Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells

Neoplasia

Volumn 10, Issue 5, 2008, Pages 450-461

  Junk, Damian J ^a,b   Vrba, Lukas ^b   Watts, George S ^b,c   Oshiro, Marc M ^b   Martinez, Jesse D ^a,b   Futscher, Bernard W ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; BREAST EPITHELIUM; CANCER INVASION; CARCINOGENESIS; CONTROLLED STUDY; GENE CONSTRUCT; GENE MUTATION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

EID: 43249104714     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.08120     Document Type: Article

References (42)

1. B Vogelstein D Lane AJ Levine Surfing the p53 network Nature 408 2000 307 310
2. LC Chen A Neubauer W Kurisu FM Waldman BM Ljung W Goodson III ES Goldman D Moore II M Balazs E Liu Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer Proc Natl Acad Sci USA 88 1991 3847 3851
3. YH Chen CD Li EP Yap JO McGee Detection of loss of heterozygosity of p53 gene in paraffin-embedded breast cancers by non-isotopic PCR-SSCP J Pathol 177 1995 129 134
4. G Deng LC Chen DR Schott A Thor V Bhargava BM Ljung K Chew HS Smith Loss of heterozygosity and p53 gene mutations in breast cancer Cancer Res 54 1994 499 505
5. S Singh M Simon I Meybohm I Jantke W Jonat H Maass HW Goedde Human breast cancer: frequent p53 allele loss and protein overexpression Hum Genet 90 1993 635 640
6. RM Elledge DC Allred The p53 tumor suppressor gene in breast cancer Breast Cancer Res Treat 32 1994 39 47
7. B Iacopetta F Grieu B Powell R Soong K McCaul R Seshadri Analysis of p53 gene mutation by polymerase chain reaction-single strand conformation polymorphism provides independent prognostic information in node-negative breast cancer Clin Cancer Res 4 1998 1597 1602
8. IB Runnebaum M Nagarajan M Bowman D Soto S Sukumar Mutations in p53 as potential molecular markers for human breast cancer Proc Natl Acad Sci USA 88 1991 10657 10661
9. S Sjogren M Inganas T Norberg A Lindgren H Nordgren L Holmberg J Bergh The p53 gene in breast cancer: prognostic value of complementary DNA sequencing versus immunohistochemistry J Natl Cancer Inst 88 1996 173 182
10. SE Kern KW Kinzler SJ Baker JM Nigro V Rotter AJ Levine P Friedman C Prives B Vogelstein Mutant p53 proteins bind DNA abnormally in vitro Oncogene 6 1991 131 136
11. K Steinmeyer W Deppert DNA binding properties of murine p53 Oncogene 3 1988 501 507
12. A Willis EJ Jung T Wakefield X Chen Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes Oncogene 23 2004 2330 2338
13. TJ O’Farrell P Ghosh N Dobashi CY Sasaki DL Longo Comparison of the effect of mutant and wild-type p53 on global gene expression Cancer Res 64 2004 8199 8207
14. MJ Scian KE Stagliano MA Ellis S Hassan M Bowman MF Miles SP Deb S Deb Modulation of gene expression by tumor-derived p53 mutants Cancer Res 64 2004 7447 7454
15. CG Tepper JP Gregg XB Shi RL Vinall CA Baron PE Ryan PY Desprez HJ Kung RW deVere White Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells Prostate 65 2005 375 389
16. L Weisz A Zalcenstein P Stambolsky Y Cohen N Goldfinger M Oren V Rotter Transactivation of the EGR1 gene contributes to mutant p53 gain of function Cancer Res 64 2004 8318 8327
17. D Dittmer S Pati G Zambetti S Chu AK Teresky M Moore C Finlay AJ Levine Gain of function mutations in p53 Nat Genet 4 1993 42 46
18. M Hsiao J Low E Dorn D Ku P Pattengale J Yeargin M Haas Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness Am J Pathol 145 1994 702 714
19. G Shaulsky N Goldfinger V Rotter Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins Cancer Res 51 1991 5232 5237
20. GA Lang T Iwakuma YA Suh G Liu VA Rao JM Parant YA Valentin-Vega T Terzian LC Caldwell LC Strong Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome Cell 119 2004 861 872
