-
1
-
-
33646852575
-
The p53 response during DNA damage: Impact of transcriptional cofactors
-
Coutts AS, La TN. The p53 response during DNA damage: impact of transcriptional cofactors. Biochem Soc Symp 2006; 73: 181-189.
-
(2006)
Biochem Soc Symp
, vol.73
, pp. 181-189
-
-
Coutts, A.S.1
La, T.N.2
-
2
-
-
79960024581
-
Reciprocal influence of the p53 and the hypoxic pathways
-
Sermeus A, Michiels C. Reciprocal influence of the p53 and the hypoxic pathways. Cell Death Dis 2011; 2: e164.
-
(2011)
Cell Death Dis
, vol.2
-
-
Sermeus, A.1
Michiels, C.2
-
4
-
-
78650316134
-
P53 Research: The past thirty years and the next thirty years
-
Lane D, Levine A. p53 Research: the past thirty years and the next thirty years. Cold Spring Harb Perspect Biol 2010; 2: a000893.
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
-
-
Lane, D.1
Levine, A.2
-
5
-
-
65349103899
-
Blinded by the light: The growing complexity of p53
-
Vousden KH, Prives C. Blinded by the light: the growing complexity of p53. Cell 2009; 137: 413-431.
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
6
-
-
0037812325
-
Genetic stabilization by p53 involves growth regulatory and repair pathways
-
Wiesmuller L. Genetic stabilization by p53 involves growth regulatory and repair pathways. J Biomed Biotechnol 2001; 1: 7-10.
-
(2001)
J Biomed Biotechnol
, vol.1
, pp. 7-10
-
-
Wiesmuller, L.1
-
7
-
-
84862864843
-
Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a proinvasive secretome
-
Neilsen PM, Noll JE, Suetani RJ, Schulz RB, Al-Ejeh F, Evdokiou A et al. Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a proinvasive secretome. Oncotarget 2011; 2: 1203-1217.
-
(2011)
Oncotarget
, vol.2
, pp. 1203-1217
-
-
Neilsen, P.M.1
Noll, J.E.2
Suetani, R.J.3
Schulz, R.B.4
Al-Ejeh, F.5
Evdokiou, A.6
-
8
-
-
77953482819
-
The p53 response element and transcriptional repression
-
Wang B, Xiao Z, Ko HL, Ren EC. The p53 response element and transcriptional repression. Cell Cycle 2010; 9: 870-879.
-
(2010)
Cell Cycle
, vol.9
, pp. 870-879
-
-
Wang, B.1
Xiao, Z.2
Ko, H.L.3
Ren, E.C.4
-
9
-
-
0023715595
-
A cancer family syndrome in twenty-four kindreds
-
Li FP, Fraumeni Jr. JF, Mulvihill JJ, Blattner WA, Dreyfus MG, Tucker MA et al. A cancer family syndrome in twenty-four kindreds. Cancer Res 1988; 48: 5358-5362.
-
(1988)
Cancer Res
, vol.48
, pp. 5358-5362
-
-
Li, F.P.1
Fraumeni Jr., J.F.2
Mulvihill, J.J.3
Blattner, W.A.4
Dreyfus, M.G.5
Tucker, M.A.6
-
10
-
-
84876570838
-
The TP53 website: An integrative resource centre for the TP53 mutation database and TP53 mutant analysis
-
Leroy B, Fournier JL, Ishioka C, Monti P, Inga A, Fronza G et al. The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis. Nucleic Acids Res 2013; 41: D962-D969.
-
(2013)
Nucleic Acids Res
, vol.41
-
-
Leroy, B.1
Fournier, J.L.2
Ishioka, C.3
Monti, P.4
Inga, A.5
Fronza, G.6
-
11
-
-
77955363995
-
TP53 mutations in human cancers: Origins, consequences, and clinical use
-
Olivier M, Hollstein M, Hainaut P. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol 2010; 2: a001008.
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
-
-
Olivier, M.1
Hollstein, M.2
Hainaut, P.3
-
12
-
-
11344252796
-
Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations
-
Soussi T, Kato S, Levy PP, Ishioka C. Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations. Hum Mutat 2005; 25: 6-17.
-
(2005)
Hum Mutat
, vol.25
, pp. 6-17
-
-
Soussi, T.1
Kato, S.2
Levy, P.P.3
Ishioka, C.4
-
13
-
-
69249164841
-
Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: A case for newborn screening?
-
Achatz MI, Hainaut P, shton-Prolla P. Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: a case for newborn screening? Lancet Oncol 2009; 10: 920-925.
-
(2009)
Lancet Oncol
, vol.10
, pp. 920-925
-
-
Achatz, M.I.1
Hainaut, P.2
Shton-Prolla, P.3
-
14
-
-
0027430658
-
Screening patients for heterozygous p53 mutations using a functional assay in yeast
-
Ishioka C, Frebourg T, Yan YX, Vidal M, Friend SH, Schmidt S et al. Screening patients for heterozygous p53 mutations using a functional assay in yeast. Nat Genet 1993; 5: 124-129.
