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Volumn 27, Issue 4, 2013, Pages 281-291

Therapeutic potential of regulatory T cells in autoimmune disorders

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CELL MARKER; INTERLEUKIN 2; RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

EID: 84880805786     PISSN: 11738804     EISSN: 1179190X     Source Type: Journal    
DOI: 10.1007/s40259-013-0026-5     Document Type: Article
Times cited : (23)

References (117)
  • 1
    • 2442522323 scopus 로고    scopus 로고
    • Autoreactive T cells in healthy individuals
    • 15128778 1:CAS:528:DC%2BD2cXjs1OjtL0%3D
    • Danke NA, Koelle DM, Yee C, Beheray S, Kwok WW. Autoreactive T cells in healthy individuals. J Immunol. 2004;172(10):5967-72.
    • (2004) J Immunol , vol.172 , Issue.10 , pp. 5967-5972
    • Danke, N.A.1    Koelle, D.M.2    Yee, C.3    Beheray, S.4    Kwok, W.W.5
  • 2
    • 33645059454 scopus 로고    scopus 로고
    • Imbalance of regulatory T cells in human autoimmune diseases
    • 16476048 1:CAS:528:DC%2BD28XjtVeqsL0%3D 10.1111/j.1365-2567.2005.02317.x
    • Dejaco C, Duftner C, Grubeck-Loebenstein B, Schirmer M. Imbalance of regulatory T cells in human autoimmune diseases. Immunology. 2006;117(3):289-300.
    • (2006) Immunology , vol.117 , Issue.3 , pp. 289-300
    • Dejaco, C.1    Duftner, C.2    Grubeck-Loebenstein, B.3    Schirmer, M.4
  • 3
    • 0037099613 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
    • 12119348 1:CAS:528:DC%2BD38XlsV2ms7s%3D 10.1084/jem.20020590
    • Piccirillo CA, Letterio JJ, Thornton AM, McHugh RS, Mamura M, Mizuhara H, et al. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med. 2002;196(2):237-46.
    • (2002) J Exp Med , vol.196 , Issue.2 , pp. 237-246
    • Piccirillo, C.A.1    Letterio, J.J.2    Thornton, A.M.3    McHugh, R.S.4    Mamura, M.5    Mizuhara, H.6
  • 4
    • 33846923124 scopus 로고    scopus 로고
    • + regulatory T cells and for expansion of these cells
    • 17277105 1:CAS:528:DC%2BD2sXht1Cgtbs%3D
    • + regulatory T cells and for expansion of these cells. J Immunol. 2007;178(4):2018-27.
    • (2007) J Immunol , vol.178 , Issue.4 , pp. 2018-2027
    • Zheng, S.G.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 5
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • 11137993 1:CAS:528:DC%2BD3MXis1yluw%3D%3D 10.1038/83713
    • Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001;27(1):20-1.
    • (2001) Nat Genet , vol.27 , Issue.1 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whitesell, L.6
  • 6
    • 35448930435 scopus 로고    scopus 로고
    • +FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype
    • 17644734 1:CAS:528:DC%2BD2sXht1Smu7%2FO 10.1182/blood-2007-06-094656
    • +FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood. 2007;110(8):2983-90.
    • (2007) Blood , vol.110 , Issue.8 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 8
    • 80052287274 scopus 로고    scopus 로고
    • Helios expression is a marker of T cell activation and proliferation
    • 21918685 1:CAS:528:DC%2BC3MXht1WrtLjK 10.1371/journal.pone.0024226
    • Akimova T, Beier UH, Wang L, Levine MH, Hancock WW. Helios expression is a marker of T cell activation and proliferation. PLoS One. 2011;6(8):e24226.
    • (2011) PLoS One , vol.6 , Issue.8 , pp. 24226
    • Akimova, T.1    Beier, U.H.2    Wang, L.3    Levine, M.H.4    Hancock, W.W.5
  • 10
    • 0027479685 scopus 로고
    • Infectious" transplantation tolerance
    • 8094901 1:CAS:528:DyaK3sXhsVKjt7s%3D 10.1126/science.8094901
    • Qin S, Cobbold SP, Pope H, Elliott J, Kioussis D, Davies J, et al. "Infectious" transplantation tolerance. Science. 1993;259(5097):974-7.
    • (1993) Science , vol.259 , Issue.5097 , pp. 974-977
    • Qin, S.1    Cobbold, S.P.2    Pope, H.3    Elliott, J.4    Kioussis, D.5    Davies, J.6
  • 11
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • 8676075 1:CAS:528:DyaK28XjslaisLo%3D 10.1084/jem.183.6.2541
    • Walunas TL, Bakker CY, Bluestone JA. CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med. 1996;183(6):2541-50.
    • (1996) J Exp Med , vol.183 , Issue.6 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 13
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    • 15485635 1:CAS:528:DC%2BD2cXpvVygtLk%3D 10.1016/j.immuni.2004.09.002
    • Grossman WJ, Verbsky JW, Barchet W, Colonna M, Atkinson JP, Ley TJ. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity. 2004;21(4):589-601.
    • (2004) Immunity , vol.21 , Issue.4 , pp. 589-601
    • Grossman, W.J.1    Verbsky, J.W.2    Barchet, W.3    Colonna, M.4    Atkinson, J.P.5    Ley, T.J.6
  • 14
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • 18033300 1:CAS:528:DC%2BD2sXhtlCrtbzI 10.1038/nature06306
    • Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007;450(7169):566-9.
    • (2007) Nature , vol.450 , Issue.7169 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3    Boyd, K.4    Wang, Y.5    Vignali, K.M.6
  • 15
    • 70049118519 scopus 로고    scopus 로고
    • Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner
    • 19414764 1:CAS:528:DC%2BD1MXltlynt7g%3D 10.4049/jimmunol.0803646
    • Collison LW, Pillai MR, Chaturvedi V, Vignali DA. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol. 2009;182(10):6121-8.
    • (2009) J Immunol , vol.182 , Issue.10 , pp. 6121-6128
    • Collison, L.W.1    Pillai, M.R.2    Chaturvedi, V.3    Vignali, D.A.4
  • 16
    • 70350464351 scopus 로고    scopus 로고
    • Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    • 19783988 1:CAS:528:DC%2BD1MXhtFygsLbJ 10.1038/ni.1791
    • Murai M, Turovskaya O, Kim G, Madan R, Karp CL, Cheroutre H, et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol. 2009;10(11):1178-84.
    • (2009) Nat Immunol , vol.10 , Issue.11 , pp. 1178-1184
    • Murai, M.1    Turovskaya, O.2    Kim, G.3    Madan, R.4    Karp, C.L.5    Cheroutre, H.6
  • 17
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • 18387831 1:CAS:528:DC%2BD1cXkvV2it7c%3D 10.1016/j.immuni.2008.02.017
    • Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008;28(4):546-58.
