메뉴 건너뛰기




Volumn 3 JUL, Issue , 2012, Pages

Linking inflammation, cardiorespiratory variability, and neural control in acute inflammation via computational modeling

(11)  Dick, Thomas E a   Molkov, Yaroslav I b   Nieman, Gary c   Hsieh, Yee Hsee a   Jacono, Frank J a,d   Doyle, John e,f   Scheff, Jeremy D g   Calvano, Steve E h   Androulakis, Ioannis P g   An, Gary i   Vodovotz, Yoram j,k  


Author keywords

Heart rate variability; Inflammation; Mathematical model; Neural control; Physiologic variability

Indexed keywords


EID: 84866465712     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00222     Document Type: Article
Times cited : (35)

References (89)
  • 1
    • 34748927007 scopus 로고    scopus 로고
    • Mechanisms of sepsis-induced organ dysfunction
    • Abraham, E., and Singer, M. (2007). Mechanisms of sepsis-induced organ dysfunction. Crit. Care Med. 35,2408.
    • (2007) Crit. Care Med , vol.35 , pp. 2408
    • Abraham, E.1    Singer, M.2
  • 3
    • 0037588986 scopus 로고    scopus 로고
    • The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    • Aird, W. C. (2003). The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101,3765.
    • (2003) Blood , vol.101 , pp. 3765
    • Aird, W.C.1
  • 4
    • 77956258291 scopus 로고    scopus 로고
    • The endothelium: physiological functions and role in micro-circulatory failure during severe sepsis
    • Ait-Oufella, H., Maury, E., Lehoux, S., Guidet, B., and Offenstadt, G. (2010). The endothelium: physiological functions and role in micro-circulatory failure during severe sepsis. Intensive Care Med. 36, 1286.
    • (2010) Intensive Care Med , vol.36 , pp. 1286
    • Ait-Oufella, H.1    Maury, E.2    Lehoux, S.3    Guidet, B.4    Offenstadt, G.5
  • 5
    • 46449119246 scopus 로고    scopus 로고
    • Introduction of a agent based multi-scale modular architecture for dynamic knowledge representation of acute inflammation
    • doi: 10.1186/1742-4682-5-11
    • An, G. (2008). Introduction of a agent based multi-scale modular architecture for dynamic knowledge representation of acute inflammation. Theor. Biol Med. Model. 5. doi: 10.1186/1742-4682-5-11
    • (2008) Theor. Biol Med. Model , pp. 5
    • An, G.1
  • 6
    • 79953894415 scopus 로고    scopus 로고
    • In silico augmentation of the drug development pipeline: examples from the study of acute inflammation
    • An, G., Bartels, J., and Vodovotz, Y. (2010). In silico augmentation of the drug development pipeline: examples from the study of acute inflammation. Drug Dev. Res. 72,1.
    • (2010) Drug Dev. Res , vol.72 , pp. 1
    • An, G.1    Bartels, J.2    Vodovotz, Y.3
  • 7
    • 41849114552 scopus 로고    scopus 로고
    • Translational systems biology: introduction of an engineeringapproach to the pathophysiology of the burn patient
    • An, G., Faeder, J., and Vodovotz, Y. (2008). Translational systems biology: introduction of an engineeringapproach to the pathophysiology of the burn patient. J. Burn Care Res. 29,277.
    • (2008) J. Burn Care Res , vol.29 , pp. 277
    • An, G.1    Faeder, J.2    Vodovotz, Y.3
  • 9
    • 84864247996 scopus 로고    scopus 로고
    • Computational and systems biology in trauma and sepsis: current state and future perspectives
    • An, G., Nieman, G., and Vodovotz, Y. (2012). Computational and systems biology in trauma and sepsis: current state and future perspectives. Int. J. Burns Trauma 2, 1.
    • (2012) Int. J. Burns Trauma , vol.2 , pp. 1
    • An, G.1    Nieman, G.2    Vodovotz, Y.3
  • 10
    • 84859398826 scopus 로고    scopus 로고
    • Reflex principles of immunological homeostasis
    • Andersson, U., and Tracey, K. J. (2012). Reflex principles of immunological homeostasis. Annu. Rev. Immunol. 30,313-335.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 313-335
    • Andersson, U.1    Tracey, K.J.2
  • 11
    • 84255183707 scopus 로고    scopus 로고
    • The search for effective therapy for sepsis: back to the drawing board?
