-
1
-
-
78650037441
-
PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza A viruses in mice
-
Zhou B, Li Y, Halpin R, Hine E, Spiro DJ, Wentworth DE. 2011. PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza A viruses in mice. J. Virol. 85:357-365.
-
(2011)
J. Virol.
, vol.85
, pp. 357-365
-
-
Zhou, B.1
Li, Y.2
Halpin, R.3
Hine, E.4
Spiro, D.J.5
Wentworth, D.E.6
-
2
-
-
84871969763
-
Unstable polymerase-NP interaction is not responsible for avian influenza polymerase restriction in human cells
-
Cauldwell AV, Moncorge O, Barclay WS. 2012. Unstable polymerase-NP interaction is not responsible for avian influenza polymerase restriction in human cells. J. Virol. 87:1278-1284.
-
(2012)
J. Virol.
, vol.87
, pp. 1278-1284
-
-
Cauldwell, A.V.1
Moncorge, O.2
Barclay, W.S.3
-
3
-
-
77951043137
-
Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza viruses in mice
-
Kim JH, Hatta M, Watanabe S, Neumann G, Watanabe T, Kawaoka Y. 2010. Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza viruses in mice. J. Gen. Virol. 91:1284-1289.
-
(2010)
J. Gen. Virol.
, vol.91
, pp. 1284-1289
-
-
Kim, J.H.1
Hatta, M.2
Watanabe, S.3
Neumann, G.4
Watanabe, T.5
Kawaoka, Y.6
-
4
-
-
80052464359
-
Amino acid residues 253 and 591 of the PB2 protein of avian influenza virus A H9N2 contribute to mammalian pathogenesis
-
Mok CK, Yen HL, Yu MY, Yuen KM, Sia SF, Chan MC, Qin G, Tu WW, Peiris JS. 2011. Amino acid residues 253 and 591 of the PB2 protein of avian influenza virus A H9N2 contribute to mammalian pathogenesis. J. Virol. 85:9641-9645.
-
(2011)
J. Virol.
, vol.85
, pp. 9641-9645
-
-
Mok, C.K.1
Yen, H.L.2
Yu, M.Y.3
Yuen, K.M.4
Sia, S.F.5
Chan, M.C.6
Qin, G.7
Tu, W.W.8
Peiris, J.S.9
-
5
-
-
59649103887
-
PB2 protein of a highly pathogenic avian influenza virus strain A/chicken/Yamaguchi/7/2004 (H5N1) determines its replication potential in pigs
-
Manzoor R, Sakoda Y, Nomura N, Tsuda Y, Ozaki H, Okamatsu M, Kida H. 2009. PB2 protein of a highly pathogenic avian influenza virus strain A/chicken/Yamaguchi/7/2004 (H5N1) determines its replication potential in pigs. J. Virol. 83:1572-1578.
-
(2009)
J. Virol.
, vol.83
, pp. 1572-1578
-
-
Manzoor, R.1
Sakoda, Y.2
Nomura, N.3
Tsuda, Y.4
Ozaki, H.5
Okamatsu, M.6
Kida, H.7
-
6
-
-
77950835010
-
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells
-
Bussey KA, Bousse TL, Desmet EA, Kim B, Takimoto T. 2010. PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J. Virol. 84:4395-4406.
-
(2010)
J. Virol.
, vol.84
, pp. 4395-4406
-
-
Bussey, K.A.1
Bousse, T.L.2
Desmet, E.A.3
Kim, B.4
Takimoto, T.5
-
7
-
-
79959307361
-
Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase
-
Foeglein A, Loucaides EM, Mura M, Wise HM, Barclay WS, Digard P. 2011. Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase. J. Gen. Virol. 92:1650-1661.
-
(2011)
J. Gen. Virol.
, vol.92
, pp. 1650-1661
-
-
Foeglein, A.1
Loucaides, E.M.2
Mura, M.3
Wise, H.M.4
Barclay, W.S.5
Digard, P.6
-
8
-
-
75849136881
-
Adaptive strategies of the influenza virus polymerase for replication in humans
-
Mehle A, Doudna JA. 2009. Adaptive strategies of the influenza virus polymerase for replication in humans. Proc. Natl. Acad. Sci. U. S. A. 106:21312-21316.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 21312-21316
-
-
Mehle, A.1
Doudna, J.A.2
-
9
-
-
77958149212
-
Biological and structural characterization of a host-adapting amino acid in influenza virus
-
doi:10.1371/journal.ppat.1001034
-
Yamada S, Hatta M, Staker BL, Watanabe S, Imai M, Shinya K, Sakai-Tagawa Y, Ito M, Ozawa M, Watanabe T, Sakabe S, Li C, Kim JH, Myler PJ, Phan I, Raymond A, Smith E, Stacy R, Nidom CA, Lank SM, Wiseman RW, Bimber BN, O'Connor DH, Neumann G, Stewart LJ, Kawaoka Y. 2010. Biological and structural characterization of a host-adapting amino acid in influenza virus. PLoS Pathog. 6:e1001034. doi:10.1371/journal.ppat.1001034.
-
(2010)
PLoS Pathog
, vol.6
-
-
Yamada, S.1
Hatta, M.2
Staker, B.L.3
Watanabe, S.4
Imai, M.5
Shinya, K.6
Sakai-Tagawa, Y.7
Ito, M.8
Ozawa, M.9
Watanabe, T.10
Sakabe, S.11
Li, C.12
Kim, J.H.13
Myler, P.J.14
Phan, I.15
Raymond, A.16
Smith, E.17
Stacy, R.18
Nidom, C.A.19
Lank, S.M.20
Wiseman, R.W.21
Bimber, B.N.22
O'Connor, D.H.23
Neumann, G.24
Stewart, L.J.25
Kawaoka, Y.26
more..
-
10
-
-
0027468737
-
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range
-
Subbarao EK, London W, Murphy BR. 1993. A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J. Virol. 67:1761-1764.
-
(1993)
J. Virol
, vol.67
, pp. 1761-1764
-
-
Subbarao, E.K.1
London, W.2
Murphy, B.R.3
-
11
-
-
84871007119
-
Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells
-
doi:10.1038/ncomms1804
-
Mänz B, Brunotte L, Reuther P, Schwemmle M. 2012. Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells. Nat. Commun. 3:802. doi:10.1038/ncomms1804.
-
(2012)
Nat. Commun.
, vol.3
, pp. 802
-
-
Mänz, B.1
Brunotte, L.2
Reuther, P.3
Schwemmle, M.4
-
12
-
-
36049011840
-
Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice
-
doi:10.1371 /journal.ppat.0030133
-
Hatta M, Hatta Y, Kim JH, Watanabe S, Shinya K, Nguyen T, Lien PS, Le QM, Kawaoka Y. 2007. Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS Pathog. 3:1374-1379. doi:10.1371 /journal.ppat.0030133.
-
(2007)
PLoS Pathog
, vol.3
, pp. 1374-1379
-
-
Hatta, M.1
Hatta, Y.2
Kim, J.H.3
Watanabe, S.4
Shinya, K.5
Nguyen, T.6
Lien, P.S.7
Le, Q.M.8
Kawaoka, Y.9
-
13
-
-
73949145224
-
Molecular determinants of adaptation of highly pathogenic avian influenza H7N7 viruses to efficient replication in the human host
-
de Wit E, Munster VJ, van Riel D, Beyer WE, Rimmelzwaan GF, Kuiken T, Osterhaus AD, Fouchier RA. 2010. Molecular determinants of adaptation of highly pathogenic avian influenza H7N7 viruses to efficient replication in the human host. J. Virol. 84:1597-1606.
-
(2010)
J. Virol
, vol.84
, pp. 1597-1606
-
-
de Wit, E.1
Munster, V.J.2
van Riel, D.3
Beyer, W.E.4
Rimmelzwaan, G.F.5
Kuiken, T.6
Osterhaus, A.D.7
Fouchier, R.A.8
-
14
-
-
29444438899
-
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host
-
Gabriel G, Dauber B, Wolff T, Planz O, Klenk HD, Stech J. 2005. The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc. Natl. Acad. Sci. U. S. A. 102:18590-18595.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 18590-18595
-
-
Gabriel, G.1
Dauber, B.2
Wolff, T.3
Planz, O.4
Klenk, H.D.5
Stech, J.6
-
15
-
-
84863158873
-
Amino acids 473V and 598P of PB1 from an avian-origin influenza A virus contribute to polymerase activity, especially in mammalian cells
-
Xu C, Hu WB, Xu K, He YX, Wang TY, Chen Z, Li TX, Liu JH, Buchy P, Sun B. 2012. Amino acids 473V and 598P of PB1 from an avian-origin influenza A virus contribute to polymerase activity, especially in mammalian cells. J. Gen. Virol. 93:531-540.
-
(2012)
J. Gen. Virol
, vol.93
, pp. 531-540
-
-
Xu, C.1
Hu, W.B.2
Xu, K.3
He, Y.X.4
Wang, T.Y.5
Chen, Z.6
Li, T.X.7
Liu, J.H.8
Buchy, P.9
Sun, B.10
-
16
-
-
79960414052
-
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells
-
Bussey KA, Desmet EA, Mattiacio JL, Hamilton A, Bradel-Tretheway B, Bussey HE, Kim B, Dewhurst S, Takimoto T. 2011. PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells. J. Virol. 85:7020-7028.
-
(2011)
J. Virol.
, vol.85
, pp. 7020-7028
-
-
Bussey, K.A.1
Desmet, E.A.2
Mattiacio, J.L.3
Hamilton, A.4
Bradel-Tretheway, B.5
Bussey, H.E.6
Kim, B.7
Dewhurst, S.8
Takimoto, T.9
-
17
-
-
70450170087
-
The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model
-
Song MS, Pascua PN, Lee JH, Baek YH, Lee OJ, Kim CJ, Kim H, Webby RJ, Webster RG, Choi YK. 2009. The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model. J. Virol. 83:12325-12335.
-
(2009)
J. Virol.
, vol.83
, pp. 12325-12335
-
-
Song, M.S.1
Pascua, P.N.2
Lee, J.H.3
Baek, Y.H.4
Lee, O.J.5
Kim, C.J.6
Kim, H.7
Webby, R.J.8
Webster, R.G.9
Choi, Y.K.10
-
18
-
-
84857098515
-
Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers
-
Mehle A, Dugan VG, Taubenberger JK, Doudna JA. 2012. Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. J. Virol. 86:1750-1757.
