-
1
-
-
79953036225
-
-
WHO Technical Report Series 949, (accessed on 15 April 2013).
-
WHO Technical Report Series 949, 2010. Report of a Meeting of the WHO Expert Committee on the Control of Leishmaniases. Available online: http://apps.who.int/iris/bitstream/10665/44412/1/WHO-TRS-949-eng.pdf (accessed on 15 April 2013).
-
(2010)
Report of A Meeting of the WHO Expert Committee on the Control of Leishmaniases
-
-
-
2
-
-
0033083293
-
Recent advances in identifying and validating drug targets in trypanosomes and leishmanias
-
Barrett, M.P.; Mottram, J.C.; Goombs, G.H. Recent advances in identifying and validating drug targets in trypanosomes and leishmanias. Trends Microbiol. 1999, 7, 82-88.
-
(1999)
Trends Microbiol.
, vol.7
, pp. 82-88
-
-
Barrett, M.P.1
Mottram, J.C.2
Goombs, G.H.3
-
4
-
-
78149249050
-
Identification of attractive drug targets in neglected disease pathogens using an in silico approach
-
Crowther, G.J.; Shanmugam, D.; Carmona, S.J.; Doyle, M.A.; Herz-Fowler, C.; Berriman, M.; Nwaka, S.; Ralph, S.A.; Roos, D.S.; Van Voorhis, W.C.; et al. Identification of attractive drug targets in neglected disease pathogens using an in silico approach. PLoS Negl. Trop. Dis. 2010, 4, e804.
-
(2010)
PLoS Negl. Trop. Dis.
, vol.4
-
-
Crowther, G.J.1
Shanmugam, D.2
Carmona, S.J.3
Doyle, M.A.4
Herz-Fowler, C.5
Berriman, M.6
Nwaka, S.7
Ralph, S.A.8
Roos, D.S.9
Van Voorhis, W.C.10
-
5
-
-
84860676070
-
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected ideases-Part i
-
Schmidt, T.J.; Khalid, S.A.; Romanha, A.J.; Alves, T.M.A.; Biavatti, M.W.; Brun, R.; Da Costa, F.B.; de Castro, S.L.; Ferreira, V.F.; de Lacerda, M.V.G.; et al. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected ideases-Part I. Curr. Med. Chem. 2012, 19, 2128-2175.
-
(2012)
Curr. Med. Chem.
, vol.19
, pp. 2128-2175
-
-
Schmidt, T.J.1
Khalid, S.A.2
Romanha, A.J.3
Alves, T.M.A.4
Biavatti, M.W.5
Brun, R.6
Da Costa, F.B.7
De Castro, S.L.8
Ferreira, V.F.9
De Lacerda, M.V.G.10
-
6
-
-
0033588341
-
The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity
-
Rigden, D.J.; Phillips, S.E.V.; Michels, P.A.M.; Fothergill-Gilmore, L.A. The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity. J. Mol. Biol. 1999, 291, 615-635.
-
(1999)
J. Mol. Biol.
, vol.291
, pp. 615-635
-
-
Rigden, D.J.1
Phillips, S.E.V.2
Michels, P.A.M.3
Fothergill-Gilmore, L.A.4
-
7
-
-
84867806188
-
A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase
-
Morgan, H.P.; Walsh, M.J.; Blackburn, E.A.; Wear, M.A.; Boxer, M.B.; Shen, M.; Veith, H.; McNae, I.W.; Nowicki, M.W.; Michels, P.A.; et al. A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase. Biochem. J. 2012, 448, 67-72.
-
(2012)
Biochem. J.
, vol.448
, pp. 67-72
-
-
Morgan, H.P.1
Walsh, M.J.2
Blackburn, E.A.3
Wear, M.A.4
Boxer, M.B.5
Shen, M.6
Veith, H.7
McNae, I.W.8
Nowicki, M.W.9
Michels, P.A.10
-
8
-
-
3042842746
-
The crystal structure of glucose-6- phosphate isomerase from Leishmania mexicana reveals novel active site features
-
Cordeiro, A.T.; Michels, P.A.; Delboni, L.F.; Thiemann, O.H. The crystal structure of glucose-6- phosphate isomerase from Leishmania mexicana reveals novel active site features. Eur. J. Biochem. 2004, 271, 2765-2772.
-
(2004)
Eur. J. Biochem.
, vol.271
, pp. 2765-2772
-
-
Cordeiro, A.T.1
Michels, P.A.2
Delboni, L.F.3
Thiemann, O.H.4
-
9
-
-
58949089736
-
Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with glucose-6-phosphate at 1.6 Å resolution
-
Arsenieva, D.; Appavu, B.L.; Mazock, G.H.; Jeffery, C.J. Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with glucose-6-phosphate at 1.6 Å resolution. Proteins 2008, 74, 72-80.
-
(2008)
Proteins
, vol.74
, pp. 72-80
-
-
Arsenieva, D.1
Appavu, B.L.2
Mazock, G.H.3
Jeffery, C.J.4
-
10
-
-
34250365407
-
Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major
-
Steiner, T.; Lamerz, A.C.; Hess, P.; Breithaupt, C.; Krapp, S.; Bourenkov, G.; Huber, R.; Gerardy-Schahn, R.; Jacob, U. Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major. J. Biol. Chem. 2007, 282, 13003-13010.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 13003-13010
-
-
Steiner, T.1
Lamerz, A.C.2
Hess, P.3
Breithaupt, C.4
Krapp, S.5
Bourenkov, G.6
Huber, R.7
Gerardy-Schahn, R.8
Jacob, U.9
-
11
-
-
0032562541
-
Crystal structure of Leishmania mexicana glycosomal glyceraldehyde-3- phosphate dehydrogenase in a new crystal form confirms the putative physiological active site structure
-
Kim, H.; Hol, W.G. Crystal structure of Leishmania mexicana glycosomal glyceraldehyde-3- phosphate dehydrogenase in a new crystal form confirms the putative physiological active site structure. J. Mol. Biol. 1998, 278, 5-11.
-
(1998)
J. Mol. Biol.
, vol.278
, pp. 5-11
-
-
Kim, H.1
Hol, W.G.2
-
12
-
-
44449109653
-
Structural basis for selective inhibition of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase: Molecular docking and 3D QSAR studies
-
Guido, R.V.C.; Oliva, G.; Montanari, C.A.; Andricopulo, A.D. Structural basis for selective inhibition of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase: Molecular docking and 3D QSAR studies. J. Chem. Inf. Model. 2008, 48, 918-929.