-
(1993)
Nat Genet
, vol.5
, pp. 124-129
-
-
Ishioka, C.1
Frebourg, T.2
Yan, Y.X.3
Vidal, M.4
Friend, S.H.5
Schmidt, S.6
-
15
-
-
0042692855
-
Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity
-
Resnick MA, Inga A. Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity. Proc Natl Acad Sci USA 2003; 100: 9934-9939.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9934-9939
-
-
Resnick, M.A.1
Inga, A.2
-
16
-
-
33644763294
-
The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes
-
Menendez D, Inga A, Resnick MA. The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes. Mol Cell Biol 2006; 26: 2297-2308.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2297-2308
-
-
Menendez, D.1
Inga, A.2
Resnick, M.A.3
-
17
-
-
0030021748
-
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
-
Rowan S, Ludwig RL, Haupt Y, Bates S, Lu X, Oren M et al. Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J 1996; 15: 827-838.
-
(1996)
EMBO J
, vol.15
, pp. 827-838
-
-
Rowan, S.1
Ludwig, R.L.2
Haupt, Y.3
Bates, S.4
Lu, X.5
Oren, M.6
-
18
-
-
81355148679
-
Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras
-
Acin S, Li Z, Mejia O, Roop DR, El-Naggar AK, Caulin C. Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras. J Pathol 2011; 225: 479-489.
-
(2011)
J Pathol
, vol.225
, pp. 479-489
-
-
Acin, S.1
Li, Z.2
Mejia, O.3
Roop, D.R.4
El-Naggar, A.K.5
Caulin, C.6
-
19
-
-
34047194383
-
Crippling p53 activities via knock-in mutations in mouse models
-
Iwakuma T, Lozano G. Crippling p53 activities via knock-in mutations in mouse models. Oncogene 2007; 26: 2177-2184.
-
(2007)
Oncogene
, vol.26
, pp. 2177-2184
-
-
Iwakuma, T.1
Lozano, G.2
-
20
-
-
27744434529
-
Functional analysis of p53 tumor suppressor in yeast
-
Smardova J, Smarda J, Koptikova J. Functional analysis of p53 tumor suppressor in yeast. Differentiation 2005; 73: 261-277.
-
(2005)
Differentiation
, vol.73
, pp. 261-277
-
-
Smardova, J.1
Smarda, J.2
Koptikova, J.3
-
21
-
-
70349443284
-
When mutants gain new powers: News from the mutant p53 field
-
Brosh R, Rotter V. When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer 2009; 9: 701-713.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 701-713
-
-
Brosh, R.1
Rotter, V.2
-
22
-
-
46049118428
-
Oncogenomic approaches in exploring gain of function of mutant p53
-
Donzelli S, Biagioni F, Fausti F, Strano S, Fontemaggi G, Blandino G. Oncogenomic approaches in exploring gain of function of mutant p53. Curr Genomics 2008 9: 200-207.
-
(2008)
Curr Genomics
, vol.9
, pp. 200-207
-
-
Donzelli, S.1
Biagioni, F.2
Fausti, F.3
Strano, S.4
Fontemaggi, G.5
Blandino, G.6
-
23
-
-
33846243857
-
The oncogenic roles of p53 mutants in mouse models
-
Lozano G. The oncogenic roles of p53 mutants in mouse models. Curr Opin Genet Dev 2007; 17: 66-70.
-
(2007)
Curr Opin Genet Dev
, vol.17
, pp. 66-70
-
-
Lozano, G.1
-
24
-
-
33748168725
-
Mutant p53 gain of function: The NF-Y connection
-
Peart MJ, Prives C. Mutant p53 gain of function: the NF-Y connection. Cancer Cell 2006; 10: 173-174.
-
(2006)
Cancer Cell
, vol.10
, pp. 173-174
-
-
Peart, M.J.1
Prives, C.2
-
25
-
-
34047207337
-
TP53 mutations in human cancers: Functional selection and impact on cancer prognosis and outcomes
-
Petitjean A, Achatz MI, Borresen-Dale AL, Hainaut P, Olivier M. TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes. Oncogene 2007; 26: 2157-2165.
-
(2007)
Oncogene
, vol.26
, pp. 2157-2165
-
-
Petitjean, A.1
Achatz, M.I.2
Borresen-Dale, A.L.3
Hainaut, P.4
Olivier, M.5
-
26
-
-
34548257378
-
Gain of function of p53 cancer mutants in disrupting critical DNA damage response pathways
-
Song H, Xu Y. Gain of function of p53 cancer mutants in disrupting critical DNA damage response pathways. Cell Cycle 2007; 6: 1570-1573.
-
(2007)
Cell Cycle
, vol.6
, pp. 1570-1573
-
-
Song, H.1
Xu, Y.2
-
27
-
-
34047205431
-
Mutant p53: An oncogenic transcription factor
-
Strano S, Dell'Orso S, Di AS, Fontemaggi G, Sacchi A, Blandino G. Mutant p53: an oncogenic transcription factor. Oncogene 2007; 26: 2212-2219.