-
(2012)
J. Virol.
, vol.86
, pp. 1750-1757
-
-
Mehle, A.1
Dugan, V.G.2
Taubenberger, J.K.3
Doudna, J.A.4
-
19
-
-
0034054170
-
Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses
-
Naffakh N, Massin P, Escriou N, Crescenzo-Chaigne B, van der Werf S. 2000. Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses. J. Gen. Virol. 81:1283-1291.
-
(2000)
J. Gen. Virol.
, vol.81
, pp. 1283-1291
-
-
Naffakh, N.1
Massin, P.2
Escriou, N.3
Crescenzo-Chaigne, B.4
van der Werf, S.5
-
20
-
-
43149095780
-
Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis
-
doi:10.1186/1471-2105-9-S1-S18
-
Miotto O, Heiny A, Tan TW, August JT, Brusic V. 2008. Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis. BMC Bioinformatics 9(Suppl 1):S18. doi:10.1186/1471-2105-9-S1-S18.
-
(2008)
BMC Bioinformatics
, vol.9
, Issue.SUPPL. 1
-
-
Miotto, O.1
Heiny, A.2
Tan, T.W.3
August, J.T.4
Brusic, V.5
-
21
-
-
77949348063
-
Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains
-
doi:10.1371/journal.pone.0009025
-
Miotto O, Heiny AT, Albrecht R, Garcia-Sastre A, Tan TW, August JT, Brusic V. 2010. Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains. PLoS One 5:e9025. doi:10.1371/journal.pone.0009025.
-
(2010)
PLoS One
, vol.5
-
-
Miotto, O.1
Heiny, A.T.2
Albrecht, R.3
Garcia-Sastre, A.4
Tan, T.W.5
August, J.T.6
Brusic, V.7
-
22
-
-
33749020042
-
Genomic signatures of human versus avian influenza A viruses
-
Chen GW, Chang SC, Mok CK, Lo YL, Kung YN, Huang JH, Shih YH, Wang JY, Chiang C, Chen CJ, Shih SR. 2006. Genomic signatures of human versus avian influenza A viruses. Emerg. Infect. Dis. 12:1353- 1360.
-
(2006)
Emerg. Infect. Dis.
, vol.12
, pp. 1353-1360
-
-
Chen, G.W.1
Chang, S.C.2
Mok, C.K.3
Lo, Y.L.4
Kung, Y.N.5
Huang, J.H.6
Shih, Y.H.7
Wang, J.Y.8
Chiang, C.9
Chen, C.J.10
Shih, S.R.11
-
23
-
-
34648827866
-
Persistent host markers in pandemic and H5N1 influenza viruses
-
Finkelstein DB, Mukatira S, Mehta PK, Obenauer JC, Su X, Webster RG, Naeve CW. 2007. Persistent host markers in pandemic and H5N1 influenza viruses. J. Virol. 81:10292-10299.
-
(2007)
J. Virol.
, vol.81
, pp. 10292-10299
-
-
Finkelstein, D.B.1
Mukatira, S.2
Mehta, P.K.3
Obenauer, J.C.4
Su, X.5
Webster, R.G.6
Naeve, C.W.7
-
24
-
-
73449127243
-
Identifying changes in selective constraints: host shifts in influenza
-
doi:10.1371/journal.pcbi.1000564
-
Tamuri AU, Dos Reis M, Hay AJ, Goldstein RA. 2009. Identifying changes in selective constraints: host shifts in influenza. PLoS Comput. Biol. 5:e1000564. doi:10.1371/journal.pcbi.1000564.
-
(2009)
PLoS Comput. Biol.
, vol.5
-
-
Tamuri, A.U.1
Dos Reis, M.2
Hay, A.J.3
Goldstein, R.A.4
-
25
-
-
66149102827
-
Conserved amino acid markers from past influenza pandemic strains
-
doi:10.1186/1471-2180-9-77
-
Allen JE, Gardner SN, Vitalis EA, Slezak TR. 2009. Conserved amino acid markers from past influenza pandemic strains. BMC Microbiol. 9:77. doi:10.1186/1471-2180-9-77.
-
(2009)
BMC Microbiol
, vol.9
, pp. 77
-
-
Allen, J.E.1
Gardner, S.N.2
Vitalis, E.A.3
Slezak, T.R.4
-
26
-
-
84873745999
-
Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins
-
Patel D, Schultz LW, Umland TC. 2013. Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins. Virus Res. 172:75-80.
-
(2013)
Virus Res
, vol.172
, pp. 75-80
-
-
Patel, D.1
Schultz, L.W.2
Umland, T.C.3
-
27
-
-
67649552964
-
Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase
-
Sugiyama K, Obayashi E, Kawaguchi A, Suzuki Y, Tame JR, Nagata K, Park SY. 2009. Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase. EMBO J. 28:1803-1811.
-
(2009)
EMBO J
, vol.28
, pp. 1803-1811
-
-
Sugiyama, K.1
Obayashi, E.2
Kawaguchi, A.3
Suzuki, Y.4
Tame, J.R.5
Nagata, K.6
Park, S.Y.7
-
28
-
-
1642325300
-
Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites
-
Poole E, Elton D, Medcalf L, Digard P. 2004. Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites. Virology 321:120-133.
-
(2004)
Virology
, vol.321
, pp. 120-133
-
-
Poole, E.1
Elton, D.2
Medcalf, L.3
Digard, P.4
-
29
-
-
0032731217
-
Two separate sequences of PB2 subunit constitute the RNA cap-binding site of influenza virus RNA polymerase
-
Honda A, Mizumoto K, Ishihama A. 1999. Two separate sequences of PB2 subunit constitute the RNA cap-binding site of influenza virus RNA polymerase. Genes Cells 4:475-485.
-
(1999)
Genes Cells
, vol.4
, pp. 475-485
-
-
Honda, A.1
Mizumoto, K.2
Ishihama, A.3
-
30
-
-
43249128376
-
The structural basis for cap binding by influenza virus polymerase subunit PB2
-
Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, Sehr P, Lewis J, Ruigrok RW, Ortin J, Hart DJ, Cusack S. 2008. The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat. Struct. Mol. Biol. 15:500-506.
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, pp. 500-506
-
-
Guilligay, D.1
Tarendeau, F.2
Resa-Infante, P.3
Coloma, R.4
Crepin, T.5
Sehr, P.6
Lewis, J.7
Ruigrok, R.W.8
Ortin, J.9
Hart, D.J.10
Cusack, S.11
-
31
-
-
84870250746
-
Nuclear import of the influenza A virus transcriptional machinery
-
Hutchinson EC, Fodor E. 2012. Nuclear import of the influenza A virus transcriptional machinery. Vaccine 30:7353-7358.
-
(2012)
Vaccine
, vol.30
, pp. 7353-7358
-
-
Hutchinson, E.C.1
Fodor, E.2
-
32
-
-
65449163086
-
Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue
-
Kuzuhara T, Kise D, Yoshida H, Horita T, Murazaki Y, Nishimura A, Echigo N, Utsunomiya H, Tsuge H. 2009. Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue. J. Biol. Chem. 284:6855- 6860.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 6855-6860
-
-
Kuzuhara, T.1
Kise, D.2
Yoshida, H.3
Horita, T.4
Murazaki, Y.5
Nishimura, A.6
Echigo, N.7
Utsunomiya, H.8
Tsuge, H.9
-
33
-
-
50649089174
-
Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus
-
He X, Zhou J, Bartlam M, Zhang R, Ma J, Lou Z, Li X, Li J, Joachimiak A, Zeng Z, Ge R, Rao Z, Liu Y. 2008. Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature 454:1123-1126.
-
(2008)
Nature
, vol.454
, pp. 1123-1126
-
-
He, X.1
Zhou, J.2
Bartlam, M.3
Zhang, R.4
Ma, J.5
Lou, Z.6
Li, X.7
Li, J.8
Joachimiak, A.9
Zeng, Z.10
Ge, R.11
Rao, Z.12
Liu, Y.13
-
34
-
-
50649122962
-
The structural basis for an essential subunit interaction in influenza virus RNA polymerase
-
Obayashi E, Yoshida H, Kawai F, Shibayama N, Kawaguchi A, Nagata K, Tame JR, Park SY. 2008. The structural basis for an essential subunit interaction in influenza virus RNA polymerase. Nature 454:1127-1131.
-
(2008)
Nature
, vol.454
, pp. 1127-1131
-
-
Obayashi, E.1
Yoshida, H.2
Kawai, F.3
Shibayama, N.4
Kawaguchi, A.5
Nagata, K.6
Tame, J.R.7
Park, S.Y.8
-
35
-
-
0033169059
-
Distinct regions of influenza virus PB1 polymerase subunit recognizevRNAand cRNA templates
-
Gonzalez S, Ortin J. 1999. Distinct regions of influenza virus PB1 polymerase subunit recognizevRNAand cRNA templates.EMBOJ. 18:3767- 3775.
-
(1999)
EMBOJ
, vol.18
, pp. 3767-3775
-
-
Gonzalez, S.1
Ortin, J.2
-
36
-
-
0030805223
-
The fourth genus in the Orthomyxoviridae: sequence analyses of two Thogoto virus polymerase proteins and comparison with influenza viruses
-
Leahy MB, Dessens JT, Weber F, Kochs G, Nuttall PA. 1997. The fourth genus in the Orthomyxoviridae: sequence analyses of two Thogoto virus polymerase proteins and comparison with influenza viruses. Virus Res. 50:215-224.
-
(1997)
Virus Res
, vol.50
, pp. 215-224
-
-
Leahy, M.B.1
Dessens, J.T.2
Weber, F.3
Kochs, G.4
Nuttall, P.A.5
-
37
-
-
0032189818
-
RNA-dependent activation of primer RNA production by influenza virus polymerase: different regions of the same protein subunit constitute the two required RNA-binding sites
-
Li ML, Ramirez BC, Krug RM. 1998. RNA-dependent activation of primer RNA production by influenza virus polymerase: different regions of the same protein subunit constitute the two required RNA-binding sites. EMBO J. 17:5844-5852.
-
(1998)
EMBO J
, vol.17
, pp. 5844-5852
-
-
Li, M.L.1
Ramirez, B.C.2
Krug, R.M.3
-
38
-
-
0032889312
-
Characterization of influenza virus PB1 protein binding to viral RNA: two separate regions of the protein contribute to the interaction domain
-
Gonzalez S, Ortin J. 1999. Characterization of influenza virus PB1 protein binding to viral RNA: two separate regions of the protein contribute to the interaction domain. J. Virol. 73:631-637.
