Identification of attractive drug targets in neglected- disease pathogens using an in Silico approach

PLoS Neglected Tropical Diseases

Volumn 4, Issue 8, 2010, Pages

  Crowther, Gregory J ^a   Shanmugam, Dhanasekaran ^b   Carmona, Santiago J ^c   Doyle, Maria A ^d,g   Hertz Fowler, Christiane ^e,h   Berriman, Matthew ^e   Nwaka, Solomon ^f   Ralph, Stuart A ^d   Roos, David S ^b   van Voorhis, Wesley C ^a   Agüero, Fernán ^c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^f WORLD HEALTH ORGANIZATION   (Switzerland)

^g PETER MACCALLUM CANCER CENTRE   (Australia)

^h UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATOVAQUONE; CYCLOGUANIL; CYTOCHROME B; DAPSONE; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; EFLORNITHINE; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); FLUCONAZOLE; ISONIAZID; MICROORGANISM PROTEIN; ORNITHINE DECARBOXYLASE; PROGUANIL; PYRIMETHAMINE; RIFAMPICIN; RNA POLYMERASE; STEROL 14ALPHA DEMETHYLASE; SULFADIAZINE; SULFADOXINE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; HELMINTH PROTEIN; PROTOZOAL PROTEIN;

ARTICLE; BRUGIA MALAYI; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG TARGETING; GENE TARGETING; GENETIC DATABASE; GENOME ANALYSIS; HELMINTH; INFORMATION PROCESSING; LEISHMANIA MAJOR; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PARASITE SURVIVAL; PLASMODIUM FALCIPARUM; PROTEIN DATABASE; PROTEOMICS; SCHISTOSOMA MANSONI; SEQUENCE ANALYSIS; TOXOPLASMA GONDII; TROPICAL DISEASE; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; ANIMAL; BIOLOGY; DRUG ANTAGONISM; DRUG DEVELOPMENT; HUMAN; METHODOLOGY; PHYSIOLOGY;

ANIMALS; ANTI-INFECTIVE AGENTS; BACTERIAL PROTEINS; COMPUTATIONAL BIOLOGY; DRUG DISCOVERY; HELMINTH PROTEINS; HUMANS; PROTOZOAN PROTEINS;

EID: 78149249050     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000804     Document Type: Article

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