-
(2007)
Oncogene
, vol.26
, pp. 2212-2219
-
-
Strano, S.1
Dell'Orso, S.2
Di, A.S.3
Fontemaggi, G.4
Sacchi, A.5
Blandino, G.6
-
28
-
-
84856693441
-
Mutant p53 protein, master regulator of human malignancies: A report on the Fifth Mutant p53 Workshop
-
Blandino G, Deppert W, Hainaut P, Levine A, Lozano G, Olivier M et al. Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop. Cell Death Differ 2012; 19: 180-183.
-
(2012)
Cell Death Differ
, vol.19
, pp. 180-183
-
-
Blandino, G.1
Deppert, W.2
Hainaut, P.3
Levine, A.4
Lozano, G.5
Olivier, M.6
-
29
-
-
29944443554
-
The UMD TP53 database and website: Update and revisions
-
Hamroun D, Kato S, Ishioka C, Claustres M, Beroud C, Soussi T. The UMD TP53 database and website: update and revisions. Hum Mutat 2006 27: 14-20.
-
(2006)
Hum Mutat
, vol.27
, pp. 14-20
-
-
Hamroun, D.1
Kato, S.2
Ishioka, C.3
Claustres, M.4
Beroud, C.5
Soussi, T.6
-
30
-
-
77954498887
-
COMPASSS (COMplex PAttern of Sequence Search Software), a simple and effective tool for mining complex motifs in whole genomes
-
Maccari G, Gemignani F, Landi S. COMPASSS (COMplex PAttern of Sequence Search Software), a simple and effective tool for mining complex motifs in whole genomes. Bioinformatics 2010; 26: 1777-1778.
-
(2010)
Bioinformatics
, vol.26
, pp. 1777-1778
-
-
MacCari, G.1
Gemignani, F.2
Landi, S.3
-
31
-
-
46249084702
-
Noncanonical DNA motifs as transactivation targets by wild type and mutant p53
-
Jordan JJ, Menendez D, Inga A, Noureddine M, Bell DA, Resnick MA. Noncanonical DNA motifs as transactivation targets by wild type and mutant p53. PLoS Genet 2008; 4: e1000104.
-
(2008)
PLoS Genet
, vol.4
-
-
Jordan, J.J.1
Menendez, D.2
Inga, A.3
Noureddine, M.4
Bell, D.A.5
Resnick, M.A.6
-
33
-
-
61449172037
-
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
-
Huang dW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44-57.
-
(2009)
Nat Protoc
, vol.4
, pp. 44-57
-
-
Huang, D.W.1
Sherman, B.T.2
Lempicki, R.A.3
-
34
-
-
84869090231
-
Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis
-
Nikulenkov F, Spinnler C, Li H, Tonelli C, Shi Y, Turunen M et al. Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis. Cell Death Differ 2012; 19: 1992-2002.
-
(2012)
Cell Death Differ
, vol.19
, pp. 1992-2002
-
-
Nikulenkov, F.1
Spinnler, C.2
Li, H.3
Tonelli, C.4
Shi, Y.5
Turunen, M.6
-
35
-
-
0035920197
-
Transcriptional repression by p53 through direct binding to a novel DNA element
-
Johnson RA, Ince TA, Scotto KW. Transcriptional repression by p53 through direct binding to a novel DNA element. J Biol Chem 2001; 276: 27716-27720.
-
(2001)
J Biol Chem
, vol.276
, pp. 27716-27720
-
-
Johnson, R.A.1
Ince, T.A.2
Scotto, K.W.3
-
36
-
-
0033591217
-
P53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor
-
Budhram-Mahadeo V, Morris PJ, Smith MD, Midgley CA, Boxer LM, Latchman DS. p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. J Biol Chem 1999; 274: 15237-15244.
-
(1999)
J Biol Chem
, vol.274
, pp. 15237-15244
-
-
Budhram-Mahadeo, V.1
Morris, P.J.2
Smith, M.D.3
Midgley, C.A.4
Boxer, L.M.5
Latchman, D.S.6
-
37
-
-
0036479115
-
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
-
Hoffman WH, Biade S, Zilfou JT, Chen J, Murphy M. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem 2002; 277: 3247-3257.
-
(2002)
J Biol Chem
, vol.277
, pp. 3247-3257
-
-
Hoffman, W.H.1
Biade, S.2
Zilfou, J.T.3
Chen, J.4
Murphy, M.5
-
38
-
-
79957859089
-
To repress or not to repress: This is the guardian's question
-
Rinn JL, Huarte M. To repress or not to repress: this is the guardian's question. Trends Cell Biol 2011; 21: 344-353.