-
(1999)
J. Virol.
, vol.73
, pp. 631-637
-
-
Gonzalez, S.1
Ortin, J.2
-
39
-
-
67249100913
-
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site
-
Yuan P, Bartlam M, Lou Z, Chen S, Zhou J, He X, Lv Z, Ge R, Li X, Deng T, Fodor E, Rao Z, Liu Y. 2009. Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature 458:909-913.
-
(2009)
Nature
, vol.458
, pp. 909-913
-
-
Yuan, P.1
Bartlam, M.2
Lou, Z.3
Chen, S.4
Zhou, J.5
He, X.6
Lv, Z.7
Ge, R.8
Li, X.9
Deng, T.10
Fodor, E.11
Rao, Z.12
Liu, Y.13
-
40
-
-
84863754680
-
An overlapping protein-coding region in influenza A virus segment 3 modulates the host response
-
Jagger BW, Wise HM, Kash JC, Walters KA, Wills NM, Xiao YL, Dunfee RL, Schwartzman LM, Ozinsky A, Bell GL, Dalton RM, Lo A, Efstathiou S, Atkins JF, Firth AE, Taubenberger JK, Digard P. 2012. An overlapping protein-coding region in influenza A virus segment 3 modulates the host response. Science 337:199-204.
-
(2012)
Science
, vol.337
, pp. 199-204
-
-
Jagger, B.W.1
Wise, H.M.2
Kash, J.C.3
Walters, K.A.4
Wills, N.M.5
Xiao, Y.L.6
Dunfee, R.L.7
Schwartzman, L.M.8
Ozinsky, A.9
Bell, G.L.10
Dalton, R.M.11
Lo, A.12
Efstathiou, S.13
Atkins, J.F.14
Firth, A.E.15
Taubenberger, J.K.16
Digard, P.17
-
41
-
-
36549071098
-
Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding
-
Maier HJ, Kashiwagi T, Hara K, Brownlee GG. 2008. Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding. Virology 370:194-204.
-
(2008)
Virology
, vol.370
, pp. 194-204
-
-
Maier, H.J.1
Kashiwagi, T.2
Hara, K.3
Brownlee, G.G.4
-
42
-
-
0024346154
-
Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domains
-
de la Luna S, Martinez C, Ortin J. 1989. Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domains. Virus Res. 13: 143-155.
-
(1989)
Virus Res
, vol.13
, pp. 143-155
-
-
de la Luna, S.1
Martinez, C.2
Ortin, J.3
-
43
-
-
0034892686
-
PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators
-
Huarte M, Sanz-Ezquerro JJ, Roncal F, Ortin J, Nieto A. 2001. PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. J. Virol. 75:8597-8604.
-
(2001)
J. Virol.
, vol.75
, pp. 8597-8604
-
-
Huarte, M.1
Sanz-Ezquerro, J.J.2
Roncal, F.3
Ortin, J.4
Nieto, A.5
-
44
-
-
0031778876
-
Influenza virus nucleoprotein interacts with influenza virus polymerase proteins
-
Biswas SK, Boutz PL, Nayak DP. 1998. Influenza virus nucleoprotein interacts with influenza virus polymerase proteins. J. Virol. 72:5493- 5501.
-
(1998)
J. Virol.
, vol.72
, pp. 5493-5501
-
-
Biswas, S.K.1
Boutz, P.L.2
Nayak, D.P.3
-
45
-
-
84864120828
-
Sequence in the influenza A virus nucleoprotein required for viral polymerase binding and RNA synthesis
-
Marklund JK, Ye Q, Dong J, Tao YJ, Krug RM. 2012. Sequence in the influenza A virus nucleoprotein required for viral polymerase binding and RNA synthesis. J. Virol. 86:7292-7297.
-
(2012)
J. Virol.
, vol.86
, pp. 7292-7297
-
-
Marklund, J.K.1
Ye, Q.2
Dong, J.3
Tao, Y.J.4
Krug, R.M.5
-
46
-
-
84861325395
-
Identification and characterization of three novel nuclear export signals in the influenza A virus nucleoprotein
-
Yu M, Liu X, Cao S, Zhao Z, Zhang K, Xie Q, Chen C, Gao S, Bi Y, Sun L, Ye X, Gao GF, Liu W. 2012. Identification and characterization of three novel nuclear export signals in the influenza A virus nucleoprotein. J. Virol. 86:4970-4980.
-
(2012)
J. Virol.
, vol.86
, pp. 4970-4980
-
-
Yu, M.1
Liu, X.2
Cao, S.3
Zhao, Z.4
Zhang, K.5
Xie, Q.6
Chen, C.7
Gao, S.8
Bi, Y.9
Sun, L.10
Ye, X.11
Gao, G.F.12
Liu, W.13
-
47
-
-
0035133124
-
Cellular splicing factor RAF-2p48/NPI-5/BAT1/UAP56 interacts with the influenza virus nucleoprotein and enhances viralRNAsynthesis
-
Momose F, Basler CF, O'Neill RE, Iwamatsu A, Palese P, Nagata K. 2001. Cellular splicing factor RAF-2p48/NPI-5/BAT1/UAP56 interacts with the influenza virus nucleoprotein and enhances viralRNAsynthesis. J. Virol. 75:1899-1908.
-
(2001)
J. Virol.
, vol.75
, pp. 1899-1908
-
-
Momose, F.1
Basler, C.F.2
O'Neill, R.E.3
Iwamatsu, A.4
Palese, P.5
Nagata, K.6
-
48
-
-
0033587599
-
Oligomerization of the influenza virus nucleoprotein: identification of positive and negative sequence elements
-
Elton D, Medcalf E, Bishop K, Digard P. 1999. Oligomerization of the influenza virus nucleoprotein: identification of positive and negative sequence elements. Virology 260:190-200.
-
(1999)
Virology
, vol.260
, pp. 190-200
-
-
Elton, D.1
Medcalf, E.2
Bishop, K.3
Digard, P.4
-
49
-
-
33845890539
-
The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA
-
Ye Q, Krug RM, Tao YJ. 2006. The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA. Nature 444:1078- 1082.
-
(2006)
Nature
, vol.444
, pp. 1078-1082
-
-
Ye, Q.1
Krug, R.M.2
Tao, Y.J.3
-
50
-
-
84875985517
-
Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein
-
doi:10.1371/journal.ppat.1003279
-
Mänz B, Dornfeld D, Götz V, Zell R, Zimmermann P, Haller O, Kochs G, Schwemmmle M. 2013. Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein. PLoS Pathog. 9:e1003279. doi:10.1371/journal.ppat.1003279.
-
(2013)
PLoS Pathog
, vol.9
-
-
Mänz, B.1
Dornfeld, D.2
Götz, V.3
Zell, R.4
Zimmermann, P.5
Haller, O.6
Kochs, G.7
Schwemmmle, M.8
-
51
-
-
0032981158
-
Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments
-
Digard P, Elton D, Bishop K, Medcalf E, Weeds A, Pope B. 1999. Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments. J. Virol. 73:2222-2231.
-
(1999)
J. Virol.
, vol.73
, pp. 2222-2231
-
-
Digard, P.1
Elton, D.2
Bishop, K.3
Medcalf, E.4
Weeds, A.5
Pope, B.6
-
52
-
-
84872000172
-
A second CRM1-dependent nuclear export signal in the influenza A virus NS2 protein contributes to the nuclear export of viral ribonucleoproteins
-
Huang S, Chen J, Chen Q, Wang H, Yao Y, Chen J, Chen Z. 2013. A second CRM1-dependent nuclear export signal in the influenza A virus NS2 protein contributes to the nuclear export of viral ribonucleoproteins. J. Virol. 87:767-778.
-
(2013)
J. Virol.
, vol.87
, pp. 767-778
-
-
Huang, S.1
Chen, J.2
Chen, Q.3
Wang, H.4
Yao, Y.5
Chen, J.6
Chen, Z.7
-
53
-
-
84872028152
-
Emerging roles for the influenza A virus nuclear export protein (NEP)
-
doi:10.1371 /journal.ppat.1003019
-
Paterson D, Fodor E. 2012. Emerging roles for the influenza A virus nuclear export protein (NEP). PLoS Pathog. 8:e1003019. doi:10.1371 /journal.ppat.1003019.
-
(2012)
PLoS Pathog
, vol.8
-
-
Paterson, D.1
Fodor, E.2
-
54
-
-
0026576063
-
Evolution and ecology of influenza A viruses
-
Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. 1992. Evolution and ecology of influenza A viruses. Microbiol. Rev. 56:152- 179.
-
(1992)
Microbiol. Rev.
, vol.56
, pp. 152-179
-
-
Webster, R.G.1
Bean, W.J.2
Gorman, O.T.3
Chambers, T.M.4
Kawaoka, Y.5
-
55
-
-
19544369652
-
Avian H5N1 influenza in cats
-
Kuiken T, Rimmelzwaan G, van Riel D, van Amerongen G, Baars M, Fouchier R, Osterhaus A. 2004. Avian H5N1 influenza in cats. Science 306:241.
-
(2004)
Science
, vol.306
, pp. 241
-
-
Kuiken, T.1
Rimmelzwaan, G.2
van Riel, D.3
van Amerongen, G.4
Baars, M.5
Fouchier, R.6
Osterhaus, A.7
-
56
-
-
22944457912
-
Influenza: lessons from past pandemics, warnings from current incidents
-
Horimoto T, Kawaoka Y. 2005. Influenza: lessons from past pandemics, warnings from current incidents. Nat. Rev. Microbiol. 3:591-600.
-
(2005)
Nat. Rev. Microbiol.
, vol.3
, pp. 591-600
-
-
Horimoto, T.1
Kawaoka, Y.2
-
57
-
-
14444284599
-
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness
-
Subbarao K, Klimov A, Katz J, Regnery H, Lim W, Hall H, Perdue M, Swayne D, Bender C, Huang J, Hemphill M, Rowe T, Shaw M, Xu X, Fukuda K, Cox N. 1998. Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279:393-396.
-
(1998)
Science
, vol.279
, pp. 393-396
-
-
Subbarao, K.1
Klimov, A.2
Katz, J.3
Regnery, H.4
Lim, W.5
Hall, H.6
Perdue, M.7
Swayne, D.8
Bender, C.9
Huang, J.10
Hemphill, M.11
Rowe, T.12
Shaw, M.13
Xu, X.14
Fukuda, K.15
Cox, N.16
-
58
-
-
81555208102
-
Insights on influenza pathogenesis from the grave
-
Taubenberger JK, Kash JC. 2011. Insights on influenza pathogenesis from the grave. Virus Res. 162:2-7.