-
(2008)
J. Chem. Inf. Model.
, vol.48
, pp. 918-929
-
-
Guido, R.V.C.1
Oliva, G.2
Montanari, C.A.3
Andricopulo, A.D.4
-
13
-
-
84871974927
-
Role of cytosolic glyceraldehyde-3-phosphate dehydrogenase in visceral organ infection by Leishmania donovani
-
Zhang, W.W.; McCall, L.I.; Matlashewski, G. Role of cytosolic glyceraldehyde-3-phosphate dehydrogenase in visceral organ infection by Leishmania donovani. Eukaryot. Cell 2013, 12, 70-77.
-
(2013)
Eukaryot. Cell
, vol.12
, pp. 70-77
-
-
Zhang, W.W.1
McCall, L.I.2
Matlashewski, G.3
-
14
-
-
0034658406
-
A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana
-
Suresh, S.; Turley, S.; Opperdoes, F.R.; Michels, P.A.; Hol, W.G. A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana. Structure 2000, 8, 541-552.
-
(2000)
Structure
, vol.8
, pp. 541-552
-
-
Suresh, S.1
Turley, S.2
Opperdoes, F.R.3
Michels, P.A.4
Hol, W.G.5
-
15
-
-
0038737949
-
Leishmania mexicana glycerol-3-phosphate dehydrogenase showed conformational changes upon binding a bi-substrate adduct
-
Choe, J.; Guerra, D.; Michels, P.A.; Hol, W.G. Leishmania mexicana glycerol-3-phosphate dehydrogenase showed conformational changes upon binding a bi-substrate adduct. J. Mol. Biol. 2003, 329, 335-349.
-
(2003)
J. Mol. Biol.
, vol.329
, pp. 335-349
-
-
Choe, J.1
Guerra, D.2
Michels, P.A.3
Hol, W.G.4
-
16
-
-
33644535470
-
Structural differences in triosephosphate isomerase from different species and discovery of a multitrypanosomatid inhibitor
-
Olivares-Illana, V.; Pérez-Montfort, R.; López-Calahorra, F.; Costas, M.; Rodríguez-Romero, A.; Tuena de Gómez-Puyou, M.; Gómez-Puyou, A. Structural differences in triosephosphate isomerase from different species and discovery of a multitrypanosomatid inhibitor. Biochemistry 2006, 45, 2556-2560.
-
(2006)
Biochemistry
, vol.45
, pp. 2556-2560
-
-
Olivares-Illana, V.1
Pérez-Montfort, R.2
López-Calahorra, F.3
Costas, M.4
Rodríguez-Romero, A.5
Tuena De Gómez-Puyou, M.6
Gómez-Puyou, A.7
-
17
-
-
77953514501
-
Atomic resolution crystallography of a complex of triosephosphate isomerase with a reaction-intermediate analog: New insight in the proton transfer reaction mechanism
-
Alahuhta, M.; Wierenga, R.K. Atomic resolution crystallography of a complex of triosephosphate isomerase with a reaction-intermediate analog: New insight in the proton transfer reaction mechanism. Proteins 2010, 78, 1878-1888.
-
(2010)
Proteins
, vol.78
, pp. 1878-1888
-
-
Alahuhta, M.1
Wierenga, R.K.2
-
18
-
-
84859109633
-
Cloning overexpression and characterization of Leishmania donovani triosephosphate isomerase
-
Kumar, K.; Bhargava, P.; Roy, U. Cloning, overexpression and characterization of Leishmania donovani triosephosphate isomerase. Exp. Parasitol. 2012, 130, 430-436.
-
(2012)
Exp. Parasitol.
, vol.130
, pp. 430-436
-
-
Kumar, K.1
Bhargava, P.2
Roy, U.3
-
19
-
-
84863884120
-
Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation
-
Fyfe, P.K.; Westrop, G.D.; Silva, A.M.; Coombs, G.H.; Hunter, W.N. Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation. Proc. Natl. Acad. Sci. USA 2012, 109, 11693-11698.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 11693-11698
-
-
Fyfe, P.K.1
Westrop, G.D.2
Silva, A.M.3
Coombs, G.H.4
Hunter, W.N.5
-
20
-
-
0035171565
-
Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants
-
Garami, A.; Mehlert, A.; Ilg, T. Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate- mannose synthase gene deletion mutants. Mol. Cell Biol. 2001, 21, 8168-8183.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 8168-8183
-
-
Garami, A.1
Mehlert, A.2
Ilg, T.3
-
21
-
-
37849007277
-
Catalysis and structural properties of Leishmania infantum glyoxalase II: Trypanothione specificity and phylogeny
-
Silva, M.S.; Barata, L.; Ferreira A.E.N.; Romão, S.; Tomás, A.M.; Freire, A.P.; Cordeiro, C. Catalysis and structural properties of Leishmania infantum glyoxalase II: Trypanothione specificity and phylogeny. Biochemistry 2008, 47, 195-204.
-
(2008)
Biochemistry
, vol.47
, pp. 195-204
-
-
Silva, M.S.1
Barata, L.2
Ferreira, A.E.N.3
Romão, S.4
Tomás, A.M.5
Freire, A.P.6
Cordeiro, C.7
-
22
-
-
30044446214
-
Characterization of the gene encoding glyoxalase II from Leishmania donovani: A potential target for anti-parasite drugs
-
Padmanabhan, P.K.; Mukherjee, A.; Madhubala, R. Characterization of the gene encoding glyoxalase II from Leishmania donovani: A potential target for anti-parasite drugs. Biochem. J. 2006, 393, 227-234.
-
(2006)
Biochem. J.
, vol.393
, pp. 227-234
-
-
Padmanabhan, P.K.1
Mukherjee, A.2
Madhubala, R.3
-
23
-
-
18944383472
-
Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modeling and computer simulation
-
Silva, M.S.; Ferreira, A.E.N.; Tomás, A.M.; Cordeiro, C.; Freire, A.P. Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modeling and computer simulation. FEBS J. 2005, 272, 2388-2398.
-
(2005)
FEBS J.
, vol.272
, pp. 2388-2398
-
-
Silva, M.S.1
Ferreira, A.E.N.2
Tomás, A.M.3
Cordeiro, C.4
Freire, A.P.5
-
25
-
-
84863678206
-
In vitro and in vivo activity of a palladacycle complex on Leishmania (Leishmania) amazonensis
-
Paladi, C.D.S.; Pimentel, I.A.; Katz, S.; Cunha, R.L.; Judice, W.A.; Caires, A.C.; Barbiéri, C.L. In vitro and in vivo activity of a palladacycle complex on Leishmania (Leishmania) amazonensis. PLoS Negl. Trop. Dis. 2012, 6, e1626.
-
(2012)
PLoS Negl. Trop. Dis.
