severe sepsis. Crit Care Resusc 7: 32-39.
5. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, et al. (2004) Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. Bmj 329: 480.
6. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, et al. (2004) Corticosteroids for treating severe sepsis and septic shock. Cochrane Database Syst Rev. CD002243.
7. Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, et al. (2002) Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. Jama 288: 862-871.
8. Arzt E, Sauer J, Pollmacher T, Labeur M, Holsboer F, et al. (1994) Glucocorticoids suppress interleukin-1 receptor antagonist synthesis following induction by endotoxin. Endocrinology 134: 672-677.
9. Bernard GR, Luce JM, Sprung CL, Rinaldo JE, Tate RM, et al. (1987) Highdose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med 317: 1565-1570.
10. Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, et al. (2007) Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med 204: 2439-2448.
11. Marshall JC, Walker PM, Foster DM, Harris D, Ribeiro M, et al. (2002) Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescence. Crit Care 6: 342-348.
12. Meduri GU, Headley AS, Golden E, Carson SJ, Umberger RA, et al. (1998) Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial. Jama 280: 159-165.
13. Riedemann NC, Guo RF, Ward PA (2003) Novel strategies for the treatment of sepsis. Nat Med 9: 517-524.
14. Post TM, Freijer JI, DeJongh J, Danhof M (2005) Disease system analysis: basic disease progression models in degenerative disease. Pharm Res 22: 1038-1049.
15. Lauffenburger DA, Kennedy CR (1980) Analysis of a Lumped Model for Tissue Inflammation Dynamics. Mathematical Biosciences 53: 189-221.
16. Chow CC, Clermont G, Kumar R, Lagoa C, Tawadrous Z, et al. (2005) The acute inflammatory response in diverse shock states. Shock 24: 74-84.
17. Day J, Rubin J, Vodovotz Y, Chow CC, Reynolds A, et al. (2006) A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration. J Theor Biol 242: 237-256.
18. Kumar R, Clermont G, Vodovotz Y, Chow CC (2004) The dynamics of acute inflammation. J Theor Biol 230: 145-155.
19. Prince JM, Levy RM, Bartels J, Baratt A, Kane JM 3rd, et al. (2006) In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol Med 12: 88-96.
20. Reynolds A, Rubin J, Clermont G, Day J, Vodovotz Y, et al. (2006) A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation. J Theor Biol 242: 220-236.
21. Vodovotz Y, Chow CC, Bartels J, Lagoa C, Prince JM, et al. (2006) In silico models of acute inflammation in animals. Shock 26: 235-244.
22. Clermont G, Bartels J, Kumar R, Constantine G, Vodovotz Y, et al. (2004) In silico design of clinical trials: a method coming of age. Crit Care Med 32: 2061-2070.
23. Kumar R, Chow CC, Bartels JD, Clermont G, Vodovotz Y (2008) A mathematical simulation of the inflammatory response to anthrax infection. Shock 29: 104-111.
24. Foteinou P, Calvano S, Lowry S, Androulakis I (2007) An indirect response model of endotoxin-induced systemic inflammation. Journal of Critical Care 22: 337-338.
25. Yang E, Maguire T, Yarmush ML, Berthiaume F, Androulakis IP (2007) Bioinformatics analysis of the early inflammatory response in a rat thermal injury model. BMC Bioinformatics 8: 10.
26. Foteinou PT, Calvano SE, Lowry SF, Androulakis IP (2008) Modeling Endotoxin-Induced Systemic Inflammation Using an Indirect Response Approach Math Biosciences (accepted for publication).
27. Aderem A, Smith KD (2004) A systems approach to dissecting immunity and inflammation. Semin Immunol 16: 55-67.
28. Senftleben U (2003) NF-kappa B in critical diseases: a bad guy? Intensive Care Medicine 29: 1873-1876.
29. Briegel J, Jochum M, Gippner-Steppert C, Thiel M (2001) Immunomodulation in septic shock: hydrocortisone differentially regulates cytokine responses. J Am Soc Nephrol 12 Suppl 17: S70-74.