-
(2011)
Virus Res
, vol.162
, pp. 2-7
-
-
Taubenberger, J.K.1
Kash, J.C.2
-
59
-
-
0019417811
-
Evidence for the natural transmission of influenza A virus from wild ducks to swine and its potential importance for man
-
Pensaert M, Ottis K, Vandeputte J, Kaplan MM, Bachmann PA. 1981. Evidence for the natural transmission of influenza A virus from wild ducks to swine and its potential importance for man. Bull. World Health Organ. 59:75-78.
-
(1981)
Bull. World Health Organ.
, vol.59
, pp. 75-78
-
-
Pensaert, M.1
Ottis, K.2
Vandeputte, J.3
Kaplan, M.M.4
Bachmann, P.A.5
-
60
-
-
84863230485
-
A distinct lineage of influenza A virus from bats
-
Tong S, Li Y, Rivailler P, Conrardy C, Castillo DA, Chen LM, Recuenco S, Ellison JA, Davis CT, York IA, Turmelle AS, Moran D, Rogers S, Shi M, Tao Y, Weil MR, Tang K, Rowe LA, Sammons S, Xu X, Frace M, Lindblade KA, Cox NJ, Anderson LJ, Rupprecht CE, Donis RO. 2012. A distinct lineage of influenza A virus from bats. Proc. Natl. Acad. Sci. U. S. A. 109:4269-4274.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 4269-4274
-
-
Tong, S.1
Li, Y.2
Rivailler, P.3
Conrardy, C.4
Castillo, D.A.5
Chen, L.M.6
Recuenco, S.7
Ellison, J.A.8
Davis, C.T.9
York, I.A.10
Turmelle, A.S.11
Moran, D.12
Rogers, S.13
Shi, M.14
Tao, Y.15
Weil, M.R.16
Tang, K.17
Rowe, L.A.18
Sammons, S.19
Xu, X.20
Frace, M.21
Lindblade, K.A.22
Cox, N.J.23
Anderson, L.J.24
Rupprecht, C.E.25
Donis, R.O.26
more..
-
61
-
-
0033546991
-
Human infection with influenza H9N2
-
Peiris M, Yuen KY, Leung CW, Chan KH, Ip PL, Lai RW, Orr WK, Shortridge KF. 1999. Human infection with influenza H9N2. Lancet 354:916-917.
-
(1999)
Lancet
, vol.354
, pp. 916-917
-
-
Peiris, M.1
Yuen, K.Y.2
Leung, C.W.3
Chan, K.H.4
Ip, P.L.5
Lai, R.W.6
Orr, W.K.7
Shortridge, K.F.8
-
62
-
-
10744224732
-
Avian influenza A virus (H7N7) associated with human conjunc-tivitis and a fatal case of acute respiratory distress syndrome
-
Fouchier RA, Schneeberger PM, Rozendaal FW, Broekman JM, Kemink SA, Munster V, Kuiken T, Rimmelzwaan GF, Schutten M, Van Doornum GJ, Koch G, Bosman A, Koopmans M, Osterhaus AD. 2004. Avian influenza A virus (H7N7) associated with human conjunc-tivitis and a fatal case of acute respiratory distress syndrome. Proc. Natl. Acad. Sci. U. S. A. 101:1356-1361.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 1356-1361
-
-
Fouchier, R.A.1
Schneeberger, P.M.2
Rozendaal, F.W.3
Broekman, J.M.4
Kemink, S.A.5
Munster, V.6
Kuiken, T.7
Rimmelzwaan, G.F.8
Schutten, M.9
Van Doornum, G.J.10
Koch, G.11
Bosman, A.12
Koopmans, M.13
Osterhaus, A.D.14
-
63
-
-
9744277383
-
Human illness from avian influenza H7N3 British Columbia
-
Tweed SA, Skowronski DM, David ST, Larder A, Petric M, Lees W, Li Y, Katz J, Krajden M, Tellier R, Halpert C, Hirst M, Astell C, Lawrence D, Mak A. 2004. Human illness from avian influenza H7N3, British Columbia. Emerg. Infect. Dis. 10:2196-2199.
-
(2004)
Emerg. Infect. Dis.
, vol.10
, pp. 2196-2199
-
-
Tweed, S.A.1
Skowronski, D.M.2
David, S.T.3
Larder, A.4
Petric, M.5
Lees, W.6
Li, Y.7
Katz, J.8
Krajden, M.9
Tellier, R.10
Halpert, C.11
Hirst, M.12
Astell, C.13
Lawrence, D.14
Mak, A.15
-
64
-
-
12944270582
-
Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates
-
Lin YP, Shaw M, Gregory V, Cameron K, Lim W, Klimov A, Subbarao K, Guan Y, Krauss S, Shortridge K, Webster R, Cox N, Hay A. 2000. Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates. Proc. Natl. Acad. Sci. U. S. A. 97:9654-9658.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 9654-9658
-
-
Lin, Y.P.1
Shaw, M.2
Gregory, V.3
Cameron, K.4
Lim, W.5
Klimov, A.6
Subbarao, K.7
Guan, Y.8
Krauss, S.9
Shortridge, K.10
Webster, R.11
Cox, N.12
Hay, A.13
-
65
-
-
67649538978
-
Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic
-
Smith GJ, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus OG, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JS, Guan Y, Rambaut A. 2009. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459:1122-1125.
-
(2009)
Nature
, vol.459
, pp. 1122-1125
-
-
Smith, G.J.1
Vijaykrishna, D.2
Bahl, J.3
Lycett, S.J.4
Worobey, M.5
Pybus, O.G.6
Ma, S.K.7
Cheung, C.L.8
Raghwani, J.9
Bhatt, S.10
Peiris, J.S.11
Guan, Y.12
Rambaut, A.13
-
66
-
-
67649297821
-
Emergence and pandemic potential of swine-origin H1N1 influenza virus
-
Neumann G, Noda T, Kawaoka Y. 2009. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 459:931-939.
-
(2009)
Nature
, vol.459
, pp. 931-939
-
-
Neumann, G.1
Noda, T.2
Kawaoka, Y.3
-
67
-
-
84861394598
-
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
-
Imai M, Watanabe T, Hatta M, Das SC, Ozawa M, Shinya K, Zhong G, Hanson A, Katsura H, Watanabe S, Li C, Kawakami E, Yamada S, Kiso M, Suzuki Y, Maher EA, Neumann G, Kawaoka Y. 2012. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 486: 420-428.
-
(2012)
Nature
, vol.486
, pp. 420-428
-
-
Imai, M.1
Watanabe, T.2
Hatta, M.3
Das, S.C.4
Ozawa, M.5
Shinya, K.6
Zhong, G.7
Hanson, A.8
Katsura, H.9
Watanabe, S.10
Li, C.11
Kawakami, E.12
Yamada, S.13
Kiso, M.14
Suzuki, Y.15
Maher, E.A.16
Neumann, G.17
Kawaoka, Y.18
-
68
-
-
84862618108
-
Airborne transmission of influenza A/H5N1 virus between ferrets
-
Herfst S, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, Munster VJ, Sorrell EM, Bestebroer TM, Burke DF, Smith DJ, Rimmelzwaan GF, Osterhaus AD, Fouchier RA. 2012. Airborne transmission of influenza A/H5N1 virus between ferrets. Science 336:1534-1541.
-
(2012)
Science
, vol.336
, pp. 1534-1541
-
-
Herfst, S.1
Schrauwen, E.J.2
Linster, M.3
Chutinimitkul, S.4
de Wit, E.5
Munster, V.J.6
Sorrell, E.M.7
Bestebroer, T.M.8
Burke, D.F.9
Smith, D.J.10
Rimmelzwaan, G.F.11
Osterhaus, A.D.12
Fouchier, R.A.13
-
69
-
-
84856704565
-
Three-dimensional analysis of ribonucleoprotein complexes in influenza A virus
-
doi:10.1038/ncomms1647
-
Noda T, Sugita Y, Aoyama K, Hirase A, Kawakami E, Miyazawa A, Sagara H, Kawaoka Y. 2012. Three-dimensional analysis of ribonucleoprotein complexes in influenza A virus. Nat. Commun. 3:639. doi:10.1038/ncomms1647.
-
(2012)
Nat. Commun.
, vol.3
, pp. 639
-
-
Noda, T.1
Sugita, Y.2
Aoyama, K.3
Hirase, A.4
Kawakami, E.5
Miyazawa, A.6
Sagara, H.7
Kawaoka, Y.8
-
70
-
-
0024990401
-
Determination of influenza virus proteins required for genome replication
-
Huang TS, Palese P, Krystal M. 1990. Determination of influenza virus proteins required for genome replication. J. Virol. 64:5669-5673.
-
(1990)
J. Virol.
, vol.64
, pp. 5669-5673
-
-
Huang, T.S.1
Palese, P.2
Krystal, M.3
-
71
-
-
0023445054
-
Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle
-
Hsu MT, Parvin JD, Gupta S, Krystal M, Palese P. 1987. Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle. Proc. Natl. Acad. Sci. U. S. A. 84:8140-8144.
-
(1987)
Proc. Natl. Acad. Sci. U. S. A.
, vol.84
, pp. 8140-8144
-
-
Hsu, M.T.1
Parvin, J.D.2
Gupta, S.3
Krystal, M.4
Palese, P.5
-
72
-
-
0037079682
-
Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase
-
Lee MT, Bishop K, Medcalf L, Elton D, Digard P, Tiley L. 2002. Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase. Nucleic Acids Res. 30:429-438.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 429-438
-
-
Lee, M.T.1
Bishop, K.2
Medcalf, L.3
Elton, D.4
Digard, P.5
Tiley, L.6
-
73
-
-
0028123774
-
Recombinant influenza virus polymerase: requirement of both 5= and 3= viral ends for endonuclease activity
-
Hagen M, Chung TD, Butcher JA, Krystal M. 1994. Recombinant influenza virus polymerase: requirement of both 5= and 3= viral ends for endonuclease activity. J. Virol. 68:1509-1515.
-
(1994)
J. Virol.
, vol.68
, pp. 1509-1515
-
-
Hagen, M.1
Chung, T.D.2
Butcher, J.A.3
Krystal, M.4
-
74
-
-
0028245360
-
The influenza virus panhandle is involved in the initiation of transcription
-
Fodor E, Pritlove DC, Brownlee GG. 1994. The influenza virus panhandle is involved in the initiation of transcription. J. Virol. 68:4092- 4096.
-
(1994)
J. Virol.
, vol.68
, pp. 4092-4096
-
-
Fodor, E.1
Pritlove, D.C.2
Brownlee, G.G.3
-
75
-
-
0028181687
-
Influenza A virus M2 ion channel protein: a structure-function analysis
-
Holsinger LJ, Nichani D, Pinto LH, Lamb RA. 1994. Influenza A virus M2 ion channel protein: a structure-function analysis. J. Virol. 68:1551- 1563.
