-
1
-
-
0028236232
-
Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease
-
Breese EJ, Michie CA, Nicholls SW, et al. Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology. 1994; 106: 1455-1466.
-
(1994)
Gastroenterology
, vol.106
, pp. 1455-1466
-
-
Breese, E.J.1
Michie, C.A.2
Nicholls, S.W.3
-
2
-
-
0028861975
-
Antibodies to interleukin 12 abrogate established experimental colitis in mice
-
Neurath MF, Fuss I, Kelsall BL, et al. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med. 1995; 182: 1281-1290.
-
(1995)
J Exp Med
, vol.182
, pp. 1281-1290
-
-
Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
-
3
-
-
0030209985
-
Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
-
Fuss IJ, Neurath M, Boirivant M, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol. 1996; 157: 1261-1270.
-
(1996)
J Immunol
, vol.157
, pp. 1261-1270
-
-
Fuss, I.J.1
Neurath, M.2
Boirivant, M.3
-
4
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest. 2006; 116: 1310-1316.
-
(2006)
J Clin Invest
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
-
5
-
-
0031573593
-
A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease
-
Plevy SE, Landers CJ, Prehn J, et al. A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease. J Immunol. 1997; 159: 6276-6282.
-
(1997)
J Immunol
, vol.159
, pp. 6276-6282
-
-
Plevy, S.E.1
Landers, C.J.2
Prehn, J.3
-
6
-
-
0035106502
-
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease
-
Kosiewicz MM, Nast CC, Krishnan A, et al. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest. 2001; 107: 695-702.
-
(2001)
J Clin Invest
, vol.107
, pp. 695-702
-
-
Kosiewicz, M.M.1
Nast, C.C.2
Krishnan, A.3
-
7
-
-
33746548465
-
CD8+ cytotoxic T cells induce relapsing colitis in normal mice
-
Nancey S, Holvoet S, Graber I, et al. CD8+ cytotoxic T cells induce relapsing colitis in normal mice. Gastroenterology. 2006; 131: 485-496.
-
(2006)
Gastroenterology
, vol.131
, pp. 485-496
-
-
Nancey, S.1
Holvoet, S.2
Graber, I.3
-
8
-
-
2442560241
-
Optimizing Anti-TNF treatment in inflammatory bowel disease
-
DOI 10.1053/j.gastro.2004.02.070
-
Rutgeerts P, Van Assche G, Vermeire S,. Optimizing anti-TNF treatment in inflammatory bowel disease. Gastroenterology. 2004; 126: 1593-1610. (Pubitemid 38649876)
-
(2004)
Gastroenterology
, vol.126
, Issue.6
, pp. 1593-1610
-
-
Rutgeerts, P.1
Van Assche, G.2
Vermeire, S.3
-
9
-
-
44649187924
-
Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: Meta-analysis of placebo-controlled trials
-
Peyrin-Biroulet L, Deltenre P, de Suray N, et al. Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: meta-analysis of placebo-controlled trials. Clin Gastroenterol Hepatol. 2008; 6: 644-653.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 644-653
-
-
Peyrin-Biroulet, L.1
Deltenre, P.2
De Suray, N.3
-
10
-
-
0036229932
-
Binding and functional comparisons of two types of tumor necrosis factor antagonists
-
Scallon B, Cai A, Solowski N, et al. Binding and functional comparisons of two types of tumor necrosis factor antagonists. J Pharmacol Exp Ther. 2002; 301: 418-426.
-
(2002)
J Pharmacol Exp Ther
, vol.301
, pp. 418-426
-
-
Scallon, B.1
Cai, A.2
Solowski, N.3
-
11
-
-
1542377405
-
Binding activities of infliximab and etanercept to transmembrane tumor necrosis factor-alpha
-
author reply 5-6.
-
Mitoma H, Horiuchi T, Tsukamoto H,. Binding activities of infliximab and etanercept to transmembrane tumor necrosis factor-alpha. Gastroenterology. 2004; 126: 934-935; author reply 5-6.
