Targeting microglial Kchannels to treat neurodegenerative diseases: A mitochondrial issue

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2013, Pages

  Rodríguez, Manuel J ^a   Martínez Moreno, Margot ^a   Ortega, Francisco J ^a,b   Mahy, Nicole ^a  

^a CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^b HOSPITAL DURAN I REYNALS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEX PROCESSES; DYNAMIC EQUILIBRIA; EXTRACELLULAR MATRIX REMODELING; INNOVATIVE APPROACHES; MICROENVIRONMENTS; MITOCHONDRIAL ACTIVITY; NEURODEGENERATION; NEURODEGENERATIVE DISORDERS;

CELL CULTURE; CELL PROLIFERATION; DISEASE CONTROL; NEURODEGENERATIVE DISEASES; REPAIR;

MITOCHONDRIA;

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; DIAZOXIDE; GLIBENCLAMIDE; MITOCHONDRIAL DNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITINATED PROTEIN; MITOCHONDRIAL K(ATP) CHANNEL; POTASSIUM CHANNEL;

ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING AFFINITY; CHANNEL GATING; DEGENERATIVE DISEASE; ENERGY METABOLISM; ENERGY YIELD; EXCITOTOXICITY; GLUCOSE HOMEOSTASIS; HUMAN; MEMBRANE DEPOLARIZATION; METABOLIC STRESS; MICROGLIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NERVE DEGENERATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PHAGOCYTOSIS; PHENOTYPE; POTASSIUM TRANSPORT; PRESYNAPTIC POTENTIAL; RESPIRATORY BURST; RESPIRATORY CHAIN; ANIMAL; METABOLISM; REVIEW;

ANIMALS; HUMANS; MICROGLIA; MITOCHONDRIA; NEURODEGENERATIVE DISEASES; POTASSIUM CHANNELS;

EID: 84880272621     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2013/194546     Document Type: Article

References (135)

1. Ortega F. J., Vidal-Taboada J., Mahy N., Rodriguez M. J., Molecular mechanisms of acute brain injury and ensuing neurodegeneration. Brain Damage-Bridging Between Basic Research and Clinics 2012 chapter 7 Rijeka, Croatia InTech Open Access Publisher Rijeka 163 186
2. Schafer D. P., Lehrman E. K., Stevens B., The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS. Glia 2013 61 1 24 36
3. Vidal-Taboada J., Mahy N., Rodriguez M. J., Microglia, calcification and neurodegenerative diseases. Neurodegenerative Diseases-Processes, Prevention, Protection and Monitoring 2011 chapter 13 Rijeka, Croatia InTech Open Access Publisher Rijeka 301 322
4. Garden G. A., La Spada A. R., Intercellular (Mis)communication in neurodegenerative disease. Neuron 2012 73 5 886 901 2-s2.0-84858017006 10.1016/j.neuron.2012.02.017
5. Forman M. S., Trojanowski J. Q., Lee V. M., Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nature Medicine 2004 10 10 1055 1063 2-s2.0-7044238416 10.1038/nm1113 (Pubitemid 39424865)
6. Morales R., Estrada L. D., Diaz-Espinoza R., Morales-Scheihing D., Jara M. C., Castilla J., Soto C., Molecular cross talk between misfolded proteins in animal models of alzheimer's and prion diseases. Journal of Neuroscience 2010 30 13 4528 4535 2-s2.0-77950633906 10.1523/JNEUROSCI.5924-09.2010
7. 2+ coordination. PLoS ONE 2010 5 12 2-s2.0-78651247095 10.1371/journal.pone.0015875 e15875
8. Taylor J. P., Hardy J., Fischbeck K. H., Toxic proteins in neurodegenerative disease. Science 2002 296 5575 1991 1995 2-s2.0-0037077040 10.1126/science.1067122 (Pubitemid 34627514)
9. Hickman S. E., Allison E. K., El Khoury J., Microglial dysfunction and defective β -amyloid clearance pathways in aging alzheimer's disease mice. Journal of Neuroscience 2008 28 33 8354 8360 2-s2.0-51149120624 10.1523/JNEUROSCI.0616-08.2008
10. Appel S. H., Zhao W., Beers D. R., Henkel J. S., The microglial- motoneuron dialogue in ALS. Acta Myologica 2011 30 4 8 2-s2.0-79958022133
11. Mackenzie I. R. A., Activated microglia in dementia with Lewy bodies. Neurology 2000 55 1 132 134 2-s2.0-0034641287 (Pubitemid 30461015)
12. Lee H., Suk J., Bae E., Lee S., Clearance and deposition of extracellular α -synuclein aggregates in microglia. Biochemical and Biophysical Research Communications 2008 372 3 423 428 2-s2.0-44749090147 10.1016/j.bbrc.2008.05.045