-
(1994)
J. Virol.
, vol.68
, pp. 1551-1563
-
-
Holsinger, L.J.1
Nichani, D.2
Pinto, L.H.3
Lamb, R.A.4
-
76
-
-
0029998889
-
Nuclear trafficking of influenza virus ribonuleoproteins in heterokaryons
-
Whittaker G, Bui M, Helenius A. 1996. Nuclear trafficking of influenza virus ribonuleoproteins in heterokaryons. J. Virol. 70:2743-2756.
-
(1996)
J. Virol.
, vol.70
, pp. 2743-2756
-
-
Whittaker, G.1
Bui, M.2
Helenius, A.3
-
77
-
-
0030069730
-
The role of nuclear import and export in influenza virus infection
-
Whittaker G, Bui M, Helenius A. 1996. The role of nuclear import and export in influenza virus infection. Trends Cell Biol. 6:67-71.
-
(1996)
Trends Cell Biol
, vol.6
, pp. 67-71
-
-
Whittaker, G.1
Bui, M.2
Helenius, A.3
-
78
-
-
0020696905
-
The gene structure and replication of influenza virus
-
Lamb RA, Choppin PW. 1983. The gene structure and replication of influenza virus. Annu. Rev. Biochem. 52:467-506.
-
(1983)
Annu. Rev. Biochem.
, vol.52
, pp. 467-506
-
-
Lamb, R.A.1
Choppin, P.W.2
-
79
-
-
0020665686
-
Influenza virus temperature-sensitive cap (m7GpppNm)-dependent endonuclease
-
Ulmanen I, Broni B, Krug RM. 1983. Influenza virus temperature-sensitive cap (m7GpppNm)-dependent endonuclease. J. Virol. 45:27-35.
-
(1983)
J. Virol.
, vol.45
, pp. 27-35
-
-
Ulmanen, I.1
Broni, B.2
Krug, R.M.3
-
80
-
-
67249130012
-
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
-
Dias A, Bouvier D, Crepin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW. 2009. The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature 458:914-918.
-
(2009)
Nature
, vol.458
, pp. 914-918
-
-
Dias, A.1
Bouvier, D.2
Crepin, T.3
McCarthy, A.A.4
Hart, D.J.5
Baudin, F.6
Cusack, S.7
Ruigrok, R.W.8
-
81
-
-
33750267121
-
Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication
-
Deng T, Sharps JL, Brownlee GG. 2006. Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication. J. Gen. Virol. 87:3373-3377.
-
(2006)
J. Gen. Virol.
, vol.87
, pp. 3373-3377
-
-
Deng, T.1
Sharps, J.L.2
Brownlee, G.G.3
-
82
-
-
78650403082
-
Internal initiation of influenza virus replication of viral RNA and complementary RNA in vitro
-
Zhang S, Wang J, Wang Q, Toyoda T. 2010. Internal initiation of influenza virus replication of viral RNA and complementary RNA in vitro. J. Biol. Chem. 285:41194-41201.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 41194-41201
-
-
Zhang, S.1
Wang, J.2
Wang, Q.3
Toyoda, T.4
-
83
-
-
47049121009
-
Role of initiating nucleoside triphosphate concentrations in the regulation of influenza virus replication and transcription
-
Vreede FT, Gifford H, Brownlee GG. 2008. Role of initiating nucleoside triphosphate concentrations in the regulation of influenza virus replication and transcription. J. Virol. 82:6902-6910.
-
(2008)
J. Virol.
, vol.82
, pp. 6902-6910
-
-
Vreede, F.T.1
Gifford, H.2
Brownlee, G.G.3
-
84
-
-
67249108203
-
Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication
-
doi:10.1371/journal.ppat.1000462
-
Jorba N, Coloma R, Ortin J. 2009. Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication. PLoS Pathog. 5:e1000462. doi:10.1371/journal.ppat.1000462.
-
(2009)
PLoS Pathog
, vol.5
-
-
Jorba, N.1
Coloma, R.2
Ortin, J.3
-
85
-
-
79954499474
-
The influenza virus RNA synthesis machine: advances in its structure and function
-
Resa-Infante P, Jorba N, Coloma R, Ortin J. 2011. The influenza virus RNA synthesis machine: advances in its structure and function. RNA Biol. 8:207-215.
-
(2011)
RNA Biol
, vol.8
, pp. 207-215
-
-
Resa-Infante, P.1
Jorba, N.2
Coloma, R.3
Ortin, J.4
-
86
-
-
0036210827
-
The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication
-
Portela A, Digard P. 2002. The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication. J. Gen. Virol. 83:723-734.
-
(2002)
J. Gen. Virol.
, vol.83
, pp. 723-734
-
-
Portela, A.1
Digard, P.2
-
87
-
-
58149402434
-
Interaction of the influenza A virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication
-
Newcomb LL, Kuo RL, Ye Q, Jiang Y, Tao YJ, Krug RM. 2009. Interaction of the influenza A virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication. J. Virol. 83:29-36.
-
(2009)
J. Virol.
, vol.83
, pp. 29-36
-
-
Newcomb, L.L.1
Kuo, R.L.2
Ye, Q.3
Jiang, Y.4
Tao, Y.J.5
Krug, R.M.6
-
88
-
-
84875829625
-
The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes
-
doi:10.1038/ncomms2589
-
Turrell L, Lyall JW, Tiley LS, Fodor E, Vreede FT. 2013. The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes. Nat. Commun. 4:1591. doi:10.1038/ncomms2589.
-
(2013)
Nat. Commun.
, vol.4
, pp. 1591
-
-
Turrell, L.1
Lyall, J.W.2
Tiley, L.S.3
Fodor, E.4
Vreede, F.T.5
-
89
-
-
67649227447
-
NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome
-
Robb NC, Smith M, Vreede FT, Fodor E. 2009. NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. J. Gen. Virol. 90:1398-1407.
-
(2009)
J. Gen. Virol
, vol.90
, pp. 1398-1407
-
-
Robb, N.C.1
Smith, M.2
Vreede, F.T.3
Fodor, E.4
-
90
-
-
0035042067
-
Influenza A virus NEP (NS2 protein) downregulates RNA synthesis of model template RNAs
-
Bullido R, Gomez-Puertas P, Saiz MJ, Portela A. 2001. Influenza A virus NEP (NS2 protein) downregulates RNA synthesis of model template RNAs. J. Virol. 75:4912-4917.
-
(2001)
J. Virol.
, vol.75
, pp. 4912-4917
-
-
Bullido, R.1
Gomez-Puertas, P.2
Saiz, M.J.3
Portela, A.4
-
91
-
-
77954912141
-
Influenza A virus-generated small RNAs regulate the switch from transcription to replication
-
Perez JT, Varble A, Sachidanandam R, Zlatev I, Manoharan M, Garcia-Sastre A, ten Oever BR. 2010. Influenza A virus-generated small RNAs regulate the switch from transcription to replication. Proc. Natl. Acad. Sci. U. S. A. 107:11525-11530.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 11525-11530
-
-
Perez, J.T.1
Varble, A.2
Sachidanandam, R.3
Zlatev, I.4
Manoharan, M.5
Garcia-Sastre, A.6
ten Oever, B.R.7
-
92
-
-
79952068189
-
Influenza A virus expresses high levels of an unusual class of small viral leader RNAs in infected cells
-
doi:10.1128/mBio.00204-10
-
Umbach JL, Yen HL, Poon LL, Cullen BR. 2010. Influenza A virus expresses high levels of an unusual class of small viral leader RNAs in infected cells. mBio 1:e00204 -10. doi:10.1128/mBio.00204-10.
-
(2010)
mBio
, vol.1
-
-
Umbach, J.L.1
Yen, H.L.2
Poon, L.L.3
Cullen, B.R.4
-
93
-
-
84870673413
-
A small-RNA enhancer of viral polymerase activity
-
Perez JT, Zlatev I, Aggarwal S, Subramanian S, Sachidanandam R, Kim B, Manoharan M, Tenoever BR. 2012. A small-RNA enhancer of viral polymerase activity. J. Virol. 86:13475-13485.
-
(2012)
J. Virol.
, vol.86
, pp. 13475-13485
-
-
Perez, J.T.1
Zlatev, I.2
Aggarwal, S.3
Subramanian, S.4
Sachidanandam, R.5
Kim, B.6
Manoharan, M.7
Tenoever, B.R.8
-
94
-
-
84874044936
-
Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing
-
doi:10.1038/emi.2012.38
-
Selman M, Dankar SK, Forbes N, Jia JJ, Brown GE. 2012. Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing. Emerg. Microbes Infect. 1:e42. doi:10.1038/emi.2012.38.
-
(2012)
Emerg. Microbes Infect.
, vol.1
-
-
Selman, M.1
Dankar, S.K.2
Forbes, N.3
Jia, J.J.4
Brown, G.E.5
-
95
-
-
84874676641
-
Identification of novel influenza A virus proteins translated from PA Mrna
-
Muramoto Y, Noda T, Kawakami E, Akkina R, Kawaoka Y. 2013. Identification of novel influenza A virus proteins translated from PA mRNA. J. Virol. 87:2455-2462.
-
(2013)
J. Virol.
, vol.87
, pp. 2455-2462
-
-
Muramoto, Y.1
Noda, T.2
Kawakami, E.3
Akkina, R.4
Kawaoka, Y.5
-
96
-
-
0035658084
-
A novel influenza A virus mitochondrial protein that induces cell death
-
Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O'Neill R, Schickli J, Palese P, Henklein P, Bennink JR, Yewdell JW. 2001. A novel influenza A virus mitochondrial protein that induces cell death. Nat. Med. 7:1306-1312.
-
(2001)
Nat. Med.
, vol.7
, pp. 1306-1312
-
-
Chen, W.1
Calvo, P.A.2
Malide, D.3
Gibbs, J.4
Schubert, U.5
Bacik, I.6
Basta, S.7
O'Neill, R.8
Schickli, J.9
Palese, P.10
Henklein, P.11
Bennink, J.R.12
Yewdell, J.W.13
-
97
-
-
84870834635
-
Identification of a novel splice variant form of the influenza a virus m2 ion channel with an antigenically distinct ectodomain
-
doi:10.1371/journal.ppat.1002998
-
Wise HM, Hutchinson EC, Jagger BW, Stuart AD, Kang ZH, Robb N, Schwartzman LM, Kash JC, Fodor E, Firth AE, Gog JR, Taubenberger JK, Digard P. 2012. Identification of a novel splice variant form of the influenza a virus m2 ion channel with an antigenically distinct ectodomain. PLoS Pathog. 8:e1002998. doi:10.1371/journal.ppat.1002998.
