Increased serum level of interleukin-15 in rheumatoid arthritis with long term disease

Clinical and Experimental Rheumatology

Volumn 21, Issue 5, 2003, Pages 639-642

  Gonzalez Alvaro, Isidoro ^a   Ortiz, Ana Maria ^a   Garcia Vicuña, Rosario ^a   Balsa, Alejandro ^b   Pascual Salcedo, Dora ^b   Laffon, Armando ^a  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

IL 15; Rheumatoid arthritis; SLE; Spondyloarthropathies

Indexed keywords

ANTIRHEUMATIC AGENT; INTERLEUKIN 15; RHEUMATOID FACTOR;

ADULT; AGE; AGED; ARTICLE; BLOOD DONOR; BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMOGRAPHY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENDER; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRESCRIPTION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SERODIAGNOSIS; SPONDYLOARTHROPATHY; STATISTICAL SIGNIFICANCE; SYNOVITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; BLOOD; COMPARATIVE STUDY; MIDDLE AGED; SPINE DISEASE; TIME;

AGED; ARTHRITIS, RHEUMATOID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-15; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; SPINAL DISEASES; SYNOVITIS; TIME FACTORS;

EID: 0141987785     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. McINNES IB, LIEW FY: Interleukin 15: A proinflammatory role in rheumatoid arthritis synovitis. Immunol Today 1998; 19: 75-9.
2. MOTTONEN M, ISOMAKI P, LUUKKAINEN R, TOIVANEN P, PUNNONEN J, LASSILA O: Interleukin-15 up-regulates the expression of CD154 on synovial fluid T cells. Immunology 2000; 100: 238-44.
3. ORTIZ A, GARCIA-VICUÑA R, SANCHO D, LAFFON A, SÁNCHEZ-MADRID F, GONZÁLEZ ALVARO I: Cyclosporin A inhibits CD69 expression induced on synovial fluid and peripheral blood lymphocytes by IL-15. J Rheumatol 2000.
4. HARADA S, YAMAMURA M, OKAMOTO H et al.: Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum 1999; 42: 1508-16.
5. ZIOLKOWSKA M, KOC A, LUSZCZYKIEWICZ G et al.: High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol 2000; 164: 2832-8.
6. KLIMIUK PA, SIERAKOWSKI S, LATOSIEWICZ R, CYLWIK B, SKOWRONSKI J, CHWIECKO J: Serum cytokines in different histological variants of rheumatoid arthritis. J Rheumatol 2001; 28: 1211-7.
7. CORDERO OJ, SALGADO FJ, MERA-VARELA A, NOGUEIRA M: Serum interleukin-12, interleukin-15, soluble CD26, and adenosine deaminase in patients with rheumatoid arthritis. Rheumatol Int 2001; 21: 69-74.
8. ARINGER M, STUMMVOLL GH, STEINER G et al.: Serum interleukin-15 is elevated in systemic lupus erythematosus. Rheumatology (Oxford) 2001; 40: 876-81.
9. ARNETT FC, EDWORTHY SM, BLOCH DA et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
10. PREVOO ML, van't HOF MA, KUPER HH, van LEEUWEN MA, van de PUTTE LB, van RIEL PL: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995; 38: 44-8.
11. DOUGADOS M, van der LINDEN S, JUHLIN R et al.: The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum 1991; 34: 1218-27.
12. SUZUKI J, MORIMOTO S, AMANO H, TOKANO Y, TAKASAKI Y, HASHIMOTO H: Serum levels of interleukin 15 in patients with rheumatic diseases. J Rheumatol 2001; 28: 2389-91.
13. ROBAK E, ROBAK T, WOZNIACKA A, ZAKPRELICH M, SYSA-JEDRZEJOWSKA A, STEPIEN H: Proinflammatory interferon-gamma-inducing monokines (interleukin-12, interleukin-18, interleukin-15) - Serum profile in patients with systemic lupus erythematosus. Eur Cytokine Netw 2002; 13: 364-8.
14. RUCHATZ H, LEUNG BP, WEI XQ, McINNES IB, LIEW FY: Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: A role for IL-15 in development of antigen-induced immunopathology. J Immunol 1998; 160: 5654-60.