13. Deleidi M., Hallett P. J., Koprich J. B., Chung C., Isacson O., The toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration. Journal of Neuroscience 2010 30 48 16091 16101 2-s2.0-78649745833 10.1523/JNEUROSCI.2400-10.2010
14. Koprich J. B., Reske-Nielsen C., Mithal P., Isacson O., Neuroinflammation mediated by IL-1 β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. Journal of Neuroinflammation 2008 5, article 8 2-s2.0-42249115877 10.1186/1742-2094-5-8 (Pubitemid 351546594)
15. Orr C. F., Rowe D. B., Mizuno Y., Mori H., Halliday G. M., A possible role for humoral immunity in the pathogenesis of Parkinson's disease. Brain 2005 128 11 2665 2674 2-s2.0-27644531857 10.1093/brain/awh625 (Pubitemid 41552950)
16. Deleidi M., Maetzler W., Protein clearance mechanisms of alpha-synuclein and amyloid-beta in lewy body disorders. International Journal of Alzheimer's Disease 2012 2012 9 10.1155/2012/391438 391438
17. Zilka N., Stozicka Z., Kovac A., Pilipcinec E., Bugos O., Novak M., Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy. Journal of Neuroimmunology 2009 209 1-2 16 25 2-s2.0-64549107543 10.1016/j.jneuroim.2009. 01.013
18. Mandrekar S., Jiang Q., Lee C. Y. D., Koenigsknecht-Talboo J., Holtzman D. M., Landreth G. E., Microglia mediate the clearance of soluble a β through fluid phase macropinocytosis. Journal of Neuroscience 2009 29 13 4252 4262 2-s2.0-65249170245 10.1523/JNEUROSCI.5572-08.2009
19. Lau A., Tymianski M., Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Archiv European Journal of Physiology 2010 460 2 525 542 2-s2.0-77955570062 10.1007/s00424-010-0809-1
20. Obrenovitch T. P., Urenjak J., Zilkha E., Jay T. M., Excitotoxicity in neurological disorders-the glutamate paradox. International Journal of Developmental Neuroscience 2000 18 2-3 281 287 2-s2.0-0034012860 10.1016/S0736-5748(99)00096-9 (Pubitemid 30129201)
21. Rodríguez M. J., Pugliese M., Mahy N., Drug abuse, brain calcification and glutamate-induced neurodegeneration. Current Drug Abuse Reviews 2009 2 1 99 112 2-s2.0-70349784065 10.2174/1874473710902010099
22. Rodríguez M. J., Robledo P., Andrade C., Mahy N., In vivo co-ordinated interactions between inhibitory systems to control glutamate-mediated hippocampal excitability. Journal of Neurochemistry 2005 95 3 651 661 2-s2.0-27644474134 10.1111/j.1471-4159.2005.03394.x (Pubitemid 41567158)
23. Sapolsky R. M., Cellular defenses against excitotoxic insults. Journal of Neurochemistry 2001 76 6 1601 1611 2-s2.0-0035100691 10.1046/j.1471-4159.2001. 00203.x (Pubitemid 32221098)
24. Rodríguez M. J., Bernal F., Andrés N., Malpesa Y., Mahy N., Excitatory amino acids and neurodegeneration: a hypothetical role of calcium precipitation. International Journal of Developmental Neuroscience 2000 18 2-3 299 307 2-s2.0-0342546015 10.1016/S0736-5748(99)00098-2 (Pubitemid 30129203)
25. Ramonet D., Rodríguez M. J., Fredriksson K., Bernal F., Mahy N., In vivo neuroprotective adaptation of the glutamate/glutamine cycle to neuronal death. Hippocampus 2004 14 5 586 594 2-s2.0-3242799212 10.1002/hipo.10188 (Pubitemid 39107013)
26. Biber K., Neumann H., Inoue K., Boddeke H. W. G. M., Neuronal "On" and "Off" signals control microglia. Trends in Neurosciences 2007 30 11 596 602 2-s2.0-35748939409 10.1016/j.tins.2007.08.007 (Pubitemid 350051426)
27. Dutta G., Barber D. S., Zhang P., Doperalski N. J., Liu B., Involvement of dopaminergic neuronal cystatin C in neuronal injury-induced microglial activation and neurotoxicity. Journal of Neurochemistry 2012 122 752 763
28. Streit W. J., Microglia and neuroprotection: implications for Alzheimer's disease. Brain Research Reviews 2005 48 2 234 239 2-s2.0-17844404517 10.1016/j.brainresrev.2004.12.013 (Pubitemid 40585754)