-
(2004)
Gastroenterology
, vol.126
, pp. 934-935
-
-
Mitoma, H.1
Horiuchi, T.2
Tsukamoto, H.3
-
12
-
-
14044252848
-
Adalimumab induces apoptosis of human monocytes: A comparative study with infliximab and etanercept
-
Shen C, Assche GV, Colpaert S, et al. Adalimumab induces apoptosis of human monocytes: a comparative study with infliximab and etanercept. Aliment Pharmacol Ther. 2005; 21: 251-258.
-
(2005)
Aliment Pharmacol Ther
, vol.21
, pp. 251-258
-
-
Shen, C.1
Assche, G.V.2
Colpaert, S.3
-
13
-
-
0036151047
-
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
-
ten Hove T, van Montfrans C, Peppelenbosch MP, et al. Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut. 2002; 50: 206-211.
-
(2002)
Gut
, vol.50
, pp. 206-211
-
-
Ten Hove, T.1
Van Montfrans, C.2
Peppelenbosch, M.P.3
-
14
-
-
0038047689
-
Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease
-
Van den Brande JM, Braat H, van den Brink GR, et al. Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease. Gastroenterology. 2003; 124: 1774-1785.
-
(2003)
Gastroenterology
, vol.124
, pp. 1774-1785
-
-
Van Den Brande, J.M.1
Braat, H.2
Van Den Brink, G.R.3
-
15
-
-
0036678630
-
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease
-
Suenaert P, Bulteel V, Lemmens L, et al. Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease. Am J Gastroenterol. 2002; 97: 2000-2004.
-
(2002)
Am J Gastroenterol
, vol.97
, pp. 2000-2004
-
-
Suenaert, P.1
Bulteel, V.2
Lemmens, L.3
-
16
-
-
0032913394
-
Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial
-
D'Haens G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: a European multicenter trial. Gastroenterology. 1999; 116: 1029-1034.
-
(1999)
Gastroenterology
, vol.116
, pp. 1029-1034
-
-
D'Haens, G.1
Van Deventer, S.2
Van Hogezand, R.3
-
17
-
-
16844365788
-
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
-
Sakaguchi S,. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005; 6: 345-352.
-
(2005)
Nat Immunol
, vol.6
, pp. 345-352
-
-
Sakaguchi, S.1
-
18
-
-
0142152433
-
Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation
-
Dubois B, Chapat L, Goubier A, et al. Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation. Blood. 2003; 102: 3295-3301.
-
(2003)
Blood
, vol.102
, pp. 3295-3301
-
-
Dubois, B.1
Chapat, L.2
Goubier, A.3
-
19
-
-
69349093381
-
Sequential role of plasmacytoid dendritic cells and regulatory t cells in oral tolerance
-
Dubois B, Joubert G, de Aguero MG, et al. Sequential role of plasmacytoid dendritic cells and regulatory t cells in oral tolerance. Gastroenterology. 2009; 137: 1019-1028.
-
(2009)
Gastroenterology
, vol.137
, pp. 1019-1028
-
-
Dubois, B.1
Joubert, G.2
De Aguero, M.G.3
-
20
-
-
33746377279
-
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
-
Izcue A, Coombes JL, Powrie F,. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev. 2006; 212: 256-271.
-
(2006)
Immunol Rev
, vol.212
, pp. 256-271
-
-
Izcue, A.1
Coombes, J.L.2
Powrie, F.3
-
21
-
-
0031568001
-
Induction and prevention of colonic inflammation in IL-2-deficient mice
-
Ehrhardt RO, Ludviksson BR, Gray B, et al. Induction and prevention of colonic inflammation in IL-2-deficient mice. J Immunol. 1997; 158: 566-573.
-
(1997)
J Immunol
, vol.158
, pp. 566-573
-
-
Ehrhardt, R.O.1
Ludviksson, B.R.2
Gray, B.3
-
22
-
-
0028519015
-
Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
-
Powrie F, Leach MW, Mauze S, et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity. 1994; 1: 553-562.