    • Angus, D. C. (2011). The search for effective therapy for sepsis: back to the drawing board? JAMA 306, 2614.
    • (2011) JAMA , vol.306 , pp. 2614
    • Angus, D.C.1
  • 12
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    • Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., and Pinsky, M. R. (2001). Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29,1303.
    • (2001) Crit. Care Med , vol.29 , pp. 1303
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 14
    • 0025710312 scopus 로고
    • Anonymous. Increase in National Hospital Discharge Survey rates for septicemia-United States 1979-1987
    • Anonymous. (1990). Increase in National Hospital Discharge Survey rates for septicemia-United States,1979-1987. MMWR Morb. Mortal. Wkly Rep. 39,31.
    • (1990) MMWR Morb. Mortal. Wkly Rep , vol.39 , pp. 31
  • 15
    • 0029988782 scopus 로고    scopus 로고
    • Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology, and the North American Society of Pacing, and Electrophysiology. Eur
    • Anonymous
    • Anonymous. (1996). Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology, and the North American Society of Pacing, and Electrophysiology. Eur. Heart J. 17,354.
    • (1996) Heart J , vol.17 , pp. 354
  • 16
    • 78049412575 scopus 로고    scopus 로고
    • Effect of baroreceptor stimulation on the respiratory pattern: insights into respiratory-sympathetic interactions
    • Baekey, D. M., Molkov, Y. I., Paton, J. F., Rybak, I. A., and Dick, T. E. (2010). Effect of baroreceptor stimulation on the respiratory pattern: insights into respiratory-sympathetic interactions. Respir. Physiol. Neurobiol. 174, 135.
    • (2010) Respir. Physiol. Neurobiol , vol.174 , pp. 135
    • Baekey, D.M.1    Molkov, Y.I.2    Paton, J.F.3    Rybak, I.A.4    Dick, T.E.5
  • 17
    • 68049089963 scopus 로고    scopus 로고
    • Microcirculation and mitochondria in sepsis: getting out of breath
    • Balestra, G. M., Legrand, M., and Ince, C. (2009). Microcirculation and mitochondria in sepsis: getting out of breath. Curr. Opin. Anaesthe-siol. 22, 184.
    • (2009) Curr. Opin. Anaesthe-siol , vol.22 , pp. 184
    • Balestra, G.M.1    Legrand, M.2    Ince, C.3
  • 20
    • 0027215981 scopus 로고
    • Compartmentalization of the acute cytokine response in humans after intravenous endotoxin administration
    • Boujoukos, A. J., Martich, G. D., Supin-ski, E., and Suffredini, A. F. (1993). Compartmentalization of the acute cytokine response in humans after intravenous endotoxin administration. J. Appl. Physiol. 74, 3027.
    • (1993) J. Appl. Physiol , vol.74 , pp. 3027
    • Boujoukos, A.J.1    Martich, G.D.2    Supin-ski, E.3    Suffredini, A.F.4
  • 21
    • 62849124778 scopus 로고    scopus 로고
    • The digital patient: predicting physiologic dynamics with mathematical models
    • Buchman, T. G. (2009). The digital patient: predicting physiologic dynamics with mathematical models. Crit. Care Med. 37, 1167.
    • (2009) Crit. Care Med , vol.37 , pp. 1167
    • Buchman, T.G.1
  • 24
    • 33745932547 scopus 로고    scopus 로고
    • Compartmentalization of the inflammatory response in sepsis and SIRS
    • Cavaillon, J. M., and Annane, D. (2006). Compartmentalization of the inflammatory response in sepsis and SIRS.J. Endotoxin Res. 12, 151.
    • (2006) J. Endotoxin Res. , vol.12 , pp. 151
    • Cavaillon, J.M.1    Annane, D.2
  • 25
    • 34247145917 scopus 로고    scopus 로고
    • Characteristics of heart rate variability can predict impending septic shock in emergency department patients with sepsis
    • Chen, W L., and Kuo, C. D. (2007). Characteristics of heart rate variability can predict impending septic shock in emergency department patients with sepsis. Acad. Emerg. Med. 14, 392.