30. Rhen T, Cidlowski JA (2005) Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 353: 1711-1723.
31. van der Poll T, Barber AE, Coyle SM, Lowry SF (1996) Hypercortisolemia increases plasma interleukin-10 concentrations during human endotoxemia-a clinical research center study. J Clin Endocrinol Metab 81: 3604-3606.
32. Klinke DJ, Ustyugova IV, Brundage KM, J.B. B (2008) Modulating Temporal Control of NF-kappaB Activation: Implications for Therapeutic and Assay Selection (un-edited manuscript). Biophys J BioFAST.
33. Hoffmann A, Levchenko A, Scott ML, Baltimore D (2002) The IkappaB-NFkappaB signaling module: temporal control and selective gene activation. Science 298: 1241-1245.
34. Romascin AD, Foster DM, Marshall JC (1998) Let the Cells Speak: Neutrophils as Biologic Markers of the Inflammatory Response Sepsis 2: 119-125.
35. Barber AE, Coyle SM, Marano MA, Fischer E, Calvano SE, et al. (1993) Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. J Immunol 150: 1999-2006.
36. Barnes PJ, Karin M (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071.
37. Bornstein SR, Briegel J (2003) A new role for glucocorticoids in septic shock: balancing the immune response. Am J Respir Crit Care Med 167: 485-486.
38. Hawes AS, Rock CS, Keogh CV, Lowry SF, Calvano SE (1992) In vivo effects of the antiglucocorticoid RU 486 on glucocorticoid and cytokine responses to Escherichia coli endotoxin. Infect Immun 60: 2641-2647.
39. Keh D, Boehnke T, Weber-Cartens S, Schulz C, Ahlers O, et al. (2003) Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 167: 512-520.
40. Richardson RP, Rhyne CD, Fong Y, Hesse DG, Tracey KJ, et al. (1989) Peripheral blood leukocyte kinetics following in vivo lipopolysaccharide (LPS) administration to normal human subjects. Influence of elicited hormones and cytokines. Ann Surg 210: 239-245.
41. Sato N, Koeda K, Ikeda K, Kimura Y, Aoki K, et al. (2002) Randomized study of the benefits of preoperative corticosteroid administration on the postoperative morbidity and cytokine response in patients undergoing surgery for esophageal cancer. Ann Surg 236: 184-190.
42. Lefering R, Neugebauer EA (1995) Steroid controversy in sepsis and septic shock: a meta-analysis. Crit Care Med 23: 1294-1303.
43. Klaitman V, Almog Y (2003) Corticosteroids in sepsis: a new concept for an old drug. Isr Med Assoc J 5: 51-55.
44. Zurakowski R, Teel AR (2006) A model predictive control based scheduling method for HIV therapy. J Theor Biol 238: 368-382.
45. Foteinou PT, Calvano SE, Lowry SF, Androulakis IP (2008) Translational Potential of Systems-based Models of Inflammation Clinical and Translational Science, accepted for publication..
46. Vodovotz Y, Csete M, Bartels J, Chang S, An G (2008) Translational systems biology of inflammation. PLoS Comput Biol 4: e1000014.
47. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, et al. (2005) A network-based analysis of systemic inflammation in humans. Nature 437: 1032-1037.
48. Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, et al. (2005) Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A 102: 4801-4806.
49. Storey JD, Xiao W, Leek JT, Tompkins RG, Davis RW (2005) Significance analysis of time course microarray experiments. Proc Natl Acad Sci U S A 102: 12837-12842.
50. Wells CA, Ravasi T, Hume DA (2005) Inflammation suppressor genes: please switch out all the lights. J Leukoc Biol 78: 9-13.
51. Mager DE, Wyska E, Jusko WJ (2003) Diversity of mechanism-based pharmacodynamic models. Drug Metab Dispos 31: 510-518.
52. Jin JY, Almon RR, DuBois DC, Jusko WJ (2003) Modeling of corticosteroid pharmacogenomics in rat liver using gene microarrays. J Pharmacol Exp Ther 307: 93-109.
53. Krzyzanski W, Jusko WJ (1997) Mathematical formalism for the properties of four basic models of indirect pharmacodynamic responses. J Pharmacokinet Biopharm 25: 107-123.