    • (2008) Immunity , vol.28 , Issue.4 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3    Fontenot, J.4    Castelli, L.5    Ye, X.6
  • 18
    • 0037310355 scopus 로고    scopus 로고
    • Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo
    • 12538682 1:CAS:528:DC%2BD3sXnvVOmtw%3D%3D
    • Sundstedt A, O'Neill EJ, Nicolson KS, Wraith DC. Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J Immunol. 2003;170(3):1240-8.
    • (2003) J Immunol , vol.170 , Issue.3 , pp. 1240-1248
    • Sundstedt, A.1    O'Neill, E.J.2    Nicolson, K.S.3    Wraith, D.C.4
  • 19
    • 0036346861 scopus 로고    scopus 로고
    • Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
    • 12161590 1:CAS:528:DC%2BD38XntFSktbs%3D 10.1136/jmg.39.8.537
    • Wildin RS, Smyk-Pearson S, Filipovich AH. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet. 2002;39(8):537-45.
    • (2002) J Med Genet , vol.39 , Issue.8 , pp. 537-545
    • Wildin, R.S.1    Smyk-Pearson, S.2    Filipovich, A.H.3
  • 21
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • 15280421 1:CAS:528:DC%2BD2cXmsVCktbg%3D 10.1084/jem.20040165
    • Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med. 2004;200(3):277-85.
    • (2004) J Exp Med , vol.200 , Issue.3 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6
  • 22
    • 4444300314 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    • 15457445 10.1002/art.20499
    • van Amelsfort JM, Jacobs KM, Bijlsma JW, Lafeber FP, Taams LS. CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum. 2004;50(9):2775-85.
    • (2004) Arthritis Rheum , vol.50 , Issue.9 , pp. 2775-2785
    • Van Amelsfort, J.M.1    Jacobs, K.M.2    Bijlsma, J.W.3    Lafeber, F.P.4    Taams, L.S.5
  • 23
    • 51449116424 scopus 로고    scopus 로고
    • +CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis
    • 18649874 1:CAS:528:DC%2BD1cXhtFWlsr3M 10.1016/j.cellimm.2008.05.007
    • +CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis. Cell Immunol. 2008;253(1-2):92-101.
    • (2008) Cell Immunol , vol.253 , Issue.1-2 , pp. 92-101
    • Han, G.M.1    O'Neil-Andersen, N.J.2    Zurier, R.B.3    Lawrence, D.A.4
  • 24
    • 17644384896 scopus 로고    scopus 로고
    • +T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
    • 15807863 1:STN:280:DC%2BD2M7nsFyisw%3D%3D 10.1111/j.1365-2249.2005.02754. x
    • +T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol. 2005;140(2):360-7.
    • (2005) Clin Exp Immunol , vol.140 , Issue.2 , pp. 360-367
    • Mottonen, M.1    Heikkinen, J.2    Mustonen, L.3    Isomaki, P.4    Luukkainen, R.5    Lassila, O.6
  • 25
    • 79960705112 scopus 로고    scopus 로고
    • + regulatory T cells in inflammatory bowel disease
    • 21791023 1:CAS:528:DC%2BC3MXhtFyqtrzO 10.1111/j.1751-2980.2011.00505.x
    • + regulatory T cells in inflammatory bowel disease. J Dig Dis. 2011;12(4):286-94.
    • (2011) J Dig Dis , vol.12 , Issue.4 , pp. 286-294
    • Wang, Y.1    Liu, X.P.2    Zhao, Z.B.3    Chen, J.H.4    Yu, C.G.5
  • 26
    • 27144480654 scopus 로고    scopus 로고
    • + regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis
    • 16237044 1:CAS:528:DC%2BD2MXhtFahur3P
    • + regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol. 2005;175(9):5591-5.
    • (2005) J Immunol , vol.175 , Issue.9 , pp. 5591-5595
    • Reddy, J.1    Waldner, H.2    Zhang, X.3    Illes, Z.4    Wucherpfennig, K.W.5    Sobel, R.A.6
  • 27
    • 77958136352 scopus 로고    scopus 로고
    • Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes
    • 20810982 1:CAS:528:DC%2BC3cXhtFyisrrN 10.4049/jimmunol.1001860
    • Marwaha AK, Crome SQ, Panagiotopoulos C, Berg KB, Qin H, Ouyang Q, et al. Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol. 2010;185(7):3814-8.
    • (2010) J Immunol , vol.185 , Issue.7 , pp. 3814-3818
    • Marwaha, A.K.1    Crome, S.Q.2    Panagiotopoulos, C.3    Berg, K.B.4    Qin, H.5    Ouyang, Q.6
  • 28
    • 66949171924 scopus 로고    scopus 로고
    • + T cells expressing the FoxP3 transcription factor
    • 19464196 1:CAS:528:DC%2BD1MXpsFCnurk%3D 10.1016/j.immuni.2009.03.019
    • + T cells expressing the FoxP3 transcription factor. Immunity. 2009;30(6):899-911.
    • (2009) Immunity , vol.30 , Issue.6 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3    Shima, T.4    Wing, K.5    Niwa, A.6
  • 29
    • 77449143100 scopus 로고    scopus 로고
    • Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects
    • 19875613 1:CAS:528:DC%2BC3cXhvVyru74%3D 10.2337/db09-0694
    • Long SA, Cerosaletti K, Bollyky PL, Tatum M, Shilling H, Zhang S, et al. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes. 2010;59(2):407-15.
    • (2010) Diabetes , vol.59 , Issue.2 , pp. 407-415
    • Long, S.A.1    Cerosaletti, K.2    Bollyky, P.L.3    Tatum, M.4    Shilling, H.5    Zhang, S.6
  • 31
    • 13944270218 scopus 로고    scopus 로고
    • +CD25high regulatory T cells in human autoimmune diabetes
    • 15725577 1:CAS:528:DC%2BD2MXhslWltLg%3D 10.1016/j.jaut.2004.11.004
    • +CD25high regulatory T cells in human autoimmune diabetes. J Autoimmun. 2005;24(1):55-62.
    • (2005) J Autoimmun , vol.24 , Issue.1 , pp. 55-62
    • Putnam, A.L.1    Vendrame, F.2    Dotta, F.3    Gottlieb, P.A.4
  • 32
    • 1842732224 scopus 로고    scopus 로고
    • + regulatory T cells in patients with multiple sclerosis
    • 15067033 1:CAS:528:DC%2BD2cXjtVejurw%3D 10.1084/jem.20031579
    • + regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004;199(7):971-9.