    • (2007) Acad. Emerg. Med , vol.14 , pp. 392
    • Chen, W.L.1    Kuo, C.D.2
  • 26
    • 33644817266 scopus 로고    scopus 로고
    • Mathematical models of periodic breathing and their usefulness in understanding cardiovascular and respiratory disorders
    • Cherniack, N. S., and Longobardo, G. S. (2006). Mathematical models of periodic breathing and their usefulness in understanding cardiovascular and respiratory disorders. Exp. Physiol. 91,295.
    • (2006) Exp. Physiol , vol.91 , pp. 295
    • Cherniack, N.S.1    Longobardo, G.S.2
  • 29
    • 50849133535 scopus 로고    scopus 로고
    • Neuroimmunology of the circadian clock
    • Coogan, A. N., and Wyse, C. A. (2008). Neuroimmunology of the circadian clock. Brain Res. 1232, 104.
    • (2008) Brain Res , vol.1232 , pp. 104
    • Coogan, A.N.1    Wyse, C.A.2
  • 30
    • 33746733585 scopus 로고    scopus 로고
    • The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies
    • Cotton, B. A., Guy, J. S., Morris, J. A. Jr., andAbumrad,N.N. (2006). The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock 26,115.
    • (2006) Shock , vol.26 , pp. 115
    • Cotton, B.A.1    Guy, J.S.2    Morris Jr., J.A.3    Abumrad, N.N.4
  • 31
    • 0036500834 scopus 로고    scopus 로고
    • Reverse engineering of biological complexity
    • Csete, M. E., and Doyle, J. C. (2002). Reverse engineering of biological complexity. Science 295, 1664.
    • (2002) Science , vol.295 , pp. 1664
    • Csete, M.E.1    Doyle, J.C.2
  • 32
    • 47849114337 scopus 로고    scopus 로고
    • An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: results from parameter space reduction
    • Daun, S., Rubin, J., Vodovotz, Y., Roy, A., Parker, R., and Clermont, G. (2008). An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: results from parameter space reduction. J. Theor. Biol. 253, 843.
    • (2008) J. Theor. Biol. , vol.253 , pp. 843
    • Daun, S.1    Rubin, J.2    Vodovotz, Y.3    Roy, A.4    Parker, R.5    Clermont, G.6
  • 33
    • 69949137692 scopus 로고    scopus 로고
    • Steroid hormone pulsing drives cyclic gene expression
    • Desvergne, B., and Heligon, C. (2009). Steroid hormone pulsing drives cyclic gene expression. Nat. Cell Biol. 11,1051.
    • (2009) Nat. Cell Biol , vol.11 , pp. 1051
    • Desvergne, B.1    Heligon, C.2
  • 34
    • 79960263429 scopus 로고    scopus 로고
    • Vagal-dependent nonlinear variability in the respiratory pattern of anesthetized, spontaneously breathing rats
    • Dhingra, R. R., Jacono, F. J., Fishman, M., Loparo, K. A., Rybak, I. A., and Dick, T. E. (2011). Vagal-dependent nonlinear variability in the respiratory pattern of anesthetized, spontaneously breathing rats. J. Appl. Physiol. 111,272.
    • (2011) J. Appl. Physiol , vol.111 , pp. 272
    • Dhingra, R.R.1    Jacono, F.J.2    Fishman, M.3    Loparo, K.A.4    Rybak, I.A.5    Dick, T.E.6
  • 37
    • 57849104348 scopus 로고    scopus 로고
    • Modeling endotoxin-induced systemic inflammation using an indirect response approach
    • Foteinou, P. T., Calvano, S. E., Lowry, S. F., and Androulakis, I. P. (2009a). Modeling endotoxin-induced systemic inflammation using an indirect response approach. Math. Biosci. 217,27.
    • (2009) Math. Biosci , vol.217 , pp. 27
    • Foteinou, P.T.1    Calvano, S.E.2    Lowry, S.F.3    Androulakis, I.P.4
  • 39
    • 77953214777 scopus 로고    scopus 로고
    • Multiscale model for the assessment of autonomic dysfunction in human endotoxemia
    • Foteinou, P. T., Calvano, S. E., Lowry, S. F., and Androulakis, I. P. (2010). Multiscale model for the assessment of autonomic dysfunction in human endotoxemia. Physiol. Genomics 42, 5.