21. KP Olive DA Tuveson ZC Ruhe B Yin NA Willis RT Bronson D Crowley T Jacks Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome Cell 119 2004 847 860
22. MR Stampfer P Yaswen Culture models of human mammary epithelial cell transformation J Mammary Gland Biol Neoplasia 5 2000 365 378
23. MR Stampfer P Yaswen Human epithelial cell immortalization as a step in carcinogenesis Cancer Lett 194 2003 199 208
24. P Yaswen MR Stampfer Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells Int J Biochem Cell Biol 34 2002 1382 1394
25. MR Stampfer J Garbe G Levine S Lichtsteiner AP Vasserot P Yaswe Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells Proc Natl Acad Sci USA 98 2001 4498 4503
26. Y Li J Pan JL Li JH Lee C Tunkey K Saraf JC Garbe MZ Whitley SA Jelinsky MR Stampfer Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized Mol Cancer 6 2007 7
27. GH Nonet MR Stampfer K Chin JW Gray CC Collins P Yaswen The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells Cancer Res 61 2001 1250 1254
28. K Rao O Alper KE Opheim G Bonnet K Wolfe E Bryant S O’Hara Larivee P Porter JK McDougall Cytogenetic characterization and H- ras associated transformation of immortalized human mammary epithelial cells Cancer Cell Int 6 2006 15
29. MM Oshiro GS Watts RJ Wozniak DJ Junk JL Munoz-Rodriguez FE Domann BW Futscher Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression Oncogene 22 2003 3624 3634
30. DT Odom N Zizlsperger DB Gordon GW Bell NJ Rinaldi HL Murray TL Volkert J Schreiber PA Rolfe DK Gifford Control of pancreas and liver gene expression by HNF transcription factors Science 303 2004 1378 1381
31. RJ Wozniak WT Klimecki SS Lau Y Feinstein BW Futscher 5-Aza-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation Oncogene 26 2007 77 90
32. GK Smyth Limma: linear models for microarray data R Gentleman S Dudoit R Irizarry W Huber Bioinformatics and Computational Biology Solutions Using R and Bioconductor 2005 Springer New York 397 420
33. TC He S Zhou LT da Costa J Yu KW Kinzler B Vogelstein A simplified system for generating recombinant adenoviruses Proc Natl Acad Sci USA 95 1998 2509 2514
34. KB Spurgers DL Gold KR Coombes NL Bohnenstiehl B Mullins RE Meyn CJ Logothetis TJ McDonnell Identification of cell cycle regulatory genes as principal targets of p53 -mediated transcriptional repression J Biol Chem 281 2006 25134 25142
35. J Milner EA Medcalf Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation Cell 65 1991 765 774
36. A Chicas P Molina J Bargonetti Mutant p53 forms a complex with Sp1 on HIV-LTR DNA Biochem Biophys Res Commun 279 2000 383 390
37. S Di Agostino S Strano V Emiliozzi V Zerbini M Mottolese A Sacchi G Blandino G Piaggio Gain of function of mutant p53 : the mutant p53 /NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation Cancer Cell 10 2006 191 202
38. J Sampath D Sun VJ Kidd J Grenet A Gandhi LH Shapiro Q Wang GP Zambetti JD Schuetz Mutant p53 cooperates with ETS and selectively upregulates human MDR1 not MRP1 J Biol Chem 276 2001 39359 39367
39. N Sato AR Parker N Fukushima Y Miyagi CA Iacobuzio-Donahue JR Eshleman M Goggins Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma Oncogene 24 2005 850 858
40. AE Varga NV Stourman Q Zheng AF Safina L Quan X Li K Sossey-Alaoui AV Bakin Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta Oncogene 24 2005 5043 5052
41. 2+-activated chloride channel CLCA2 Cancer Res 59 1999 5488 5491
42. P Dong M Tada JI Hamada A Nakamura T Moriuchi N Sakuragi p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells Clin Exp Metastasis 24 2007 471 483