Crystal structure of Leishmania mexicana glycosomal glyceraldehyde-3-phosphate dehydrogenase in a new crystal form confirms the putative physiological active site structure

Journal of Molecular Biology

Volumn 278, Issue 1, 1998, Pages 5-11

  Kim, Hidong ^a   Hol, Wim G J ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Drug design; Glyceraldehyde 3 phosphate dehydrogenase; Phosphate binding; Trypanosome; X ray structure

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHOSPHATE;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; LEISHMANIA MEXICANA; MOLECULAR MODEL; NONHUMAN; PH; PRIORITY JOURNAL; R FACTOR; X RAY CRYSTALLOGRAPHY;

LEISHMANIA MEXICANA;

EID: 0032562541     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.1661     Document Type: Article

References (26)

1. Brock T.D., Smith D.W., Madigan M.T. Biology of Microorganisms. 1984;503 Prentice-Hall, Inc, Englewood Cliffs, NJ, USA
2. Brünger A.T. X-PLOR, Version 3.1, A System for X-Ray Crystallography and NMR. 1992;Yale University Press, New Haven, CT
3. Buehner M., Ford G.C., Moras D., Olsen K.W., Rossmann M.G. Structure determination of crystalline lobster D-glyceraldehyde-3-phosphate dehydrogenase. J. Mol. Biol. 82:1974;563-585
4. CCP4. The CCP4 suite programs for protein crystallography. Acta Crystallog. sect. D. 50:1994;760-763
5. Duée E., Olivier-Deyris L., Fanchon E., Corbier C., Branlant G., Dideberg O. Comparison of the structures of wild-type and a N313 T mutant of Escherichia coli glyceraldehyde-3-phosphate dehydrogenase implication for NAD binding and cooperativity. J. Mol. Biol. 257:1996;814-838
6. Fothergill-Gillmore L.A., Michels P.A. Evolution of glycolysis. Prog. Biophys. Mol. Biol. 59:1993;105-235
7. Hannaert V., Blaauw M., Kohl L., Allert S., Opperdoes F.R., Michels P.A.M. Molecular analysis of the cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase in Leishmania mexicana. Mol. Biochem. Parasitol. 55:1992;115-126
8. Hannaert V., Callens M., Opperdoes F.R., Michels P.A. Purification and characterization of the native and the recombinant Leishmania mexicana glycosomal glyceraldhyde-3-phosphate dehydrogenase. Eur. J. Biochem. 225:1994;143-149
9. Harris J.I., Waters M. Glyceraldehyde-3-phosphate dehydrogenase. Boyer P.D. The Enzymes. 1976;1-49
10. Hodel A., Kim S.-H., Brünger A.T. Model bias in macromolecular crystal structures. Acta Crystallog. sect. A. 48:1992;851-859
11. Jones T.A., Zou J.Y., Cowan S.W., Kjeldgaard M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallog. Sect. A. 46:1991;110-119
12. Kim H., Feil I.K., Verlinde C.L.M.J., Petra P., Hol W.G.J. Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana implications for structure-based drug design and a new position for the inorganic phosphate binding site. Biochemistry. 34:1995;14975-14986
13. Korndörfer I., Steipe B., Huber R., Tomschy A., Jaenicke R. The crystal structure of holo-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic bacteriumThermotoga maritima at 2.5 Å resolution. J. Mol. Biol. 246:1995;511-521
14. Kraulis P.J. MOLSCRIPT a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallog. 24:1991;946-950
15. Moras D., Olsen K.W., Sabesan M.N., Buehner M., Ford G.C., Rossmann M.G. Studies of asymmetry in the three-dimensional structure of lobster glyceraldehyde-3-phosphate dehydrogenase. J. Biol. Chem. 250:1975;9137-9162
16. Olivier L., Buisson G., Fanchon E., Corbier C., Branlant G., Dideberg O. Crystallization and preliminary X-ray diffraction studies of Escherichia coli glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallog. sect. D. 51:1995;245-247
17. Opperdoes F.R. Compartmentation of carbohydrate metabolism in trypanosomes. Annu. Rev. Microbiol. 41:1987;127-151
18. Otwinowski Z. Sawyer L., Isaacs N., Bailey S. Data Collection and Processing. Proceedings of the CCP4 Study Weekend. 1993;56-62 SERC Daresbury Laboratory, Warrington, UK
19. Read R.J. Improved Fourier coefficients for maps using phases from partial structures with errors. Acta Crystallog. Sect. A. 42:1986;140-149
20. Read R.J., Wierenga R.K., Groendijk H., Hol W.G.J., Lambeir A., Opperdoes F.R. Preliminary crystallographic studies of glycosomal glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei. J. Mol. Biol. 194:1987;573-575
21. Skarżyński T., Moody P.C.E., Wonacott A.J. Structure of hologlyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus. J. Mol. Biol. 193:1987;171-187
22. Tanner J., Hecht R.M., Pisegna M., Seth D.M., Krause K.L. Preliminary crystallographic analysis of glyceraldehyde-3-phosphate dehydrogenase from the extreme thermophileThermus aquaticus. Acta Crystallog. sect. D. 50:1994;744-748
23. Tanner J.J., Hecht R.M., Krause K.L. Determinants of enzyme thermostability observed in the molecular structure of Thermus aquaticusD -glyceraldehyde-3-phosphate dehydrogenase at 2.5 Å resolution. Biochemistry. 35:1996;2597-2609
24. Vellieux F.M.D., Hajdu J., Hol W.G. Refined 3.2 Å structure of glycosomal holo glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei. Acta Crystallog. sect. D. 51:1995;575-589
25. Verlinde C.L.M.J., Hol W.G.J. Structure-based drug design progress, results and challenges. Structure. 2:1994;577-587
26. Watson H.C., Duée E., Mercer W.D. Low resolution structure of glyceraldehyde-3-phosphate dehydrogenase. Nature New Biol. 240:1972;130-139