    • (2004) J Exp Med , vol.199 , Issue.7 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 34
    • 33846900430 scopus 로고    scopus 로고
    • +CD25high T regulatory cell function in patients with active systemic lupus erythematosus
    • 17277168 1:CAS:528:DC%2BD2sXht1Cntrw%3D
    • +CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol. 2007;178(4):2579-88.
    • (2007) J Immunol , vol.178 , Issue.4 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 35
    • 47249083906 scopus 로고    scopus 로고
    • +CD25high T cells in patients with new-onset systemic lupus erythematosus
    • 18505426 1:STN:280:DC%2BD1crivFyhsw%3D%3D 10.1111/j.1365-2249.2008.03686. x
    • +CD25high T cells in patients with new-onset systemic lupus erythematosus. Clin Exp Immunol. 2008;153(2):182-7.
    • (2008) Clin Exp Immunol , vol.153 , Issue.2 , pp. 182-187
    • Zhang, B.1    Zhang, X.2    Tang, F.3    Zhu, L.4    Liu, Y.5
  • 36
    • 32044442306 scopus 로고    scopus 로고
    • Meta-analysis of the association of CTLA-4 exon-1 +49A/G polymorphism with rheumatoid arthritis
    • 16133179 1:CAS:528:DC%2BD28Xjs1Sksg%3D%3D 10.1007/s00439-005-0033-9
    • Han S, Li Y, Mao Y, Xie Y. Meta-analysis of the association of CTLA-4 exon-1 +49A/G polymorphism with rheumatoid arthritis. Hum Genet. 2005;118(1):123-32.
    • (2005) Hum Genet , vol.118 , Issue.1 , pp. 123-132
    • Han, S.1    Li, Y.2    Mao, Y.3    Xie, Y.4
  • 37
    • 4444354041 scopus 로고    scopus 로고
    • Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus
    • 15138458 1:CAS:528:DC%2BD2cXlvVeiu7s%3D 10.1038/sj.ejhg.5201214
    • Barreto M, Santos E, Ferreira R, Fesel C, Fontes MF, Pereira C, et al. Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus. Eur J Hum Genet. 2004;12(8):620-6.
    • (2004) Eur J Hum Genet , vol.12 , Issue.8 , pp. 620-626
    • Barreto, M.1    Santos, E.2    Ferreira, R.3    Fesel, C.4    Fontes, M.F.5    Pereira, C.6
  • 38
    • 58049196774 scopus 로고    scopus 로고
    • Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
    • 19036923 1:CAS:528:DC%2BD1cXhsFamu7vN 10.1073/pnas.0806855105
    • Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR. Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc Natl Acad Sci USA. 2008;105(49):19396-401.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.49 , pp. 19396-19401
    • Flores-Borja, F.1    Jury, E.C.2    Mauri, C.3    Ehrenstein, M.R.4
  • 40
    • 65449149735 scopus 로고    scopus 로고
    • Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus
    • 18800986 1:CAS:528:DC%2BD1MXmsFWjsr4%3D 10.1111/j.1365-2567.2008.02937.x
    • Suen JL, Li HT, Jong YJ, Chiang BL, Yen JH. Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus. Immunology. 2009;127(2):196-205.
    • (2009) Immunology , vol.127 , Issue.2 , pp. 196-205
    • Suen, J.L.1    Li, H.T.2    Jong, Y.J.3    Chiang, B.L.4    Yen, J.H.5
  • 41
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • 12610626 1:CAS:528:DC%2BD3sXhsV2rsbs%3D 10.1038/nature01355
    • Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003;421(6924):744-8.
    • (2003) Nature , vol.421 , Issue.6924 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6
  • 42
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • 14662908 1:CAS:528:DC%2BD3sXpvFakur4%3D 10.1084/jem.20030896
    • Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med. 2003;198(12):1951-7.
    • (2003) J Exp Med , vol.198 , Issue.12 , pp. 1951-1957
    • Murphy, C.A.1    Langrish, C.L.2    Chen, Y.3    Blumenschein, W.4    McClanahan, T.5    Kastelein, R.A.6
  • 43
    • 45249097325 scopus 로고    scopus 로고
    • Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity
    • 18373953 1:CAS:528:DC%2BD1cXmt12qsrs%3D 10.1016/j.clim.2008.01.019
    • Wong CK, Lit LC, Tam LS, Li EK, Wong PT, Lam CW. Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin Immunol. 2008;127(3):385-93.
    • (2008) Clin Immunol , vol.127 , Issue.3 , pp. 385-393
    • Wong, C.K.1    Lit, L.C.2    Tam, L.S.3    Li, E.K.4    Wong, P.T.5    Lam, C.W.6
  • 44
    • 0034869941 scopus 로고    scopus 로고
    • Serum interleukin-15 is elevated in systemic lupus erythematosus
    • 1:CAS:528:DC%2BD3MXntVKgsb4%3D 10.1093/rheumatology/40.8.876
    • Aringer M, Stummvoll GH, Steiner G, Koller M, Steiner CW, Hofler E, et al. Serum interleukin-15 is elevated in systemic lupus erythematosus. Rheumatology (Oxford). 2001;40(8):876-81.
    • (2001) Rheumatology (Oxford) , vol.40 , Issue.8 , pp. 876-881
    • Aringer, M.1    Stummvoll, G.H.2    Steiner, G.3    Koller, M.4    Steiner, C.W.5    Hofler, E.6
  • 46
    • 0034161692 scopus 로고    scopus 로고
    • High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism
    • 10679127 1:CAS:528:DC%2BD3cXhsVKhur0%3D
    • Ziolkowska M, Koc A, Luszczykiewicz G, Ksiezopolska-Pietrzak K, Klimczak E, Chwalinska-Sadowska H, et al. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol. 2000;164(5):2832-8.
    • (2000) J Immunol , vol.164 , Issue.5 , pp. 2832-2838
    • Ziolkowska, M.1    Koc, A.2    Luszczykiewicz, G.3    Ksiezopolska-Pietrzak, K.4    Klimczak, E.5    Chwalinska-Sadowska, H.6
  • 47
    • 84857712400 scopus 로고    scopus 로고
    • + monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population
    • 22006178 1:CAS:528:DC%2BC38XivVGjtbg%3D 10.1002/art.33418
    • + monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population. Arthritis Rheum. 2012;64(3):671-7.
    • (2012) Arthritis Rheum , vol.64 , Issue.3 , pp. 671-677
    • Rossol, M.1    Kraus, S.2    Pierer, M.3    Baerwald, C.4    Wagner, U.5
  • 48
    • 65549088243 scopus 로고    scopus 로고
    • IL-17-producing human peripheral regulatory T cells retain suppressive function
    • 19171879 1:CAS:528:DC%2BD1MXlvVGisLc%3D 10.1182/blood-2008-10-183251
    • Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, et al. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009;113(18):4240-9.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4240-4249
    • Beriou, G.1    Costantino, C.M.2    Ashley, C.W.3    Yang, L.4    Kuchroo, V.K.5    Baecher-Allan, C.6
  • 49
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • 18585065 1:CAS:528:DC%2BD1cXptF2mtLo%3D 10.1016/j.immuni.2008.05.007
    • Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 2008;29(1):44-56.