, vol.6
-
-
Paladi, C.D.S.1
Pimentel, I.A.2
Katz, S.3
Cunha, R.L.4
Judice, W.A.5
Caires, A.C.6
Barbiéri, C.L.7
-
26
-
-
38649127203
-
Oligopeptidase B: A processing peptidase involved in pathogenesis
-
Coetzer, T.H.T.; Goldring, J.P.D.; Huson, L.E.J. Oligopeptidase B: A processing peptidase involved in pathogenesis. Biochemie 2008, 90, 336-344.
-
(2008)
Biochemie
, vol.90
, pp. 336-344
-
-
Coetzer, T.H.T.1
Goldring, J.P.D.2
Huson, L.E.J.3
-
27
-
-
78649901973
-
Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor
-
McLuskey, K.; Paterson, N.G.; Bland, N.D.; Isaacs, N.W.; Mottram, J.C. Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. J. Biol. Chem. 2010, 285, 39249-39259.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 39249-39259
-
-
McLuskey, K.1
Paterson, N.G.2
Bland, N.D.3
Isaacs, N.W.4
Mottram, J.C.5
-
28
-
-
78650952631
-
The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion
-
Swenerton, R.K.; Zhang, S.; Sajid, M.; Medzihradszky, K.F.; Craik, C.S.; Kelly, B.L.; McKerrow, J.H. The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. J. Biol. Chem. 2011, 286, 429-240.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 429-240
-
-
Swenerton, R.K.1
Zhang, S.2
Sajid, M.3
Medzihradszky, K.F.4
Craik, C.S.5
Kelly, B.L.6
McKerrow, J.H.7
-
29
-
-
84862892803
-
Crystal structure of dihydroorotate dehydrogenase from Leishmania major
-
Cordeiro, A.T.; Feliciano, P.R.; Pinkeiro, M.P.; Nonato, M.C. Crystal structure of dihydroorotate dehydrogenase from Leishmania major. Biochemie 2012, 94, 1739-1748.
-
(2012)
Biochemie
, vol.94
, pp. 1739-1748
-
-
Cordeiro, A.T.1
Feliciano, P.R.2
Pinkeiro, M.P.3
Nonato, M.C.4
-
30
-
-
84877804038
-
Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase
-
Pinheiro, M.P.; Emery, F.D.S.; Nonato, M.C. Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr. Pharm. Des. 2013, 19, 2615-2627.
-
(2013)
Curr. Pharm. Des.
, vol.19
, pp. 2615-2627
-
-
Pinheiro, M.P.1
Emery, F.D.S.2
Nonato, M.C.3
-
31
-
-
0034652380
-
Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids
-
Camacho, A.; Hidalgo-Zarco, F.; Bernier-Villamor, V.; Ruiz-Pérez, L.M.; González-Pacanowska, D. Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids. Biochem. J. 2000, 346, 163-168.
-
(2000)
Biochem. J.
, vol.346
, pp. 163-168
-
-
Camacho, A.1
Hidalgo-Zarco, F.2
Bernier-Villamor, V.3
Ruiz-Pérez, L.M.4
González-Pacanowska, D.5
-
32
-
-
24944499627
-
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target
-
Nguyen, C.; Kasinathan, G.; Leal-Cortijo, I.; Musso-Buendia, A.; Kaiser, M.; Brun, R.; Ruiz-Pérez, L.M.; Johansson, N.G.; González- Pacanowska, D.; Gilbert, I.H. Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J. Med. Chem. 2005, 48, 5942-5954.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 5942-5954
-
-
Nguyen, C.1
Kasinathan, G.2
Leal-Cortijo, I.3
Musso-Buendia, A.4
Kaiser, M.5
Brun, R.6
Ruiz-Pérez, L.M.7
Johansson, N.G.8
González-Pacanowska, D.9
Gilbert, I.H.10
-
33
-
-
79955544332
-
The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine
-
Hemsworth, G.R.; Moroz, O.V.; Fogg, M.J.; Scott, B.; Bosch-Navarrete, C.; González-Pacanowska, D.; Wilson, K.S. The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine. J. Biol. Chem. 2011, 286, 16470-16481.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 16470-16481
-
-
Hemsworth, G.R.1
Moroz, O.V.2
Fogg, M.J.3
Scott, B.4
Bosch-Navarrete, C.5
González-Pacanowska, D.6
Wilson, K.S.7
-
34
-
-
80053232281
-
The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation
-
Gazanion, E.; Garcia, D.; Silvestre, R.; Gérard, C.; Guichou, J.F.; Labesse, G.; Seveno, M.; Cordeiro-Da-Silva, A.; Ouaissi, A.; Sereno, D.; et al. The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation. Mol. Microbiol. 2011, 82, 21-38.
-
(2011)
Mol. Microbiol.
, vol.82
, pp. 21-38
-
-
Gazanion, E.1
Garcia, D.2
Silvestre, R.3
Gérard, C.4
Guichou, J.F.5
Labesse, G.6
Seveno, M.7
Cordeiro-Da-Silva, A.8
Ouaissi, A.9
Sereno, D.10
-
35
-
-
0033597783
-
Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-Å crystal structure
-
Shi, W.; Schramm, V.L.; Almo, S.C. Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-Å crystal structure. J. Biol. Chem. 1999, 274, 21114-21120.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21114-21120
-
-
Shi, W.1
Schramm, V.L.2
Almo, S.C.3
-
36
-
-
0035668550
-
A nonspecific nucleoside hydrolase from Leishmania donovani: Implications for purine salvage by the parasite
-
Cui, L.; Rajasekariah, G.R.; Martin, S.K. A nonspecific nucleoside hydrolase from Leishmania donovani: Implications for purine salvage by the parasite. Gene 2001, 280, 153-162.
-
(2001)
Gene
, vol.280
, pp. 153-162
-
-
Cui, L.1
Rajasekariah, G.R.2
Martin, S.K.3
-
37
-
-
84867981287
-
Kinetics and docking studies of two potential new inhibitors of the nucleoside hydrolase from Leishmania donovani
-
Rennó, M.N.; França, T.C.; Nico, D.; Palatnik-de-Sousa, C.B.; Tinoco, L.W.; Figueroa-Villar, J.D. Kinetics and docking studies of two potential new inhibitors of the nucleoside hydrolase from Leishmania donovani. Eur. J. Med. Chem. 2012, 56, 301-307.
-
(2012)
Eur. J. Med. Chem.
