The possible role of TNF-α and IL-2 in inducing tumor-associated metabolic alterations

Surgery Today

Volumn 26, Issue 1, 1996, Pages 36-41

  Noguchi, Yoshikazu ^a   Makino, Tatsuo ^a   Yoshikawa, Takaki ^a   Nomura, Katsutoshi ^a   Fukuzawa, Kuniyasu ^a   Matsumoto, Akihiko ^a   Yamada, Takuko ^b  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

Author keywords

cancer cachexia; interleukin 2; lipoprotein lipase; malic enzyme; phosphoenolpyruvate carboxykinase; tumor necrosis factor (TNF)

Indexed keywords

INTERLEUKIN 2; LIPOPROTEIN LIPASE; MALATE DEHYDROGENASE (DECARBOXYLATING); PYRUVATE KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CACHEXIA; CANCER; CONTROLLED STUDY; FOOD INTAKE; HYPERTRIGLYCERIDEMIA; LIPID METABOLISM; MALE; METABOLIC DISORDER; METABOLISM; NONHUMAN; PATHOGENESIS; RAT;

ANIMALS; CACHEXIA; CARCINOGENS; ENERGY INTAKE; ENERGY METABOLISM; INTERLEUKIN-2; LIPOPROTEIN LIPASE; MALATE DEHYDROGENASE; MALE; METHYLCHOLANTHRENE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RATS; RATS, INBRED F344; SARCOMA, EXPERIMENTAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030040152     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00311989     Document Type: Article

References (26)

1. Kawakami M, Cerami A (1981) Studies of endotoxin-induced decrease in lipoprotein lipase activity. J Exp Med 154:631-637
2. Beutler B, Cerami A (1986) Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature 320:584-588
3. Greenberg AS, Nordan RP, McIntosh J, Cvalvo JC, Scow RD, Joblons D (1992) Interleukin-6 reduces lipoprotein lipase activity in adipose tissue in vivo and in 3T3-L1 adipocytes: a possible role for interleukin-6 in cancer cachexia. Cancer Res 52:4113-4116
4. Noguchi Y, Vydelingum NA, Brennan MF (1989) The reversal of increased gluconeogenesis in the tumor-bearing rat by tumor removal and food intake. Surgery 106:423-431
5. Younes RN, Vydelingum NA, Noguchi Y, Brennan MF (1990) Lipid kinetic alterations in tumor-bearing rats: reversal by tumor excision. J Surg Res 48:324-328
6. Noguchi Y, Vydelingum NA, Yopunes RN, Fried SK, Brennan MF (1991) Tumor-induced alterations in tissue lipoprotein lipase activity and mRNA levels. Cancer Res 51:863-869
7. Noguchi Y, Vydelingum NA, Brennan MF (1993) Evidence for tumor-induced alterations in hepatic lipogenesis and fatty acid oxidation. J Surg Res 55:357-363
8. Bucolo G, David H (1972) Quantitative determination of serum triglyceride by the use of enzymes. Clin Chem 19:476-482
9. Chang HC, Lane MD (1966) The enzymatic carboxylation of phosphoenolpyruvate: II. Purification and properties of liver mitochondrial phosphoenolpyruvate carboxykinase. J Biol Chem 241:2413-2420
10. Hsu RY, Lardy HA (1969) Malic enzyme. Methods Enzymol 13:230-235
11. Bradford MA (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal Biochem 72:248-254
12. Nilsson-Ehle P, Garfunkel AS, Schotz MC (1980) Lipolytic enzyme and plasma lipoprotein lipase metabolism. Ann Rev Biochem 49:668-63
13. Moldawer LL, Andersson C, Gelin J, Lundholm KG (1988) Regulation of food intake and hepatic protein synthesis by recombinant-derived cytokines. Am J Physiol 254:450-456
14. Norton JA (1991) Mechanisms of cancer cachexia. Hematol Oncol Clin North Am 103-123
15. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B (1975) An endotoxin-induced serum factor that causes necrosis of tumours. Proc Natl Acad Sci USA 72:3666-3670
16. Oliff A (1988) The role of tumor necrosis factor (cachectin) in cachexia. Cell 54:141-142
17. Mahony SM, Tisdale MJ (1989) Role of prostaglandins in tumor necrosis factor-induced weight loss. Br J Cancer 60:51-55
18. Michie HR, Sherman ML, Spriggs DR, Christie RJ, Wilmore DW (1989) Chronic TNF infusion causes anemia and not accelerated nitrogen loss. Ann Surg 104:280-286
19. Darling G, Fraker DL, Jensen JC, Gorschboth CM, Northon JA (1990) Cachectic effects of recombinant tumor necrosis factor in rats. Cancer Res 50:4008-4013
20. Mahony SM, Tisdale MJ (1988) Induction of weight loss and metabolic alterations by human recombinant tumor necrosis factor. Br J Cancer 58:345-349
21. Feingold KR, Grunfeld C (1987) Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat liver in vitro. J Clin Invest 80:184-190
22. Textor SC, Margolin K, Blayney D, Carlson J, Doroshow J (1987) Adrenal volume and hormonal changes during therapeutic administration of recombinant interleukin-2 in man. Am J Med 83:1055-1061
23. Rosenberg SA, Lotze MT, Muul LM, Leitman S, Chang AE, Ettinghausen SE, Matory YL, Skibber JM, Shiloni E, Vetto JT, Seipp CA, Simpson L, Reichert CM (1985) Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 313:1485-1492
24. Rosenberg SA, Spiess P, Lafreniere R (1986) A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science 233:1318-1321
25. Rosenberg SA, Lotze MT, Muul LM, Chang AE, Avis FP, Leitman S, Linehan WM, Robertson CN, Lee RE, Rubin JT, Seipp LA, Simpson CG, White DE (1987) A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. New Engl J Med 316:889-867
26. Kasid A, Director EP, Rosenberg SA (1989) Induction of endogenous cytokine-mRNA in circulating peripheral blood mononuclear cells by IL-2 administration to cancer patients. J Immunol 143:736-739