    • (2008) Immunity , vol.29 , Issue.1 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3    Kang, H.S.4    Chung, Y.5    Pappu, B.P.6
  • 50
    • 59849085588 scopus 로고    scopus 로고
    • Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
    • 19109157 1:CAS:528:DC%2BD1cXhsFCis7bK
    • Lal G, Zhang N, van der Touw W, Ding Y, Ju W, Bottinger EP, et al. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol. 2009;182(1):259-73.
    • (2009) J Immunol , vol.182 , Issue.1 , pp. 259-273
    • Lal, G.1    Zhang, N.2    Van Der Touw, W.3    Ding, Y.4    Ju, W.5    Bottinger, E.P.6
  • 51
    • 70449717294 scopus 로고    scopus 로고
    • Epigenetic mechanisms of regulation of Foxp3 expression
    • 19641188 1:CAS:528:DC%2BD1MXhsVSmsb%2FP 10.1182/blood-2009-05-219584
    • Lal G, Bromberg JS. Epigenetic mechanisms of regulation of Foxp3 expression. Blood. 2009;114(18):3727-35.
    • (2009) Blood , vol.114 , Issue.18 , pp. 3727-3735
    • Lal, G.1    Bromberg, J.S.2
  • 53
    • 80555126845 scopus 로고    scopus 로고
    • CTLA-4-Ig therapy diminishes the frequency but enhances the function of Treg cells in patients with rheumatoid arthritis
    • 21487894 1:CAS:528:DC%2BC3MXhtValur7M 10.1007/s10875-011-9527-5
    • Alvarez-Quiroga C, Abud-Mendoza C, Doniz-Padilla L, Juarez-Reyes A, Monsivais-Urenda A, Baranda L, et al. CTLA-4-Ig therapy diminishes the frequency but enhances the function of Treg cells in patients with rheumatoid arthritis. J Clin Immunol. 2011;31(4):588-95.
    • (2011) J Clin Immunol , vol.31 , Issue.4 , pp. 588-595
    • Alvarez-Quiroga, C.1    Abud-Mendoza, C.2    Doniz-Padilla, L.3    Juarez-Reyes, A.4    Monsivais-Urenda, A.5    Baranda, L.6
  • 54
    • 85008254167 scopus 로고    scopus 로고
    • Infliximab reduces the frequency of interleukin 17-producing cells and the amounts of interleukin 17 in patients with rheumatoid arthritis
    • 20601897 1:CAS:528:DC%2BC3cXhtlOqsbfE
    • Shen H, Xia L, Lu J, Xiao W. Infliximab reduces the frequency of interleukin 17-producing cells and the amounts of interleukin 17 in patients with rheumatoid arthritis. J Investig Med. 2010;58(7):905-8.
    • (2010) J Investig Med , vol.58 , Issue.7 , pp. 905-908
    • Shen, H.1    Xia, L.2    Lu, J.3    Xiao, W.4
  • 55
    • 78650080500 scopus 로고    scopus 로고
    • Therapy with anti-TNFalpha antibody enhances number and function of Foxp3(+) regulatory T cells in inflammatory bowel diseases
    • 20848510 10.1002/ibd.21308
    • Boschetti G, Nancey S, Sardi F, Roblin X, Flourie B, Kaiserlian D. Therapy with anti-TNFalpha antibody enhances number and function of Foxp3(+) regulatory T cells in inflammatory bowel diseases. Inflamm Bowel Dis. 2011;17(1):160-70.
    • (2011) Inflamm Bowel Dis , vol.17 , Issue.1 , pp. 160-170
    • Boschetti, G.1    Nancey, S.2    Sardi, F.3    Roblin, X.4    Flourie, B.5    Kaiserlian, D.6
  • 57
    • 84858110063 scopus 로고    scopus 로고
    • Adalimumab specifically induces CD3(+) CD4(+) CD25(high) Foxp3(+) CD127(-) T-regulatory cells and decreases vascular endothelial growth factor plasma levels in refractory immuno-mediated uveitis: A non-randomized pilot intervention study
    • 1:CAS:528:DC%2BC38Xjs1Cru7s%3D 10.1038/eye.2011.320
    • Calleja S, Cordero-Coma M, Rodriguez E, Llorente M, Franco M, Ruiz de Morales JG. Adalimumab specifically induces CD3(+) CD4(+) CD25(high) Foxp3(+) CD127(-) T-regulatory cells and decreases vascular endothelial growth factor plasma levels in refractory immuno-mediated uveitis: a non-randomized pilot intervention study. Eye (Lond). 2012;26(3):468-77.
    • (2012) Eye (Lond) , vol.26 , Issue.3 , pp. 468-477
    • Calleja, S.1    Cordero-Coma, M.2    Rodriguez, E.3    Llorente, M.4    Franco, M.5    Ruiz De Morales, J.G.6
  • 58
    • 84864481289 scopus 로고    scopus 로고
    • Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis
    • 22488116 1:CAS:528:DC%2BC38XhtV2gtb7K 10.1002/art.34477
    • Samson M, Audia S, Janikashvili N, Ciudad M, Trad M, Fraszczak J, et al. Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis. Arthritis Rheum. 2012;64(8):2499-503.
    • (2012) Arthritis Rheum , vol.64 , Issue.8 , pp. 2499-2503
    • Samson, M.1    Audia, S.2    Janikashvili, N.3    Ciudad, M.4    Trad, M.5    Fraszczak, J.6
  • 59
    • 79960912796 scopus 로고    scopus 로고
    • Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: A randomised, double-blind, placebo-controlled trial
    • 21719096 1:CAS:528:DC%2BC3MXpsFeju70%3D 10.1016/S0140-6736(11)60886-6
    • Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, et al. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet. 2011;378(9789):412-9.
    • (2011) Lancet , vol.378 , Issue.9789 , pp. 412-419
    • Orban, T.1    Bundy, B.2    Becker, D.J.3    Dimeglio, L.A.4    Gitelman, S.E.5    Goland, R.6
  • 60
    • 84863857793 scopus 로고    scopus 로고
    • Optimizing outcomes in patients with rheumatoid arthritis and an inadequate response to anti-TNF treatment
    • 1:CAS:528:DC%2BC38XpsVahtbo%3D 10.1093/rheumatology/kes115
    • Emery P. Optimizing outcomes in patients with rheumatoid arthritis and an inadequate response to anti-TNF treatment. Rheumatology (Oxford). 2012;51(Suppl 5):v22-30.
