Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression

Oncogene

Volumn 28, Issue 41, 2009, Pages 3663-3670

  Thirkettle, H J ^a   Mills, I G ^a   Whitaker, H C ^a   Neal, D E ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

LYRIC AEG 1; Nucleus; PLZF; Repression; Transcription

Indexed keywords

HISTONE DEACETYLASE;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BREAST METASTASIS; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL GROWTH; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYBRID; MAMMAL CELL; MELANOMA; MOLECULAR MECHANICS; NONHUMAN; ONCOGENE; ONCOGENE C H RAS; ONCOGENE C LYRIC AEG 1; ONCOGENE C MYC; ONCOGENE C PLZF; PRIORITY JOURNAL; PROMOTER REGION; REPRESSOR GENE; YEAST;

CELL ADHESION MOLECULES; CELL NUCLEUS; GENE EXPRESSION REGULATION; HELA CELLS; HISTONE DEACETYLASES; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 70350066361     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.223     Document Type: Article

References (28)

1. Ash SC, Yang DQ, Britt DE. (2008). LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. Biochem Biophys Res Commun 371: 333-338.
2. Ball HJ, Melnick A, Shaknovich R, Kohanski RA, Licht JD. (1999). The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase. Nucleic Acids Res 27: 4106-4113.
3. Bernardo MV, Yelo E, Gimeno L, Campillo JA, Parrado A. (2007). Identification of apoptosis-related PLZF target genes. Biochem Biophys Res Commun 359: 317-322.
4. Brooke GN, Parker MG, Bevan CL. (2008). Mechanisms of androgen receptor activation in advanced prostate cancer: differential co-activator recruitment and gene expression. Oncogene 27: 2941-2950.
5. Brown DM, Ruoslahti E. (2004). Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5: 365-374.
6. Carvalho T, Almeida F, Calapez A, Lafarga M, Berciano MT, Carmo-Fonseca M. (1999). The spinal muscular atrophy disease gene product, SMN: a link between snRNP biogenesis and the Cajal (coiled) body. J Cell Biol 147: 715-728.
7. Chao TT, Chang CC, Shih HM. (2007). SUMO modification modulates the transrepression activity of PLZF. Biochem Biophys Res Commun 358: 475-482.
8. Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z et al. (2004). HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF. Oncogene 23: 8777-8784.
9. David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A. (1998). Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene 16: 2549-2556.
10. Emdad L, Sarkar D, Su ZZ, Randolph A, Boukerche H, Valerie K et al. (2006). Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 66: 1509-1516.
11. Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F et al. (2009). MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 15: 9-20.
12. Jiang F, Wang Z. (2004). Identification and characterization of PLZF as a prostatic androgen-responsive gene. Prostate 59: 426-435.
13. Kamitani T, Kito K, Nguyen HP, Wada H, Fukuda-Kamitani T, Yeh ET. (1998). Identification of three major sentrinization sites in PML. J Biol Chem 273: 26675-26682.
14. Kang SI, Chang WJ, Cho SG, Kim IY. (2003). Modification of promyelocytic leukemia zinc finger protein (PLZF) by SUMO-1 conjugation regulates its transcriptional repressor activity. J Biol Chem 278: 51479-51483.
15. Kelly KF, Daniel JM. (2006). POZ for effect-POZ-ZF transcription factors in cancer and development. Trends Cell Biol 16: 578-587.
16. Kikugawa T, Kinugasa Y, Shiraishi K, Nanba D, Nakashiro K, Tanji N et al. (2006). PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation. Prostate 66: 1092-1099.
17. Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y et al. (2007). Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 26: 7647-7655.
18. Kwong LN, Chin L. (2009). The metastasis problem gets stickier. Cancer Cell 15: 1-2.
19. Lee SG, Su ZZ, Emdad L, Sarkar D, Fisher PB. (2006). Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci USA 103: 17390-17395.
20. Li J, Zhang N, Song LB, Liao WT, Jiang LL, Gong LY et al. (2008). Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 14: 3319-3326.
21. McConnell MJ, Chevallier N, Berkofsky-Fessler W, Giltnane JM, Malani RB, Staudt LM et al. (2003). Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expression. Mol Cell Biol 23: 9375-9388.
22. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB. (2008). Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 68: 1478-1484.
23. Seeler JS, Dejean A. (1999). The PML nuclear bodies: actors or extras? Curr Opin Genet Dev 9: 362-367.
24. Shaknovich R, Yeyati PL, Ivins S, Melnick A, Lempert C, Waxman S et al. (1998). The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apoptosis. Mol Cell Biol 18: 5533-5545.
25. Sutherland HG, Lam YW, Briers S, Lamond AI, Bickmore WA. (2004). 3D3/lyric: a novel transmembrane protein of the endoplas-mic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res 294: 94-105.
26. Thirkettle HJ, Girling J, Warren AY, Mills IG, Sahadevan K, Leung H et al. (2009). LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clin Cancer Res 15: 3003-3013.
27. Waghray A, Feroze F, Schober MS, Yao F, Wood C, Puravs E et al. (2001). Identification of androgen-regulated genes in the prostate cancer cell line LNCaP by serial analysis of gene expression and proteomic analysis. Proteomics 1: 1327-1338.
28. Whitaker HC, Stanbury DP, Brinham C, Girling J, Hanrahan S, Totty N et al. (2007). Labeling and identification of LNCaP cell surface proteins: a pilot study. Prostate 67: 943-954.