Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1819, Issue 1, 2012, Pages 78-83

  Zhang, Shijian ^a,b,c   Wang, Qiang ^a   Wang, Jinlan ^a   Mizumoto, Kiyohisa ^d   Toyoda, Tetsuya ^a,e,f  

^a INSTITUTE PASTEUR OF SHANGHAI   (China)

^b FUDAN UNIVERSITY   (China)

^c Roche R and D Center China Ltd   (China)

^d KITASATO UNIVERSITY   (Japan)

^e NAGOYA CITY UNIVERSITY   (Japan)

^f Tokyo Metropolitan Institute of Medical Biology   (Japan)

Author keywords

Cap 1 RNA binding; Cap dependent nuclease; Influenza virus; PB2; RNA polymerase; Transcription

Indexed keywords

ENDONUCLEASE; RNA POLYMERASE; RNA POLYMERASE PB2; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; BACULOVIRUS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; IN VITRO STUDY; INFLUENZA VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA BINDING; RNA CAPPING; VIRUS REPLICATION; WILD TYPE;

GENE EXPRESSION REGULATION, VIRAL; HEK293 CELLS; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MUTATION; NUCLEOTIDYLTRANSFERASES; PROTEIN STRUCTURE, TERTIARY; RNA CAP-BINDING PROTEINS; RNA CAPS; RNA REPLICASE; TRANSCRIPTION, GENETIC; VIRAL PROTEINS;

HUMAN INFLUENZA VIRUS; MAMMALIA; ORTHOMYXOVIRIDAE;

EID: 84055224044     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2011.11.006     Document Type: Article

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