-
(2012)
PLoS Pathog
, vol.8
-
-
Wise, H.M.1
Hutchinson, E.C.2
Jagger, B.W.3
Stuart, A.D.4
Kang, Z.H.5
Robb, N.6
Schwartzman, L.M.7
Kash, J.C.8
Fodor, E.9
Firth, A.E.10
Gog, J.R.11
Taubenberger, J.K.12
Digard, P.13
-
98
-
-
33749330704
-
Functional association between viral and cellular transcription during influenza virus infection
-
Engelhardt OG, Fodor E. 2006. Functional association between viral and cellular transcription during influenza virus infection. Rev. Med. Virol. 16:329-345.
-
(2006)
Rev. Med. Virol
, vol.16
, pp. 329-345
-
-
Engelhardt, O.G.1
Fodor, E.2
-
99
-
-
0020451825
-
Spliced and unspliced messenger RNAs synthesized from cloned influenza virusMDNA in an SV40 vector: expression of the influenza virus membrane protein (M1)
-
Lamb RA, Lai CJ. 1982. Spliced and unspliced messenger RNAs synthesized from cloned influenza virusMDNA in an SV40 vector: expression of the influenza virus membrane protein (M1). Virology 123:237-256.
-
(1982)
Virology
, vol.123
, pp. 237-256
-
-
Lamb, R.A.1
Lai, C.J.2
-
100
-
-
0021287765
-
Expression of unspliced NS1 mRNA, spliced NS2 mRNA, and a spliced chimera mRNA from cloned influenza virus NS DNA in an SV40 vector
-
Lamb RA, Lai CJ. 1984. Expression of unspliced NS1 mRNA, spliced NS2 mRNA, and a spliced chimera mRNA from cloned influenza virus NS DNA in an SV40 vector. Virology 135:139-147.
-
(1984)
Virology
, vol.135
, pp. 139-147
-
-
Lamb, R.A.1
Lai, C.J.2
-
101
-
-
0028024644
-
Nuclear import of microinjected influenza virus ribonucleoproteins
-
Kemler I, Whittaker G, Helenius A. 1994. Nuclear import of microinjected influenza virus ribonucleoproteins. Virology 202:1028-1033.
-
(1994)
Virology
, vol.202
, pp. 1028-1033
-
-
Kemler, I.1
Whittaker, G.2
Helenius, A.3
-
102
-
-
84876308496
-
The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in mice
-
Zaraket H, Bridges OA, Russell CJ. 2013. The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in mice. J. Virol. 87:4826-4834.
-
(2013)
J. Virol.
, vol.87
, pp. 4826-4834
-
-
Zaraket, H.1
Bridges, O.A.2
Russell, C.J.3
-
104
-
-
78650480681
-
Origin of the 1918 pandemic H1N1 influenza A virus as studied by codon usage patterns and phylogenetic analysis
-
Anhlan D, Grundmann N, Makalowski W, Ludwig S, Scholtissek C. 2011. Origin of the 1918 pandemic H1N1 influenza A virus as studied by codon usage patterns and phylogenetic analysis. RNA 17:64-73.
-
(2011)
RNA
, vol.17
, pp. 64-73
-
-
Anhlan, D.1
Grundmann, N.2
Makalowski, W.3
Ludwig, S.4
Scholtissek, C.5
-
105
-
-
46449083518
-
Patterns of evolution and host gene mimicry in influenza and other RNA viruses
-
doi:10.1371/journal.ppat.1000079
-
Greenbaum BD, Levine AJ, Bhanot G, Rabadan R. 2008. Patterns of evolution and host gene mimicry in influenza and other RNA viruses. PLoS Pathog. 4:e1000079. doi:10.1371/journal.ppat.1000079.
-
(2008)
PLoS Pathog
, vol.4
-
-
Greenbaum, B.D.1
Levine, A.J.2
Bhanot, G.3
Rabadan, R.4
-
106
-
-
33751214219
-
Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes
-
Rabadan R, Levine AJ, Robins H. 2006. Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes. J. Virol. 80:11887-11891.
-
(2006)
J. Virol.
, vol.80
, pp. 11887-11891
-
-
Rabadan, R.1
Levine, A.J.2
Robins, H.3
-
107
-
-
84869214374
-
Contribution of NS1 effector domain dimerization to influenza A virus replication and virulence
-
Ayllon J, Russell RJ, Garcia-Sastre A, Hale BG. 2012. Contribution of NS1 effector domain dimerization to influenza A virus replication and virulence. J. Virol. 86:13095-13098.
-
(2012)
J. Virol.
, vol.86
, pp. 13095-13098
-
-
Ayllon, J.1
Russell, R.J.2
Garcia-Sastre, A.3
Hale, B.G.4
-
108
-
-
79959823372
-
The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein
-
doi:10.1371/journal.ppat.1002067
-
Varga ZT, Ramos I, Hai R, Schmolke M, Garcia-Sastre A, Fernandez-Sesma A, Palese P. 2011. The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein. PLoS Pathog. 7:e1002067. doi:10.1371/journal.ppat.1002067.
-
(2011)
PLoS Pathog
, vol.7
-
-
Varga, Z.T.1
Ramos, I.2
Hai, R.3
Schmolke, M.4
Garcia-Sastre, A.5
Fernandez-Sesma, A.6
Palese, P.7
-
109
-
-
41149143074
-
Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase
-
Dittmann J, Stertz S, Grimm D, Steel J, Garcia-Sastre A, Haller O, Kochs G. 2008. Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase. J. Virol. 82:3624-3631.
-
(2008)
J. Virol.
, vol.82
, pp. 3624-3631
-
-
Dittmann, J.1
Stertz, S.2
Grimm, D.3
Steel, J.4
Garcia-Sastre, A.5
Haller, O.6
Kochs, G.7
-
110
-
-
79961202011
-
The viral nucleoprotein determines Mx sensitivity of influenza A viruses
-
Zimmermann P, Manz B, Haller O, Schwemmle M, Kochs G. 2011. The viral nucleoprotein determines Mx sensitivity of influenza A viruses. J. Virol. 85:8133-8140.
-
(2011)
J. Virol.
, vol.85
, pp. 8133-8140
-
-
Zimmermann, P.1
Manz, B.2
Haller, O.3
Schwemmle, M.4
Kochs, G.5
-
111
-
-
33645058912
-
The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/ 1203/04
-
Salomon R, Franks J, Govorkova EA, Ilyushina NA, Yen HL, Hulse-Post DJ, Humberd J, Trichet M, Rehg JE, Webby RJ, Webster RG, Hoffmann E. 2006. The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/ 1203/04. J. Exp. Med. 203:689-697.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 689-697
-
-
Salomon, R.1
Franks, J.2
Govorkova, E.A.3
Ilyushina, N.A.4
Yen, H.L.5
Hulse-Post, D.J.6
Humberd, J.7
Trichet, M.8
Rehg, J.E.9
Webby, R.J.10
Webster, R.G.11
Hoffmann, E.12
-
112
-
-
0026517494
-
Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers
-
Clements ML, Subbarao EK, Fries LF, Karron RA, London WT, Murphy BR. 1992. Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers. J. Clin. Microbiol. 30:655-662.
-
(1992)
J. Clin. Microbiol.
, vol.30
, pp. 655-662
-
-
Clements, M.L.1
Subbarao, E.K.2
Fries, L.F.3
Karron, R.A.4
London, W.T.5
Murphy, B.R.6
-
113
-
-
48649085166
-
An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase
-
Mehle A, Doudna JA. 2008. An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase. Cell Host Microbe 4:111-122.
-
(2008)
Cell Host Microbe
, vol.4
, pp. 111-122
-
-
Mehle, A.1
Doudna, J.A.2
-
114
-
-
77956839458
-
Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase
-
Moncorge O, Mura M, Barclay WS. 2010. Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase. J. Virol. 84:9978-9986.
-
(2010)
J. Virol.
, vol.84
, pp. 9978-9986
-
-
Moncorge, O.1
Mura, M.2
Barclay, W.S.3
-
116
-
-
79959725144
-
Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse
-
doi:10.1371/journal.pone.0021740
-
Ping J, Keleta L, Forbes NE, Dankar S, Stecho W, Tyler S, Zhou Y, Babiuk L, Weingartl H, Halpin RA, Boyne A, Bera J, Hostetler J, Fedorova NB, Proudfoot K, Katzel DA, Stockwell TB, Ghedin E, Spiro DJ, Brown EG. 2011. Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse. PLoS One 6:e21740. doi:10.1371/journal.pone.0021740.
-
(2011)
PLoS One
, vol.6
-
-
Ping, J.1
Keleta, L.2
Forbes, N.E.3
Dankar, S.4
Stecho, W.5
Tyler, S.6
Zhou, Y.7
Babiuk, L.8
Weingartl, H.9
Halpin, R.A.10
Boyne, A.11
Bera, J.12
Hostetler, J.13
Fedorova, N.B.14
Proudfoot, K.15
Katzel, D.A.16
Stockwell, T.B.17
Ghedin, E.18
Spiro, D.J.19
Brown, E.G.20
more..
-
117
-
-
50849137828
-
Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit
-
doi:10.1371/journal.ppat.1000136
-
Tarendeau F, Crepin T, Guilligay D, Ruigrok RW, Cusack S, Hart DJ. 2008. Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog. 4:e1000136. doi:10.1371/journal.ppat.1000136.
-
(2008)
PLoS Pathog
, vol.4
-
-
Tarendeau, F.1
Crepin, T.2
Guilligay, D.3
Ruigrok, R.W.4
Cusack, S.5
Hart, D.J.6
-
118
-
-
59249096926
-
Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
-
doi:10.1371/journal.ppat.1000252
-
Steel J, Lowen AC, Mubareka S, Palese P. 2009. Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog. 5:e1000252. doi:10.1371/journal.ppat.1000252.
-
(2009)
PLoS Pathog
, vol.5
-
-
Steel, J.1
Lowen, A.C.2
Mubareka, S.3
Palese, P.4
-
119
-
-
0035026051
-
Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses
-
Massin P, van der Werf S, Naffakh N. 2001. Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses. J. Virol. 75:5398-5404.
-
(2001)
J. Virol.
, vol.75
, pp. 5398-5404
-
-
Massin, P.1
van der Werf, S.2
Naffakh, N.3
-
120
-
-
34247565021
-
Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells
-
Labadie K, Dos Santos Afonso E, Rameix-Welti MA, van der Werf S, Naffakh N. 2007. Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells. Virology 362:271-282.
