메뉴 건너뛰기




Volumn 38, Issue 6, 2012, Pages 398-406

Proline dehydrogenase (oxidase) in cancer

Author keywords

Metabolic stress; Oncogene; Proline dehydrogenase oxidase; Reactive oxygen species; Tumor suppressor

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATE; HYPOXIA INDUCIBLE FACTOR; MICRORNA; MICRORNA 23B; MYC PROTEIN; OXIDOREDUCTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLINE; PROLINE DEHYDROGENASE; PROTEIN P53; PYRROLINE 5 CARBOXYLATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84871240190     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1036     Document Type: Review
Times cited : (69)

References (56)
  • 1
    • 0020037709 scopus 로고
    • Stimulation of the hexosemonophosphate-pentose pathway by pyrroline-5-carboxylate in cultured cells
    • Phang, J. M., Downing, S. J., Yeh, G. C., Smith, R. J., Williams, J. A., et al. (1982) Stimulation of the hexosemonophosphate-pentose pathway by pyrroline-5-carboxylate in cultured cells. J. Cell Physiol. 110, 255-261.
    • (1982) J. Cell Physiol. , vol.110 , pp. 255-261
    • Phang, J.M.1    Downing, S.J.2    Yeh, G.C.3    Smith, R.J.4    Williams, J.A.5
  • 2
    • 0021333231 scopus 로고
    • The effect of pyrroline-5-carboxylic acid on nucleotide metabolism in erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient subjects
    • Yeh, G. C., Roth, E. F. Jr., Phang, J. M., Harris, S. C., Nagel, R. L., et al. (1984) The effect of pyrroline-5-carboxylic acid on nucleotide metabolism in erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient subjects. J. Biol. Chem. 259, 5454-5458.
    • (1984) J. Biol. Chem. , vol.259 , pp. 5454-5458
    • Yeh, G.C.1    Roth Jr, E.F.2    Phang, J.M.3    Harris, S.C.4    Nagel, R.L.5
  • 3
    • 0021994031 scopus 로고
    • The regulatory functions of proline and pyrroline-5-carboxylic acid
    • Phang, J. M. (1985) The regulatory functions of proline and pyrroline-5-carboxylic acid. Curr. Top. Cell Regul. 25, 91-132.
    • (1985) Curr. Top. Cell Regul. , vol.25 , pp. 91-132
    • Phang, J.M.1
  • 4
    • 0030480101 scopus 로고    scopus 로고
    • Reciprocal regulation of delta 1-pyrroline-5-carboxylate synthetase and proline dehydrogenase genes controls proline levels during and after osmotic stress in plants
    • Peng, Z., Lu, Q., and Verma, D. P. (1996) Reciprocal regulation of delta 1-pyrroline-5-carboxylate synthetase and proline dehydrogenase genes controls proline levels during and after osmotic stress in plants. Mol. Gen. Genet. 253, 334-341.
    • (1996) Mol. Gen. Genet. , vol.253 , pp. 334-341
    • Peng, Z.1    Lu, Q.2    Verma, D.P.3
  • 5
    • 0006032360 scopus 로고
    • Familial hyperprolinemia, cerebral dysfunction and renal anomalies occuring in a family with hereditary nephropathy and deafness
    • Schafer, I. A., Scriver, C. R., and Efron, M. L. (1962) Familial hyperprolinemia, cerebral dysfunction and renal anomalies occuring in a family with hereditary nephropathy and deafness. N. Engl. J. Med. 267, 51-60.
    • (1962) N. Engl. J. Med. , vol.267 , pp. 51-60
    • Schafer, I.A.1    Scriver, C.R.2    Efron, M.L.3
  • 6
    • 0003154749 scopus 로고    scopus 로고
    • Disorders of proline and hydroxyproline metabolism
    • Scriver, C. R., Beaudet, A. L., Sly, W. S., Valle, D., eds.). pp. -, McGraw-Hill, New York.
    • Phang, J. M., Hu, C. A., and Valle, D. (2001) Disorders of proline and hydroxyproline metabolism. In Metabolic and Molecular Bases of Inherited Disease. (Scriver, C. R., Beaudet, A. L., Sly, W. S., Valle, D., eds.). pp. 1821-1838, McGraw-Hill, New York.