    • (2012) Rheumatology (Oxford) , vol.51 , Issue.SUPPL. 5
    • Emery, P.1
  • 61
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • 10899917 1:CAS:528:DC%2BD3cXkvFGiu7c%3D 10.1084/jem.192.2.303
    • Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2000;192(2):303-10.
    • (2000) J Exp Med , vol.192 , Issue.2 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3    Uede, T.4    Shimizu, J.5    Sakaguchi, N.6
  • 63
    • 0346119234 scopus 로고    scopus 로고
    • Modulation of tryptophan catabolism by regulatory T cells
    • 14578884 1:CAS:528:DC%2BD3sXpt1Sntrs%3D 10.1038/ni1003
    • Fallarino F, Grohmann U, Hwang KW, Orabona C, Vacca C, Bianchi R, et al. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol. 2003;4(12):1206-12.
    • (2003) Nat Immunol , vol.4 , Issue.12 , pp. 1206-1212
    • Fallarino, F.1    Grohmann, U.2    Hwang, K.W.3    Orabona, C.4    Vacca, C.5    Bianchi, R.6
  • 64
    • 33746336533 scopus 로고    scopus 로고
    • The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology
    • 16903911 1:CAS:528:DC%2BD28XpvFegt70%3D 10.1111/j.0105-2896.2006.00419.x
    • Sansom DM, Walker LS. The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol Rev. 2006;212:131-48.
    • (2006) Immunol Rev , vol.212 , pp. 131-148
    • Sansom, D.M.1    Walker, L.S.2
  • 66
    • 84868007895 scopus 로고    scopus 로고
    • Combined use of etanercept and MTX restores CD4(+)/CD8 (+) ratio and Tregs in spleen and thymus in collagen-induced arthritis
    • Huang B, Wang QT, Song SS, Wu YJ, Ma YK, Zhang LL, et al. Combined use of etanercept and MTX restores CD4(+)/CD8 (+) ratio and Tregs in spleen and thymus in collagen-induced arthritis. Inflamm Res. 2012;61(11):1229-39.
    • (2012) Inflamm Res , vol.61 , Issue.11 , pp. 1229-1239
    • Huang, B.1    Wang, Q.T.2    Song, S.S.3    Wu, Y.J.4    Ma, Y.K.5    Zhang, L.L.6
  • 67
    • 43449135305 scopus 로고    scopus 로고
    • TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    • 18368049 1:CAS:528:DC%2BD1cXls12msL4%3D 10.1038/nature06878
    • Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 2008;453(7192):236-40.
    • (2008) Nature , vol.453 , Issue.7192 , pp. 236-240
    • Zhou, L.1    Lopes, J.E.2    Chong, M.M.3    Ivanov, I.I.4    Min, R.5    Victora, G.D.6
  • 68
    • 77950119759 scopus 로고    scopus 로고
    • Vitamin D supplementation and regulatory T cells in apparently healthy subjects: Vitamin D treatment for autoimmune diseases?
    • 20684175
    • Prietl B, Pilz S, Wolf M, Tomaschitz A, Obermayer-Pietsch B, Graninger W, et al. Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases? Isr Med Assoc J. 2010;12(3):136-9.
    • (2010) Isr Med Assoc J , vol.12 , Issue.3 , pp. 136-139
    • Prietl, B.1    Pilz, S.2    Wolf, M.3    Tomaschitz, A.4    Obermayer-Pietsch, B.5    Graninger, W.6
  • 69
    • 33845720114 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    • 17179460 1:CAS:528:DC%2BD28XhtlCqtL3J 10.1001/jama.296.23.2832
    • Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006;296(23):2832-8.
    • (2006) JAMA , vol.296 , Issue.23 , pp. 2832-2838
    • Munger, K.L.1    Levin, L.I.2    Hollis, B.W.3    Howard, N.S.4    Ascherio, A.5
  • 70
    • 68949140898 scopus 로고    scopus 로고
    • Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis
    • 19675671 10.1371/journal.pone.0006635 1:CAS:528:DC%2BD1MXhtVemtL%2FE
    • Smolders J, Thewissen M, Peelen E, Menheere P, Tervaert JW, Damoiseaux J, et al. Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. PLoS One. 2009;4(8):e6635.
    • (2009) PLoS One , vol.4 , Issue.8 , pp. 6635
    • Smolders, J.1    Thewissen, M.2    Peelen, E.3    Menheere, P.4    Tervaert, J.W.5    Damoiseaux, J.6
  • 71
    • 84867448448 scopus 로고    scopus 로고
    • Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation
    • 23075451 1:CAS:528:DC%2BC3sXit1CnsL4%3D 10.1186/ar4060
    • Terrier B, Derian N, Schoindre Y, Chaara W, Geri G, Zahr N, et al. Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. Arthritis Res Ther. 2012;14(5):R221.
    • (2012) Arthritis Res Ther , vol.14 , Issue.5 , pp. 221
    • Terrier, B.1    Derian, N.2    Schoindre, Y.3    Chaara, W.4    Geri, G.5    Zahr, N.6
  • 72
    • 84863557417 scopus 로고    scopus 로고
    • Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and decline of residual beta-cell function in new-onset type 1 diabetes mellitus
    • 22751874 10.1001/archpediatrics.2012.164
    • Gabbay MA, Sato MN, Finazzo C, Duarte AJ, Dib SA. Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and decline of residual beta-cell function in new-onset type 1 diabetes mellitus. Arch Pediatr Adolesc Med. 2012;166(7):601-7.
    • (2012) Arch Pediatr Adolesc Med , vol.166 , Issue.7 , pp. 601-607
    • Gabbay, M.A.1    Sato, M.N.2    Finazzo, C.3    Duarte, A.J.4    Dib, S.A.5
  • 73
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • 16908486 1:CAS:528:DC%2BD28XpsFKmtbc%3D 10.1056/NEJMoa063842
    • Suntharalingam G, Perry MR, Ward S, Brett SJ, Castello-Cortes A, Brunner MD, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med. 2006;355(10):1018-28.
    • (2006) N Engl J Med , vol.355 , Issue.10 , pp. 1018-1028
    • Suntharalingam, G.1    Perry, M.R.2    Ward, S.3    Brett, S.J.4    Castello-Cortes, A.5    Brunner, M.D.6
  • 74
    • 0031569177 scopus 로고    scopus 로고
    • CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
    • 9058834 1:CAS:528:DyaK2sXhvVOltro%3D
    • Chatenoud L, Primo J, Bach JF. CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immunol. 1997;158(6):2947-54.