-
(2007)
Virology
, vol.362
, pp. 271-282
-
-
Labadie, K.1
Dos Santos Afonso, E.2
Rameix-Welti, M.A.3
van der Werf, S.4
Naffakh, N.5
-
121
-
-
59749097063
-
Avian influenza A virus polymerase association with nucleoprotein, but not polymerase assembly, is impaired in human cells during the course of infection
-
Rameix-Welti MA, Tomoiu A, Dos Santos Afonso E, van der Werf S, Naffakh N. 2009. Avian influenza A virus polymerase association with nucleoprotein, but not polymerase assembly, is impaired in human cells during the course of infection. J. Virol. 83:1320-1331.
-
(2009)
J. Virol.
, vol.83
, pp. 1320-1331
-
-
Rameix-Welti, M.A.1
Tomoiu, A.2
Dos Santos Afonso, E.3
van der Werf, S.4
Naffakh, N.5
-
122
-
-
84860526518
-
Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627
-
doi:10.1371/journal.pone.0036415
-
Ng AK, Chan WH, Choi ST, Lam MK, Lau KF, Chan PK, Au SW, Fodor E, Shaw PC. 2012. Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627. PLoS One 7:e36415. doi:10.1371/journal.pone.0036415.
-
(2012)
PLoS One
, vol.7
-
-
Ng, A.K.1
Chan, W.H.2
Choi, S.T.3
Lam, M.K.4
Lau, K.F.5
Chan, P.K.6
Au, S.W.7
Fodor, E.8
Shaw, P.C.9
-
123
-
-
80054995402
-
Reversion of PB2-627E to -627K during replication of an H5N1 clade 2 2 virus in mammalian hosts depends on the origin of the nucleoprotein
-
Bogs J, Kalthoff D, Veits J, Pavlova S, Schwemmle M, Manz B, Mettenleiter TC, Stech J. 2011. Reversion of PB2-627E to -627K during replication of an H5N1 clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein. J. Virol. 85:10691-10698.
-
(2011)
J. Virol.
, vol.85
, pp. 10691-10698
-
-
Bogs, J.1
Kalthoff, D.2
Veits, J.3
Pavlova, S.4
Schwemmle, M.5
Manz, B.6
Mettenleiter, T.C.7
Stech, J.8
-
124
-
-
84863128008
-
Combination of PB2 271A and SR polymorphism at positions 590/591 is critical for viral replication and virulence of swine influenza virus in cultured cells and in vivo
-
Liu Q, Qiao C, Marjuki H, Bawa B, Ma J, Guillossou S, Webby RJ, Richt JA, Ma W. 2012. Combination of PB2 271A and SR polymorphism at positions 590/591 is critical for viral replication and virulence of swine influenza virus in cultured cells and in vivo. J. Virol. 86:1233-1237.
-
(2012)
J. Virol.
, vol.86
, pp. 1233-1237
-
-
Liu, Q.1
Qiao, C.2
Marjuki, H.3
Bawa, B.4
Ma, J.5
Guillossou, S.6
Webby, R.J.7
Richt, J.A.8
Ma, W.9
-
125
-
-
33847624936
-
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit
-
Tarendeau F, Boudet J, Guilligay D, Mas PJ, Bougault CM, Boulo S, Baudin F, Ruigrok RW, Daigle N, Ellenberg J, Cusack S, Simorre JP, Hart DJ. 2007. Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat. Struct. Mol. Biol. 14:229-233.
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 229-233
-
-
Tarendeau, F.1
Boudet, J.2
Guilligay, D.3
Mas, P.J.4
Bougault, C.M.5
Boulo, S.6
Baudin, F.7
Ruigrok, R.W.8
Daigle, N.9
Ellenberg, J.10
Cusack, S.11
Simorre, J.P.12
Hart, D.J.13
-
126
-
-
40349113426
-
Interaction of polymerase subunit PB2andNPwith importin alpha1 is a determinant of host range of influenza A virus
-
doi:10.1371/journal.ppat.0040011
-
Gabriel G, Herwig A, Klenk HD. 2008. Interaction of polymerase subunit PB2andNPwith importin alpha1 is a determinant of host range of influenza A virus. PLoS Pathog. 4:e11. doi:10.1371/journal.ppat.0040011.
-
(2008)
PLoS Pathog
, vol.4
-
-
Gabriel, G.1
Herwig, A.2
Klenk, H.D.3
-
127
-
-
84857468667
-
Human-like PB2 627K influenza virus polymerase activity is regulated by importin-alpha1 and -alpha7
-
doi:10.1371/journal.ppat.1002488
-
Hudjetz B, Gabriel G. 2012. Human-like PB2 627K influenza virus polymerase activity is regulated by importin-alpha1 and -alpha7. PLoS Pathog. 8:e1002488. doi:10.1371/journal.ppat.1002488.
-
(2012)
PLoS Pathog
, vol.8
-
-
Hudjetz, B.1
Gabriel, G.2
-
128
-
-
80052576674
-
Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins
-
doi:10.1128/mBio.00151-11
-
Bortz E, Westera L, Maamary J, Steel J, Albrecht RA, Manicassamy B, Chase G, Martinez-Sobrido L, Schwemmle M, Garcia-Sastre A. 2011. Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins. mBio 2:e00151-11. doi:10.1128/mBio.00151-11.
-
(2011)
mBio
, vol.2
-
-
Bortz, E.1
Westera, L.2
Maamary, J.3
Steel, J.4
Albrecht, R.A.5
Manicassamy, B.6
Chase, G.7
Martinez-Sobrido, L.8
Schwemmle, M.9
Garcia-Sastre, A.10
-
129
-
-
84857508889
-
The RNA polymerase PB2 subunit of influenza A/HongKong/156/1997 (H5N1) restricts the replication of reassortant ribonucleoprotein complexes [corrected]
-
doi:10.1371/journal.pone.0032634
-
Nakazono Y, Hara K, Kashiwagi T, Hamada N, Watanabe H. 2012. The RNA polymerase PB2 subunit of influenza A/HongKong/156/1997 (H5N1) restricts the replication of reassortant ribonucleoprotein complexes [corrected]. PLoS One 7:e32634. doi:10.1371/journal.pone.0032634.
-
(2012)
PLoS One
, vol.7
-
-
Nakazono, Y.1
Hara, K.2
Kashiwagi, T.3
Hamada, N.4
Watanabe, H.5
-
130
-
-
80053398495
-
Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex
-
Aggarwal S, Dewhurst S, Takimoto T, Kim B. 2011. Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex. J. Biol. Chem. 286:34504-34513.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 34504-34513
-
-
Aggarwal, S.1
Dewhurst, S.2
Takimoto, T.3
Kim, B.4
-
131
-
-
78751622104
-
Differential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virus
-
Gabriel G, Klingel K, Otte A, Thiele S, Hudjetz B, Arman-Kalcek G, Sauter M, Shmidt T, Rother F, Baumgarte S, Keiner B, Hartmann E, Bader M, Brownlee GG, Fodor E, Klenk HD. 2011. Differential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virus. Nat. Commun. 2:156.
-
(2011)
Nat. Commun.
, vol.2
, pp. 156
-
-
Gabriel, G.1
Klingel, K.2
Otte, A.3
Thiele, S.4
Hudjetz, B.5
Arman-Kalcek, G.6
Sauter, M.7
Shmidt, T.8
Rother, F.9
Baumgarte, S.10
Keiner, B.11
Hartmann, E.12
Bader, M.13
Brownlee, G.G.14
Fodor, E.15
Klenk, H.D.16
-
132
-
-
84055224044
-
Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity
-
Zhang S, Wang Q, Wang J, Mizumoto K, Toyoda T. 2012. Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity. Biochim. Biophys. Acta 1819:78-83.
-
(2012)
Biochim. Biophys. Acta
, vol.1819
, pp. 78-83
-
-
Zhang, S.1
Wang, Q.2
Wang, J.3
Mizumoto, K.4
Toyoda, T.5
-
133
-
-
33746815630
-
Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding
-
Hara K, Schmidt FI, Crow M, Brownlee GG. 2006. Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding. J. Virol. 80:7789-7798.
-
(2006)
J. Virol.
, vol.80
, pp. 7789-7798
-
-
Hara, K.1
Schmidt, F.I.2
Crow, M.3
Brownlee, G.G.4
-
134
-
-
0038371106
-
Threonine 157 of influenza virus PA polymerase subunit modulates RNA replication in infectious viruses
-
Huarte M, Falcon A, Nakaya Y, Ortin J, Garcia-Sastre A, Nieto A. 2003. Threonine 157 of influenza virus PA polymerase subunit modulates RNA replication in infectious viruses. J. Virol. 77:6007-6013.
-
(2003)
J. Virol.
, vol.77
, pp. 6007-6013
-
-
Huarte, M.1
Falcon, A.2
Nakaya, Y.3
Ortin, J.4
Garcia-Sastre, A.5
Nieto, A.6
-
135
-
-
37849052232
-
The influenza virus resource at the National Center for Biotechnology Information
-
Bao Y, Bolotov P, Dernovoy D, Kiryutin B, Zaslavsky L, Tatusova T, Ostell J, Lipman D. 2008. The influenza virus resource at the National Center for Biotechnology Information. J. Virol. 82:596-601.
-
(2008)
J. Virol.
, vol.82
, pp. 596-601
-
-
Bao, Y.1
Bolotov, P.2
Dernovoy, D.3
Kiryutin, B.4
Zaslavsky, L.5
Tatusova, T.6
Ostell, J.7
Lipman, D.8
-
136
-
-
34548169547
-
Differential polymerase activity in avian and mammalian cells determines host range of influenza virus
-
Gabriel G, Abram M, Keiner B, Wagner R, Klenk HD, Stech J. 2007. Differential polymerase activity in avian and mammalian cells determines host range of influenza virus. J. Virol. 81:9601-9604.
-
(2007)
J. Virol.
, vol.81
, pp. 9601-9604
-
-
Gabriel, G.1
Abram, M.2
Keiner, B.3
Wagner, R.4
Klenk, H.D.5
Stech, J.6
-
137
-
-
79956295593
-
Mutations in PA, NP, and HA of a pandemic (H1N1) 2009 influenza virus contribute to its adaptation to mice
-
Sakabe S, Ozawa M, Takano R, Iwastuki-Horimoto K, Kawaoka Y. 2011. Mutations in PA, NP, and HA of a pandemic (H1N1) 2009 influenza virus contribute to its adaptation to mice. Virus Res. 158: 124 -129.
