CAMP signalling in Trypanosoma brucei

International Journal for Parasitology

Volumn 31, Issue 5-6, 2001, Pages 491-498

  Seebeck, Thomas ^a   Gong, KewWei ^a   Kunz, Stefan ^a   Schaub, Rahel ^a   Shalaby, Tarek ^a   Zoraghi, Roya ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Adenylyl cyclase; cAMP; Drug target; Protein kinase A regulatory subunit; Sleeping sickness

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHODIESTERASE; PROTEIN SUBUNIT;

AFRICAN TRYPANOSOMIASIS; AMINO TERMINAL SEQUENCE; CONFERENCE PAPER; ENZYME ACTIVITY; HOST PARASITE INTERACTION; IMMUNOPRECIPITATION; MEDICAL RESEARCH; NONHUMAN; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; TRYPANOSOMA BRUCEI;

ADENYLATE CYCLASE; ANIMALS; CYCLIC AMP; HUMANS; PHOSPHORIC DIESTER HYDROLASES; SIGNAL TRANSDUCTION; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

MAMMALIA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0035339851     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(01)00164-3     Document Type: Review

References (37)

1. The GAF domain: An evolutionary link between diverse phototransducing proteins
2. Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD)
3. The in vitro differentiation of pleomorphic Trypanosoma brucei form bloodstream into procyclic from requires neither intermediary nor stumpy stage
4. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
5. Crystallisation and preliminary X-ray analysis of thecatalytic domain of the adenylate cyclase GRESAG4.1 from Trypanosoma brucei
6. Therapeutic potential of phosphodiesterase-4 and -3 inhibitors in Th1-mediated autoimmune disease
7. Cytosolic adenylyl cyclase defines a unique signalling molecule in mammals
8. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor
9. Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents
10. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
11. The guanylyl cyclase receptors
12. Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuit
13. Spatial dynamics of second messengers: IP3 and cAMP as long-range and associative messengers
14. Sildenafil: A review of its use in erectile dysfunction
15. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells
16. Cyclic AMP signalling in trypanosomatids
17. Spontaneous dimerization and leucine-zipper induced activation of the recombinant catalytic domain of a new adenylyl cyclase of Trypanosoma brucei, GRESAG4.4B
18. Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae
19. Both IgM and IgG anti-VSG antibodies initiate a cycle of aggregation-disaggregation of bloodstream forms of Trypanosoma brucei without damage to the parasite
20. X-ray structure of the GCN4 leucine zipper, a two-stranded parallel coiled-coil
21. The genes and transcripts of an antigen gene expression site from T. brucei
22. The relationship of epinephrine and glucagon to liver phosphorylase. IV. Effect of epinephrine and glucagon on the reactivation of phosphorylase in liver homogenates
23. Transient adenylate cyclase activation accompanies differentiation of Trypanosoma brucei from bloodstream to procyclic forms
24. Simultaneous but independent activation of adenylate cyclase and glycophosphatidyl phospholipase C under stress conditions in Trypanosoma brucei
25. The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene
26. A family of putative receptor adenylate cyclases from Leishmania donovani
27. Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae
28. The role of phosphodiesterase enzymes in allergy and asthma
29. Complexity and diversity of mammalian adenylyl cyclases
30. Trypanosoma cruzi adenylyl cyclase is encoded by a complex multigene family
31. Two-metal ion catalysis in adenylyl cyclase
32. Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway
33. 3′,5′ cyclic AMP phosphodiesterase from Trypanosoma gambiense
34. Adenylate cyclase from Trypanosoma gambiense
35. Atomic structure of PDE4: Insights into phosphodiesterase mechanism and specificity
36. Guanylyl cyclase expression in specific sensory neurons: A new family of chemosensory receptors