    • (1997) J Immunol , vol.158 , Issue.6 , pp. 2947-2954
    • Chatenoud, L.1    Primo, J.2    Bach, J.F.3
  • 75
    • 80051471700 scopus 로고    scopus 로고
    • Teplizumab for treatment of type 1 diabetes (Protege study): 1-year results from a randomised, placebo-controlled trial
    • 21719095 1:CAS:528:DC%2BC3MXpvFWltbs%3D 10.1016/S0140-6736(11)60931-8
    • Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry RJ Jr, et al. Teplizumab for treatment of type 1 diabetes (Protege study): 1-year results from a randomised, placebo-controlled trial. Lancet. 2011;378(9790):487-97.
    • (2011) Lancet , vol.378 , Issue.9790 , pp. 487-497
    • Sherry, N.1    Hagopian, W.2    Ludvigsson, J.3    Jain, S.M.4    Wahlen, J.5    Ferry, Jr.R.J.6
  • 76
    • 53049110126 scopus 로고    scopus 로고
    • New immunosuppressive approaches: Oral administration of CD3-specific antibody to treat autoimmunity
    • 18804221 1:CAS:528:DC%2BD1cXht1eitrrK 10.1016/j.jns.2008.07.027
    • Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso A, et al. New immunosuppressive approaches: oral administration of CD3-specific antibody to treat autoimmunity. J Neurol Sci. 2008;274(1-2):9-12.
    • (2008) J Neurol Sci , vol.274 , Issue.1-2 , pp. 9-12
    • Ochi, H.1    Abraham, M.2    Ishikawa, H.3    Frenkel, D.4    Yang, K.5    Basso, A.6
  • 77
    • 77249178418 scopus 로고    scopus 로고
    • Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells
    • 19756989 1:CAS:528:DC%2BC3cXhvFans7k%3D 10.1007/s10875-009-9323-7
    • Ilan Y, Zigmond E, Lalazar G, Dembinsky A, Ben Ya'acov A, Hemed N, et al. Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells. J Clin Immunol. 2010;30(1):167-77.
    • (2010) J Clin Immunol , vol.30 , Issue.1 , pp. 167-177
    • Ilan, Y.1    Zigmond, E.2    Lalazar, G.3    Dembinsky, A.4    Ben Ya'Acov, A.5    Hemed, N.6
  • 78
    • 74849107553 scopus 로고    scopus 로고
    • + Treg cells and induces sustained amelioration of collagen-induced arthritis
    • 20039431 1:CAS:528:DC%2BC3cXhtFGnurbE 10.1002/art.25058
    • + Treg cells and induces sustained amelioration of collagen-induced arthritis. Arthritis Rheum. 2010;62(1):171-8.
    • (2010) Arthritis Rheum , vol.62 , Issue.1 , pp. 171-178
    • Notley, C.A.1    McCann, F.E.2    Inglis, J.J.3    Williams, R.O.4
  • 79
    • 0033985780 scopus 로고    scopus 로고
    • + immunoregulatory T cells is antigen nonspecific
    • 10605010 1:CAS:528:DC%2BD3cXisVyk
    • + immunoregulatory T cells is antigen nonspecific. J Immunol. 2000;164(1):183-90.
    • (2000) J Immunol , vol.164 , Issue.1 , pp. 183-190
    • Thornton, A.M.1    Shevach, E.M.2
  • 80
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • 15184499 1:CAS:528:DC%2BD2cXkvV2jsLg%3D 10.1084/jem.20040139
    • Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med. 2004;199(11):1455-65.
    • (2004) J Exp Med , vol.199 , Issue.11 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3    Finger, E.B.4    Szot, G.5    Ye, J.6
  • 81
    • 76349093141 scopus 로고    scopus 로고
    • Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes
    • 19690518 1:CAS:528:DC%2BD1MXhtVWhsbfL 10.1038/mt.2009.197
    • Bresson D, Fradkin M, Manenkova Y, Rottembourg D, von Herrath M. Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes. Mol Ther. 2010;18(2):307-16.
    • (2010) Mol Ther , vol.18 , Issue.2 , pp. 307-316
    • Bresson, D.1    Fradkin, M.2    Manenkova, Y.3    Rottembourg, D.4    Von Herrath, M.5
  • 82
    • 0036314243 scopus 로고    scopus 로고
    • Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice
    • 11872661 1:CAS:528:DC%2BD38XitFSgs7g%3D 10.2337/diabetes.51.3.638
    • Rabinovitch A, Suarez-Pinzon WL, Shapiro AM, Rajotte RV, Power R. Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice. Diabetes. 2002;51(3):638-45.
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 638-645
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Shapiro, A.M.3    Rajotte, R.V.4    Power, R.5
  • 84
    • 79251589897 scopus 로고    scopus 로고
    • Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells
    • 21253593 1:CAS:528:DC%2BC3MXosVygug%3D%3D 10.1371/journal.pone.0015868
    • Golovina TN, Mikheeva T, Brusko TM, Blazar BR, Bluestone JA, Riley JL. Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells. PLoS One. 2011;6(1):e15868.
    • (2011) PLoS One , vol.6 , Issue.1 , pp. 15868
    • Golovina, T.N.1    Mikheeva, T.2    Brusko, T.M.3    Blazar, B.R.4    Bluestone, J.A.5    Riley, J.L.6
  • 85
    • 84865478468 scopus 로고    scopus 로고
    • Rapamycin/IL-2 Combination Therapy in Patients with Type 1 Diabetes Augments Tregs yet Transiently Impairs beta-Cell Function
    • Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, et al. Rapamycin/IL-2 Combination Therapy in Patients with Type 1 Diabetes Augments Tregs yet Transiently Impairs beta-Cell Function. Diabetes. 2012;61(9):2340-8.
    • (2012) Diabetes , vol.61 , Issue.9 , pp. 2340-2348
    • Long, S.A.1    Rieck, M.2    Sanda, S.3    Bollyky, J.B.4    Samuels, P.L.5    Goland, R.6
  • 86
    • 82955247641 scopus 로고    scopus 로고
    • Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment
    • 22063316 1:CAS:528:DC%2BC3MXhsV2rsLjP 10.1016/j.jaut.2011.10.001
    • Bresson D, Fousteri G, Manenkova Y, Croft M, von Herrath M. Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment. J Autoimmun. 2011;37(4):342-51.
    • (2011) J Autoimmun , vol.37 , Issue.4 , pp. 342-351
    • Bresson, D.1    Fousteri, G.2    Manenkova, Y.3    Croft, M.4    Von Herrath, M.5
  • 87
    • 14744285671 scopus 로고    scopus 로고
    • Triggering of OX40 (CD134) on CD4(+)CD25 + T cells blocks their inhibitory activity: A novel regulatory role for OX40 and its comparison with GITR
    • 15591118 1:CAS:528:DC%2BD2MXivFGmtL4%3D 10.1182/blood-2004-07-2959
    • Valzasina B, Guiducci C, Dislich H, Killeen N, Weinberg AD, Colombo MP. Triggering of OX40 (CD134) on CD4(+)CD25 + T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood. 2005;105(7):2845-51.