29. Sloane J. A., Blitz D., Margolin Z., Vartanian T., A clear and present danger: endogenous ligands of Toll-like receptors. NeuroMolecular Medicine 2010 12 2 149 163 2-s2.0-77956394741 10.1007/s12017-009-8094-x
30. Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M., The chemokine system in diverse forms of macrophage activation and polarization. Trends in Immunology 2004 25 12 677 686 2-s2.0-7644231561 10.1016/j.it.2004.09. 015 (Pubitemid 39457982)
31. Stolzing A., Grune T., Impairment of protein homeostasis and decline of proteasome activity in microglial cells from adult wistar rats. Journal of Neuroscience Research 2003 71 2 264 271 2-s2.0-0037438153 10.1002/jnr.10478 (Pubitemid 36055471)
32. Stolzing A., Widmer R., Jung T., Voss P., Grune T., Tocopherol-mediated modulation of age-related changes in microglial cells: turnover of extracellular oxidized protein material. Free Radical Biology and Medicine 2006 40 12 2126 2135 2-s2.0-33745139199 10.1016/j.freeradbiomed.2006.02.011 (Pubitemid 43903100)
33. Graeber M. B., Streit W. J., Microglia: biology and pathology. Acta Neuropathologica 2010 119 1 89 105 2-s2.0-77649184973 10.1007/s00401-009-0622-0
34. Chen J., Connor K. M., Smith L. E. H., Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration. Journal of Clinical Investigation 2007 117 10 2758 2762 2-s2.0-34948895675 10.1172/JCI33513 (Pubitemid 47529606)
35. Croisier E., Graeber M. B., Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration. Acta Neuropathologica 2006 112 5 517 530 2-s2.0-33749669607 10.1007/s00401-006-0119-z (Pubitemid 44550676)
36. Streit W. J., Braak H., Xue Q., Bechmann I., Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathologica 2009 118 4 475 485 2-s2.0-69949118284 10.1007/s00401-009-0556-6
37. Schwartz M., Butovsky O., Brück W., Hanisch U., Microglial phenotype: is the commitment reversible? Trends in Neurosciences 2006 29 2 68 74 2-s2.0-32044442102 10.1016/j.tins.2005.12.005 (Pubitemid 43202595)
38. de Yebra L., Malpesa Y., Ursu G., Pugliese M., Liévens J., Goff L. K., Mahy N., Dissociation between hippocampal neuronal loss, astroglial and microglial reactivity after pharmacologically induced reverse glutamate transport. Neurochemistry International 2006 49 7 691 697 2-s2.0-33750010360 10.1016/j.neuint.2006.06.008 (Pubitemid 44572572)
39. Dirscherl K., Karlstetter M., Ebert S., Kraus D., Hlawatsch J., Walczak Y., Moehle C., Fuchshofer R., Langmann T., Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. Journal of Neuroinflammation 2010 7, article 3 2-s2.0-76749083375 10.1186/1742-2094-7-3
40. Block M. L., Zecca L., Hong J., Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Reviews Neuroscience 2007 8 1 57 69 2-s2.0-33845768784 10.1038/nrn2038 (Pubitemid 46011999)
41. Desler C., Rasmussen L. J., Mitochondria in biology and medicine. Mitochondrion 2012 12 4 472 476
42. Csordás G., Hajnóczky G., SR/ER-mitochondrial local communication: calcium and ROS. Biochimica et Biophysica Acta 2009 1787 11 1352 1362 2-s2.0-68649116755 10.1016/j.bbabio.2009.06.004
43. West A. P., Brodsky I. E., Rahner C., Woo D. K., Erdjument-Bromage H., Tempst P., Walsh M. C., Choi Y., Shadel G. S., Ghosh S., TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 2011 472 7344 476 480 2-s2.0-79955532516 10.1038/nature09973
44. Vogel R. O., Janssen R. J. R. J., van den Brand M. A. M., Dieteren C. E. J., Verkaart S., Koopman W. J. H., Willems P. H. G. M., Pluk W., van den Heuvel L. P. W. J., Smeitink J. A. M., Nijtmans L. G. J., Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. Genes & Development 2007 21 5 615 624 2-s2.0-33947129099 10.1101/gad.408407 (Pubitemid 46409475)
45. Murphy M. P., How mitochondria produce reactive oxygen species. Biochemical Journal 2009 417 1 1 13 2-s2.0-58249093939 10.1042/BJ20081386