    • (2010) Physiol. Genomics , vol.42 , pp. 5
    • Foteinou, P.T.1    Calvano, S.E.2    Lowry, S.F.3    Androulakis, I.P.4
  • 41
    • 79951965650 scopus 로고    scopus 로고
    • Improvements in the reconstruction of time-varying gene regulatory networks: dynamic programming and regularization by information sharing among genes
    • Grzegorczyk, M., and Husmeier, D. (2011). Improvements in the reconstruction of time-varying gene regulatory networks: dynamic programming and regularization by information sharing among genes. Bioinfor-matics 27, 693-699.
    • (2011) Bioinfor-matics , vol.27 , pp. 693-699
    • Grzegorczyk, M.1    Husmeier, D.2
  • 43
    • 80052459939 scopus 로고    scopus 로고
    • Lung and brainstem cytokine levels are associated with breathing pattern changes in a rodent model of acute lung injury
    • Jacono, F J., Mayer, C. A., Hsieh, Y H., Wilson, C. G., and Dick, T. E. (2011). Lung and brainstem cytokine levels are associated with breathing pattern changes in a rodent model of acute lung injury. Respir. Physiol. Neurobiol. 178,429.
    • (2011) Respir. Physiol. Neurobiol , vol.178 , pp. 429
    • Jacono, F.J.1    Mayer, C.A.2    Hsieh, Y.H.3    Wilson, C.G.4    Dick, T.E.5
  • 46
    • 33751222859 scopus 로고    scopus 로고
    • The role of initial trauma in the host's response to injury and hemorrhage: insights from a comparison of mathematical simulations and hepatic transcriptomic analysis
    • Lagoa, C. E., Bartels, J., Baratt, A., Tseng, G., Clermont, G., Fink, M. P., Billiar, T. R., and Vodovotz, Y (2006). The role of initial trauma in the host's response to injury and hemorrhage: insights from a comparison of mathematical simulations and hepatic transcriptomic analysis. Shock 26, 592.
    • (2006) Shock , vol.26 , pp. 592
    • Lagoa, C.E.1    Bartels, J.2    Baratt, A.3    Tseng, G.4    Clermont, G.5    Fink, M.P.6    Billiar, T.R.7    Vodovotz, Y.8
  • 48
    • 77956912421 scopus 로고    scopus 로고
    • The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration
    • Lightman, S. L., and Conway-Campbell, B. L. (2010). The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration. Nat. Rev. Neurosci. 11, 710.
    • (2010) Nat. Rev. Neurosci , vol.11 , pp. 710
    • Lightman, S.L.1    Conway-Campbell, B.L.2
  • 49
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin, G. S.,Mannino, D. M., Eaton, S., and Moss, M. (2003). The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. 348,1546.
    • (2003) N. Engl. J. Med , vol.348 , pp. 1546
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 52
    • 83455234966 scopus 로고    scopus 로고
    • Drug for severe sepsis is withdrawn from market, fails to reduce mortality
    • Mitka, M. (2011). Drug for severe sepsis is withdrawn from market, fails to reduce mortality. JAMA 306, 2439.
    • (2011) JAMA , vol.306 , pp. 2439
    • Mitka, M.1
  • 53
    • 0035657085 scopus 로고    scopus 로고
    • Hemorrhage alters neuroendocrine, hemo dynamic, and compartment-specific TNF responses to LPS
    • Molina, P. E., Bagby, G. J., and Stahls, P. (2001). Hemorrhage alters neuroendocrine, hemo dynamic, and compartment-specific TNF responses to LPS. Shock 16, 459.
    • (2001) Shock , vol.16 , pp. 459
    • Molina, P.E.1    Bagby, G.J.2    Stahls, P.3
  • 55
    • 79959354634 scopus 로고    scopus 로고
    • Intermittent hypoxia-induced sensitiza-tion of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats
    • Molkov, Y. I., Zoccal, D. B., Moraes, D. J., Paton, J. F., MacHado, B. H., and Rybak, I. A. (2011). Intermittent hypoxia-induced sensitiza-tion of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats. J. Neurophysiol. 105, 3080.
    • (2011) J. Neurophysiol , vol.105 , pp. 3080
    • Molkov, Y.I.1    Zoccal, D.B.2    Moraes, D.J.3    Paton, J.F.4    MacHado, B.H.5    Rybak, I.A.6
  • 59
    • 75149172745 scopus 로고    scopus 로고
    • The acute inflammatory response in trauma/hemorrhage and traumatic brain injury: current state and emerging prospects
    • Namas, R., Ghuma, A., Hermus, L., Zamora, R., Okonkwo, D. O., Billiar, T. R., and Vodovotz, Y. (2009b). The acute inflammatory response in trauma/hemorrhage and traumatic brain injury: current state and emerging prospects. Libyan J. Med. 4, 136.