-
(2011)
Trends Cell Biol
, vol.21
, pp. 344-353
-
-
Rinn, J.L.1
Huarte, M.2
-
39
-
-
79955009769
-
One function-multiple mechanisms: The manifold activities of p53 as a transcriptional repressor
-
Bohlig L, Rother K. One function-multiple mechanisms: the manifold activities of p53 as a transcriptional repressor. J Biomed Biotechnol 2011; 2011: 464916.
-
(2011)
J Biomed Biotechnol
, vol.2011
, pp. 464916
-
-
Bohlig, L.1
Rother, K.2
-
40
-
-
80052183233
-
Wildtype p53 controls cell motility and invasion by dual regulation of MET expression
-
Hwang CI, Matoso A, Corney DC, Flesken-Nikitin A, Korner S, Wang W et al. Wildtype p53 controls cell motility and invasion by dual regulation of MET expression. Proc Natl Acad Sci USA 2011; 108: 14240-14245.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 14240-14245
-
-
Hwang, C.I.1
Matoso, A.2
Corney, D.C.3
Flesken-Nikitin, A.4
Korner, S.5
Wang, W.6
-
41
-
-
33749026967
-
ARID3B induces malignant transformation of mouse embryonic fibroblasts and is strongly associated with malignant neuroblastoma
-
Kobayashi K, Era T, Takebe A, Jakt LM, Nishikawa S. ARID3B induces malignant transformation of mouse embryonic fibroblasts and is strongly associated with malignant neuroblastoma. Cancer Res 2006; 66: 8331-8336.
-
(2006)
Cancer Res
, vol.66
, pp. 8331-8336
-
-
Kobayashi, K.1
Era, T.2
Takebe, A.3
Jakt, L.M.4
Nishikawa, S.5
-
42
-
-
0034709652
-
The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia
-
Maltepe E, Keith B, Arsham AM, Brorson JR, Simon MC. The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia. Biochem Biophys Res Commun 2000; 273: 231-238.
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 231-238
-
-
Maltepe, E.1
Keith, B.2
Arsham, A.M.3
Brorson, J.R.4
Simon, M.C.5
-
43
-
-
84870187592
-
Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice
-
Kanojia D, Zhou W, Zhang J, Jie C, Lo PK, Wang Q et al. Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice. Proteomics 2012; 12: 3407-3415.
-
(2012)
Proteomics
, vol.12
, pp. 3407-3415
-
-
Kanojia, D.1
Zhou, W.2
Zhang, J.3
Jie, C.4
Lo, P.K.5
Wang, Q.6
-
44
-
-
8344260568
-
Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species
-
Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K et al. Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 2004; 119: 529-542.
-
(2004)
Cell
, vol.119
, pp. 529-542
-
-
Pham, C.G.1
Bubici, C.2
Zazzeroni, F.3
Papa, S.4
Jones, J.5
Alvarez, K.6
-
45
-
-
0033571363
-
H-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties
-
Epsztejn S, Glickstein H, Picard V, Slotki IN, Breuer W, Beaumont C et al. H-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties. Blood 1999; 94: 3593-3603.
-
(1999)
Blood
, vol.94
, pp. 3593-3603
-
-
Epsztejn, S.1
Glickstein, H.2
Picard, V.3
Slotki, I.N.4
Breuer, W.5
Beaumont, C.6
-
46
-
-
79952759169
-
Heavy chain ferritin siRNA delivered by cationic liposomes increases sensitivity of cancer cells to chemotherapeutic agents
-
Liu X, Madhankumar AB, Slagle-Webb B, Sheehan JM, Surguladze N, Connor JR. Heavy chain ferritin siRNA delivered by cationic liposomes increases sensitivity of cancer cells to chemotherapeutic agents. Cancer Res 2011; 71: 2240-2249.
-
(2011)
Cancer Res
, vol.71
, pp. 2240-2249
-
-
Liu, X.1
Madhankumar, A.B.2
Slagle-Webb, B.3
Sheehan, J.M.4
Surguladze, N.5
Connor, J.R.6
-
47
-
-
84873527068
-
The functional role of the novel biomarker karyopherin alpha 2 (KPNA2) in cancer
-
Christiansen A, Dyrskjot L. The functional role of the novel biomarker karyopherin alpha 2 (KPNA2) in cancer. Cancer Lett 2013; 331: 18-23.
-
(2013)
Cancer Lett
, vol.331
, pp. 18-23
-
-
Christiansen, A.1
Dyrskjot, L.2
-
48
-
-
56749102128
-
Par complex in cancer: A regulator of normal cell polarity joins the dark side
-
Aranda V, Nolan ME, Muthuswamy SK. Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene 2008; 27: 6878-6887.
-
(2008)
Oncogene
, vol.27
, pp. 6878-6887
-
-
Aranda, V.1
Nolan, M.E.2
Muthuswamy, S.K.3
-
49
-
-
62449278758
-
Targeting p53 for enhanced radio- and chemo-sensitivity
-
Lu C, El-Deiry WS. Targeting p53 for enhanced radio- and chemo-sensitivity. Apoptosis 2009; 14: 597-606.