, vol.56
, pp. 301-307
-
-
Rennó, M.N.1
França, T.C.2
Nico, D.3
Palatnik-De-Sousa, C.B.4
Tinoco, L.W.5
Figueroa-Villar, J.D.6
-
38
-
-
79959236902
-
Molecular adaptability of nucleoside diphosphate kinase b from trypanosomatid parasites: Stability, oligomerization and structural determinants of nucleotide binding
-
Souza, T.A.C.B.; Trindade, D.M.; Tonoli, C.C.C.; Santos, C.R.; Ward, R.J.; Arni, R.K.; Oliveira, A.H.C.; Murakami, M.T. Molecular adaptability of nucleoside diphosphate kinase b from trypanosomatid parasites: Stability, oligomerization and structural determinants of nucleotide binding. Mol. BioSyst. 2011, 7, 2189-2195.
-
(2011)
Mol. BioSyst.
, vol.7
, pp. 2189-2195
-
-
Souza, T.A.C.B.1
Trindade, D.M.2
Tonoli, C.C.C.3
Santos, C.R.4
Ward, R.J.5
Arni, R.K.6
Oliveira, A.H.C.7
Murakami, M.T.8
-
39
-
-
0035339851
-
CAMP signaling in Trypanosoma brucei
-
Seebeck, T.; Gong, K.W.; Kunz, S.; Schaub, R.; Shalaby, T.; Zorghi, R. cAMP signaling in Trypanosoma brucei. Int. J. Parasitol. 2001, 31, 491-498.
-
(2001)
Int. J. Parasitol.
, vol.31
, pp. 491-498
-
-
Seebeck, T.1
Gong, K.W.2
Kunz, S.3
Schaub, R.4
Shalaby, T.5
Zorghi, R.6
-
40
-
-
35748936134
-
Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors
-
Wang, H.; Yan, Z.; Geng, J.; Kunz, S.; Seebeck, T.; Ke, H. Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Mol. Microbiol. 2007, 66, 1029-1038.
-
(2007)
Mol. Microbiol.
, vol.66
, pp. 1029-1038
-
-
Wang, H.1
Yan, Z.2
Geng, J.3
Kunz, S.4
Seebeck, T.5
Ke, H.6
-
41
-
-
67949120333
-
Leishmania major: Effect of protein kinase A and phosphodiesterase activity on infectivity and proliferation of promastigotes
-
Malki-Feldman, L.; Jaffe, C.L. Leishmania major: Effect of protein kinase A and phosphodiesterase activity on infectivity and proliferation of promastigotes. Exp. Parasitol. 2009, 123, 39-44.
-
(2009)
Exp. Parasitol.
, vol.123
, pp. 39-44
-
-
Malki-Feldman, L.1
Jaffe, C.L.2
-
42
-
-
0030921824
-
New approaches to Leishmania chemotherapy: Pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity
-
Nare, B.; Luba, J.; Hardy, L.W.; Beverly, S. New approaches to Leishmania chemotherapy: Pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity. Parasitology 1997, 114, S101-S110.
-
(1997)
Parasitology
, vol.114
-
-
Nare, B.1
Luba, J.2
Hardy, L.W.3
Beverly, S.4
-
43
-
-
0035014839
-
Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites
-
Gourley, D.G.; Schüttelkopf, A.W.; Leonard, G.A.; Luba, J.; Hardy, L.W.; Beverley, S.M.; Hunter, W.N. Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites. Nat. Struct. Biol. 2001, 8, 521-525.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 521-525
-
-
Gourley, D.G.1
Schüttelkopf, A.W.2
Leonard, G.A.3
Luba, J.4
Hardy, L.W.5
Beverley, S.M.6
Hunter, W.N.7
-
44
-
-
78751684265
-
In silico screening, structure-activity relationship, and biologic evaluation of selective pteridine reductase inhibitors targeting visceral leishmaniasis
-
Kaur, J.; Kumar, P.; Tyagi, S.; Pathak, R.; Batra, S.; Singh, P.; Singh, N. In silico screening, structure-activity relationship, and biologic evaluation of selective pteridine reductase inhibitors targeting visceral leishmaniasis. Antimicrob. Agents Chemother. 2011, 55, 659-666.
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 659-666
-
-
Kaur, J.1
Kumar, P.2
Tyagi, S.3
Pathak, R.4
Batra, S.5
Singh, P.6
Singh, N.7
-
45
-
-
84872451434
-
Biochemical effects of riluzole on Leishmania parasites
-
Guerrieri, D.; Ferrari, S.; Costi, M.P.; Michels, P.A. Biochemical effects of riluzole on Leishmania parasites. Exp. Parasitol. 2013, 133, 250-254.
-
(2013)
Exp. Parasitol.
, vol.133
, pp. 250-254
-
-
Guerrieri, D.1
Ferrari, S.2
Costi, M.P.3
Michels, P.A.4
-
46
-
-
0037470198
-
Myristoyl-CoA: Protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites
-
Price, H.P.; Menon, M.R.; Panethymitaki, C.; Goulding, D.; McKean, P.G.; Smith, D.F. Myristoyl-CoA: Protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites. J. Biol. Chem. 2003, 278, 7206-7214.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 7206-7214
-
-
Price, H.P.1
Menon, M.R.2
Panethymitaki, C.3
Goulding, D.4
McKean, P.G.5
Smith, D.F.6
-
47
-
-
77950406212
-
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness
-
Frearson, J.A.; Brand, S.; McElroy, S.P.; Cleghorn, L.A.; Smid, O.; Stojanovski, L.; Price, H.P.; Guther, M.L.; Torrie, L.S.; Robinson, D.A.; et al. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature 2010, 464, 728-732.
-
(2010)
Nature
, vol.464
, pp. 728-732
-
-
Frearson, J.A.1
Brand, S.2
McElroy, S.P.3
Cleghorn, L.A.4
Smid, O.5
Stojanovski, L.6
Price, H.P.7
Guther, M.L.8
Torrie, L.S.9
Robinson, D.A.10
-
48
-
-
77950344649
-
N-myristoyltransferase from Leishmania donovani: Structural and functional characterisation of a potential drug target for visceral leishmaniasis
-
Brannigan, J.A.; Smith, B.A.; Yu, Z.; Brzozowski, A.M.; Hodgkinson, M.R.; Maroof, A.; Price, H.P.; Meier, F.; Leatherbarrow, R.J.; Tate, E.W.; et al. N-myristoyltransferase from Leishmania donovani: Structural and functional characterisation of a potential drug target for visceral leishmaniasis. J. Mol. Biol. 2010, 396, 985-999.
-
(2010)
J. Mol. Biol.
, vol.396
, pp. 985-999
-
-
Brannigan, J.A.1
Smith, B.A.2
Yu, Z.3
Brzozowski, A.M.4
Hodgkinson, M.R.5
Maroof, A.6
Price, H.P.7
Meier, F.8
Leatherbarrow, R.J.9
Tate, E.W.10
-
49
-
-
33847147625
-
Structure of cyclophilin from Leishmania donovani at 1.97 Å resolution
-
Venugopal, V.; Sen, B.; Datta, A.K.; Banerjee, R. Structure of cyclophilin from Leishmania donovani at 1.97 Å resolution. Acta Crystallogr. Sect. F 2007, F63, 60-64.
