-
1
-
-
0027996240
-
PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major
-
Bello A.R., Nare B., Freedman D., Hardy L., Beverley S.M. PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:11442-11446.
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, pp. 11442-11446
-
-
Bello, A.R.1
Nare, B.2
Freedman, D.3
Hardy, L.4
Beverley, S.M.5
-
2
-
-
40349108458
-
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
-
Cavazzuti A., Paglietti G., Hunter W.N., Gamarro F., Piras S., Loriga M., et al. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:1448-1453.
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, pp. 1448-1453
-
-
Cavazzuti, A.1
Paglietti, G.2
Hunter, W.N.3
Gamarro, F.4
Piras, S.5
Loriga, M.6
-
3
-
-
0026490217
-
Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo
-
Chéramy A., Barbeito L., Godeheu G., Glowinski J. Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo. Neuroscience Letters 1992, 147:209-212.
-
(1992)
Neuroscience Letters
, vol.147
, pp. 209-212
-
-
Chéramy, A.1
Barbeito, L.2
Godeheu, G.3
Glowinski, J.4
-
4
-
-
33748794547
-
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
-
Chou T.C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacological Reviews 2006, 58:621-681.
-
(2006)
Pharmacological Reviews
, vol.58
, pp. 621-681
-
-
Chou, T.C.1
-
5
-
-
0037090528
-
Life without transcriptional control? From fly to man and back again
-
Clayton C.E. Life without transcriptional control? From fly to man and back again. EMBO Journal 2002, 21:1881-1888.
-
(2002)
EMBO Journal
, vol.21
, pp. 1881-1888
-
-
Clayton, C.E.1
-
6
-
-
0025049856
-
Gene replacement in parasitic protozoa
-
Cruz A., Beverley S.M. Gene replacement in parasitic protozoa. Nature 1990, 348:171-173.
-
(1990)
Nature
, vol.348
, pp. 171-173
-
-
Cruz, A.1
Beverley, S.M.2
-
7
-
-
0035853522
-
Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin
-
Cunningham M.L., Titus R.G., Turco S.J., Beverley S.M. Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin. Science 2001, 292:285-287.
-
(2001)
Science
, vol.292
, pp. 285-287
-
-
Cunningham, M.L.1
Titus, R.G.2
Turco, S.J.3
Beverley, S.M.4
-
8
-
-
78651093844
-
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase
-
Ferrari S., Morandi F., Motiejunas D., Nerini E., Henrich S., Luciani R., et al. Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. Journal of Medicinal Chemistry 2011, 54:211-221.
-
(2011)
Journal of Medicinal Chemistry
, vol.54
, pp. 211-221
-
-
Ferrari, S.1
Morandi, F.2
Motiejunas, D.3
Nerini, E.4
Henrich, S.5
Luciani, R.6
-
9
-
-
0031282556
-
Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways
-
Hardy L.W., Matthews W., Nare B., Beverley S.M. Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways. Experimental Parasitology 1997, 87:157-169.
-
(1997)
Experimental Parasitology
, vol.87
, pp. 157-169
-
-
Hardy, L.W.1
Matthews, W.2
Nare, B.3
Beverley, S.M.4
-
10
-
-
0025409320
-
Dihydrofolate reductase-thymidylate synthase in protozoa
-
Ivanetich K.M., Santi D.V. Dihydrofolate reductase-thymidylate synthase in protozoa. Experimental Parasitology 1990, 70:367-371.
-
(1990)
Experimental Parasitology
, vol.70
, pp. 367-371
-
-
Ivanetich, K.M.1
Santi, D.V.2
-
11
-
-
0025678398
-
Quantitative in vitro drug potency and drug susceptibility evaluation of Leishmania spp. from patients unresponsive to pentavalent antimony therapy
-
Jackson J.E., Tally J.D., Ellis W.Y., Mebrahtu Y.B., Lawyer P.G., Were J.B., et al. Quantitative in vitro drug potency and drug susceptibility evaluation of Leishmania spp. from patients unresponsive to pentavalent antimony therapy. The American Journal of Tropical Medicine and Hygiene 1990, 43:464-480.
-
(1990)
The American Journal of Tropical Medicine and Hygiene
, vol.43
, pp. 464-480
-
-
Jackson, J.E.1
Tally, J.D.2
Ellis, W.Y.3
Mebrahtu, Y.B.4
Lawyer, P.G.5
Were, J.B.6
-
12
-
-
33645883558
-
Progresses in the field of drug design to combat tropical protozoan parasitic diseases
-
Linares G.E., Ravaschino E.L., Rodriguez J.B. Progresses in the field of drug design to combat tropical protozoan parasitic diseases. Current Medicinal Chemistry 2006, 13:335-360.
-
(2006)
Current Medicinal Chemistry
, vol.13
, pp. 335-360
-
-
Linares, G.E.1
Ravaschino, E.L.2
Rodriguez, J.B.3
-
13
-
-
34447544346
-
Living in a phagolysosome; metabolism of Leishmania amastigotes
-
McConville M.J., de Souza D., Saunders E., Likic V.A., Naderer T. Living in a phagolysosome; metabolism of Leishmania amastigotes. Trends in Parasitology 2007, 23:368-375.
