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Volumn 62, Issue 1, 2010, Pages 171-178

Anti-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; COLLAGEN TYPE 2; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; MONOCLONAL ANTIBODY CD3; TRANSCRIPTION FACTOR FOXP3;

EID: 74849107553     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.25058     Document Type: Article
Times cited : (53)

References (37)
  • 2
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy
    • Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J Exp Med 2004;200:277-85.
    • (2004) J Exp Med , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6
  • 3
    • 37349019689 scopus 로고    scopus 로고
    • Accumulation of FoxP3-expressing CD4+CD25+ T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis
    • Jiao Z, Wang W, Jia R, Li J, You H, Chen L, et al. Accumulation of FoxP3-expressing CD4+CD25+ T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis. Scand J Rheumatol 2007;36:428-33.
    • (2007) Scand J Rheumatol , vol.36 , pp. 428-433
    • Jiao, Z.1    Wang, W.2    Jia, R.3    Li, J.4    You, H.5    Chen, L.6
  • 4
    • 4444300314 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    • Van Amelsfort JM, Jacobs KM, Bijlsma JW, Lafeber FP, Taams LS. CD4+CD25+ regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 2004;50: 2775-85.
    • (2004) Arthritis Rheum , vol.50 , pp. 2775-2785
    • Van Amelsfort, J.M.1    Jacobs, K.M.2    Bijlsma, J.W.3    Lafeber, F.P.4    Taams, L.S.5
  • 5
    • 20144370643 scopus 로고    scopus 로고
    • The role of regulatory T cells in antigen-induced arthritis: Aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells
    • Frey O, Petrow PK, Gajda M, Siegmund K, Huehn J, Scheffold A, et al. The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther 2005;7: R291-301.
    • (2005) Arthritis Res Ther , vol.7
    • Frey, O.1    Petrow, P.K.2    Gajda, M.3    Siegmund, K.4    Huehn, J.5    Scheffold, A.6
  • 6
    • 30144433577 scopus 로고    scopus 로고
    • Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: An important factor in pathogenesis, counter-regulated by endogenous IFN-γ
    • Kelchtermans H, De Klerck B, Mitera T, Van Balen M, Bullens D, Billiau A, et al. Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ. Arthritis Res Ther 2005;7:R402-15.
    • (2005) Arthritis Res Ther , vol.7
    • Kelchtermans, H.1    De Klerck, B.2    Mitera, T.3    Van Balen, M.4    Bullens, D.5    Billiau, A.6
  • 7
    • 33845933590 scopus 로고    scopus 로고
    • Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: Potential reagents to promote donor-specific transplantation tolerance
    • Jiang S, Tsang J, Game DS, Stevenson S, Lombardi G, Lechler RI. Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: potential reagents to promote donor-specific transplantation tolerance. Transplantation 2006;82: 1738-43.
    • (2006) Transplantation , vol.82 , pp. 1738-1743
    • Jiang, S.1    Tsang, J.2    Game, D.S.3    Stevenson, S.4    Lombardi, G.5    Lechler, R.I.6
  • 8
    • 0027958044 scopus 로고
    • Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
    • Chatenoud L, Thervet E, Primo J, Bach JF. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci U S A 1994;91:123-7.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 123-127
    • Chatenoud, L.1    Thervet, E.2    Primo, J.3    Bach, J.F.4
  • 9
    • 0141796312 scopus 로고    scopus 로고
    • TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    • Belghith M, Bluestone JA, Barriot S, Megret J, Bach JF, Chatenoud L. TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 2003;9:1202-8.
    • (2003) Nat Med , vol.9 , pp. 1202-1208
    • Belghith, M.1    Bluestone, J.A.2    Barriot, S.3    Megret, J.4    Bach, J.F.5    Chatenoud, L.6
  • 10
    • 34547204632 scopus 로고    scopus 로고
    • Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
    • You S, Leforban B, Garcia C, Bach JF, Bluestone JA, Chatenoud L. Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci U S A 2007;104:6335-40.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6335-6340
    • You, S.1    Leforban, B.2    Garcia, C.3    Bach, J.F.4    Bluestone, J.A.5    Chatenoud, L.6
  • 12
    • 20044375937 scopus 로고    scopus 로고
    • A single course of anti-CD3 monoclonal antibody hOKT3γ1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
    • Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, et al. A single course of anti-CD3 monoclonal antibody hOKT3γ1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005;54:1763-9.
    • (2005) Diabetes , vol.54 , pp. 1763-1769
    • Herold, K.C.1    Gitelman, S.E.2    Masharani, U.3    Hagopian, W.4    Bisikirska, B.5    Donaldson, D.6
  • 13
    • 26444515022 scopus 로고    scopus 로고
    • TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs
    • Bisikirska B, Colgan J, Luban J, Bluestone JA, Herold KC. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest 2005; 115:2904-13.