-
(2007)
Acta Crystallogr. Sect. F
, vol.F63
, pp. 60-64
-
-
Venugopal, V.1
Sen, B.2
Datta, A.K.3
Banerjee, R.4
-
50
-
-
77956997367
-
Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability
-
Yau, W.L.; Blisnick, T.; Taly, J.F.; Helmer-Citterich, M.; Schiene-Fischer, C.; Leclercq, O.; Li, J.; Schmidt-Arras, D.; Morales, M.A.; Notredame, C.; et al. Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability. PLoS Negl. Trop. Dis. 2010, 4, e729.
-
(2010)
PLoS Negl. Trop. Dis.
, vol.4
-
-
Yau, W.L.1
Blisnick, T.2
Taly, J.F.3
Helmer-Citterich, M.4
Schiene-Fischer, C.5
Leclercq, O.6
Li, J.7
Schmidt-Arras, D.8
Morales, M.A.9
Notredame, C.10
-
51
-
-
79951511871
-
Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate
-
Larson, E.T.; Kim, J.E.; Zucker, F.H.; Kelley, A.; Mueller, N.; Napuli, A.J.; Verlinde, C.L.M.J.; Fan, E.; Buckner, F.S.; Van Voorhis, W.C.; et al. Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochemie 2011, 93, 570-582.
-
(2011)
Biochemie
, vol.93
, pp. 570-582
-
-
Larson, E.T.1
Kim, J.E.2
Zucker, F.H.3
Kelley, A.4
Mueller, N.5
Napuli, A.J.6
Verlinde, C.L.M.J.7
Fan, E.8
Buckner, F.S.9
Van Voorhis, W.C.10
-
52
-
-
79955906146
-
The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer
-
Larson, E.T.; Kim, J.E.; Castaneda, L.J.; Napuli, A.J.; Zhang, Z.; Fan, E.; Zucker, F.H.; Verlinde, C.L.; Buckner, F.S.; Van Voorhis, W.C.; et al. The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer. J. Mol. Biol. 2011, 3, 159-176.
-
(2011)
J. Mol. Biol.
, vol.3
, pp. 159-176
-
-
Larson, E.T.1
Kim, J.E.2
Castaneda, L.J.3
Napuli, A.J.4
Zhang, Z.5
Fan, E.6
Zucker, F.H.7
Verlinde, C.L.8
Buckner, F.S.9
Van Voorhis, W.C.10
-
53
-
-
0035543633
-
Plant natural products with leishmanicidal activity
-
Chan-Bacab, M.J.; Peña-Rodríguez, LM. Plant natural products with leishmanicidal activity. Nat. Prod. Rep. 2001, 18, 674-688.
-
(2001)
Nat. Prod. Rep.
, vol.18
, pp. 674-688
-
-
Chan-Bacab, M.J.1
Peña-Rodríguez, L.M.2
-
54
-
-
19944424798
-
A review of natural products with antileishmanial activity
-
Rocha, L.G.; Almeida, J.R.G.S.; Macêdo, R.O.; Barbosa-Filho, J.M. A review of natural products with antileishmanial activity. Phytomedicine 2005, 12, 514-535.
-
(2005)
Phytomedicine
, vol.12
, pp. 514-535
-
-
Rocha, L.G.1
Almeida, J.R.G.S.2
Macêdo, R.O.3
Barbosa-Filho, J.M.4
-
55
-
-
33748570738
-
Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis
-
Salem, M.M.; Werbovetz, K.A. Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis. Curr. Med. Chem. 2006, 13, 2571-2598.
-
(2006)
Curr. Med. Chem.
, vol.13
, pp. 2571-2598
-
-
Salem, M.M.1
Werbovetz, K.A.2
-
56
-
-
53049090855
-
Leishmaniasis: Drug resistance and natural products (Review)
-
Polonio, T.; Efferth, T. Leishmaniasis: Drug resistance and natural products (Review). Int. J. Mol. Med. 2008, 22, 277-286.
-
(2008)
Int. J. Mol. Med.
, vol.22
, pp. 277-286
-
-
Polonio, T.1
Efferth, T.2
-
57
-
-
62749188869
-
Fighting against leishmaniasis: Search of alkaloids as future true potential anti-leishmanial agents
-
Mishra, B.B.; Singh, R.K.; Strivastava, A.; Tripathi, V.J.; Tiwari, V.K. Fighting against leishmaniasis: Search of alkaloids as future true potential anti-leishmanial agents. Mini-Rev. Med. Chem. 2009, 9, 107-123.
-
(2009)
Mini-Rev. Med. Chem.
, vol.9
, pp. 107-123
-
-
Mishra, B.B.1
Singh, R.K.2
Strivastava, A.3
Tripathi, V.J.4
Tiwari, V.K.5
-
58
-
-
80052472092
-
Plant derived therapeutics for the treatment of leishmaniasis
-
Sen, R.; Chatterjee, M. Plant derived therapeutics for the treatment of leishmaniasis. Phytomedicine 2011, 18, 1056-1069.
-
(2011)
Phytomedicine
, vol.18
, pp. 1056-1069
-
-
Sen, R.1
Chatterjee, M.2
-
59
-
-
84861168883
-
Antileishmanial natural products from plants
-
Ogungbe, I.V.; Singh, M.; Setzer, W.N. Antileishmanial natural products from plants. Stud. Nat. Prod. Chem. 2012, 36, 331-382.
-
(2012)
Stud. Nat. Prod. Chem.
, vol.36
, pp. 331-382
-
-
Ogungbe, I.V.1
Singh, M.2
Setzer, W.N.3
-
60
-
-
84860678568
-
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-Part II
-
Schmidt, T.J.; Khalid, S.A.; Romanha, A.J.; Alves, T.M.A.; Biavatti, M.W.; Brun, R.; Da Costa, F.B.; de Castro, S.L.; Ferreira, V.F.; de Lacerda, M.V.G.; et al. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-Part II. Curr. Med. Chem. 2012, 19, 2176-2228.
-
(2012)
Curr. Med. Chem.
, vol.19
, pp. 2176-2228
-
-
Schmidt, T.J.1
Khalid, S.A.2
Romanha, A.J.3
Alves, T.M.A.4
Biavatti, M.W.5
Brun, R.6
Da Costa, F.B.7
De Castro, S.L.8
Ferreira, V.F.9
De Lacerda, M.V.G.10
-
61
-
-
84874368479
-
Antiprotozoal activity of essential oils
-
Monzote, L.; Alarcón, O.; Setzer, W.N. Antiprotozoal activity of essential oils. Agric. Consp. Sci. 2012, 77, 167-175.
