Crystal structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei

PLoS Neglected Tropical Diseases

Volumn 4, Issue 6, 2010, Pages

  Kerr, Iain D ^a   Wu, Peng ^a,b   Marion Tsukamaki, Rachael ^a   Mackey, Zachary B ^a   Brinen, Linda S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; K 11002; N (3 PROPYLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; RHODESAIN; UNCLASSIFIED DRUG; CA 074 METHYL ESTER; DIPEPTIDE; MORPHOLIN UREA PHENYLALANYL HOMOPHENYLALANYL VINYLSULFONE PHENYL; MORPHOLIN- UREA-PHENYLALANYL-HOMOPHENYLALANYL-VINYLSULFONE-PHENYL; RECOMBINANT PROTEIN; SULFONE; TBCATB PROTEIN, TRYPANOSOMA BRUCEI;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA SEQUENCE; DRUG DETERMINATION; ENZYME SUBSTRATE COMPLEX; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN TARGETING; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; TRYPANOSOMA BRUCEI; WESTERN BLOTTING; X RAY CRYSTALLOGRAPHY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; METHODOLOGY; PROTEIN BINDING;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; DIPEPTIDES; MODELS, MOLECULAR; PROTEIN BINDING; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, PROTEIN; SULFONES; TRYPANOSOMA BRUCEI BRUCEI;

EID: 77956172941     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000701     Document Type: Article

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