46. Prinz M., Hanisch U., Murine microglial cells produce and respond to interleukin-18. Journal of Neurochemistry 1999 72 5 2215 2218 2-s2.0-0032970384 10.1046/j.1471-4159.1999.0722215.x (Pubitemid 29186031)
47. Allaman I., Bélanger M., Magistretti P. J., Astrocyte-neuron metabolic relationships: for better and for worse. Trends in Neurosciences 2011 34 2 76 87 2-s2.0-79551591722 10.1016/j.tins.2010.12.001
48. Halliday G. M., Stevens C. H., Glia: initiators and progressors of pathology in Parkinson's disease. Movement Disorders 2011 26 1 6 17 2-s2.0-79951499176 10.1002/mds.23455
49. Henkel J. S., Beers D. R., Zhao W., Appel S. H., Microglia in ALS: the good, the bad, and the resting. Journal of Neuroimmune Pharmacology 2009 4 4 389 398 2-s2.0-70449525135 10.1007/s11481-009-9171-5
50. Bernhart E., Kollroser M., Rechberger G., Reicher H., Heinemann A., Schratl P., Hallström S., Wintersperger A., Nusshold C., DeVaney T., Zorn-Pauly K., Malli R., Graier W., Malle E., Sattler W., Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture. Proteomics 2010 10 1 141 158 2-s2.0-73549123211 10.1002/pmic.200900195
51. Ulivieri C., Cell death: insights into the ultrastructure of mitochondria. Tissue and Cell 2010 42 6 339 347 2-s2.0-78649861831 10.1016/j.tice.2010.10.004
52. Youle R. J., van der Bliek A. M., Mitochondrial fission, fusion, and stress. Science 2012 337 6098 1062 1105
53. Cahard D., Canat X., Carayon P., Roque C., Casellas P., Le Fur G., Subcellular localization of peripheral benzodiazepine receptors on human leukocytes. Laboratory Investigation 1994 70 1 23 28 2-s2.0-0028204793 (Pubitemid 24080101)
54. Papadopoulos V., Boujrad N., Ikonomovic M. D., Ferrara P., Vidic B., Topography of the Leydig cell mitochondrial peripheral-type benzodiazepine receptor. Molecular and Cellular Endocrinology 1994 104 R5 R9
55. Bernal F., Petegnief V., Rodríguez M. J., Ursu G., Pugliese M., Mahy N., Nimodipine inhibits TMB-8 potentiation of AMPA-induced hippocampal neurodegeneration. Journal of Neuroscience Research 2009 87 5 1240 1249 2-s2.0-65949103634 10.1002/jnr.21930
56. Petegnief V., Ursu G., Bernal F., Mahy N., Nimodipine and TMB-8 potentiate the AMPA-induced lesion in the basal ganglia. Neurochemistry International 2004 44 4 287 291 2-s2.0-0242268072 10.1016/S0197-0186(03)00136-0 (Pubitemid 37340139)
57. Banati R. B., Newcombe J., Gunn R. N., Cagnin A., Turkheimer F., Heppner F., Price G., Wegner F., Giovannoni G., Miller D. H., Perkin G. D., Smith T., Hewson A. K., Bydder G., Kreutzberg G. W., Jones T., Cuzner M. L., Myers R., The peripheral benzodiazepine binding site in the brain in multiple sclerosis. Quantitative in vivo imaging of microglia as a measure of disease activity. Brain 2000 123 11 2321 2337 2-s2.0-0033768486
58. Malka F., Lombès A., Rojo M., Organization, dynamics and transmission of mitochondrial DNA: focus on vertebrate nucleoids. Biochimica et Biophysica Acta 2006 1763 5-6 463 472 2-s2.0-33745748154 10.1016/j.bbamcr.2006. 04.001 (Pubitemid 44015946)
59. Takai D., Isobe K., Hayashi J., Transcomplementation between different types of respiration-deficient mitochondria with different pathogenic mutant mitochondrial DNAs. Journal of Biological Chemistry 1999 274 16 11199 11202 2-s2.0-0033574532 10.1074/jbc.274.16.11199 (Pubitemid 29191111)
60. Kubli D. A., Gustafsson A. B., Mitochondria and mitophagy: the yin and yang of cell death control. Circulation Research 2012 111 9 1208 1221
61. Santos D., Cardoso S. M., Mitochondrial dynamics and neuronal fate in Parkinson's disease. Mitochondrion 2012 12 4 428 437
62. van Bergen N. J., Crowston J. G., Kearns L. S., Staffieri S. E., Hewitt A. W., Cohn A. C., Mackey D. A., Trounce I. A., Mitochondrial oxidative phosphorylation compensation may preserve vision in patients with OPA1-linked autosomal dominant optic atrophy. PLoS ONE 2011 6 6 2-s2.0-79959418295 10.1371/journal.pone.0021347 e21347
