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Volumn 30, Issue 2, 2009, Pages 196-206

L-Glutamine-induced apoptosis in microglia is mediated by mitochondrial dysfunction

Author keywords

Ammonium; Cell death; Mouse; Oxidative stress

Indexed keywords

AMMONIA; CASPASE 3; CASPASE 9; GLUTAMATE AMMONIA LIGASE; GLUTAMINASE; GLUTAMINE; REACTIVE OXYGEN METABOLITE;

EID: 67651174723     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2009.06828.x     Document Type: Article
Times cited : (29)

References (28)
  • 1
    • 33750608704 scopus 로고    scopus 로고
    • Glutamine: A Trojan horse in ammonia neurotoxicity
    • Albrecht, J. Norenberg, M.D. (2006) Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology, 44, 788 794.
    • (2006) Hepatology , vol.44 , pp. 788-794
    • Albrecht, J.1    Norenberg, M.D.2
  • 2
    • 27644561355 scopus 로고    scopus 로고
    • Neuroenergetics and the kinetic design of excitatory synapses
    • Attwell, D. Gibb, A. (2005) Neuroenergetics and the kinetic design of excitatory synapses. Nat. Rev. Neurosci., 6, 841 849.
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 841-849
    • Attwell, D.1    Gibb, A.2
  • 4
    • 33750481898 scopus 로고    scopus 로고
    • The glutamate-glutamine cycle as an inducible, protective face of macrophage activation
    • Gras, G., Porcheray, F., Samah, B. Leone, C. (2006) The glutamate-glutamine cycle as an inducible, protective face of macrophage activation. J. Leukoc. Biol., 80, 1067 1075.
    • (2006) J. Leukoc. Biol. , vol.80 , pp. 1067-1075
    • Gras, G.1    Porcheray, F.2    Samah, B.3    Leone, C.4
  • 5
    • 47849099861 scopus 로고    scopus 로고
    • Ammonium-dependent hydrogen peroxide production by mitochondria
    • Grivennikova, V.G., Cecchini, G. Vinogradov, A.D. (2008) Ammonium-dependent hydrogen peroxide production by mitochondria. FEBS Lett., 582, 2719 2724.
    • (2008) FEBS Lett. , vol.582 , pp. 2719-2724
    • Grivennikova, V.G.1    Cecchini, G.2    Vinogradov, A.D.3
  • 6
    • 0037301661 scopus 로고    scopus 로고
    • The Yin and Yang of NMDA receptor signalling
    • Hardingham, G.E. Bading, H. (2003) The Yin and Yang of NMDA receptor signalling. Trends Neurosci., 26, 81 89.
    • (2003) Trends Neurosci. , vol.26 , pp. 81-89
    • Hardingham, G.E.1    Bading, H.2
  • 7
    • 48849088677 scopus 로고    scopus 로고
    • Bioenergetics of cerebral ischemia: A cellular perspective
    • Hertz, L. (2008) Bioenergetics of cerebral ischemia: a cellular perspective. Neuropharmacology, 55, 289 309.
    • (2008) Neuropharmacology , vol.55 , pp. 289-309
    • Hertz, L.1
  • 8
    • 8444243043 scopus 로고    scopus 로고
    • Astrocytic control of glutamatergic activity: Astrocytes as stars of the show
    • Hertz, L. Zielke, H.R. (2004) Astrocytic control of glutamatergic activity: astrocytes as stars of the show. Trends Neurosci., 27, 735 743.
    • (2004) Trends Neurosci. , vol.27 , pp. 735-743
    • Hertz, L.1    Zielke, H.R.2
  • 9
    • 34248163885 scopus 로고    scopus 로고
    • Bacterial hydrogen peroxide contributes to cerebral hyperemia during early stages of experimental pneumococcal meningitis
    • Hoffmann, O.M., Becker, D. Weber, J.R. (2007) Bacterial hydrogen peroxide contributes to cerebral hyperemia during early stages of experimental pneumococcal meningitis. J. Cereb. Blood Flow Metab., 27, 1792 1797.
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 1792-1797
    • Hoffmann, O.M.1    Becker, D.2    Weber, J.R.3
  • 10
    • 2542491081 scopus 로고    scopus 로고
    • Glutamine-induced free radical production in cultured astrocytes
    • Jayakumar, A.R., Rama Rao, K.V., Schousboe, A. Norenberg, M.D. (2004) Glutamine-induced free radical production in cultured astrocytes. Glia, 46, 296 301.
    • (2004) Glia , vol.46 , pp. 296-301
    • Jayakumar, A.R.1    Rama Rao, K.V.2    Schousboe, A.3    Norenberg, M.D.4
  • 11
    • 25144489068 scopus 로고    scopus 로고
    • Overview of cell death signaling pathways
    • Jin, Z. El-Deiry, W.S. (2005) Overview of cell death signaling pathways. Cancer Biol. Ther., 4, 139 163.
    • (2005) Cancer Biol. Ther. , vol.4 , pp. 139-163
    • Jin, Z.1    El-Deiry, W.S.2
  • 13
    • 27844495164 scopus 로고    scopus 로고
    • Molecular basis of programmed cell death involved in neurodegeneration
    • Krantic, S., Mechawar, N., Reix, S. Quirion, R. (2005) Molecular basis of programmed cell death involved in neurodegeneration. Trends Neurosci., 28, 670 676.
    • (2005) Trends Neurosci. , vol.28 , pp. 670-676
    • Krantic, S.1    Mechawar, N.2    Reix, S.3    Quirion, R.4
  • 14
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • DOI 10.1152/physrev.00013.2006