    • (2001) Metabolic and Molecular Bases of Inherited Disease , pp. 1821-1838
    • Phang, J.M.1    Hu, C.A.2    Valle, D.3
  • 8
    • 53849120906 scopus 로고    scopus 로고
    • PRODH variants and risk for schizophrenia
    • Willis, A., Bender, H. U., Steel, G., and Valle, D. (2008) PRODH variants and risk for schizophrenia. Amino Acids 35, 673-679.
    • (2008) Amino Acids , vol.35 , pp. 673-679
    • Willis, A.1    Bender, H.U.2    Steel, G.3    Valle, D.4
  • 9
    • 77955619986 scopus 로고    scopus 로고
    • Proline metabolism and microenvironmental stress
    • Phang, J. M., Liu, W., and Zabirnyk, O. (2010) Proline metabolism and microenvironmental stress. Annu. Rev. Nutr. 30, 441-463.
    • (2010) Annu. Rev. Nutr. , vol.30 , pp. 441-463
    • Phang, J.M.1    Liu, W.2    Zabirnyk, O.3
  • 10
    • 84859236400 scopus 로고    scopus 로고
    • Proline metabolism and cancer
    • Phang, J. M. and Liu, W. (2012) Proline metabolism and cancer. Front Biosci. 17, 1835-1845.
    • (2012) Front Biosci. , vol.17 , pp. 1835-1845
    • Phang, J.M.1    Liu, W.2
  • 11
    • 0018890003 scopus 로고
    • Metabolism of proline and the hydroxyprolines
    • Adams, E. and Frank, L. (1980) Metabolism of proline and the hydroxyprolines. Annu. Rev. Biochem. 49, 1005-1061.
    • (1980) Annu. Rev. Biochem. , vol.49 , pp. 1005-1061
    • Adams, E.1    Frank, L.2
  • 12
    • 24944529262 scopus 로고    scopus 로고
    • MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells
    • Liu, Y., Borchert, G. L., Donald, S. P., Surazynski, A., Hu, C. A., et al. (2005) MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells. Carcinogenesis 26, 1335-1342.
    • (2005) Carcinogenesis , vol.26 , pp. 1335-1342
    • Liu, Y.1    Borchert, G.L.2    Donald, S.P.3    Surazynski, A.4    Hu, C.A.5
  • 13
    • 67650087634 scopus 로고    scopus 로고
    • Regulation and function of proline oxidase under nutrient stress
    • Pandhare, J., Donald, S. P., Cooper, S. K., and Phang, J. M. (2009) Regulation and function of proline oxidase under nutrient stress. J. Cell Biochem. 107, 759-768.
    • (2009) J. Cell Biochem. , vol.107 , pp. 759-768
    • Pandhare, J.1    Donald, S.P.2    Cooper, S.K.3    Phang, J.M.4
  • 15
    • 0035266127 scopus 로고    scopus 로고
    • Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species
    • Donald, S. P., Sun, X. Y., Hu, C. A., Yu, J., Mei, J. M., et al. (2001) Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. Cancer Res. 61, 1810-1815.
    • (2001) Cancer Res. , vol.61 , pp. 1810-1815
    • Donald, S.P.1    Sun, X.Y.2    Hu, C.A.3    Yu, J.4    Mei, J.M.5
  • 16
    • 0038322048 scopus 로고    scopus 로고
    • Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomas
    • Maxwell, S. A. and Rivera, A. (2003) Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomas. J. Biol. Chem. 278, 9784-9789.
    • (2003) J. Biol. Chem. , vol.278 , pp. 9784-9789
    • Maxwell, S.A.1    Rivera, A.2
  • 17
    • 33644850483 scopus 로고    scopus 로고
    • Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms
    • Pandhare, J., Cooper, S. K., and Phang, J. M. (2006) Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms. J. Biol. Chem. 281, 2044-2052.
    • (2006) J. Biol. Chem. , vol.281 , pp. 2044-2052
    • Pandhare, J.1    Cooper, S.K.2    Phang, J.M.3
  • 18
    • 33748671329 scopus 로고    scopus 로고
    • Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling
    • Liu, Y., Borchert, G. L., Surazynski, A., Hu, C. A., and Phang, J. M. (2006) Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. Oncogene 25, 5640-5647.
    • (2006) Oncogene , vol.25 , pp. 5640-5647
    • Liu, Y.1    Borchert, G.L.2    Surazynski, A.3    Hu, C.A.4    Phang, J.M.5
  • 19
    • 20044372348 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest
    • Lu, M., Kwan, T., Yu, C., Chen, F., Freedman, B., et al. (2005) Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest. J. Biol. Chem. 280, 6742-6751.