    • (2005) Blood , vol.105 , Issue.7 , pp. 2845-2851
    • Valzasina, B.1    Guiducci, C.2    Dislich, H.3    Killeen, N.4    Weinberg, A.D.5    Colombo, M.P.6
  • 92
    • 84864424816 scopus 로고    scopus 로고
    • Antigen-specific TGF-beta-induced regulatory T cells but not natural Tregs ameliorate autoimmune arthritis by shifting the balance of Th17 toward Treg cells
    • Kong N, Lan Q, Chen M, Wang J, Shi W, Horwitz DA, et al. Antigen-specific TGF-beta-induced regulatory T cells but not natural Tregs ameliorate autoimmune arthritis by shifting the balance of Th17 toward Treg cells. Arthritis Rheum. 2012;64(8):2548-58.
    • (2012) Arthritis Rheum , vol.64 , Issue.8 , pp. 2548-2558
    • Kong, N.1    Lan, Q.2    Chen, M.3    Wang, J.4    Shi, W.5    Horwitz, D.A.6
  • 93
    • 79960453738 scopus 로고    scopus 로고
    • A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
    • 21723159 1:CAS:528:DC%2BC3MXpt1ait7w%3D 10.1016/j.immuni.2011.03.029
    • Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity. 2011;35(1):109-22.
    • (2011) Immunity , vol.35 , Issue.1 , pp. 109-122
    • Haribhai, D.1    Williams, J.B.2    Jia, S.3    Nickerson, D.4    Schmitt, E.G.5    Edwards, B.6
  • 94
    • 84864967278 scopus 로고    scopus 로고
    • Adoptive transfer of all-trans-retinal-induced regulatory T cells ameliorates experimental autoimmune arthritis in an interferon-gamma knockout model.
    • Jeon EJ, Yoon BY, Lim JY, Oh HJ, Park HS, Park MJ, et al. Adoptive transfer of all-trans-retinal-induced regulatory T cells ameliorates experimental autoimmune arthritis in an interferon-gamma knockout model. Autoimmunity. 2012;45(6):460-9.
    • (2012) Autoimmunity , vol.45 , Issue.6 , pp. 460-469
    • Jeon, E.J.1    Yoon, B.Y.2    Lim, J.Y.3    Oh, H.J.4    Park, H.S.5    Park, M.J.6
  • 97
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • 12522256 1:CAS:528:DC%2BD3sXhtFarsbw%3D 10.1126/science.1079490
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299(5609):1057-61.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 98
    • 34848858303 scopus 로고    scopus 로고
    • Enhanced efficacy of regulatory T cell transfer against increasing resistance, by elevated Foxp3 expression induced in arthritic murine hosts
    • 17763426 1:CAS:528:DC%2BD2sXht1GgtbzF 10.1002/art.22846
    • Ohata J, Miura T, Johnson TA, Hori S, Ziegler SF, Kohsaka H. Enhanced efficacy of regulatory T cell transfer against increasing resistance, by elevated Foxp3 expression induced in arthritic murine hosts. Arthritis Rheum. 2007;56(9):2947-56.
    • (2007) Arthritis Rheum , vol.56 , Issue.9 , pp. 2947-2956
    • Ohata, J.1    Miura, T.2    Johnson, T.A.3    Hori, S.4    Ziegler, S.F.5    Kohsaka, H.6
  • 99
    • 73149093194 scopus 로고    scopus 로고
    • Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis
    • 19884493 1:CAS:528:DC%2BD1MXhsFGlsbnK 10.1073/pnas.0907396106
    • Wright GP, Notley CA, Xue SA, Bendle GM, Holler A, Schumacher TN, et al. Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proc Natl Acad Sci USA. 2009;106(45):19078-83.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.45 , pp. 19078-19083
    • Wright, G.P.1    Notley, C.A.2    Xue, S.A.3    Bendle, G.M.4    Holler, A.5    Schumacher, T.N.6
  • 100
    • 84867495893 scopus 로고    scopus 로고
    • PTD-hFOXP3 protein acts as an immune regulator to convert human CD4(+) CD25(-) T cells to regulatory T-like cells
    • Liu X, Xu X, Lin X, Tian Y, Ji B, Xia S, et al. PTD-hFOXP3 protein acts as an immune regulator to convert human CD4(+) CD25(-) T cells to regulatory T-like cells. J Cell Biochem. 2012;113(12):3797-809.
    • (2012) J Cell Biochem , vol.113 , Issue.12 , pp. 3797-3809
    • Liu, X.1    Xu, X.2    Lin, X.3    Tian, Y.4    Ji, B.5    Xia, S.6
  • 101
    • 77955380678 scopus 로고    scopus 로고
    • Human antigen-specific regulatory T cells generated by T cell receptor gene transfer
    • 20668510 10.1371/journal.pone.0011726 1:CAS:528:DC%2BC3cXpsVaksr0%3D
    • Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, et al. Human antigen-specific regulatory T cells generated by T cell receptor gene transfer. PLoS One. 2010;5(7):e11726.
    • (2010) PLoS One , vol.5 , Issue.7 , pp. 11726
    • Brusko, T.M.1    Koya, R.C.2    Zhu, S.3    Lee, M.R.4    Putnam, A.L.5    McClymont, S.A.6
  • 102
    • 0035313447 scopus 로고    scopus 로고
    • Regulatory activity of autocrine IL-10 on dendritic cell functions
    • 11254683 1:CAS:528:DC%2BD3MXit1Oksb4%3D
    • Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G. Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol. 2001;166(7):4312-8.
    • (2001) J Immunol , vol.166 , Issue.7 , pp. 4312-4318
    • Corinti, S.1    Albanesi, C.2    La Sala, A.3    Pastore, S.4    Girolomoni, G.5
  • 103
    • 64149088746 scopus 로고    scopus 로고
    • Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity
    • 19252500 1:CAS:528:DC%2BD1MXisVOrtLw%3D 10.1038/nm.1925
    • Manicassamy S, Ravindran R, Deng J, Oluoch H, Denning TL, Kasturi SP, et al. Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity. Nat Med. 2009;15(4):401-9.
    • (2009) Nat Med , vol.15 , Issue.4 , pp. 401-409
    • Manicassamy, S.1    Ravindran, R.2    Deng, J.3    Oluoch, H.4    Denning, T.L.5    Kasturi, S.P.6
  • 104
    • 69049116053 scopus 로고    scopus 로고
    • Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    • 19668220 1:CAS:528:DC%2BD1MXps1ahurg%3D 10.1038/ni.1772
    • Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, et al. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol. 2009;10(9):981-91.
