Genetic stabilization by p53 involves growth regulatory and repair pathways

Journal of Biomedicine and Biotechnology

Volumn 2001, Issue 1, 2001, Pages 7-10

  Wiesmüller, Lisa ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ATM PROTEIN; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; INTERMEDIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; RAD51 PROTEIN; SOMATOMEDIN BINDING PROTEIN 3;

APOPTOSIS; CANCER INHIBITION; CELL GROWTH; DNA REPAIR; DNA TRANSCRIPTION; GENE REARRANGEMENT; GENETIC STABILITY; GENOME ANALYSIS; GENOTOXICITY; HUMAN; PROTEIN FUNCTION; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; ULTRAVIOLET RADIATION;

EID: 0037812325     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/S1110724301000043     Document Type: Review

References (45)

1. McGill G, Fisher DE. p53 and cancer therapy: a double-edged sword. J Clin Invest. 1999;104:223-225.
2. Sherr CJ. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 1998;12:2984-2991.
3. Lane DP. Cancer: p53, guardian of the genome. Nature. 1992;358:15-16.
4. Levine A. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323-331.
5. Nelson WG, Kastan MB. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol Cell Biol. 1994;14:1815-1823.
6. Ljungman M, Zhang F, Chen F, Rainbow AJ, McKay BC. Inhibition of RNA polymerase II as a trigger for the p53 response. Oncogene. 1999;18:583-592.
7. Lane D. Awakening angels. Nature. 1998;394:616-617.
8. Sakaguchi K, Herrera JE, Saito S, et al. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 1998;12:2831-2841.
9. Wang X, Ohnishi K, Takahashi A, Ohnishi T. Poly(ADPribosyl)ation is required for p53-dependent signal transduction induced by radiation. Oncogene. 1998;17:2819-2825.
10. Bunz F, Dutriaux A, Lengauer C, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 1998;282:1497-1501.
11. Hermeking H, Lengauer C, Polyak K, et al. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell. 1997;1:3-11.
12. Smith ML, Chen I-T, Zhan Q, et al. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 1994;266:1376-1380.
13. Kazantsev A, Sancar A. Does the p53 up-regulated Gadd45 protein have a role in excision repair? Science. 1995;270:1003-1004.
14. Kearsey JM, Shivji MKK, Hall PA, Wood RD. Does the p53 up-regulated Gadd45 protein have a role in excision repair? Science. 1995;270:1004-1005.
15. Carrier F, Georgel PT, Pourquier P, et al. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol. 1999;19:1673-1685.
16. Cip1. Oncogene. 1995;11:1675-1683.
17. Gottlieb E, Lindner S, Oren M. Relationship of sequence-specific transactivation and p53-regulated apoptosis in interleukin 3-dependent hematopoietic cells. Cell Growth Differ. 1996;7:301-310.
18. Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 1992;356:215-221.
19. WAF1/CIP1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995;82:675-684.
20. Komarov PG, Komarova EA, Kondratov RV, et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science. 1999;285:1733-1737.
21. Oberosler P, Hloch P, Ramsperger U, Stahl H. p53-catalyzed annealing of complementary single-stranded nucleic acids. EMBO J. 1993;12:2389-2396.
22. Brain R, Jenkins JR. Human p53 directs DNA strand reassociation and is photolabeled by 8-azido ATP. Oncogene. 1994;9:1775-1780.
23. Mummenbrauer T, Janus F, Müller B, Wiesmüller L, Deppert W, Große F. p53 protein exhibits 3′-to-5′ exonuclease activity. Cell. 1996;85:1089-1099.
24. Janus F, Albrechtsen N, Dornreiter I, Wiesmüller L, Grosse F, Deppert W. The dual role model for p53 in maintaining genomic integrity. Cell Mol Life Sci. 1999;55:12-27.
25. Blander G, Kipnis J, Leal JFM, Yu C-E, Schellenberg GD, Oren M. Physical and functional interaction between p53 and the Werner's syndrome protein. Biol Chem. 1999;274:29463-29469.
26. Ford JM, Hanawalt PC. Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. Proc Natl Acad Sci USA. 1995;92:8876-8880.
27. Wang XW, Yeh H, Schaeffer L, et al. p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat Genet. 1995;10:188-195.
28. Ishizaki K, Ejima Y, Matsunaga T, et al. Increased UV-induced SCEs but normal repair of DNA damage in p53-deficient mouse cells. Int J Cancer. 1994;58:254-257.
29. Wiesmüller L, Cammenga J, Deppert WW. In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes. J Virol. 1996;70:737-744.
30. Mekeel KL, Tang W, Kachnic LA, Luo C-M, DeFrank JS, Powell SN. Inactivation of p53 results in high rates of homologous recombination. Oncogene. 1997;14:1847-1857.
31. Bertrand P, Rouillard D, Boulet A, Levalois C, Soussi T, Lopez BS. Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing amutant p53 protein. Oncogene. 1997;14:1117-1122.
32. Dudenhöffer C, Rohaly G, Will K, Deppert W, Wiesmüller L. Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination. Mol Cell Biol. 1998;18:5332-5342.
33. Marmorstein LY, Ouchi T, Aaronson SA. The BRCA2 gene product functionally interacts with p53 and RAD51. Proc Natl Acad Sci USA. 1998;95:13869-13874.
34. WAF1/CIP1. Nature. 1997;11:187-190.
35. Patel KJ,Yu VPCC, Lee H, et al. Involvement of Brca2 in DNA repair. Mol Cell. 1998;1:347-357.
36. Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science. 1998;281:1009-1012.
37. Yuan SS, Lee SY, Chen G, Song M, Tomlinson GE, Lee EY. BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo. Cancer Res. 1999;59:3547-3551.
38. Huang P. Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein. Oncogene. 1998;17:261-270.
39. Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem. 1996;65:101-133.
40. Cranston A, Bocker T, Reitmair A, et al. Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nat Genet. 1997;17:114-118.
41. Saintigny Y, Rouillard D, Chaput B, Soussi T, Lopez BS. Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint. Oncogene. 1999;18:3553-3563.
42. Dudenhöffer C, Kurth M, Janus F, Deppert W, Wiesmüller L. Dissociation of the recombination control and the sequence-specific p53. Oncogene. 1999;18:5773-5784.
43. Powell SN, Willers H, McCarthy E, Tang W, Wu B. Homologous recombination is suppressed by p53, independently from transactivation of p21 or activation of the G1/S cell cycle checkpoint, Program and Abstracts, Keystone Symposium on Molecular and Cellular Biology: "Molecular Mechanisms in DNA Replication and Recombination". Taos, New Mexico, USA. February 16-22: 117. Abstract.
44. Gersten KM, Kemp CJ. Normal meiotic recombination in p53-deficient mice. Nat Genet. 1997;17:378-179.
45. Xia SJ, Shammas MA, Shmookler Reis RJ. Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase. Mol Cell Biol. 1997;17:7151-7158.