-
(2009)
Apoptosis
, vol.14
, pp. 597-606
-
-
Lu, C.1
El-Deiry, W.S.2
-
50
-
-
84857443702
-
The p53 network: Cellular and systemic DNA damage responses in aging and cancer
-
Reinhardt HC, Schumacher B. The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet 2012; 28: 128-136.
-
(2012)
Trends Genet
, vol.28
, pp. 128-136
-
-
Reinhardt, H.C.1
Schumacher, B.2
-
52
-
-
77952212178
-
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
-
Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci USA 2010; 107: 7455-7460.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7455-7460
-
-
Hu, W.1
Zhang, C.2
Wu, R.3
Sun, Y.4
Levine, A.5
Feng, Z.6
-
53
-
-
77952227625
-
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
-
Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S et al. Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci USA 2010; 107: 7461-7466.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7461-7466
-
-
Suzuki, S.1
Tanaka, T.2
Poyurovsky, M.V.3
Nagano, H.4
Mayama, T.5
Ohkubo, S.6
-
54
-
-
43049139541
-
P53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
-
Kawauchi K, Araki K, Tobiume K, Tanaka N. p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol 2008; 10: 611-618.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 611-618
-
-
Kawauchi, K.1
Araki, K.2
Tobiume, K.3
Tanaka, N.4
-
55
-
-
44649108882
-
Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation
-
Kawauchi K, Araki K, Tobiume K, Tanaka N. Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation. Biochem Biophys Res Commun 2008; 372: 137-141.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 137-141
-
-
Kawauchi, K.1
Araki, K.2
Tobiume, K.3
Tanaka, N.4
-
56
-
-
1942506067
-
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
-
Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res 2004; 64: 2627-2633.
-
(2004)
Cancer Res
, vol.64
, pp. 2627-2633
-
-
Schwartzenberg-Bar-Yoseph, F.1
Armoni, M.2
Karnieli, E.3
-
57
-
-
66249086606
-
P53 regulates mtDNA copy number and mitocheckpoint pathway
-
Kulawiec M, Ayyasamy V, Singh KK. p53 regulates mtDNA copy number and mitocheckpoint pathway. J Carcinog 2009; 8: 8.
-
(2009)
J Carcinog
, vol.8
, pp. 8
-
-
Kulawiec, M.1
Ayyasamy, V.2
Singh, K.K.3
-
58
-
-
65449137587
-
Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis
-
Lebedeva MA, Eaton JS, Shadel GS. Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochim Biophys Acta 2009; 1787: 328-334.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 328-334
-
-
Lebedeva, M.A.1
Eaton, J.S.2
Shadel, G.S.3
-
59
-
-
34547114031
-
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
-
Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007; 67: 6745-6752.
-
(2007)
Cancer Res
, vol.67
, pp. 6745-6752
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
Lum, J.J.4
Deberardinis, R.J.5
Zhao, F.6
-
60
-
-
84857372561
-
P53, a novel regulator of lipid metabolism pathways
-
Goldstein I, Ezra O, Rivlin N, Molchadsky A, Madar S, Goldfinger N et al. p53, a novel regulator of lipid metabolism pathways. J Hepatol 2012; 56: 656-662.
-
(2012)
J Hepatol
, vol.56
, pp. 656-662
-
-
Goldstein, I.1
Ezra, O.2
Rivlin, N.3
Molchadsky, A.4
Madar, S.5
Goldfinger, N.6
-
61
-
-
84871821537
-
Metabolic changes in cancer: Beyond the Warburg effect
-
Wu W, Zhao S. Metabolic changes in cancer: beyond the Warburg effect. Acta Biochim Biophys Sin (Shanghai) 2013; 45: 18-26.
-
(2013)
Acta Biochim Biophys Sin (Shanghai)
, vol.45
, pp. 18-26
-
-
Wu, W.1
Zhao, S.2
-
62
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O et al. p53 regulates mitochondrial respiration. Science 2006; 312: 1650-1653.
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
-
64
-
-
84871240190
-
Proline dehydrogenase (oxidase) in cancer
-
Liu W, Phang JM. Proline dehydrogenase (oxidase) in cancer. Biofactors 2012; 38: 398-406.
-
(2012)
Biofactors
, vol.38
, pp. 398-406
-
-
Liu, W.1
Phang, J.M.2
-
65
-
-
5644225629
-
Modulation of gene expression by tumor-derived p53 mutants
-
Scian MJ, Stagliano KE, Ellis MA, Hassan S, Bowman M, Miles MF et al. Modulation of gene expression by tumor-derived p53 mutants. Cancer Res 2004; 64: 7447-7454.
-
(2004)
Cancer Res
, vol.64
, pp. 7447-7454
-
-
Scian, M.J.1
Stagliano, K.E.2
Ellis, M.A.3
Hassan, S.4
Bowman, M.5
Miles, M.F.6
-
66
-
-
28544432790
-
The differential effects of mutant p53 alleles on advanced murine lung cancer
-
Jackson EL, Olive KP, Tuveson DA, Bronson R, Crowley D, Brown M et al. The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res 2005; 65: 10280-10288.