63. Matute C., Domercq M., Sánchez-Gómez M., Glutamate-mediated glial injury: mechanisms and clinical importance. Glia 2006 53 2 212 224 2-s2.0-33644797572 10.1002/glia.20275
64. Fischer M. T., Sharma R., Lim J. L., Haider L., Frischer J. M., Drexhage J., Mahad D., Bradl M., van Horssen J., Lassmann H., NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain 2012 135 3 886 899 2-s2.0-84857538385 10.1093/brain/aws012
65. Gras G., Porcheray F., Samah B., Leone C., The glutamate-glutamine cycle as an inducible, protective face of macrophage activation. Journal of Leukocyte Biology 2006 80 5 1067 1075 2-s2.0-33750481898 10.1189/jlb.0306153 (Pubitemid 44646312)
66. Svoboda N., Kerschbaum H. H., L-Glutamine-induced apoptosis in microglia is mediated by mitochondrial dysfunction. European Journal of Neuroscience 2009 30 2 196 206 2-s2.0-67651174723 10.1111/j.1460-9568.2009.06828.x
67. Rizzuto R., De Stefani D., Raffaello A., Mammucari C., Mitochondria as sensors and regulators of calcium signaling. Nature Reviews Molecular Cell Biology 2012 13 9 566 578
68. 2+ transport. Journal of Bioenergetics and Biomembranes 1994 26 5 495 508 2-s2.0-0027999790 10.1007/BF00762734 (Pubitemid 24378752)
69. McCormack J. G., Denton R. M., The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex. Biochemical Journal 1979 180 3 533 544 2-s2.0-0018363365 (Pubitemid 9208285)
70. McCormack J. G., Halestrap A. P., Denton R. M., Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiological Reviews 1990 70 2 391 425 2-s2.0-0025319665 (Pubitemid 20140186)
71. Rossignol R., Gilkerson R., Aggeler R., Yamagata K., Remington S. J., Capaldi R. A., Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Research 2004 64 3 985 993 2-s2.0-0842325793 10.1158/0008-5472.CAN-03-1101 (Pubitemid 38176901)
72. + channels. Pflugers Archiv European Journal of Physiology 1990 415 4 479 483 2-s2.0-0025162079 10.1007/BF00373626 (Pubitemid 20040708)
73. + channels in cardiac muscle. Journal of Molecular and Cellular Cardiology 2012 52 3 596 607 2-s2.0-84857639609 10.1016/j.yjmcc.2011.12.012
74. Levin B. E., Glucosensing neurons do more than just sense glucose. International Journal of Obesity 2001 25 5 S68 S72 2-s2.0-0035709033 10.1038/sj/ijo/0801916 (Pubitemid 34146327)
75. Kline C. F., Kurata H. T., Hund T. J., Cunha S. R., Koval O. M., Wright P. J., Christensen M., Anderson M. E., Nichols C. G., Mohler P. J., Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation. Proceedings of the National Academy of Sciences of the United States of America 2009 106 39 16669 16674 2-s2.0-70349736178 10.1073/pnas.0907138106
76. Craig T. J., Ashcroft F. M., Proks P., How ATP inhibits the open K ATP channel. Journal of General Physiology 2008 132 1 131 144 2-s2.0-48749119758 10.1085/jgp.200709874
77. Nichols C. G., Lederer W. J., Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. American Journal of Physiology 1991 261 6 H1675 H1686 2-s2.0-0026344826
78. Proks P., Ashcroft F. M., Modeling K ATP channel gating and its regulation. Progress in Biophysics and Molecular Biology 2009 99 1 7 19 2-s2.0-61749092746 10.1016/j.pbiomolbio.2008.10.002
79. Wheeler A., Wang C., Yang K., Fang K., Davis K., Styer A. M., Mirshahi U., Moreau C., Revilloud J., Vivaudou M., Liu S., Mirshahi T., Chan K. W., Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (K ATP) channels. Molecular Pharmacology 2008 74 5 1333 1344 2-s2.0-54349104463 10.1124/mol.108.048355
80. Chan K. W., Zhang H., Logothetis D. E., N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. The EMBO Journal 2003 22 15 3833 3843 2-s2.0-0042025073 10.1093/emboj/cdg376 (Pubitemid 36975711)
81. + channels in the absence of the sulphonylurea receptor. Nature 1997 387 6629 179 183 2-s2.0-0031005755 10.1038/387179a0 (Pubitemid 27209432)
82. Nichols C. G., K ATP channels as molecular sensors of cellular metabolism. Nature 2006 440 7083 470 476 2-s2.0-33645322386 10.1038/nature04711
