The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site

Journal of Biological Chemistry

Volumn 286, Issue 36, 2011, Pages 31232-31240

  Morgan, Hugh P ^a   McNae, Iain W ^a   Nowicki, Matthew W ^a   Zhong, Wenhe ^a   Michels, Paul A M ^b   Auld, Douglas S ^c   Fothergill Gilmore, Linda A ^a   Walkinshaw, Malcolm D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b DE DUVE INSTITUTE   (Belgium)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALLOSTERIC EFFECTORS; CLINICAL USE; DISULFONIC ACID; DYE MOLECULE; LEISHMANIA; MIMETICS; MODE OF ACTION; PYRUVATE KINASE; SULFONATE GROUPS; SURAMIN; SYNERGISTIC EFFECT; TRYPANOSOMA CRUZI; TRYPANOSOME INFECTIONS;

EXPERIMENTS; MAMMALS; MOLECULES;

ENZYMES;

ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BENZOTHIAZOLE DERIVATIVE; ENZYME INHIBITOR; ISOENZYME; PYRUVATE KINASE; PYRUVATE KINASE INHIBITOR; SURAMIN; TRYPAN BLUE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING COMPETITION; BINDING KINETICS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; HUMAN; IC 50; KINETOPLASTIDA; LEISHMANIA MEXICANA; LIVER; MUSCLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRYPANOSOMA CRUZI;

ADENOSINE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LEISHMANIA MEXICANA; MICE; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRUVATE KINASE; SURAMIN; TRYPAN BLUE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

LEISHMANIA MEXICANA; MUS; TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

EID: 80052397343     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.212613     Document Type: Article

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