    • (2009) Libyan J. Med , vol.4 , pp. 136
    • Namas, R.1    Ghuma, A.2    Hermus, L.3    Zamora, R.4    Okonkwo, D.O.5    Billiar, T.R.6    Vodovotz, Y.7
  • 63
    • 0035152225 scopus 로고    scopus 로고
    • Experimental models of gram-negative sepsis
    • Parker, S. J., and Watkins, P. E. (2001). Experimental models of gram-negative sepsis. Br. J. Surg. 88,22.
    • (2001) Br. J. Surg , vol.88 , pp. 22
    • Parker, S.J.1    Watkins, P.E.2
  • 64
    • 0028943513 scopus 로고
    • Autonomic control of the heart and peripheral vessels in human septic shock
    • Piepoli, M., Garrard, C. S., Kontoyan-nis, D. A., and Bernardi, L. (1995). Autonomic control of the heart and peripheral vessels in human septic shock. Intensive Care Med. 21, 112.
    • (1995) Intensive Care Med , vol.21 , pp. 112
    • Piepoli, M.1    Garrard, C.S.2    Kontoyan-nis, D.A.3    Bernardi, L.4
  • 68
    • 34447623219 scopus 로고    scopus 로고
    • Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure
    • Protti, A., and Singer, M. (2006). Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure. Crit. Care 10,228
    • (2006) Crit. Care , vol.10 , pp. 228
    • Protti, A.1    Singer, M.2
  • 69
    • 0029348036 scopus 로고
    • Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture
    • Remick, D., Manohar, P., Bolgos, G., Rodriguez, J., Moldawer, L., and Wollenberg, G. (1995). Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture. Shock 4, 89.
    • (1995) Shock , vol.4 , pp. 89
    • Remick, D.1    Manohar, P.2    Bolgos, G.3    Rodriguez, J.4    Moldawer, L.5    Wollenberg, G.6
  • 70
    • 70249111112 scopus 로고    scopus 로고
    • Early loss of heart rate complexity predicts mortality regardless of mechanism, anatomic location, or severity of injury in 2178 trauma patients
    • Riordan,W.P.Jr.,Norris,P.R.,Jenkins,J. M., and Morris, J. A. Jr. (2009). Early loss of heart rate complexity predicts mortality regardless of mechanism, anatomic location, or severity of injury in 2178 trauma patients. J. Surg. Res. 156,283.
    • (2009) J. Surg. Res. , vol.156 , pp. 283
    • Riordan Jr., W.P.1    Norris, P.R.2    Jenkins, J.M.3    Morris Jr., J.A.4
  • 74
    • 0025869206 scopus 로고
    • Vagal afferent activity increases dynamical dimension of respiration in rats
    • Sammon, M. P., and Bruce, E. N. (1991). Vagal afferent activity increases dynamical dimension of respiration in rats. J. Appl. Physiol. 70, 1748.
    • (1991) J. Appl. Physiol , vol.70 , pp. 1748
    • Sammon, M.P.1    Bruce, E.N.2
  • 75
    • 77952597821 scopus 로고    scopus 로고
    • Modeling the influence of circadian rhythms on the acute inflammatory response
    • Scheff, J. D., Calvano, S. E., Lowry, S. E, and Androulakis, I. P. (2010). Modeling the influence of circadian rhythms on the acute inflammatory response. J. Theor. Biol. 264, 1068.
    • (2010) J. Theor. Biol , vol.264 , pp. 1068
    • Scheff, J.D.1    Calvano, S.E.2    Lowry, S.3    Androulakis, E.I.P.4
  • 76
    • 84856659886 scopus 로고    scopus 로고
    • Tran-scriptional implications of ultradian glucocorticoid secretion in home-ostasis and in the acute stress response
    • Scheff, J. D., Calvano, S. E., Lowry, S. F., and Androulakis, I. P. (2012). Tran-scriptional implications of ultradian glucocorticoid secretion in home-ostasis and in the acute stress response. Physiol. Genomics 44, 121.