    • (2005) J. Biol. Chem. , vol.280 , pp. 6742-6751
    • Lu, M.1    Kwan, T.2    Yu, C.3    Chen, F.4    Freedman, B.5
  • 20
    • 69249123718 scopus 로고    scopus 로고
    • Proline oxidase functions as a mitochondrial tumor suppressor in human cancers
    • Liu, Y., Borchert, G. L., Donald, S. P., Diwan, B. A., Anver, M., et al. (2009) Proline oxidase functions as a mitochondrial tumor suppressor in human cancers. Cancer Res. 69, 6414-6422.
    • (2009) Cancer Res. , vol.69 , pp. 6414-6422
    • Liu, Y.1    Borchert, G.L.2    Donald, S.P.3    Diwan, B.A.4    Anver, M.5
  • 21
    • 56249120580 scopus 로고    scopus 로고
    • Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers
    • Liu, Y., Borchert, G. L., Surazynski, A., and Phang, J. M. (2008) Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. Oncogene 27, 6729-6737.
    • (2008) Oncogene , vol.27 , pp. 6729-6737
    • Liu, Y.1    Borchert, G.L.2    Surazynski, A.3    Phang, J.M.4
  • 23
    • 33947520506 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
    • Koivunen, P., Hirsila, M., Remes, A. M., Hassinen, I. E., Kivirikko, K. I., et al. (2007) Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J. Biol. Chem. 282, 4524-4532.
    • (2007) J. Biol. Chem. , vol.282 , pp. 4524-4532
    • Koivunen, P.1    Hirsila, M.2    Remes, A.M.3    Hassinen, I.E.4    Kivirikko, K.I.5
  • 24
    • 77956342208 scopus 로고    scopus 로고
    • miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer
    • Liu, W., Zabirnyk, O., Wang, H., Shiao, Y. H., Nickerson, M. L., et al. (2010) miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer. Oncogene 29, 4914-4924.
    • (2010) Oncogene , vol.29 , pp. 4914-4924
    • Liu, W.1    Zabirnyk, O.2    Wang, H.3    Shiao, Y.H.4    Nickerson, M.L.5
  • 26
    • 40849086158 scopus 로고    scopus 로고
    • Identification of a p53-response element in the promoter of the proline oxidase gene
    • Maxwell, S. A. and Kochevar, G. J. (2008) Identification of a p53-response element in the promoter of the proline oxidase gene. Biochem. Biophys. Res. Commun. 369, 308-313.
    • (2008) Biochem. Biophys. Res. Commun. , vol.369 , pp. 308-313
    • Maxwell, S.A.1    Kochevar, G.J.2
  • 27
    • 23844477888 scopus 로고    scopus 로고
    • The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway
    • Rivera, A. and Maxwell, S. A. (2005) The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway. J. Biol. Chem. 280, 29346-29354.
    • (2005) J. Biol. Chem. , vol.280 , pp. 29346-29354
    • Rivera, A.1    Maxwell, S.A.2
  • 28
    • 28644448262 scopus 로고    scopus 로고
    • Savior and slayer: the two faces of p53
    • Bensaad, K. and Vousden, K. H. (2005) Savior and slayer: the two faces of p53. Nat. Med. 11, 1278-1279.
    • (2005) Nat. Med. , vol.11 , pp. 1278-1279
    • Bensaad, K.1    Vousden, K.H.2
  • 29
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: the growing complexity of p53
    • Vousden, K. H. and Prives, C. (2009) Blinded by the light: the growing complexity of p53. Cell 137, 413-431.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 31
    • 49749134678 scopus 로고    scopus 로고
    • PPARgamma and proline oxidase in cancer
    • Phang, J. M., Pandhare, J., Zabirnyk, O., and Liu, Y. (2008) PPARgamma and proline oxidase in cancer. PPAR Res. 2008, 542694.
    • (2008) PPAR Res. , vol.2008 , pp. 542694
    • Phang, J.M.1    Pandhare, J.2    Zabirnyk, O.3    Liu, Y.4
  • 32
    • 84859254879 scopus 로고    scopus 로고
    • PPAR gamma, bioactive lipids, and cancer progression
    • Robbins, G. T. and Nie, D. (2012) PPAR gamma, bioactive lipids, and cancer progression. Front Biosci. 17, 1816-1834.