-
(1994)
Immunity
, vol.1
, pp. 553-562
-
-
Powrie, F.1
Leach, M.W.2
Mauze, S.3
-
23
-
-
0029956024
-
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
-
Powrie F, Carlino J, Leach MW, et al. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med. 1996; 183: 2669-2674.
-
(1996)
J Exp Med
, vol.183
, pp. 2669-2674
-
-
Powrie, F.1
Carlino, J.2
Leach, M.W.3
-
24
-
-
0027521572
-
Interleukin-10-deficient mice develop chronic enterocolitis
-
Kuhn R, Lohler J, Rennick D, et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993; 75: 263-274.
-
(1993)
Cell
, vol.75
, pp. 263-274
-
-
Kuhn, R.1
Lohler, J.2
Rennick, D.3
-
25
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S,. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003; 299: 1057-1061.
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
26
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot JD, Gavin MA, Rudensky AY,. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003; 4: 330-336.
-
(2003)
Nat Immunol
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
27
-
-
0035162560
-
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
-
Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001; 27: 68-73.
-
(2001)
Nat Genet
, vol.27
, pp. 68-73
-
-
Brunkow, M.E.1
Jeffery, E.W.2
Hjerrild, K.A.3
-
28
-
-
0035163909
-
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
-
Wildin RS, Ramsdell F, Peake J, et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001; 27: 18-20.
-
(2001)
Nat Genet
, vol.27
, pp. 18-20
-
-
Wildin, R.S.1
Ramsdell, F.2
Peake, J.3
-
29
-
-
0038434099
-
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
-
Gambineri E, Torgerson TR, Ochs HD,. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr Opin Rheumatol. 2003; 15: 430-435.
-
(2003)
Curr Opin Rheumatol
, vol.15
, pp. 430-435
-
-
Gambineri, E.1
Torgerson, T.R.2
Ochs, H.D.3
-
30
-
-
20444434616
-
Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease
-
Maul J, Loddenkemper C, Mundt P, et al. Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology. 2005; 128: 1868-1878.
-
(2005)
Gastroenterology
, vol.128
, pp. 1868-1878
-
-
Maul, J.1
Loddenkemper, C.2
Mundt, P.3
-
31
-
-
36249014365
-
Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease
-
Saruta M, Yu QT, Fleshner PR, et al. Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease. Clin Immunol. 2007; 125: 281-290.
-
(2007)
Clin Immunol
, vol.125
, pp. 281-290
-
-
Saruta, M.1
Yu, Q.T.2
Fleshner, P.R.3
-
32
-
-
0024810567
-
Classification of inflammatory bowel disease
-
discussion 16-19.
-
Lennard-Jones JE,. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl. 1989; 170: 2-6; discussion 16-19.
-
(1989)
Scand J Gastroenterol Suppl
, vol.170
, pp. 2-6
-
-
Lennard-Jones, J.E.1
-
33
-
-
33751207432
-
Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells
-
Banham AH,. Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. Trends Immunol. 2006; 27: 541-544.
-
(2006)
Trends Immunol
, vol.27
, pp. 541-544
-
-
Banham, A.H.1
-
34
-
-
33645891652
-
An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis
-
Takahashi M, Nakamura K, Honda K, et al. An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis. Dig Dis Sci. 2006; 51: 677-686.
-
(2006)
Dig Dis Sci
, vol.51
, pp. 677-686
-
-
Takahashi, M.1
Nakamura, K.2
Honda, K.3
-
35
-
-
34249309861
-
Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis
-
Yu QT, Saruta M, Avanesyan A, et al. Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis. Inflamm Bowel Dis. 2007; 13: 191-199.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 191-199
-
-
Yu, Q.T.1
Saruta, M.2
Avanesyan, A.3
-
36
-
-
3543140687
-
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
-
Ehrenstein MR, Evans JG, Singh A, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med. 2004; 200: 277-285.