-
(2011)
Virus Res
, vol.158
, pp. 124-129
-
-
Sakabe, S.1
Ozawa, M.2
Takano, R.3
Iwastuki-Horimoto, K.4
Kawaoka, Y.5
-
138
-
-
84875796093
-
Reassortment complements spontaneous mutation in influenza A virus NP and M1 genes to accelerate adaptation to a new host
-
Ince WL, Gueye-Mbaye A, Bennink JR, Yewdell JW. 2013. Reassortment complements spontaneous mutation in influenza A virus NP and M1 genes to accelerate adaptation to a new host. J. Virol. 87:4330-4338.
-
(2013)
J. Virol.
, vol.87
, pp. 4330-4338
-
-
Ince, W.L.1
Gueye-Mbaye, A.2
Bennink, J.R.3
Yewdell, J.W.4
-
139
-
-
77956625295
-
Adaptation of pandemic H1N1 influenza viruses in mice
-
Ilyushina NA, Khalenkov AM, Seiler JP, Forrest HL, Bovin NV, Marjuki H, Barman S, Webster RG, Webby RJ. 2010. Adaptation of pandemic H1N1 influenza viruses in mice. J. Virol. 84:8607-8616.
-
(2010)
J. Virol.
, vol.84
, pp. 8607-8616
-
-
Ilyushina, N.A.1
Khalenkov, A.M.2
Seiler, J.P.3
Forrest, H.L.4
Bovin, N.V.5
Marjuki, H.6
Barman, S.7
Webster, R.G.8
Webby, R.J.9
-
140
-
-
78449245226
-
Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype
-
doi:10.1371/journal.ppat.1001145
-
Ye J, Sorrell EM, Cai Y, Shao H, Xu K, Pena L, Hickman D, Song H, Angel M, Medina RA, Manicassamy B, Garcia-Sastre A, Perez DR. 2010. Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype? PLoS Pathog. 6:e1001145. doi:10.1371/journal.ppat.1001145.
-
(2010)
PLoS Pathog
, vol.6
-
-
Ye, J.1
Sorrell, E.M.2
Cai, Y.3
Shao, H.4
Xu, K.5
Pena, L.6
Hickman, D.7
Song, H.8
Angel, M.9
Medina, R.A.10
Manicassamy, B.11
Garcia-Sastre, A.12
Perez, D.R.13
-
141
-
-
0029026692
-
Mutational analysis of influenza virus promoter elements in vivo
-
Neumann G, Hobom G. 1995. Mutational analysis of influenza virus promoter elements in vivo. J. Gen. Virol. 76(Pt 7):1709 -1717.
-
(1995)
J. Gen. Virol.
, vol.76
, Issue.PART 7
, pp. 1709-1717
-
-
Neumann, G.1
Hobom, G.2
-
142
-
-
0032884864
-
Interaction of influenza virus polymerase with viral RNA in the 'corkscrew' conformation
-
Flick R, Hobom G. 1999. Interaction of influenza virus polymerase with viral RNA in the 'corkscrew' conformation. J. Gen. Virol. 80(Pt 10): 2565-2572.
-
(1999)
J. Gen. Virol.
, vol.80
, Issue.PART 10
, pp. 2565-2572
-
-
Flick, R.1
Hobom, G.2
-
143
-
-
0036935390
-
Differential effect of nucleotide substitutions in the 3= arm of the influenza A virus vRNA promoter on transcription/replication by avian and human polymerase complexes is related to the nature of PB2 amino acid 627
-
Crescenzo-Chaigne B, van der Werf S, Naffakh N. 2002. Differential effect of nucleotide substitutions in the 3= arm of the influenza A virus vRNA promoter on transcription/replication by avian and human polymerase complexes is related to the nature of PB2 amino acid 627. Virology 303:240-252.
-
(2002)
Virology
, vol.303
, pp. 240-252
-
-
Crescenzo-Chaigne, B.1
van der Werf, S.2
Naffakh, N.3
-
144
-
-
84867422166
-
Competition between influenza A virus genome segments
-
doi:10.1371/journal.pone.0047529
-
Widjaja I, de Vries E, Rottier PJ, de Haan CA. 2012. Competition between influenza A virus genome segments. PLoS One 7:e47529. doi:10.1371/journal.pone.0047529.
-
(2012)
PLoS One
, vol.7
-
-
Widjaja, I.1
de Vries, E.2
Rottier, P.J.3
de Haan, C.A.4
-
145
-
-
84861313040
-
Recombinant influenza A viruses with en-hanced levels of PB1 and PA viral protein expression
-
Belicha-Villanueva A, Rodriguez-Madoz JR, Maamary J, Baum A, Bernal-Rubio D, Minguito de la Escalera M, Fernandez-Sesma A, Garcia-Sastre A. 2012. Recombinant influenza A viruses with en-hanced levels of PB1 and PA viral protein expression. J. Virol. 86: 5926 -5930.
-
(2012)
J. Virol.
, vol.86
, pp. 5926-5930
-
-
Belicha-Villanueva, A.1
Rodriguez-Madoz, J.R.2
Maamary, J.3
Baum, A.4
Bernal-Rubio, D.5
Minguito de la Escalera, M.6
Fernandez-Sesma, A.7
Garcia-Sastre, A.8
-
147
-
-
77958569432
-
Structure of influenza virus ribonucleoprotein complexes and their packaging into virions
-
Noda T, Kawaoka Y. 2010. Structure of influenza virus ribonucleoprotein complexes and their packaging into virions. Rev. Med. Virol. 20: 380-391.
-
(2010)
Rev. Med. Virol.
, vol.20
, pp. 380-391
-
-
Noda, T.1
Kawaoka, Y.2
-
149
-
-
0029911606
-
Nonconserved nucleotides at the 3= and 5= ends of an influenza A virus RNA play an important role in viral RNA replication
-
Zheng H, Palese P, Garcia-Sastre A. 1996. Nonconserved nucleotides at the 3= and 5= ends of an influenza A virus RNA play an important role in viral RNA replication. Virology 217:242-251.
-
(1996)
Virology
, vol.217
, pp. 242-251
-
-
Zheng, H.1
Palese, P.2
Garcia-Sastre, A.3
-
150
-
-
40449116417
-
Heterologous influenza vRNA segments with identical non-coding sequences stimulate viral RNA replication in trans
-
doi:10.1186/1743-422X-5-2
-
Ng SS, Li OT, Cheung TK, Malik Peiris JS, Poon LL. 2008. Heterologous influenza vRNA segments with identical non-coding sequences stimulate viral RNA replication in trans. Virol. J. 5:2. doi:10.1186/1743 -422X-5-2.
-
(2008)
Virol. J.
, vol.5
, pp. 2
-
-
Ng, S.S.1
Li, O.T.2
Cheung, T.K.3
Malik Peiris, J.S.4
Poon, L.L.5
-
151
-
-
84870557895
-
Evolution of complementary nucleotides in 5= and 3= untranslated regions of influenza A virus genomic segments
-
Suzuki Y, Kobayashi Y. 2013. Evolution of complementary nucleotides in 5= and 3= untranslated regions of influenza A virus genomic segments. Infect. Genet. Evol. 13:175-179.
-
(2013)
Infect. Genet. Evol
, vol.13
, pp. 175-179
-
-
Suzuki, Y.1
Kobayashi, Y.2
-
152
-
-
79956333329
-
Evolution of the influenza A virus untranslated regions
-
Furuse Y, Oshitani H. 2011. Evolution of the influenza A virus untranslated regions. Infect. Genet. Evol. 11:1150-1154.
-
(2011)
Infect. Genet. Evol.
, vol.11
, pp. 1150-1154
-
-
Furuse, Y.1
Oshitani, H.2
-
153
-
-
0017664181
-
A single gene determines the host range of influenza virus
-
Almond JW. 1977. A single gene determines the host range of influenza virus. Nature 270:617-618.
-
(1977)
Nature
, vol.270
, pp. 617-618
-
-
Almond, J.W.1
-
154
-
-
34249694755
-
Pneumo- and neurotropism of avian origin Italian highly pathogenic avian influenza H7N1 isolates in experimentally infected mice
-
Rigoni M, Shinya K, Toffan A, Milani A, Bettini F, Kawaoka Y, Cattoli G, Capua I. 2007. Pneumo- and neurotropism of avian origin Italian highly pathogenic avian influenza H7N1 isolates in experimentally infected mice. Virology 364:28-35.
-
(2007)
Virology
, vol.364
, pp. 28-35
-
-
Rigoni, M.1
Shinya, K.2
Toffan, A.3
Milani, A.4
Bettini, F.5
Kawaoka, Y.6
Cattoli, G.7
Capua, I.8
-
155
-
-
72849148491
-
Ostrich involvement in the selection of H5N1 influenza virus possessing mammalian-type amino acids in the PB2 protein
-
Shinya K, Makino A, Ozawa M, Kim JH, Sakai-Tagawa Y, Ito M, Le QM, Kawaoka Y. 2009. Ostrich involvement in the selection of H5N1 influenza virus possessing mammalian-type amino acids in the PB2 protein. J. Virol. 83:13015-13018.
-
(2009)
J. Virol.
, vol.83
, pp. 13015-13018
-
-
Shinya, K.1
Makino, A.2
Ozawa, M.3
Kim, J.H.4
Sakai-Tagawa, Y.5
Ito, M.6
Le, Q.M.7
Kawaoka, Y.8
-
156
-
-
84870795662
-
Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry
-
doi:10.1371/journal.ppat.1002993
-
Hutchinson EC, Denham EM, Thomas B, Trudgian DC, Hester SS, Ridlova G, York A, Turrell L, Fodor E. 2012. Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry. PLoS Pathog. 8:e1002993. doi:10.1371/journal.ppat.1002993.
-
(2012)
PLoS Pathog
, vol.8
-
-
Hutchinson, E.C.1
Denham, E.M.2
Thomas, B.3
Trudgian, D.C.4
Hester, S.S.5
Ridlova, G.6
York, A.7
Turrell, L.8
Fodor, E.9
-
157
-
-
79956303456
-
Influenza A virus interacts extensively with the cellular SUMOylation system during infection
-
Pal S, Santos A, Rosas JM, Ortiz-Guzman J, Rosas-Acosta G. 2011. Influenza A virus interacts extensively with the cellular SUMOylation system during infection. Virus Res. 158:12-27.
-
(2011)
Virus Res
, vol.158
, pp. 12-27
-
-
Pal, S.1
Santos, A.2
Rosas, J.M.3
Ortiz-Guzman, J.4
Rosas-Acosta, G.5
|