-
(2005)
Cancer Res
, vol.65
, pp. 10280-10288
-
-
Jackson, E.L.1
Olive, K.P.2
Tuveson, D.A.3
Bronson, R.4
Crowley, D.5
Brown, M.6
-
67
-
-
77149146794
-
A common gain of function of p53 cancer mutants in inducing genetic instability
-
Liu DP, Song H, Xu Y. A common gain of function of p53 cancer mutants in inducing genetic instability. Oncogene 2010; 29: 949-956.
-
(2010)
Oncogene
, vol.29
, pp. 949-956
-
-
Liu, D.P.1
Song, H.2
Xu, Y.3
-
68
-
-
50049112746
-
Molecular basis of the Li-Fraumeni syndrome: An update from the French LFS families
-
Bougeard G, Sesboue R, Baert-Desurmont S, Vasseur S, Martin C, Tinat J et al. Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families. J Med Genet 2008; 45: 535-538.
-
(2008)
J Med Genet
, vol.45
, pp. 535-538
-
-
Bougeard, G.1
Sesboue, R.2
Baert-Desurmont, S.3
Vasseur, S.4
Martin, C.5
Tinat, J.6
-
69
-
-
81355154522
-
Mutant p53 gain of function is interwoven into the hallmarks of cancer
-
Solomon H, Madar S, Rotter V. Mutant p53 gain of function is interwoven into the hallmarks of cancer. J Pathol 2011; 225: 475-478.
-
(2011)
J Pathol
, vol.225
, pp. 475-478
-
-
Solomon, H.1
Madar, S.2
Rotter, V.3
-
70
-
-
3142658180
-
Correlation of molecular genetic analysis of p53, MDM2, p16, PTEN, and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma
-
Ushio Y, Tada K, Shiraishi S, Kamiryo T, Shinojima N, Kochi M et al. Correlation of molecular genetic analysis of p53, MDM2, p16, PTEN, and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma. Front Biosci 2003; 8: e281-e288.
-
(2003)
Front Biosci
, vol.8
-
-
Ushio, Y.1
Tada, K.2
Shiraishi, S.3
Kamiryo, T.4
Shinojima, N.5
Kochi, M.6
-
71
-
-
0032696081
-
Mutations in exons 5-8 of the p53 gene, independent of their type and location, are associated with increased apoptosis and mitosis in invasive breast carcinoma
-
van Slooten HJ, van De Vijver MJ, Borresen AL, Eyfjord JE, Valgardsdottir R, Scherneck S et al. Mutations in exons 5-8 of the p53 gene, independent of their type and location, are associated with increased apoptosis and mitosis in invasive breast carcinoma. J Pathol 1999; 189: 504-513.
-
(1999)
J Pathol
, vol.189
, pp. 504-513
-
-
Van Slooten, H.J.1
Van De Vijver, M.J.2
Borresen, A.L.3
Eyfjord, J.E.4
Valgardsdottir, R.5
Scherneck, S.6
-
72
-
-
0028071555
-
Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
-
Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994; 54: 4855-4878.
-
(1994)
Cancer Res
, vol.54
, pp. 4855-4878
-
-
Greenblatt, M.S.1
Bennett, W.P.2
Hollstein, M.3
Harris, C.C.4
-
73
-
-
0030626833
-
Distinct effects of various p53 mutants on differentiation and viability of human K562 leukemia cells
-
Kremenetskaya OS, Logacheva NP, Baryshnikov AY, Chumakov PM, Kopnin BP. Distinct effects of various p53 mutants on differentiation and viability of human K562 leukemia cells. Oncol Res 1997; 9: 155-166.
-
(1997)
Oncol Res
, vol.9
, pp. 155-166
-
-
Kremenetskaya, O.S.1
Logacheva, N.P.2
Baryshnikov, A.Y.3
Chumakov, P.M.4
Kopnin, B.P.5
-
74
-
-
0035904394
-
The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth
-
Cadwell C, Zambetti GP. The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth. Gene 2001; 277: 15-30.
-
(2001)
Gene
, vol.277
, pp. 15-30
-
-
Cadwell, C.1
Zambetti, G.P.2
-
75
-
-
0029062595
-
Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants
-
Lin J, Teresky AK, Levine AJ. Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants. Oncogene 1995; 10: 2387-2390.
-
(1995)
Oncogene
, vol.10
, pp. 2387-2390
-
-
Lin, J.1
Teresky, A.K.2
Levine, A.J.3
-
76
-
-
0034671945
-
Oncogenic mutations of the p53 tumor suppressor: The demons of the guardian of the genome
-
Sigal A, Rotter V. Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res 2000; 60: 6788-6793.