    • (2005) J Clin Invest , vol.115 , pp. 2904-2913
    • Bisikirska, B.1    Colgan, J.2    Luban, J.3    Bluestone, J.A.4    Herold, K.C.5
  • 14
    • 37149037678 scopus 로고    scopus 로고
    • Collagen-induced arthritis as a model of hyperalgesia: Functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade
    • Inglis JJ, Notley CA, Essex D, Wilson AW, Feldmann M, Anand P, et al. Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade. Arthritis Rheum 2007;56:4015-23.
    • (2007) Arthritis Rheum , vol.56 , pp. 4015-4023
    • Inglis, J.J.1    Notley, C.A.2    Essex, D.3    Wilson, A.W.4    Feldmann, M.5    Anand, P.6
  • 15
    • 0037313086 scopus 로고    scopus 로고
    • CD3-specific antibody-induced active tolerance: From bench to bedside
    • Chatenoud L. CD3-specific antibody-induced active tolerance: from bench to bedside. Nat Rev Immunol 2003;3:123-32.
    • (2003) Nat Rev Immunol , vol.3 , pp. 123-132
    • Chatenoud, L.1
  • 16
    • 58149166804 scopus 로고    scopus 로고
    • Blockade of tumor necrosis factor in collageninduced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    • Notley CA, Inglis JJ, Alzabin S, McCann FE, McNamee KE, Williams RO. Blockade of tumor necrosis factor in collageninduced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J Exp Med 2008;205:2491-7.
    • (2008) J Exp Med , vol.205 , pp. 2491-2497
    • Notley, C.A.1    Inglis, J.J.2    Alzabin, S.3    McCann, F.E.4    McNamee, K.E.5    Williams, R.O.6
  • 17
    • 34250222393 scopus 로고    scopus 로고
    • CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression
    • Singh RP, La Cava A, Wong M, Ebling F, Hahn BH. CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression. J Immunol 2007;178:7649-57.
    • (2007) J Immunol , vol.178 , pp. 7649-7657
    • Singh, R.P.1    La Cava, A.2    Wong, M.3    Ebling, F.4    Hahn, B.H.5
  • 18
    • 0029102761 scopus 로고
    • An anti-murine CD3 monoclonal antibody with a low affinity for Fc γ receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity
    • Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, et al. An anti-murine CD3 monoclonal antibody with a low affinity for Fc γ receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity. J Immunol 1995;155: 1544-55.
    • (1995) J Immunol , vol.155 , pp. 1544-1555
    • Alegre, M.L.1    Tso, J.Y.2    Sattar, H.A.3    Smith, J.4    Desalle, F.5    Cole, M.6
  • 19
    • 17044425656 scopus 로고    scopus 로고
    • Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis
    • Kohm AP, Williams JS, Bickford AL, McMahon JS, Chatenoud L, Bach JF, et al. Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis. J Immunol 2005;174:4525-34.
    • (2005) J Immunol , vol.174 , pp. 4525-4534
    • Kohm, A.P.1    Williams, J.S.2    Bickford, A.L.3    McMahon, J.S.4    Chatenoud, L.5    Bach, J.F.6
  • 20
    • 0031569177 scopus 로고    scopus 로고
    • CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
    • Chatenoud L, Primo J, Bach JF. CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immunol 1997;158: 2947-54.
    • (1997) J Immunol , vol.158 , pp. 2947-2954
    • Chatenoud, L.1    Primo, J.2    Bach, J.F.3
  • 21
    • 43249097073 scopus 로고    scopus 로고
    • CD3-specific antibody-induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells
    • Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W. CD3-specific antibody-induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells. Nat Med 2008;14:528-35.
    • (2008) Nat Med , vol.14 , pp. 528-535
    • Perruche, S.1    Zhang, P.2    Liu, Y.3    Saas, P.4    Bluestone, J.A.5    Chen, W.6
  • 22
    • 17644384896 scopus 로고    scopus 로고
    • CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
    • Mottonen M, Heikkinen J, Mustonen L, Isomaki P, Luukkainen R, Lassila O. CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 2005;140:360-7.
    • (2005) Clin Exp Immunol , vol.140 , pp. 360-367
    • Mottonen, M.1    Heikkinen, J.2    Mustonen, L.3    Isomaki, P.4    Luukkainen, R.5    Lassila, O.6
  • 23
    • 33750351338 scopus 로고    scopus 로고
    • Koenders MI, Joosten LA, van den Berg WB. Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Ann Rheum Dis 2006;65 Suppl 3:iii29-33.
    • Koenders MI, Joosten LA, van den Berg WB. Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Ann Rheum Dis 2006;65 Suppl 3:iii29-33.