-
(2012)
Agric. Consp. Sci.
, vol.77
, pp. 167-175
-
-
Monzote, L.1
Alarcón, O.2
Setzer, W.N.3
-
62
-
-
46849089254
-
Recent developments in fragment-based drug discovery
-
Congreve, M.; Chessari, G.; Tisi, D.; Woodhead, A.J. Recent developments in fragment-based drug discovery. J. Med. Chem. 2008, 51, 3661-3680.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 3661-3680
-
-
Congreve, M.1
Chessari, G.2
Tisi, D.3
Woodhead, A.J.4
-
63
-
-
61349165523
-
Docking virtual high throughput screening and in silico fragment-based drug design
-
Zoete, V.; Grosdidier, A.; Michielin, O. Docking, virtual high throughput screening and in silico fragment-based drug design. J. Cell Mol. Med. 2009, 13, 238-248.
-
(2009)
J. Cell Mol. Med.
, vol.13
, pp. 238-248
-
-
Zoete, V.1
Grosdidier, A.2
Michielin, O.3
-
64
-
-
77952087102
-
Bioactive diterpenes from the aerial parts of Anisochilus harmandii
-
Lekphrom, R.; Kanokmedhakul, S.; Kanokmedhakul, K. Bioactive diterpenes from the aerial parts of Anisochilus harmandii. Planta Med. 2010, 76, 726-728.
-
(2010)
Planta Med.
, vol.76
, pp. 726-728
-
-
Lekphrom, R.1
Kanokmedhakul, S.2
Kanokmedhakul, K.3
-
65
-
-
74949119012
-
Structure determination of grandifotane A from Khaya grandifoliola by NMR, X-ray diffraction, and ECD calculation
-
Yuan, T.; Zhu, R.X.; Zhang, H.; Odeku, O.A.; Yang, S.P.; Liao, S.G.; Yue, J.M. Structure determination of grandifotane A from Khaya grandifoliola by NMR, X-ray diffraction, and ECD calculation. Org. Lett. 2010, 12, 252-255.
-
(2010)
Org. Lett.
, vol.12
, pp. 252-255
-
-
Yuan, T.1
Zhu, R.X.2
Zhang, H.3
Odeku, O.A.4
Yang, S.P.5
Liao, S.G.6
Yue, J.M.7
-
66
-
-
77953663813
-
Ethnobotanical survey of antimalarial plants used in Ogun State, southwest Nigeria
-
Idowu, O.A.; Soniran, O.T.; Ajana, O.; Aworinde, D.O. Ethnobotanical survey of antimalarial plants used in Ogun State, southwest Nigeria. Afr. J. Pharm. Pharmacol. 2010, 4, 55-60.
-
(2010)
Afr. J. Pharm. Pharmacol.
, vol.4
, pp. 55-60
-
-
Idowu, O.A.1
Soniran, O.T.2
Ajana, O.3
Aworinde, D.O.4
-
67
-
-
0033990397
-
In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae)
-
Bickii, J.; Njifutie, N.; Foyere, J.A.; Basco, L.K.; Ringwald, P. In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae). J. Ethnopharmacol. 2000, 69, 27-33.
-
(2000)
J. Ethnopharmacol.
, vol.69
, pp. 27-33
-
-
Bickii, J.1
Njifutie, N.2
Foyere, J.A.3
Basco, L.K.4
Ringwald, P.5
-
68
-
-
34447530386
-
Isolation of antileishmanial sterol from the fruits of Cassia fistula using bioguided fractionation
-
Sartorelli, P.; Andrade, S.P.; Melhem, M.S.C.; Prado, F.O.; Tempone, A.G. Isolation of antileishmanial sterol from the fruits of Cassia fistula using bioguided fractionation. Phytother. Res. 2007, 21, 644-647.
-
(2007)
Phytother. Res.
, vol.21
, pp. 644-647
-
-
Sartorelli, P.1
Andrade, S.P.2
Melhem, M.S.C.3
Prado, F.O.4
Tempone, A.G.5
-
69
-
-
34548649224
-
Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds
-
Hoet, S.; Pieters, L.; Muccioli, G.G.; Habib-Jiwan, J.L.; Opperdoes, F.R.; Quetin-Leclercq, J. Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. J. Nat. Prod. 2007, 70, 1360-1363.
-
(2007)
J. Nat. Prod.
, vol.70
, pp. 1360-1363
-
-
Hoet, S.1
Pieters, L.2
Muccioli, G.G.3
Habib-Jiwan, J.L.4
Opperdoes, F.R.5
Quetin-Leclercq, J.6
-
70
-
-
80755136896
-
In vitro anti-trypanosomal activities of crude extracts, b-sitosterol and α-sulfur from Buchholzia coriacea seed
-
Nweze, N.E.; Anene, B.M.; Asuzu, I.U. In vitro anti-trypanosomal activities of crude extracts, b-sitosterol and α-sulfur from Buchholzia coriacea seed. Afr. J. Biotechnol. 2011, 10, 15626-15632.
-
(2011)
Afr. J. Biotechnol.
, vol.10
, pp. 15626-15632
-
-
Nweze, N.E.1
Anene, B.M.2
Asuzu, I.U.3
-
71
-
-
84864619678
-
In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants
-
Setzer, W.N.; Ogungbe, I.V. In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants. PLoS Negl. Trop. Dis. 2012, 6, e1727.
-
(2012)
PLoS Negl. Trop. Dis.
, vol.6
-
-
Setzer, W.N.1
Ogungbe, I.V.2
-
72
-
-
77956172941
-
Crystal structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei
-
Kerr, I.D.; Wu, P.; Marion-Tsukamaki, R.; Mackey, Z.B.; Brinen, L.S. Crystal structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei. PLoS Negl. Trop. Dis. 2010, 4, e701.
-
(2010)
PLoS Negl. Trop. Dis.
, vol.4
-
-
Kerr, I.D.1
Wu, P.2
Marion-Tsukamaki, R.3
Mackey, Z.B.4
Brinen, L.S.5
-
73
-
-
84893123906
-
Crystal structure of Leishmania major dihydroorotate dehydrogenase
-
doi:10.2210/pdb3gye/pdb
-
Cordeiro, A.T.; Feliciano, P.R.; Nonato, M.C. Crystal structure of Leishmania major dihydroorotate dehydrogenase. Biochimie 2012, doi:10.2210/pdb3gye/pdb.