54. Saklatvala J, Dean J, Clark A (2003) Control of the expression of inflammatory response genes. Biochem Soc Symp. pp 95-106.
55. Ihekwaba AE, Broomhead DS, Grimley RL, Benson N, Kell DB (2004) Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: the roles of IKK and IkappaBalpha. Syst Biol (Stevenage) 1: 93-103.
56. Krishna S, Jensen MH, Sneppen K (2006) Minimal model of spiky oscillations in NF-kappaB signaling. Proc Natl Acad Sci U S A 103: 10840-10845.
57. Lehmann V, Freudenberg MA, Galanos C (1987) Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice. J Exp Med 165: 657-663.
58. Rifkind D (1967) Prevention by polymyxin B of endotoxin lethality in mice. J Bacteriol 93: 1463-1464.
59. Tschaikowsky K, Schmidt J, Meisner M (1998) Modulation of mouse endotoxin shock by inhibition of phosphatidylcholine-specific phospholipase C. J Pharmacol Exp Ther 285: 800-804.
60. Carmody RJ, Chen YH (2007) Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling. Cell Mol Immunol 4: 31-41.
61. Abreu MT, Arnold ET, Thomas LS, Gonsky R, Zhou Y, et al. (2002) TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J Biol Chem 277: 20431-20437.
62. Mahony DSO, Pham U, Iyer R, Hawn TR, Liles WC (2008) Differential constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages. International Journal of Medical Sciences 5: 1-8.
63. Almon RR, DuBois DC, Brandenburg EH, Shi W, Zhang S, et al. (2002) Pharmacodynamics and pharmacogenomics of diverse receptor-mediated effects of methylprednisolone in rats using microarray analysis. J Pharmacokinet Pharmacodyn 29: 103-129.
64. Almon RR, Dubois DC, Jin JY, Jusko WJ (2005) Pharmacogenomic responses of rat liver to methylprednisolone: an approach to mining a rich microarray time series. Aaps J 7: E156-194.
65. Almon RR, DuBois DC, Jusko WJ (2007) A microarray analysis of the temporal response of liver to methylprednisolone: a comparative analysis of two dosing regimens. Endocrinology 148: 2209-2225.
66. Almon RR, Lai W, DuBois DC, Jusko WJ (2005) Corticosteroid-regulated genes in rat kidney: mining time series array data. Am J Physiol Endocrinol Metab 289: E870-882.
67. DuBois DC, Xu ZX, McKay L, Almon RR, Pyszcznski N, et al. (1995) Differential dynamics of receptor down-regulation and tyrosine aminotransferase induction following glucocorticoid treatment. J Steroid Biochem Mol Biol 54: 237-243.
68. Jusko WJ (1994) Receptor-mediated pharmacodynamics of corticosteroids. Prog Clin Biol Res 387: 261-270.
69. Sun YN, DuBois DC, Almon RR, Jusko WJ (1998) Fourth-generation model for corticosteroid pharmacodynamics: a model for methylprednisolone effects on receptor/gene-mediated glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. J Pharmacokinet Biopharm 26: 289-317.
70. Xu ZX, Sun YN, DuBois DC, Almon RR, Jusko WJ (1995) Third-generation model for corticosteroid pharmacodynamics: roles of glucocorticoid receptor mRNA and tyrosine aminotransferase mRNA in rat liver. J Pharmacokinet Biopharm 23: 163-181.
71. Jusko WJ, DuBois D, Almon R (2005) Sixth-Generation Model for Corticosteroid Pharmacodynamics: Multi-Hormonal Regulation of Tyrosine Aminotransferase in Rat Liver. J Pharmacokin Pharmacodyn.
72. Ramakrishnan R, DuBois DC, Almon RR, Pyszczynski NA, Jusko WJ (2002) Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats. J Pharmacokinet Pharmacodyn 29: 1-24.
73. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M (1995) Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270: 286-290.
74. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr (1995) Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 270: 283-286.
75. Shin HJ, Lee H, Park JD, Hyun HC, Sohn HO, et al. (2007) Kinetics of binding of LPS to recombinant CD14, TLR4, and MD-2 proteins. Mol Cells 24: 119-124.