Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model

Journal of Biological Chemistry

Volumn 285, Issue 17, 2010, Pages 12892-12898

  Morgan, Hugh P ^a   McNae, Iain W ^a   Nowicki, Matthew W ^a   Hannaert, Véronique ^b   Michels, Paul A M ^b   Fothergill Gilmore, Linda A ^a   Walkinshaw, Malcolm D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b DE DUVE INSTITUTE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC CONTROL; ALLOSTERIC MECHANISMS; ALLOSTERIC REGULATION; C-DOMAIN; CELLULAR PROCESS; CONFORMATIONAL CHANGE; EFFECTOR BINDING; LEISHMANIA; MOLECULAR MECHANISM; PYRUVATE KINASE; RATE MANAGEMENT; RIGID BODY; ROCKING MOTION; SALT BRIDGES; TETRAMERIC ENZYMES; TETRAMERS; THERMAL STABILITY;

THERMOGRAVIMETRIC ANALYSIS;

ENZYMES;

PROTEIN SUBUNIT; PYRUVATE KINASE;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STABILITY; ENZYME STRUCTURE; LEISHMANIA MEXICANA; LIGAND BINDING; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; THERMOSTABILITY;

ALLOSTERIC REGULATION; ANIMALS; LEISHMANIA MEXICANA; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; PYRUVATE KINASE;

LEISHMANIA MEXICANA;

EID: 77951230850     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.079905     Document Type: Article

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