    • (2012) Front Biosci. , vol.17 , pp. 1816-1834
    • Robbins, G.T.1    Nie, D.2
  • 33
    • 43049135219 scopus 로고    scopus 로고
    • Transactivation of ERalpha by Rosiglitazone induces proliferation in breast cancer cells
    • Talbert, D. R., Allred, C. D., Zaytseva, Y. Y., and Kilgore, M. W. (2008) Transactivation of ERalpha by Rosiglitazone induces proliferation in breast cancer cells. Breast Cancer Res. Treat. 108, 23-33.
    • (2008) Breast Cancer Res. Treat. , vol.108 , pp. 23-33
    • Talbert, D.R.1    Allred, C.D.2    Zaytseva, Y.Y.3    Kilgore, M.W.4
  • 34
    • 77950890848 scopus 로고    scopus 로고
    • Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy
    • Zabirnyk, O., Liu, W., Khalil, S., Sharma, A., and Phang, J. M. (2010) Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. Carcinogenesis 31, 446-454.
    • (2010) Carcinogenesis , vol.31 , pp. 446-454
    • Zabirnyk, O.1    Liu, W.2    Khalil, S.3    Sharma, A.4    Phang, J.M.5
  • 35
    • 34248192254 scopus 로고    scopus 로고
    • Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes
    • Govindarajan, R., Ratnasinghe, L., Simmons, D. L., Siegel, E. R., Midathada, M. V., et al. (2007) Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. J. Clin. Oncol. 25, 1476-1481.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1476-1481
    • Govindarajan, R.1    Ratnasinghe, L.2    Simmons, D.L.3    Siegel, E.R.4    Midathada, M.V.5
  • 36
    • 34548304321 scopus 로고    scopus 로고
    • Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation
    • Kim, K. Y., Ahn, J. H., and Cheon, H. G. (2007) Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation. Mol. Pharmacol. 72, 674-685.
    • (2007) Mol. Pharmacol. , vol.72 , pp. 674-685
    • Kim, K.Y.1    Ahn, J.H.2    Cheon, H.G.3
  • 37
    • 81755176483 scopus 로고    scopus 로고
    • Troglitazone induced apoptosis via PPARgamma activated POX-induced ROS formation in HT29 cells
    • Wang, J., Lv, X., Shi, J., Hu, X., and Du, Y. (2011) Troglitazone induced apoptosis via PPARgamma activated POX-induced ROS formation in HT29 cells. Biomed. Environ. Sci. 24, 391-399.
    • (2011) Biomed. Environ. Sci. , vol.24 , pp. 391-399
    • Wang, J.1    Lv, X.2    Shi, J.3    Hu, X.4    Du, Y.5
  • 38
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
    • Nagy, L., Tontonoz, P., Alvarez, J. G., Chen, H., and Evans, R. M. (1998) Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell. 93, 229-240.
    • (1998) Cell. , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.3    Chen, H.4    Evans, R.M.5
  • 39
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel, D. P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 40
    • 84861891911 scopus 로고    scopus 로고
    • Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
    • Liu, W., Le, A., Hancock, C., Lane, A. N., Dang, C. V., et al. (2012) Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc. Natl. Acad. Sci. USA 109, 8983-8988.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 8983-8988
    • Liu, W.1    Le, A.2    Hancock, C.3    Lane, A.N.4    Dang, C.V.5
  • 41
    • 0028198531 scopus 로고
    • Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma
    • Xu, H. J., Quinlan, D. C., Davidson, A. G., Hu, S. X., Summers, C. L., et al. (1994) Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma. J. Natl. Cancer Inst. 86, 695-699.
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 695-699
    • Xu, H.J.1    Quinlan, D.C.2    Davidson, A.G.3    Hu, S.X.4    Summers, C.L.5
  • 42
    • 84859475161 scopus 로고    scopus 로고
    • Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
    • Zarse, K., Schmeisser, S., Groth, M., Priebe, S., Beuster, G., et al. (2012) Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab. 15, 451-465.
    • (2012) Cell Metab. , vol.15 , pp. 451-465
    • Zarse, K.1    Schmeisser, S.2    Groth, M.3    Priebe, S.4    Beuster, G.5
  • 44
    • 66349095388 scopus 로고    scopus 로고
    • Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry
    • Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., et al. (2009) Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res. 69, 4918-4925.
    • (2009) Cancer Res. , vol.69 , pp. 4918-4925
    • Hirayama, A.1    Kami, K.2    Sugimoto, M.3    Sugawara, M.4    Toki, N.5
  • 45
    • 33646576169 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tumor metastasis
    • Deryugina, E. I. and Quigley, J. P. (2006) Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev. 25, 9-34.