-
(2007)
Trends in Parasitology
, vol.23
, pp. 368-375
-
-
McConville, M.J.1
de Souza, D.2
Saunders, E.3
Likic, V.A.4
Naderer, T.5
-
14
-
-
0033991437
-
A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue
-
Mikus J., Steverding D. A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue. Parasitology International 2000, 48:265-269.
-
(2000)
Parasitology International
, vol.48
, pp. 265-269
-
-
Mikus, J.1
Steverding, D.2
-
15
-
-
0000969567
-
Morphology ultrastructure and life cycles
-
Academic Press Inc., London, (Chapter 2)
-
Molyneux D.H., Killick-Kendrick R. Morphology ultrastructure and life cycles. The Leishmaniases in Biology and Medicine 1987, vol. 1:121-176. Academic Press Inc., London, (Chapter 2).
-
(1987)
The Leishmaniases in Biology and Medicine
, vol.1
, pp. 121-176
-
-
Molyneux, D.H.1
Killick-Kendrick, R.2
-
16
-
-
80053395366
-
Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania
-
Moreira W., Leprohon P., Ouellette M. Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania. Cell Death & Disease 2011, 2011(2):e201. 10.1038/cddis.2011.83.
-
(2011)
Cell Death & Disease
, vol.2011
, Issue.2
-
-
Moreira, W.1
Leprohon, P.2
Ouellette, M.3
-
17
-
-
0030946111
-
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major
-
Nare B., Hardy L.W., Beverley S.M. The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major. Journal of Biological Chemistry 1997, 272:13883-13891.
-
(1997)
Journal of Biological Chemistry
, vol.272
, pp. 13883-13891
-
-
Nare, B.1
Hardy, L.W.2
Beverley, S.M.3
-
18
-
-
67349132416
-
PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major
-
Nare B., Garraway L.A., Vickers T.J., Beverley S.M. PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major. Current Genetics 2009, 55:287-299.
-
(2009)
Current Genetics
, vol.55
, pp. 287-299
-
-
Nare, B.1
Garraway, L.A.2
Vickers, T.J.3
Beverley, S.M.4
-
19
-
-
0036176478
-
Pterin transport and metabolism in Leishmania and related trypanosomatid parasites
-
Ouellette M., Drummerlsmith J., El Fadili A., Kundig C., Richard D., Roy G. Pterin transport and metabolism in Leishmania and related trypanosomatid parasites. International Journal of Parasitology 2002, 32:385-398.
-
(2002)
International Journal of Parasitology
, vol.32
, pp. 385-398
-
-
Ouellette, M.1
Drummerlsmith, J.2
El Fadili, A.3
Kundig, C.4
Richard, D.5
Roy, G.6
-
20
-
-
0026779424
-
A novel antifolate resistance gene on the amplified H circle of Leishmania
-
Papadopoulou B., Roy G., Ouellette M. A novel antifolate resistance gene on the amplified H circle of Leishmania. EMBO Journal 1992, 11:3601-3688.
-
(1992)
EMBO Journal
, vol.11
, pp. 3601-3688
-
-
Papadopoulou, B.1
Roy, G.2
Ouellette, M.3
-
21
-
-
0023141861
-
Folate utilisation by Leishmania species and the identification of intracellular derivatives and folate-metabolising enzymes
-
Scott D.A., Coombs G.H., Sanderson B.E. Folate utilisation by Leishmania species and the identification of intracellular derivatives and folate-metabolising enzymes. Molecular and Biochemical Parasitology 1987, 23:139-149.
-
(1987)
Molecular and Biochemical Parasitology
, vol.23
, pp. 139-149
-
-
Scott, D.A.1
Coombs, G.H.2
Sanderson, B.E.3
-
22
-
-
47249120852
-
Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes
-
Sienkiewicz N., Jarosławski S., Wyllie S., Fairlamb A.H. Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes. Molecular Microbiology 2008, 69:520-533.
-
(2008)
Molecular Microbiology
, vol.69
, pp. 520-533
-
-
Sienkiewicz, N.1
Jarosławski, S.2
Wyllie, S.3
Fairlamb, A.H.4
-
23
-
-
0034114654
-
Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors
-
Van Triest B., Pinedo H.M., Giaccone G., Peters G.J. Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors. Annals of Oncology 2000, 11:385-391.
-
(2000)
Annals of Oncology
, vol.11
, pp. 385-391
-
-
Van Triest, B.1
Pinedo, H.M.2
Giaccone, G.3
Peters, G.J.4
-
24
-
-
0003961250
-
-
WHO Expert Committee, WHO, Geneva
-
WHO Expert Committee The Leishmaniasis 1984, WHO, Geneva.
-
(1984)
The Leishmaniasis
-
-
|