Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

Nature

Volumn 486, Issue 7403, 2012, Pages 420-428

  Imai, Masaki ^a   Watanabe, Tokiko ^a,b   Hatta, Masato ^a   Das, Subash C ^a   Ozawa, Makoto ^a,c   Shinya, Kyoko ^d   Zhong, Gongxun ^a   Hanson, Anthony ^a   Katsura, Hiroaki ^c   Watanabe, Shinji ^a,b   Li, Chengjun ^a   Kawakami, Eiryo ^b   Yamada, Shinya ^c   Kiso, Maki ^c   Suzuki, Yasuo ^e   Maher, Eileen A ^a   Neumann, Gabriele ^a   Kawaoka, Yoshihiro ^a,b,c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d KOBE UNIVERSITY   (Japan)

^e CHUBU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS HEMAGGLUTININ;

AVIAN INFLUENZA; CHEMICAL BINDING; DISEASE TRANSMISSION; EXPERIMENTAL STUDY; LESION; MOLECULAR ANALYSIS; MORALITY; MUSTELID; PATHOGENICITY; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FERRET; GENE MUTATION; INFLUENZA A; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; NONHUMAN; PANDEMIC INFLUENZA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRAL RESPIRATORY TRACT INFECTION; VIRUS MUTATION; VIRUS TRANSMISSION; VIRUS VIRULENCE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BIOTERRORISM; BIRDS; BODY FLUIDS; CELL LINE; DOGS; EVOLUTION, MOLECULAR; FEMALE; FERRETS; HEK293 CELLS; HELA CELLS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HOT TEMPERATURE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA, HUMAN; MOLECULAR EPIDEMIOLOGY; ORTHOMYXOVIRIDAE INFECTIONS; PANDEMICS; POPULATION SURVEILLANCE; PROTEIN STABILITY; REASSORTANT VIRUSES; RECEPTORS, VIRUS; RESPIRATORY SYSTEM; SECURITY MEASURES; ZOONOSES;

EID: 84861394598     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10831     Document Type: Article

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