    • (2006) Cancer Metastasis Rev. , vol.25 , pp. 9-34
    • Deryugina, E.I.1    Quigley, J.P.2
  • 47
    • 0019334421 scopus 로고
    • Linkage of the HMP pathway to ATP generation by the proline cycle
    • Phang, J. M., Downing, S. J., and Yeh, G. C. (1980) Linkage of the HMP pathway to ATP generation by the proline cycle. Biochem. Biophys. Res. Commun. 93, 462-470.
    • (1980) Biochem. Biophys. Res. Commun. , vol.93 , pp. 462-470
    • Phang, J.M.1    Downing, S.J.2    Yeh, G.C.3
  • 48
    • 0028904867 scopus 로고
    • On the mechanism of interaction of steroids with human glucose 6-phosphate dehydrogenase
    • Gordon, G., Mackow, M. C., and Levy, H. R. (1995) On the mechanism of interaction of steroids with human glucose 6-phosphate dehydrogenase. Arch. Biochem. Biophys. 318, 25-29.
    • (1995) Arch. Biochem. Biophys. , vol.318 , pp. 25-29
    • Gordon, G.1    Mackow, M.C.2    Levy, H.R.3
  • 49
    • 53849096017 scopus 로고    scopus 로고
    • The metabolism of proline, a stress substrate, modulates carcinogenic pathways
    • Phang, J. M., Donald, S. P., Pandhare, J., and Liu, Y. (2008) The metabolism of proline, a stress substrate, modulates carcinogenic pathways. Amino Acids 35, 681-690.
    • (2008) Amino Acids , vol.35 , pp. 681-690
    • Phang, J.M.1    Donald, S.P.2    Pandhare, J.3    Liu, Y.4
  • 50
    • 33750044112 scopus 로고    scopus 로고
    • Stress and mTORture signaling
    • Reiling, J. H. and Sabatini, D. M. (2006) Stress and mTORture signaling. Oncogene 25, 6373-6383.
    • (2006) Oncogene , vol.25 , pp. 6373-6383
    • Reiling, J.H.1    Sabatini, D.M.2
  • 51
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta, S., Peterson, T. R., and Sabatini, D. M. (2010) Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol. Cell 40, 310-322.
    • (2010) Mol. Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 52
    • 84863896166 scopus 로고    scopus 로고
    • Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments
    • Liu, W., Glunde, K., Bhujwalla, Z. M., Raman, V., Sharma, A., et al. Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments. Cancer Res., 72, 3677-3686.
    • Cancer Res. , vol.72 , pp. 3677-3686
    • Liu, W.1    Glunde, K.2    Bhujwalla, Z.M.3    Raman, V.4    Sharma, A.5
  • 53
    • 0032540012 scopus 로고    scopus 로고
    • PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz, P., Nagy, L., Alvarez, J. G., Thomazy, V. A., and Evans, R. M. (1998) PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93, 241-252.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3    Thomazy, V.A.4    Evans, R.M.5
  • 54
    • 8344242016 scopus 로고    scopus 로고
    • Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study
    • Suzuki, K., Ito, Y., Wakai, K., Kawado, M., Hashimoto, S., et al. (2004) Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study. Cancer Epidemiol. Biomarkers Prev. 13, 1781-1787.
    • (2004) Cancer Epidemiol. Biomarkers Prev. , vol.13 , pp. 1781-1787
    • Suzuki, K.1    Ito, Y.2    Wakai, K.3    Kawado, M.4    Hashimoto, S.5
  • 55
    • 34548511826 scopus 로고    scopus 로고
    • Oxidized LDL, serum oxidizability and serum lipid levels in patients with breast or ovarian cancer
    • Delimaris, I., Faviou, E., Antonakos, G., Stathopoulou, E., Zachari, A., et al. (2007) Oxidized LDL, serum oxidizability and serum lipid levels in patients with breast or ovarian cancer. Clin. Biochem. 40, 1129-1134.
    • (2007) Clin. Biochem. , vol.40 , pp. 1129-1134
    • Delimaris, I.1    Faviou, E.2    Antonakos, G.3    Stathopoulou, E.4    Zachari, A.5
  • 56
    • 35348886043 scopus 로고    scopus 로고
    • Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein
    • Cao, Y. and Klionsky, D. J. (2007) Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res. 17, 839-849.
    • (2007) Cell Res. , vol.17 , pp. 839-849
    • Cao, Y.1    Klionsky, D.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.