Crystal structure of an avian influenza polymerase PA N reveals an endonuclease active site

Nature

Volumn 458, Issue 7240, 2009, Pages 909-913

  Yuan, Puwei ^a   Bartlam, Mark ^b   Lou, Zhiyong ^c   Chen, Shoudeng ^a   Zhou, Jie ^a   He, Xiaojing ^a   Lv, Zongyang ^a   Ge, Ruowen ^d   Li, Xuemei ^a,c   Deng, Tao ^b,e   Fodor, Ervin ^e   Rao, Zihe ^a,b,c   Liu, Yingfang ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b NANKAI UNIVERSITY   (China)

^c TSINGHUA UNIVERSITY   (China)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; MAGNESIUM ION; POLYMERASE PA; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG; VIRUS ENZYME;

AVIAN INFLUENZA; CATALYSIS; CRYSTAL STRUCTURE; ENZYME; MAGNESIUM; MUTAGENICITY; RNA;

ARTICLE; AVIAN INFLUENZA; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS A H5N1; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; VIRUS STRAIN;

ANIMALS; BIRDS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENDONUCLEASES; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; MODELS, MOLECULAR; PROTEIN SUBUNITS; RNA REPLICASE; VIRAL PROTEINS;

AVES; ORTHOMYXOVIRIDAE;

EID: 67249100913     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07720     Document Type: Article

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