83. M. Ashcroft F., M. Gribble F., New windows on the mechanism of action of K ATP channel openers. Trends in Pharmacological Sciences 2000 21 11 439 445 2-s2.0-0034326402 10.1016/S0165-6147(00)01563-7
84. Ashcroft F. M., Harrison D. E., Ashcroft S. J. H., Glucose induces closure of single potassium channels in isolated rat pancreatic β -cells. Nature 1984 312 5993 446 448 2-s2.0-0021741559 (Pubitemid 15217837)
85. + channels. Journal of Physiology 2000 528 3 509 520 2-s2.0-0034325296
86. Rosenblum W. I., ATP-sensitive potassium channels in the cerebral circulation. Stroke 2003 34 6 1547 1552 2-s2.0-0037637590 10.1161/01.STR. 0000070425.98202.B5 (Pubitemid 36693532)
87. 2 underlies glutamate-dependent inhibition of striatal dopamine release. Proceedings of the National Academy of Sciences of the United States of America 2003 100 20 11729 11734 2-s2.0-0141482021 10.1073/pnas.1834314100 (Pubitemid 37206003)
88. Yamada K., Juan Juan Ji J. J. J., Yuan H., Miki T., Sato S., Horimoto N., Shimizu T., Seino S., Inagaki N., Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science 2001 292 5521 1543 1546 2-s2.0-0035947177 10.1126/science.1059829 (Pubitemid 32493422)
89. + currents in human microglia. Neuroscience 2001 104 4 1175 1184 2-s2.0-0035800001 10.1016/S0306-4522(01)00119-1 (Pubitemid 32701976)
90. Ramonet D., Rodríguez M. J., Pugliese M., Mahy N., Putative glucosensing property in rat and human activated microglia. Neurobiology of Disease 2004 17 1 1 9 2-s2.0-4444377609 10.1016/j.nbd.2003.11.019 (Pubitemid 39209307)
91. Ortega F. J., Gimeno-Bayon J., Espinosa-Parrilla J. F., Carrasco J. L., Batlle M., Pugliese M., Mahy N., Rodríguez M. J., ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia-ischemia in rats. Experimental Neurology 2012 235 1 282 296 2-s2.0-84859922500 10.1016/j.expneurol.2012.02.010
92. Ortega F. J., Jolkkonen J., Mahy N., Rodríguez M. J., Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism 2013 33 356 364
93. Ardehali H., O'Rourke B., Mitochondrial K ATP channels in cell survival and death. Journal of Molecular and Cellular Cardiology 2005 39 1 7 16 2-s2.0-20644434910 10.1016/j.yjmcc.2004.12.003 (Pubitemid 40836042)
94. Garlid K. D., Paucek P., Yarov-Yarovoy V., Sun X., Schindler P. A., The mitochondrial K ATP channel as a receptor for potassium channel openers. Journal of Biological Chemistry 1996 271 15 8796 8799 2-s2.0-0029664623
95. Clement J. P. IV, Kunjilwar K., Gonzalez G., Schwanstecher M., Panten U., Aguilar-Bryan L., Bryan J., Association and stoichiometry of K ATP channel subunits. Neuron 1997 18 5 827 838 2-s2.0-0030996141 10.1016/S0896-6273(00) 80321-9 (Pubitemid 27232792)
96. Melander A., Lebovitz H. E., Faber O. K., Sulfonylureas: why, which, and how? Diabetes Care 1990 13 3 18 25 2-s2.0-0025131606 (Pubitemid 20323807)
97. Simard J. M., Woo S. K., Schwartzbauer G. T., Gerzanich V., Sulfonylurea receptor 1 in central nervous system injury: a focused review. Journal of Cerebral Blood Flow & Metabolism 2012 32 1699 1717
98. Dörschner H., Brekardin E., Uhde I., Schwanstecher C., Schwanstecher M., Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure. Molecular Pharmacology 1999 55 6 1060 1066 2-s2.0-0039351106 (Pubitemid 29252373)
99. Shyng S., Ferrigni T., Nichols C. G., Regulation of K ATP channel activity by diazoxide and MgADP: distinct functions of the two nucleotide binding folds of the sulfonylurea receptor. Journal of General Physiology 1997 110 6 643 654 2-s2.0-0030609142 10.1085/jgp.110.6.643 (Pubitemid 27524605)
100. Petit P., Loubatieres-Mariani M. M., Potassium channels of the insulin-secreting B cell. Fundamental & Clinical Pharmacology 1992 6 3 123 134 2-s2.0-0026642473
101. Koch Weser J., Diazoxide. The New England Journal of Medicine 1976 294 23 1271 1274 2-s2.0-0017140402