    • (2012) Physiol. Genomics , vol.44 , pp. 121
    • Scheff, J.D.1    Calvano, S.E.2    Lowry, S.F.3    Androulakis, I.P.4
  • 77
    • 80052072238 scopus 로고    scopus 로고
    • Modelingautonomicregulation of cardiac function and heart rate variability in human endotox-emia
    • Scheff, J. D., Mavroudis, P. D., Calvano, S. E., Lowry, S. F., and Androulakis, I. P. (2011a). Modelingautonomicregulation of cardiac function and heart rate variability in human endotox-emia. Physiol Genomics 43, 951.
    • (2011) Physiol Genomics , vol.43 , pp. 951
    • Scheff, J.D.1    Mavroudis, P.D.2    Calvano, S.E.3    Lowry, S.F.4    Androulakis, I.P.5
  • 79
    • 0030000877 scopus 로고    scopus 로고
    • Hypothesis: com-partmentalization of cytokines in intraabdominal infection [review]
    • Schein, M., Wittmann, D. H., Holzheimer, R., and Condon, R. E. (1996). Hypothesis: com-partmentalization of cytokines in intraabdominal infection [review]. Surgery 119,694.
    • (1996) Surgery , vol.119 , pp. 694
    • Schein, M.1    Wittmann, D.H.2    Holzheimer, R.3    Condon, R.E.4
  • 80
    • 67749139592 scopus 로고    scopus 로고
    • Mathematical modeling of post-hemorrhage inflammation in mice: studies using a novel, computer-controlled, closed-loop hemorrhage apparatus
    • Torres, A., Bentley, T., Bartels, J., Sarkar, J., Barclay, D., Namas, R., Con-stantine, G., Zamora, R., Puyana, J. C., and Vodovotz, Y. (2009). Mathematical modeling of post-hemorrhage inflammation in mice: studies using a novel, computer-controlled, closed-loop hemorrhage apparatus. Shock 32, 172.
    • (2009) Shock , vol.32 , pp. 172
    • Torres, A.1    Bentley, T.2    Bartels, J.3    Sarkar, J.4    Barclay, D.5    Namas, R.6    Con-stantine, G.7    Zamora, R.8    Puyana, J.C.9    Vodovotz, Y.10
  • 85
    • 57749172576 scopus 로고    scopus 로고
    • Mechanistic simulations of inflammation: current state and future prospects
    • Vodovotz, Y., Constantine, G., Rubin, J., Csete, M., Voit, E. O., and An, G. (2009). Mechanistic simulations of inflammation: current state and future prospects. Math. Biosci. 217, 1.
    • (2009) Math. Biosci. , vol.217 , pp. 1
    • Vodovotz, Y.1    Constantine, G.2    Rubin, J.3    Csete, M.4    Voit, E.O.5    An, G.6
  • 86
    • 43249089766 scopus 로고    scopus 로고
    • Translational systems biology of inflammation
    • doi:10.1371/journal.pcbi.10000141
    • Vodovotz, Y., Csete, M., Bartels, J., Chang, S., and An, G. (2008). Translational systems biology of inflammation. PLoS. Comput. Biol. 4, e1000014. doi:10.1371/ journal.pcbi.10000141
    • (2008) PLoS. Comput. Biol. , vol.4 , pp. 1000014
    • Vodovotz, Y.1    Csete, M.2    Bartels, J.3    Chang, S.4    An, G.5
  • 87
    • 0042832200 scopus 로고    scopus 로고
    • Long-term mortality and medical care charges in patients with severe sepsis
    • Weycker, D., Akhras, K. S., Edelsberg, J., Angus, D. C., and Oster, G. (2003). Long-term mortality and medical care charges in patients with severe sepsis. Crit. Care Med. 31, 2316.
    • (2003) Crit. Care Med. , vol.31 , pp. 2316
    • Weycker, D.1    Akhras, K.S.2    Edelsberg, J.3    Angus, D.C.4    Oster, G.5
  • 89
    • 67650621089 scopus 로고    scopus 로고
    • Identification of global transcriptional dynamics
    • doi:10.1371/journal.pone.0005992
    • Yang, E. H., Almon, R. R., Dubois, D. C., Jusko, W. J., and Androulakis, I. P. (2009). Identification of global transcriptional dynamics. PLoS ONE 4, e5992. doi:10.1371/journal.pone.0005992
    • (2009) PLoS ONE , vol.4 , pp. 5992
    • Yang, E.H.1    Almon, R.R.2    Dubois, D.C.3    Jusko, W.J.4    Androulakis, I.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.