-
(2000)
Cancer Res
, vol.60
, pp. 6788-6793
-
-
Sigal, A.1
Rotter, V.2
-
77
-
-
84880298880
-
Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis
-
Dong P, Karaayvaz M, Jia N, Kaneuchi M, Hamada J, Watari H et al. Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis. Oncogene 2012; 32: 3286-3295.
-
(2012)
Oncogene
, vol.32
, pp. 3286-3295
-
-
Dong, P.1
Karaayvaz, M.2
Jia, N.3
Kaneuchi, M.4
Hamada, J.5
Watari, H.6
-
78
-
-
84860745157
-
MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function
-
Donzelli S, Fontemaggi G, Fazi F, Di AS, Padula F, Biagioni F et al. MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function. Cell Death Differ 2012; 19: 1038-1048.
-
(2012)
Cell Death Differ
, vol.19
, pp. 1038-1048
-
-
Donzelli, S.1
Fontemaggi, G.2
Fazi, F.3
Di, A.S.4
Padula, F.5
Biagioni, F.6
-
79
-
-
84868359914
-
Allele specific gain-of-function activity of p53 mutants in lung cancer cells
-
Vaughan CA, Frum R, Pearsall I, Singh S, Windle B, Yeudall A et al. Allele specific gain-of-function activity of p53 mutants in lung cancer cells. Biochem Biophys Res Commun 2012; 428: 6-10.
-
(2012)
Biochem Biophys Res Commun
, vol.428
, pp. 6-10
-
-
Vaughan, C.A.1
Frum, R.2
Pearsall, I.3
Singh, S.4
Windle, B.5
Yeudall, A.6
-
80
-
-
84856117319
-
P53 mutants induce transcription of NF-kappaB2 in H1299 cells through CBP and STAT binding on the NF-kappaB2 promoter and gain of function activity
-
Vaughan CA, Singh S, Windle B, Sankala HM, Graves PR, Andrew YW et al. p53 mutants induce transcription of NF-kappaB2 in H1299 cells through CBP and STAT binding on the NF-kappaB2 promoter and gain of function activity. Arch Biochem Biophys 2012; 518: 79-88.
-
(2012)
Arch Biochem Biophys
, vol.518
, pp. 79-88
-
-
Vaughan, C.A.1
Singh, S.2
Windle, B.3
Sankala, H.M.4
Graves, P.R.5
Andrew, Y.W.6
-
81
-
-
77951982002
-
Mutant p53-induced up-regulation of mitogen-activated protein kinase kinase 3 contributes to gain of function
-
Gurtner A, Starace G, Norelli G, Piaggio G, Sacchi A, Bossi G. Mutant p53-induced up-regulation of mitogen-activated protein kinase kinase 3 contributes to gain of function. J Biol Chem 2010; 285: 14160-14169.
-
(2010)
J Biol Chem
, vol.285
, pp. 14160-14169
-
-
Gurtner, A.1
Starace, G.2
Norelli, G.3
Piaggio, G.4
Sacchi, A.5
Bossi, G.6
-
82
-
-
84862636275
-
Mutant p53: One name, many proteins
-
Freed-Pastor WA, Prives C. Mutant p53: one name, many proteins. Genes Dev 2012; 26: 1268-1286.
-
(2012)
Genes Dev
, vol.26
, pp. 1268-1286
-
-
Freed-Pastor, W.A.1
Prives, C.2
-
83
-
-
0033603494
-
P73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
-
Davison TS, Vagner C, Kaghad M, Ayed A, Caput D, Arrowsmith CH. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J Biol Chem 1999; 274: 18709-18714.
-
(1999)
J Biol Chem
, vol.274
, pp. 18709-18714
-
-
Davison, T.S.1
Vagner, C.2
Kaghad, M.3
Ayed, A.4
Caput, D.5
Arrowsmith, C.H.6
-
84
-
-
0041997348
-
Chemosensitivity linked to p73 function
-
Irwin MS, Kondo K, Marin MC, Cheng LS, Hahn WC, Kaelin Jr WG. Chemosensitivity linked to p73 function. Cancer Cell 2003; 3: 403-410.
-
(2003)
Cancer Cell
, vol.3
, pp. 403-410
-
-
Irwin, M.S.1
Kondo, K.2
Marin, M.C.3
Cheng, L.S.4
Hahn, W.C.5
Kaelin Jr., W.G.6
-
85
-
-
80051789515
-
P63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
-
Melino G. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ 2011; 18: 1487-1499.
-
(2011)
Cell Death Differ
, vol.18
, pp. 1487-1499
-
-
Melino, G.1
-
86
-
-
0035895624
-
From p63 to p53 across p73
-
Strano S, Rossi M, Fontemaggi G, Munarriz E, Soddu S, Sacchi A et al. From p63 to p53 across p73. FEBS Lett 2001; 490: 163-170.