-
(2012)
Biochimie
-
-
Cordeiro, A.T.1
Feliciano, P.R.2
Nonato, M.C.3
-
74
-
-
78649327457
-
Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery
-
Cheleski, J.; Rocha, J.R.; Pinheiro, M.P.; Wiggers, H.J.; da Silva, A.B.F.; Nonato, M.C.; Montanari, C.A. Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. Eur. J. Med. Chem. 2010, 45, 5899-5909.
-
(2010)
Eur. J. Med. Chem.
, vol.45
, pp. 5899-5909
-
-
Cheleski, J.1
Rocha, J.R.2
Pinheiro, M.P.3
Wiggers, H.J.4
Da Silva, A.B.F.5
Nonato, M.C.6
Montanari, C.A.7
-
75
-
-
84855848964
-
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors
-
Brand, S.; Cleghorn, L.A.; McElroy, S.P.; Robinson, D.A.; Smith, V.C.; Hallyburton, I.; Harrison, J.R.; Norcross, N.R.; Spinks, D.; Bayliss, T.; et al. Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J. Med. Chem. 2012, 55, 140-152.
-
(2012)
J. Med. Chem.
, vol.55
, pp. 140-152
-
-
Brand, S.1
Cleghorn, L.A.2
McElroy, S.P.3
Robinson, D.A.4
Smith, V.C.5
Hallyburton, I.6
Harrison, J.R.7
Norcross, N.R.8
Spinks, D.9
Bayliss, T.10
-
76
-
-
13244289553
-
Inhibition of Leishmania major pteridine reductase by 2, 4, 6-triaminoquinazoline: Structure of the NADPH ternary complex
-
McLuskey, K.; Gibellini, F.; Carvalho, P.; Avery, M.A.; Hunter, W.N. Inhibition of Leishmania major pteridine reductase by 2, 4, 6- triaminoquinazoline: Structure of the NADPH ternary complex. Acta Crystallogr. Sect. D 2004, D60, 1780-1785.
-
Acta Crystallogr. Sect. D
, vol.2004
, Issue.D60
, pp. 1780-1785
-
-
McLuskey, K.1
Gibellini, F.2
Carvalho, P.3
Avery, M.A.4
Hunter, W.N.5
-
77
-
-
23944516742
-
Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design
-
Schüttelkopf, A.W.; Hardy, L.W.; Beverley, S.M.; Hunter, W.N. Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design. J. Mol. Biol. 2005, 352, 105-116.
-
(2005)
J. Mol. Biol.
, vol.352
, pp. 105-116
-
-
Schüttelkopf, A.W.1
Hardy, L.W.2
Beverley, S.M.3
Hunter, W.N.4
-
78
-
-
40349108458
-
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
-
Cavazzuti, A.; Paglietti, G.; Hunter, W.N.; Gamarro, F.; Piras, S.; Loriga, M.; Allecca, S.; Corona, P.; McLuskey, K.; Tulloch, L.; et al. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. Proc. Natl. Acad. Sci. USA 2008, 105, 1448-1453.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 1448-1453
-
-
Cavazzuti, A.1
Paglietti, G.2
Hunter, W.N.3
Gamarro, F.4
Piras, S.5
Loriga, M.6
Allecca, S.7
Corona, P.8
McLuskey, K.9
Tulloch, L.10
-
79
-
-
73349134036
-
Structure of cyclophilin from Leishmania donovani bound to cyclosporin at 2.6 Å resolution: Correlation between structure and thermodynamic data
-
Venugopal, V.; Datta, A.K.; Bhattacharyya, D.; Dasgupta, D.; Banerjee, R. Structure of cyclophilin from Leishmania donovani bound to cyclosporin at 2.6 Å resolution: Correlation between structure and thermodynamic data. Acta Crystallogr. Sect. D 2009, D65, 1187-1195.
-
(2009)
Acta Crystallogr. Sect. D
, vol.D65
, pp. 1187-1195
-
-
Venugopal, V.1
Datta, A.K.2
Bhattacharyya, D.3
Dasgupta, D.4
Banerjee, R.5
-
80
-
-
84880833072
-
Crystal structure of dihydroorotate dehydrogenase from
-
To be published, doi:10.2210/pdb3c61/pdb
-
Arakaki, T.L.; Merritt, E.A.; Ullman, B.; Yates, P.A. Crystal structure of dihydroorotate dehydrogenase from Leishmania donovani. 2013, To be published, doi:10.2210/pdb3c61/pdb.
-
(2013)
Leishmania Donovani.
-
-
Arakaki, T.L.1
Merritt, E.A.2
Ullman, B.3
Yates, P.A.4
-
81
-
-
0028866903
-
Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: Implications for structure-based drug design and a new position for the inorganic phosphate binding site
-
Kim, H.; Feil, I.K.; Verlinde, C.L.; Petra, P.H.; Hol, W.G. Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: Implications for structure-based drug design and a new position for the inorganic phosphate binding site. Biochemistry 1995, 34, 14975-14986.
-
(1995)
Biochemistry
, vol.34
, pp. 14975-14986
-
-
Kim, H.1
Feil, I.K.2
Verlinde, C.L.3
Petra, P.H.4
Hol, W.G.5
-
82
-
-
0036851224
-
Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3- phosphate dehydrogenase
-
Choe, J.; Suresh, S.; Wisedchaisri, G.; Kennedy, K.J.; Gelb, M.H.; Hol, W.G. Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3- phosphate dehydrogenase. Chem. Biol. 2002, 9, 1189-1197.
-
(2002)
Chem. Biol.
, vol.9
, pp. 1189-1197
-
-
Choe, J.1
Suresh, S.2
Wisedchaisri, G.3
Kennedy, K.J.4
Gelb, M.H.5
Hol, W.G.6
-
83
-
-
33748958831
-
Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms
-
Kedzierski, L.; Malby, R.L.; Smith, B.J.; Perugini, M.A.; Hodder, A.N.; Ilg, T.; Colman, P.M.; Handman, E. Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms. J. Mol. Biol. 2006, 363, 215-227.
