ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia-ischemia in rats

Experimental Neurology

Volumn 235, Issue 1, 2012, Pages 282-296

  Ortega, F J ^a,b   Gimeno Bayon, J ^a,b   Espinosa Parrilla, J F ^a,b   Carrasco, J L ^a   Batlle, M ^a,b   Pugliese, M ^a,b   Mahy, N ^a,b   Rodriguez M J ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

BV2 cells; Glibenclamide; KATP channel; Microglia; Neuroprotection; Stroke; Sulphonylurea receptor

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; SULFONYLUREA RECEPTOR; SULFONYLUREA RECEPTOR 1; SULFONYLUREA RECEPTOR 2A; SULFONYLUREA RECEPTOR 2B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN NECROSIS; CELL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DOSE COMPARISON; DRUG MECHANISM; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE; MACROGLIA; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; SIGNAL TRANSDUCTION; STROKE; UPREGULATION;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYBURIDE; HYPOXIA-ISCHEMIA, BRAIN; KATP CHANNELS; MALE; MICE; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, WISTAR; RECOVERY OF FUNCTION;

EID: 84859922500     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.02.010     Document Type: Article

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