102. Warter A., Gillet B., Weryha A., Hagbe P., Simler M., Hypoglycemia due to insulinoma complicated with hepatic metastases. Excellent results after 20 months of treatment with diazoxide. Annales de Medecine Interne 1970 121 11 927 934 2-s2.0-0014874487
103. + channel in the mitochondrial inner membrane. Nature 1991 352 6332 244 247 2-s2.0-0025913049 10.1038/352244a0 (Pubitemid 21912326)
104. Bajgar R., Seetharaman S., Kowaltowski A. J., Garlid K. D., Paucek P., Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain. Journal of Biological Chemistry 2001 276 36 33369 33374 2-s2.0-0035823614 10.1074/jbc.M103320200
105. + channel in the brain. Brain Research 2003 994 1 27 36 2-s2.0-0344012088 10.1016/j.brainres.2003.09.046 (Pubitemid 37452434)
106. + channels in mitochondria. Biochemical and Biophysical Research Communications 1997 241 3 693 697 2-s2.0-0031590711 10.1006/bbrc.1997.7891 (Pubitemid 28036719)
107. + channels: possible mechanism of cardioprotection. Circulation Research 1997 81 6 1072 1082 2-s2.0-0030780773 (Pubitemid 27514958)
108. Iwai T., Tanonaka K., Koshimizu M., Takeo S., Preservation of mitochondrial function by diazoxide during sustained ischaemia in the rat heart. British Journal of Pharmacology 2000 129 6 1219 1227 2-s2.0-0034018057 (Pubitemid 30153979)
109. Iwai T., Tanonaka K., Motegi K., Inoue R., Kasahara S., Takeo S., Nicorandil preserves mitochondrial function during ischemia in perfused rat heart. European Journal of Pharmacology 2002 446 1-3 119 127 2-s2.0-0037141766 10.1016/S0014-2999(02)01645-X (Pubitemid 34722565)
110. Morin D., Assaly R., Paradis S., Berdeaux A., Inhibition of mitochondrial membrane permeability as a putative pharmacological target for cardioprotection. Current Medicinal Chemistry 2009 16 33 4382 4398 2-s2.0-70450180180 10.2174/092986709789712871
111. Peart J. N., Gross G. J., Sarcolemmal and mitochondrial K ATP channels and myocardial ischemic preconditioning. Journal of Cellular and Molecular Medicine 2002 6 4 453 464 2-s2.0-0038362291 (Pubitemid 44146430)
112. Brustovetsky T., Shalbuyeva N., Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive K ATP channel in rat brain nonsynaptosomal mitochondria. Journal of Physiology 2005 568 1 47 59 2-s2.0-26844476810 10.1113/jphysiol.2005.091199 (Pubitemid 41448619)
113. Hansson M. J., Morota S., Teilum M., Mattiasson G., Uchino H., Elmér E., Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume. Journal of Biological Chemistry 2010 285 1 741 750 2-s2.0-73649092745 10.1074/jbc.M109. 017731
114. Hanley P. J., Dröse S., Brandt U., Lareau R. A., Banerjee A. L., Srivastava D. K., Banaszak L. J., Barycki J. J., van Veldhoven P. P., Daut J., 5-hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for β -oxidation of fatty acids. Journal of Physiology 2005 562 2 307 318 2-s2.0-19944430244 10.1113/jphysiol.2004.073932
115. 2+ transients in rat ventricular myocytes. Circulation 2002 105 22 2666 2671 2-s2.0-0037024327 10.1161/01.CIR.0000016831.41648.04 (Pubitemid 34596045)
116. Garlid K. D., Halestrap A. P., The mitochondrial K ATP channel-Fact or fiction? Journal of Molecular and Cellular Cardiology 2012 52 3 578 583 2-s2.0-84857627495 10.1016/j.yjmcc.2011.12.011
117. + cycle. Biochimica et Biophysica Acta 2003 1606 1-3 23 41 2-s2.0-0142011184 10.1016/S0005-2728(03)00108-7 (Pubitemid 37267868)
118. + channel of heart mitochondria. American Journal of Physiology 2001 280 2 H649 H657 2-s2.0-0034996661
119. Huang Q., Guo Z., Yu Y., Ghatnekar G. S., Ghatnekar A. V., Bu M., Guo X., Liu S., Wang F., Feng Z., Bu S., Diazoxide inhibits aortic endothelial cell apoptosis in diabetic rats via activation of ERK. Acta Diabetologica 2011 1 10 2-s2.0-79955441285 10.1007/s00592-011-0288-7
120. Foster D. B., Ho A. S., Rucker J., Garlid A. O., Chen L., Sidor A., Garlid K. D., O'Rourke B., Mitochondrial ROMK channel is a molecular component of mito K ATP. Circulation Research 2012 111 4 446 454