-
(2004)
J Exp Med
, vol.200
, pp. 277-285
-
-
Ehrenstein, M.R.1
Evans, J.G.2
Singh, A.3
-
37
-
-
25444495492
-
Increased spontaneous apoptosis of CD4+CD25+ T cells in patients with active rheumatoid arthritis is reduced by infliximab
-
Toubi E, Kessel A, Mahmudov Z, et al. Increased spontaneous apoptosis of CD4+CD25+ T cells in patients with active rheumatoid arthritis is reduced by infliximab. Ann N Y Acad Sci. 2005; 1051: 506-514.
-
(2005)
Ann N y Acad Sci
, vol.1051
, pp. 506-514
-
-
Toubi, E.1
Kessel, A.2
Mahmudov, Z.3
-
38
-
-
34547788180
-
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
-
Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med. 2007; 204: 1757-1764.
-
(2007)
J Exp Med
, vol.204
, pp. 1757-1764
-
-
Coombes, J.L.1
Siddiqui, K.R.2
Arancibia-Carcamo, C.V.3
-
39
-
-
33646370647
-
TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
-
Valencia X, Stephens G, Goldbach-Mansky R, et al. TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood. 2006; 108: 253-261.
-
(2006)
Blood
, vol.108
, pp. 253-261
-
-
Valencia, X.1
Stephens, G.2
Goldbach-Mansky, R.3
-
40
-
-
34250864955
-
Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells
-
Chen X, Baumel M, Mannel DN, et al. Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells. J Immunol. 2007; 179: 154-161.
-
(2007)
J Immunol
, vol.179
, pp. 154-161
-
-
Chen, X.1
Baumel, M.2
Mannel, D.N.3
-
41
-
-
65949111746
-
FOXP3 defines regulatory T cells in human tumor and autoimmune disease
-
Kryczek I, Liu R, Wang G, et al. FOXP3 defines regulatory T cells in human tumor and autoimmune disease. Cancer Res. 2009; 69: 3995-4000.
-
(2009)
Cancer Res
, vol.69
, pp. 3995-4000
-
-
Kryczek, I.1
Liu, R.2
Wang, G.3
-
42
-
-
33846446041
-
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
-
Nadkarni S, Mauri C, Ehrenstein MR,. Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J Exp Med. 2007; 204: 33-39.
-
(2007)
J Exp Med
, vol.204
, pp. 33-39
-
-
Nadkarni, S.1
Mauri, C.2
Ehrenstein, M.R.3
-
43
-
-
33745968543
-
Regulatory T-cell compartmentalization and trafficking
-
Wei S, Kryczek I, Zou W,. Regulatory T-cell compartmentalization and trafficking. Blood. 2006; 108: 426-431.
-
(2006)
Blood
, vol.108
, pp. 426-431
-
-
Wei, S.1
Kryczek, I.2
Zou, W.3
-
44
-
-
44649189089
-
Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery
-
Ito T, Hanabuchi S, Wang YH, et al. Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity. 2008; 28: 870-880.
-
(2008)
Immunity
, vol.28
, pp. 870-880
-
-
Ito, T.1
Hanabuchi, S.2
Wang, Y.H.3
-
45
-
-
49149125958
-
Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: Implications and impact on tumor-mediated immune suppression
-
Strauss L, Bergmann C, Szczepanski MJ, et al. Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression. J Immunol. 2008; 180: 2967-2980.
-
(2008)
J Immunol
, vol.180
, pp. 2967-2980
-
-
Strauss, L.1
Bergmann, C.2
Szczepanski, M.J.3
-
46
-
-
5644263642
-
Role of LAG-3 in regulatory T cells
-
Huang CT, Workman CJ, Flies D, et al. Role of LAG-3 in regulatory T cells. Immunity. 2004; 21: 503-513.
-
(2004)
Immunity
, vol.21
, pp. 503-513
-
-
Huang, C.T.1
Workman, C.J.2
Flies, D.3
|