    • (2009) Nat Immunol , vol.10 , Issue.9 , pp. 981-991
    • Ilarregui, J.M.1    Croci, D.O.2    Bianco, G.A.3    Toscano, M.A.4    Salatino, M.5    Vermeulen, M.E.6
  • 105
    • 78650796666 scopus 로고    scopus 로고
    • Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis
    • 20967853 1:CAS:528:DC%2BC3MXitVeqsb4%3D 10.1002/art.30099
    • Arce F, Breckpot K, Stephenson H, Karwacz K, Ehrenstein MR, Collins M, et al. Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis. Arthritis Rheum. 2011;63(1):84-95.
    • (2011) Arthritis Rheum , vol.63 , Issue.1 , pp. 84-95
    • Arce, F.1    Breckpot, K.2    Stephenson, H.3    Karwacz, K.4    Ehrenstein, M.R.5    Collins, M.6
  • 106
    • 0038792101 scopus 로고    scopus 로고
    • + regulatory T cells by targeting of antigens to immature dendritic cells
    • 12543858 1:CAS:528:DC%2BD3sXkslCjs7c%3D 10.1182/blood-2002-10-3229
    • + regulatory T cells by targeting of antigens to immature dendritic cells. Blood. 2003;101(12):4862-9.
    • (2003) Blood , vol.101 , Issue.12 , pp. 4862-4869
    • Mahnke, K.1    Qian, Y.2    Knop, J.3    Enk, A.H.4
  • 107
    • 0035903326 scopus 로고    scopus 로고
    • Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    • 11560993 1:CAS:528:DC%2BD3MXmvFGgsrY%3D 10.1084/jem.194.6.769
    • Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, Rivera M, et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med. 2001;194(6):769-79.
    • (2001) J Exp Med , vol.194 , Issue.6 , pp. 769-779
    • Hawiger, D.1    Inaba, K.2    Dorsett, Y.3    Guo, M.4    Mahnke, K.5    Rivera, M.6
  • 108
    • 66649115650 scopus 로고    scopus 로고
    • + Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t
    • 19439651 1:CAS:528:DC%2BD1MXnt1SqsL4%3D 10.1073/pnas.0900621106
    • + Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t. Proc Natl Acad Sci USA. 2009;106(21):8635-40.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.21 , pp. 8635-8640
    • Ayyoub, M.1    Deknuydt, F.2    Raimbaud, I.3    Dousset, C.4    Leveque, L.5    Bioley, G.6
  • 109
    • 33846980131 scopus 로고    scopus 로고
    • Epigenetic control of the foxp3 locus in regulatory T cells
    • 17298177 10.1371/journal.pbio.0050038 1:CAS:528:DC%2BD2sXhslOru7k%3D
    • Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 2007;5(2):e38.
    • (2007) PLoS Biol , vol.5 , Issue.2 , pp. 38
    • Floess, S.1    Freyer, J.2    Siewert, C.3    Baron, U.4    Olek, S.5    Polansky, J.6
  • 110
    • 62849120700 scopus 로고    scopus 로고
    • Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance
    • 19172156 1:CAS:528:DC%2BD1MXjtlSqtb0%3D 10.1038/icb.2008.106
    • Wang L, Tao R, Hancock WW. Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance. Immunol Cell Biol. 2009;87(3):195-202.
    • (2009) Immunol Cell Biol , vol.87 , Issue.3 , pp. 195-202
    • Wang, L.1    Tao, R.2    Hancock, W.W.3
  • 111
    • 84868092910 scopus 로고    scopus 로고
    • Modulation of STAT3 in rheumatoid Synovial T cells suppresses Th17 differentiation and increases the proportion of regulatory T cells
    • Ju JH, Heo YJ, Cho ML, Jhun JY, Park JS, Oh HJ, et al. Modulation of STAT3 in rheumatoid Synovial T cells suppresses Th17 differentiation and increases the proportion of regulatory T cells. Arthritis Rheum. 2012;64(11):3543-52.
    • (2012) Arthritis Rheum , vol.64 , Issue.11 , pp. 3543-3552
    • Ju, J.H.1    Heo, Y.J.2    Cho, M.L.3    Jhun, J.Y.4    Park, J.S.5    Oh, H.J.6
  • 112
    • 48449089249 scopus 로고    scopus 로고
    • Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infection in the context of transforming growth factor-beta
    • 18268045 1:CAS:528:DC%2BD1cXlvVKjtLc%3D 10.2337/db07-1460
    • Richer MJ, Straka N, Fang D, Shanina I, Horwitz MS. Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infection in the context of transforming growth factor-beta. Diabetes. 2008;57(5):1302-11.
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1302-1311
    • Richer, M.J.1    Straka, N.2    Fang, D.3    Shanina, I.4    Horwitz, M.S.5
  • 113
    • 3242787209 scopus 로고    scopus 로고
    • Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity
    • 15263027 1:CAS:528:DC%2BD2cXmtFSqs7w%3D 10.1084/jem.20040298
    • Mendez S, Reckling SK, Piccirillo CA, Sacks D, Belkaid Y. Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J Exp Med. 2004;200(2):201-10.
    • (2004) J Exp Med , vol.200 , Issue.2 , pp. 201-210
    • Mendez, S.1    Reckling, S.K.2    Piccirillo, C.A.3    Sacks, D.4    Belkaid, Y.5
  • 114
    • 7044247947 scopus 로고    scopus 로고
    • An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection
    • 15486925 1:CAS:528:DC%2BD2cXhtVCgt73P 10.1002/hep.20454
    • Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, et al. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology. 2004;40(5):1062-71.
    • (2004) Hepatology , vol.40 , Issue.5 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3    Firpi, R.J.4    Rosen, H.R.5    Liu, C.6
  • 116
    • 84869443740 scopus 로고    scopus 로고
    • Functional tumor infiltrating TH1 and TH2 effectors in large early-stage cervical cancer are suppressed by regulatory T cells
    • 22872166 10.1097/IGC.0b013e318262aa53
    • Adurthi S, Mukherjee G, Krishnamurthy H, Sudhir K, Bafna UD, Umadevi K, et al. Functional tumor infiltrating TH1 and TH2 effectors in large early-stage cervical cancer are suppressed by regulatory T cells. Int J Gynecol Cancer. 2012;22(7):1130-7.
    • (2012) Int J Gynecol Cancer , vol.22 , Issue.7 , pp. 1130-1137
    • Adurthi, S.1    Mukherjee, G.2    Krishnamurthy, H.3    Sudhir, K.4    Bafna, U.D.5    Umadevi, K.6


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