-
(2006)
J. Mol. Biol.
, vol.363
, pp. 215-227
-
-
Kedzierski, L.1
Malby, R.L.2
Smith, B.J.3
Perugini, M.A.4
Hodder, A.N.5
Ilg, T.6
Colman, P.M.7
Handman, E.8
-
84
-
-
77951230850
-
Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model
-
Morgan, H.P.; McNae, I.W.; Nowicki, M.W.; Hannaert, V.; Michels, P.A.; Fothergill-Gilmore, L.A.; Walkinshaw, M.D. Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model. J. Biol. Chem. 2010, 285, 12892-12898.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 12892-12898
-
-
Morgan, H.P.1
McNae, I.W.2
Nowicki, M.W.3
Hannaert, V.4
Michels, P.A.5
Fothergill-Gilmore, L.A.6
Walkinshaw, M.D.7
-
85
-
-
80052397343
-
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site
-
Morgan, H.P.; McNae, I.W.; Nowicki, M.W.; Zhong, W.; Michels, P.A.; Auld, D.S.; Fothergill-Gilmore, L.A.; Walkinshaw, M.D. The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. J. Biol. Chem. 2011, 286, 31232-31240.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 31232-31240
-
-
Morgan, H.P.1
McNae, I.W.2
Nowicki, M.W.3
Zhong, W.4
Michels, P.A.5
Auld, D.S.6
Fothergill-Gilmore, L.A.7
Walkinshaw, M.D.8
-
86
-
-
79960665831
-
High resolution crystal structures of triosephosphate isomerase complexed with its suicide inhibitors: The conformational flexibility of the catalytic glutamate in its closed, liganded active site
-
Venkatesan, R.; Alahuhta, M.; Pihko, P.M.; Wierenga, R.K. High resolution crystal structures of triosephosphate isomerase complexed with its suicide inhibitors: The conformational flexibility of the catalytic glutamate in its closed, liganded active site. Protein Sci. 2011, 20, 1387-1397.
-
(2011)
Protein Sci.
, vol.20
, pp. 1387-1397
-
-
Venkatesan, R.1
Alahuhta, M.2
Pihko, P.M.3
Wierenga, R.K.4
-
87
-
-
79960662249
-
Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14α- demethylase (CYP51) from Leishmania infantum
-
Hargrove, T.Y.; Wawrzak, Z.; Liu, J.; Nes, W.D.; Waterman, M.R.; Lepesheva, G.I. Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14α- demethylase (CYP51) from Leishmania infantum. J. Biol. Chem. 2011, 286, 26838-26848.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 26838-26848
-
-
Hargrove, T.Y.1
Wawrzak, Z.2
Liu, J.3
Nes, W.D.4
Waterman, M.R.5
Lepesheva, G.I.6
-
88
-
-
84861660490
-
A gold-containing drug against parasitic polyamine metabolism: The X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition
-
Ilari, A.; Baiocco, P.; Messori, L.; Fiorillo, A.; Boffi, A.; Gramiccia, M.; Di Muccio, T.; Coltti, G. A gold-containing drug against parasitic polyamine metabolism: The X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition. Amino Acids 2012, 42, 803-811.
-
(2012)
Amino Acids
, vol.42
, pp. 803-811
-
-
Ilari, A.1
Baiocco, P.2
Messori, L.3
Fiorillo, A.4
Boffi, A.5
Gramiccia, M.6
Di Muccio, T.7
Coltti, G.8
-
89
-
-
84880795404
-
-
to be published, doi:10.2210/pdb4adw/pdb
-
Baiocco, P.; Ilari, A.; Colotti, G.; Malatesta, F.; Fiorillo, A. Crystal structure of Leishmania infantum trypanothione reductase in complex with NADPH and trypanothione. To be published, doi:10.2210/pdb4adw/pdb.
-
Crystal structure of Leishmania infantum trypanothione reductase in complex with NADPH and trypanothione
-
-
Baiocco, P.1
Ilari, A.2
Colotti, G.3
Malatesta, F.4
Fiorillo, A.5
-
90
-
-
84880809389
-
-
To be published, doi:10.2210/pdb4apn/pdb
-
Baiocco, P.; Ilari, A.; Colotti, G.; Biava, M. Structure of TR from Leishmania infantum in complex with a diarylpirrole-based inhibitor. To be published, doi:10.2210/pdb4apn/pdb.
-
Structure of TR from Leishmania infantum in complex with a diarylpirrole-based inhibitor
-
-
Baiocco, P.1
Ilari, A.2
Colotti, G.3
Biava, M.4
-
91
-
-
84880784265
-
-
Molegro Virtual Docker v 5.0. Molegro ApS: Aarhus, Denmark 2011
-
Molegro Virtual Docker v 5.0. Molegro ApS: Aarhus, Denmark, 2011.
-
-
-
-
92
-
-
33744826819
-
MolDock: A new technique for high-accuracy molecular docking
-
Thomsen, R.; Christensen, M.H. MolDock: A new technique for high-accuracy molecular docking. J. Med. Chem. 2006, 49, 3315-3321.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 3315-3321
-
-
Thomsen, R.1
Christensen, M.H.2
-
93
-
-
84880821632
-
-
Wavefunction, Inc.: Irvine, CA, USA
-
Spartan '10 for Windows, v 1.1. : Wavefunction, Inc.: Irvine, CA, USA, 2011.
-
(2011)
Spartan '10 for Windows v 1.1
-
-
-
94
-
-
0037571112
-
Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF 94
-
Halgren, T.A. Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF 94. J. Comput. Chem. 1996, 17, 490-519.
-
(1996)
J. Comput. Chem.
, vol.17
, pp. 490-519
-
-
Halgren, T.A.1
-
95
-
-
0028103275
-
The CCP4 suite: Program for protein crystallography. The CCP4 suite: Programs for protein crystallography
-
Collaborative Computational Project Number 4.
-
Collaborative Computational Project, Number 4. The CCP4 suite: Program for protein crystallography. The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 1994, 50, 760-763.
-
(1994)
Acta Crystallogr. D Biol. Crystallogr.
, vol.50
, pp. 760-763
-
-
-
96
-
-
43749083257
-
CHAINSAW: A program for mutating pdb files used as templates in molecular replacement
-
Stein, N. CHAINSAW: A program for mutating pdb files used as templates in molecular replacement. J. Appl. Crystallogr. 2008, 41, 641-643.
-
(2008)
J. Appl. Crystallogr.
, vol.41
, pp. 641-643
-
-
Stein, N.1
-
97
-
-
3543012707
-
Crystallography & NMR System: A new software suite for macromolecular structure determination
-
Brünger, A.T.; Adams, P.D.; Clore, G.M.; DeLano, W.L.; Gros, P.; Grosse-Kunstleve, R.W.; Jiang, J.S.; Kuszewski, J.; Nilges, M.; Pannu, N.S.; et al. Crystallography & NMR System: A new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 1998, 54, 905-921.
-
(1998)
Acta Crystallogr. D Biol. Crystallogr.
, vol.54
, pp. 905-921
-
-
Brünger, A.T.1
Adams, P.D.2
Clore, G.M.3
Delano, W.L.4
Gros, P.5
Grosse-Kunstleve, R.W.6
Jiang, J.S.7
Kuszewski, J.8
Nilges, M.9
Pannu, N.S.10
|