-
(2001)
FEBS Lett
, vol.490
, pp. 163-170
-
-
Strano, S.1
Rossi, M.2
Fontemaggi, G.3
Munarriz, E.4
Soddu, S.5
Sacchi, A.6
-
87
-
-
18544364361
-
Physical interaction with human tumor-derived p53 mutants inhibits p63 activities
-
Strano S, Fontemaggi G, Costanzo A, Rizzo MG, Monti O, Baccarini A et al. Physical interaction with human tumor-derived p53 mutants inhibits p63 activities. J Biol Chem 2002; 277: 18817-18826.
-
(2002)
J Biol Chem
, vol.277
, pp. 18817-18826
-
-
Strano, S.1
Fontemaggi, G.2
Costanzo, A.3
Rizzo, M.G.4
Monti, O.5
Baccarini, A.6
-
88
-
-
2342583373
-
Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53
-
Li CQ, Robles AI, Hanigan CL, Hofseth LJ, Trudel LJ, Harris CC et al. Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res 2004; 64: 3022-3029.
-
(2004)
Cancer Res
, vol.64
, pp. 3022-3029
-
-
Li, C.Q.1
Robles, A.I.2
Hanigan, C.L.3
Hofseth, L.J.4
Trudel, L.J.5
Harris, C.C.6
-
89
-
-
8544230668
-
Comparison of the effect of mutant and wild-type p53 on global gene expression
-
O'Farrell TJ, Ghosh P, Dobashi N, Sasaki CY, Longo DL. Comparison of the effect of mutant and wild-type p53 on global gene expression. Cancer Res 2004; 64: 8199-8207.
-
(2004)
Cancer Res
, vol.64
, pp. 8199-8207
-
-
O'Farrell, T.J.1
Ghosh, P.2
Dobashi, N.3
Sasaki, C.Y.4
Longo, D.L.5
-
90
-
-
47249116180
-
Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy
-
Bossi G, Marampon F, Maor-Aloni R, Zani B, Rotter V, Oren M et al. Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy. Cell Cycle 2008; 7: 1870-1879.
-
(2008)
Cell Cycle
, vol.7
, pp. 1870-1879
-
-
Bossi, G.1
Marampon, F.2
Maor-Aloni, R.3
Zani, B.4
Rotter, V.5
Oren, M.6
-
91
-
-
43249104714
-
Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells
-
Junk DJ, Vrba L, Watts GS, Oshiro MM, Martinez JD, Futscher BW. Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells. Neoplasia 2008; 10: 450-461.
-
(2008)
Neoplasia
, vol.10
, pp. 450-461
-
-
Junk, D.J.1
Vrba, L.2
Watts, G.S.3
Oshiro, M.M.4
Martinez, J.D.5
Futscher, B.W.6
-
92
-
-
33745700179
-
Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells
-
Mizuarai S, Yamanaka K, Kotani H. Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells. Cancer Res 2006; 66: 6319-6326.
-
(2006)
Cancer Res
, vol.66
, pp. 6319-6326
-
-
Mizuarai, S.1
Yamanaka, K.2
Kotani, H.3
-
93
-
-
28744435101
-
Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells
-
Tepper CG, Gregg JP, Shi XB, Vinall RL, Baron CA, Ryan PE et al. Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells. Prostate 2005; 65: 375-389.
-
(2005)
Prostate
, vol.65
, pp. 375-389
-
-
Tepper, C.G.1
Gregg, J.P.2
Shi, X.B.3
Vinall, R.L.4
Baron, C.A.5
Ryan, P.E.6
-
94
-
-
8544268687
-
Transactivation of the EGR1 gene contributes to mutant p53 gain of function
-
Weisz L, Zalcenstein A, Stambolsky P, Cohen Y, Goldfinger N, Oren M et al. Transactivation of the EGR1 gene contributes to mutant p53 gain of function. Cancer Res 2004; 64: 8318-8327.
-
(2004)
Cancer Res
, vol.64
, pp. 8318-8327
-
-
Weisz, L.1
Zalcenstein, A.2
Stambolsky, P.3
Cohen, Y.4
Goldfinger, N.5
Oren, M.6
-
95
-
-
3042573810
-
Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes
-
Scian MJ, Stagliano KE, Deb D, Ellis MA, Carchman EH, Das A et al. Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes. Oncogene 2004; 23: 4430-4443.
-
(2004)
Oncogene
, vol.23
, pp. 4430-4443
-
-
Scian, M.J.1
Stagliano, K.E.2
Deb, D.3
Ellis, M.A.4
Carchman, E.H.5
Das, A.6
-
96
-
-
27644529786
-
Tumor-derived p53 mutants induce NF-kappaB2 gene expression
-
Scian MJ, Stagliano KE, Anderson MA, Hassan S, Bowman M, Miles MF et al. Tumor-derived p53 mutants induce NF-kappaB2 gene expression. Mol Cell Biol 2005; 25: 10097-10110.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10097-10110
-
-
Scian, M.J.1
Stagliano, K.E.2
Anderson, M.A.3
Hassan, S.4
Bowman, M.5
Miles, M.F.6
|