  • 24
    • 36749081557 scopus 로고    scopus 로고
    • Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes
    • Evans HG, Suddason T, Jackson I, Taams LS, Lord GM. Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc Natl Acad Sci U S A 2007;104:1703-9.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 1703-1709
    • Evans, H.G.1    Suddason, T.2    Jackson, I.3    Taams, L.S.4    Lord, G.M.5
  • 25
    • 58049196774 scopus 로고    scopus 로고
    • Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
    • Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR. Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc Natl Acad Sci U S A 2008;105: 19396-401.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19396-19401
    • Flores-Borja, F.1    Jury, E.C.2    Mauri, C.3    Ehrenstein, M.R.4
  • 26
    • 20144387661 scopus 로고    scopus 로고
    • Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS
    • Kornfeld C, Ploquin MJ, Pandrea I, Faye A, Onanga R, Apetrei C, et al. Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J Clin Invest 2005;115:1082-91.
    • (2005) J Clin Invest , vol.115 , pp. 1082-1091
    • Kornfeld, C.1    Ploquin, M.J.2    Pandrea, I.3    Faye, A.4    Onanga, R.5    Apetrei, C.6
  • 28
    • 63849224217 scopus 로고    scopus 로고
    • Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue
    • Chaput N, Louafi S, Bardier A, Charlotte F, Vaillant JC, Menegaux F, et al. Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue. Gut 2009;58:520-9.
    • (2009) Gut , vol.58 , pp. 520-529
    • Chaput, N.1    Louafi, S.2    Bardier, A.3    Charlotte, F.4    Vaillant, J.C.5    Menegaux, F.6
  • 29
    • 0032533472 scopus 로고    scopus 로고
    • Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CD8+CD28- regulatory T cells
    • Ciubotariu R, Colovai AI, Pennesi G, Liu Z, Smith D, Berlocco P, et al. Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CD8+CD28- regulatory T cells. J Immunol 1998;161:5193-202.
    • (1998) J Immunol , vol.161 , pp. 5193-5202
    • Ciubotariu, R.1    Colovai, A.I.2    Pennesi, G.3    Liu, Z.4    Smith, D.5    Berlocco, P.6
  • 30
    • 0031812070 scopus 로고    scopus 로고
    • Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+CD28+ T cells
    • Liu Z, Tugulea S, Cortesini R, Suciu-Foca N. Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+CD28+ T cells. Int Immunol 1998;10:775-83.
    • (1998) Int Immunol , vol.10 , pp. 775-783
    • Liu, Z.1    Tugulea, S.2    Cortesini, R.3    Suciu-Foca, N.4
  • 31
    • 66949172165 scopus 로고    scopus 로고
    • Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells
    • Kiesel JR, Buchwald ZS, Aurora R. Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells. J Immunol 2009;182: 5477-87.
    • (2009) J Immunol , vol.182 , pp. 5477-5487
    • Kiesel, J.R.1    Buchwald, Z.S.2    Aurora, R.3
  • 32
    • 67449110676 scopus 로고    scopus 로고
    • Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8αα+TCRαβ+ T cells with regulatory properties
    • Smith TR, Tang X, Maricic I, Garcia Z, Fanchiang S, Kumar V. Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8αα+TCRαβ+ T cells with regulatory properties. J Immunol 2009;182:6959-68.
    • (2009) J Immunol , vol.182 , pp. 6959-6968
    • Smith, T.R.1    Tang, X.2    Maricic, I.3    Garcia, Z.4    Fanchiang, S.5    Kumar, V.6
  • 33
    • 37049026246 scopus 로고    scopus 로고
    • FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load
    • Karlsson I, Malleret B, Brochard P, Delache B, Calvo J, Le Grand R, et al. FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. J Virol 2007;81:13444-55.
    • (2007) J Virol , vol.81 , pp. 13444-13455
    • Karlsson, I.1    Malleret, B.2    Brochard, P.3    Delache, B.4    Calvo, J.5    Le Grand, R.6
  • 34
    • 34249944837 scopus 로고    scopus 로고
    • Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4
    • Joosten SA, van Meijgaarden KE, Savage ND, de Boer T, Triebel F, van der Wal A, et al. Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4. Proc Natl Acad Sci U S A 2007;104:8029-34.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 8029-8034
    • Joosten, S.A.1    van Meijgaarden, K.E.2    Savage, N.D.3    de Boer, T.4    Triebel, F.5    van der Wal, A.6
  • 35
    • 18944393671 scopus 로고    scopus 로고
    • Cell-based immunotherapy with suppressor CD8+ T cells in rheumatoid arthritis
    • Davila E, Kang YM, Park YW, Sawai H, He X, Pryshchep S, et al. Cell-based immunotherapy with suppressor CD8+ T cells in rheumatoid arthritis. J Immunol 2005;174:7292-301.
    • (2005) J Immunol , vol.174 , pp. 7292-7301
    • Davila, E.1    Kang, Y.M.2    Park, Y.W.3    Sawai, H.4    He, X.5    Pryshchep, S.6
  • 36
    • 33645964981 scopus 로고    scopus 로고
    • CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance
    • Keino H, Masli S, Sasaki S, Streilein JW, Stein-Streilein J. CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance. Invest Ophthalmol Vis Sci 2006;47:1533-42.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 1533-1542
    • Keino, H.1    Masli, S.2    Sasaki, S.3    Streilein, J.W.4    Stein-Streilein, J.5


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