    • Kroemer, G., Galluzzi, L. Brenner, C. (2007) Mitochondrial membrane permeabilization in cell death. Physiol. Rev., 87, 99 163. (Pubitemid 46209992)
    • (2007) Physiological Reviews , vol.87 , Issue.1 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 16
    • 10244226729 scopus 로고    scopus 로고
    • Ammonia neurotoxicity and the mitochondrial permeability transition
    • Norenberg, M.D., Rama Rao, K.V. Jayakumar, A.R. (2004) Ammonia neurotoxicity and the mitochondrial permeability transition. J. Bioenerg. Biomembr., 36, 303 307.
    • (2004) J. Bioenerg. Biomembr. , vol.36 , pp. 303-307
    • Norenberg, M.D.1    Rama Rao, K.V.2    Jayakumar, A.R.3
  • 17
    • 20544451967 scopus 로고    scopus 로고
    • Cerebral metabolic disturbances in the brain during acute liver failure: From hyperammonemia to energy failure and proteolysis
    • Ott, P., Clemmesen, O. Larsen, F.S. (2005) Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem. Int., 47, 13 18.
    • (2005) Neurochem. Int. , vol.47 , pp. 13-18
    • Ott, P.1    Clemmesen, O.2    Larsen, F.S.3
  • 19
    • 34848843543 scopus 로고    scopus 로고
    • Neurotransmitter receptors on microglia
    • Pocock, J.M. Kettenmann, H. (2007) Neurotransmitter receptors on microglia. Trends Neurosci., 30, 527 535.
    • (2007) Trends Neurosci. , vol.30 , pp. 527-535
    • Pocock, J.M.1    Kettenmann, H.2
  • 20
    • 0038741859 scopus 로고    scopus 로고
    • Induction of the mitochondrial permeability transition in cultured astrocytes by glutamine
    • Rama Rao, K.V., Jayakumar, A.R. Norenberg, M.D. (2003) Induction of the mitochondrial permeability transition in cultured astrocytes by glutamine. Neurochem. Int., 43, 517 523.
    • (2003) Neurochem. Int. , vol.43 , pp. 517-523
    • Rama Rao, K.V.1    Jayakumar, A.R.2    Norenberg, M.D.3
  • 21
    • 35548957889 scopus 로고    scopus 로고
    • Astrocyte metabolism and signaling during brain ischemia
    • Rossi, D.J., Brady, J.D. Mohr, C. (2007) Astrocyte metabolism and signaling during brain ischemia. Nat. Neurosci., 10, 1377 1386.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1377-1386
    • Rossi, D.J.1    Brady, J.D.2    Mohr, C.3
  • 23
    • 67651180228 scopus 로고    scopus 로고
    • Glutamine partially mediates toxic effects of ammonia in microglial cells
    • Svoboda, N. Kerschbaum, H.H. (2008) Glutamine partially mediates toxic effects of ammonia in microglial cells. FENS Abstr., 4, A052.
    • (2008) FENS Abstr. , vol.4 , pp. 052
    • Svoboda, N.1    Kerschbaum, H.H.2
  • 24
    • 34247209255 scopus 로고    scopus 로고
    • CAMP mediates ammonia-induced programmed cell death in the microglial cell line, BV-2
    • Svoboda, N., Zierler, S. Kerschbaum, H.H. (2007) cAMP mediates ammonia-induced programmed cell death in the microglial cell line, BV-2. Eur. J. Neurosci., 25, 2285 2295.
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 2285-2295
    • Svoboda, N.1    Zierler, S.2    Kerschbaum, H.H.3
  • 25
    • 34547673497 scopus 로고    scopus 로고
    • Peroxynitrite: Biochemistry, pathophysiology and development of therapeutics
    • Szabó, C., Ischiropoulos, H. Radi, R. (2007) Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat. Rev. Drug Discov., 6, 662 680.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 662-680
    • Szabó, C.1    Ischiropoulos, H.2    Radi, R.3
  • 26
    • 34547435817 scopus 로고    scopus 로고
    • Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
    • Tilleux, S. Hermans, E. (2007) Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J. Neurosci. Res., 85, 2059 2070.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 2059-2070
    • Tilleux, S.1    Hermans, E.2
  • 27
    • 0001697979 scopus 로고
    • Effect of an inhibitor of glutamine synthesis (methionine sulfoximine) on ammonia toxicity and metabolism
    • Warren, K.S. Schenker, S. (1964) Effect of an inhibitor of glutamine synthesis (methionine sulfoximine) on ammonia toxicity and metabolism. J. Lab. Clin. Med., 64, 442 449.
    • (1964) J. Lab. Clin. Med. , vol.64 , pp. 442-449
    • Warren, K.S.1    Schenker, S.2
  • 28
    • 33750697954 scopus 로고    scopus 로고
    • Ultraviolet irradiation-induced apoptosis does not trigger nuclear fragmentation but translocation of chromatin from nucleus into cytoplasm in the microglial cell-line, BV-2
    • Zierler, S., Klein, B., Furtner, T., Bresgen, N., Lutz-Meindl, U. Kerschbaum, H.H. (2006) Ultraviolet irradiation-induced apoptosis does not trigger nuclear fragmentation but translocation of chromatin from nucleus into cytoplasm in the microglial cell-line, BV-2. Brain Res., 1121, 12 21.
    • (2006) Brain Res. , vol.1121 , pp. 12-21
    • Zierler, S.1    Klein, B.2    Furtner, T.3    Bresgen, N.4    Lutz-Meindl, U.5    Kerschbaum, H.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.