121. Hu H., Sato T., Seharaseyon J., Liu Y., Johns D. C., O'Rourke B., Marbán E., Pharmacological and histochemical distinctions between molecularly defined sarcolemmal K ATP channels and native cardiac mitochondrial K ATP channels. Molecular Pharmacology 1999 55 6 1000 1005 2-s2.0-0033022308 (Pubitemid 29252364)
122. Virgili N., Espinosa-Parrilla J. F., Mancera P., Pastén-Zamorano A., Gimeno-Bayon J., Rodríguez M. J., Mahy N., Pugliese M., Oral administration of the K ATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis. Journal of Neuroinflammation 2011 8, article 149 2-s2.0-80055104589 10.1186/1742-2094-8-149
123. + channel openers protect hippocampal neurons against oxidative injury and amyloid β -peptide toxicity. Brain Research 1996 706 2 328 332 2-s2.0-0030050677 10.1016/0006-8993(95)01367-9 (Pubitemid 26048687)
124. Robin E., Simerabet M., Hassoun S. M., Adamczyk S., Tavernier B., Vallet B., Bordet R., Lebuffe G., Postconditioning in focal cerebral ischemia: role of the mitochondrial ATP-dependent potassium channel. Brain Research 2011 1375 137 146 2-s2.0-79651472049 10.1016/j.brainres.2010.12.054
125. Roseborough G., Gao D., Chen L., Trush M. A., Zhou S., Williams G. M., Wei C., The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord. American Journal of Pathology 2006 168 5 1443 1451 2-s2.0-33646535884 10.2353/ajpath.2006.050569
126. Zhou F., Yao H., Wu J., Ding J., Sun T., Hu G., Opening of microglial K ATP channels inhibits rotenone-induced neuroinflammation. Journal of Cellular and Molecular Medicine 2008 12 5A 1559 1570 2-s2.0-54049142448 10.1111/j.1582-4934.2007.00144.x
127. Mastrangelo M. A., Bowers W. J., Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice. BMC Neuroscience 2008 9, article 81 2-s2.0-51049120310 10.1186/1471-2202-9-81
128. Liu D., Pitta M., Lee J., Ray B., Lahiri D. K., Furukawa K., Mughal M., Jiang H., Villarreal J., Cutler R. G., Greig N. H., Mattson M. P., The K ATP channel activator diazoxide ameliorates amyloid- β and Tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. Journal of Alzheimer's Disease 2010 22 2 443 457 2-s2.0-78650844057 10.3233/JAD-2010-101017
129. Ma G., Fu Q., Zhang Y., Gao J., Jiang J., Bi A., Liu K., Du Y., Chen C., Cui Y., Lu L., Effects of A β 1-42 on the subunits of K ATP expression in cultured primary rat basal forebrain neurons. Neurochemical Research 2008 33 7 1419 1424 2-s2.0-44549083447 10.1007/s11064-008-9603-2
130. Caldeira G. L., Ferreira I. L., Rego A. C., Impaired transcription in Alzheimer's disease: key role in mitochondrial dysfunction and oxidative stress. Journal of Alzheimer's Disease 2013 34 115 131
131. Sadowski M., Pankiewicz J., Scholtzova H., Ji Y., Quartermain D., Jensen C. H., Duff K., Nixon R. A., Gruen R. J., Wisniewsk T., Amyloid- β deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. Journal of Neuropathology and Experimental Neurology 2004 63 5 418 428 2-s2.0-2442664058 (Pubitemid 38669663)
132. Rodríguez M. J., Martínez-Sánchez M., Bernal F., Mahy N., Heterogeneity between hippocampal and septal astroglia as a contributing factor to differential in vivo AMPA excitotoxicity. Journal of Neuroscience Research 2004 77 3 344 353 2-s2.0-3242745888 10.1002/jnr.20177 (Pubitemid 38970978)
133. Rodríguez M. J., Prats A., Malpesa Y., Andrés N., Pugliese M., Batlle M., Mahy N., Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain. Journal of Neurotrauma 2009 26 10 1823 1834 2-s2.0-70450191618 10.1089/neu.2008.0553
134. 2+ overload in rat cardiac mitochondria. Journal of Physiology 1999 519 2 347 360 2-s2.0-0033199875 10.1111/j.1469-7793. 1999.0347m.x (Pubitemid 29429999)
135. + channel for cardiac protection against ischemic injury is dependent on protein kinase C activity. Circulation Research 1999 85 8 731 741 2-s2.0-0033570269 (Pubitemid 29480814)