Organization, dynamics and transmission of mitochondrial DNA: Focus on vertebrate nucleoids

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1763, Issue 5-6, 2006, Pages 463-472

  Malka, Florence ^a   Lombès, Anne ^a   Rojo, Manuel ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Mitochondrial DNA; Mitochondrial genetics; Mitochondrial nucleoid

Indexed keywords

DNA BINDING PROTEIN; MITOCHONDRIAL DNA;

CROSS LINKING; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA BINDING; DNA POLYMORPHISM; DROSOPHILA; ELECTRON MICROSCOPY; EMBRYO DEVELOPMENT; ENDODERM; EUKARYOTE; FLUORESCENCE MICROSCOPY; GENE MUTATION; GENOTYPE; HETEROPLASMY; IMMUNOGOLD LABELING; MAMMAL; MITOCHONDRIAL GENETICS; NONHUMAN; OOCYTE DEVELOPMENT; PHYSARUM POLYCEPHALUM; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; REVIEW; SKIN FIBROBLAST; TROPHOBLAST; VERTEBRATE; XENOPUS; YEAST;

EUKARYOTA; SACCHAROMYCETALES; VERTEBRATA;

EID: 33745748154     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2006.04.001     Document Type: Review

References (137)

1. Ernster L., and Schatz G. Mitochondria: a historical review. J. Cell Biol. 91 (1981) 227s-255s
2. Williamson D. The curious history of yeast mitochondrial DNA. Nat. Rev., Genet. 3 (2002) 475-481
3. Mounolou J.C., and Lacroute F. Mitochondrial DNA: an advance in eukaryotic cell biology in the 1960s. Biol. Cell 97 (2005) 743-748
4. Burger G., Gray M.W., and Lang B.F. Mitochondrial genomes: anything goes. Trends Genet. 19 (2003) 709-716
5. Kuroiwa T. Mitochondrial nuclei. Int. Rev. Cytol. 75 (1982) 1-59
6. Contamine V., and Picard M. Maintenance and integrity of the mitochondrial genome: a plethora of nuclear genes in the budding yeast. Microbiol. Mol. Biol. Rev. 64 (2000) 281-315
7. Berger K.H., and Yaffe M.P. Mitochondrial DNA inheritance in Saccharomyces cerevisiae. Trends Microbiol. 8 (2000) 508-513
8. Scott S.V., Cassidy-Stone A., Meeusen S.L., and Nunnari J. Staying in aerobic shape: how the structural integrity of mitochondria and mitochondrial DNA is maintained. Curr. Opin. Cell Biol. 15 (2003) 482-488
9. Chen X.J., and Butow R.A. The organization and inheritance of the mitochondrial genome. Nat. Rev., Genet. 6 (2005) 815-825
10. Lukes J., Guilbride D.L., Votypka J., Zikova A., Benne R., and Englund P.T. Kinetoplast DNA network: evolution of an improbable structure. Eukaryotic Cell 1 (2002) 495-502
11. Boore J.L. Animal mitochondrial genomes. Nucleic Acids Res. 27 (1999) 1767-1780
12. Maleszka R., Skelly P.J., and Clark-Walker G.D. Rolling circle replication of DNA in yeast mitochondria. EMBO J. 10 (1991) 3923-3929
13. Bendich A.J. Structural analysis of mitochondrial DNA molecules from fungi and plants using moving pictures and pulsed-field gel electrophoresis. J. Mol. Biol. 255 (1996) 564-588
14. Dujon B. Mitochondrial genetics and functions. In: Strathern J.N., Jones E.W., and Broach J.R. (Eds). The Molecular Biology of the Yeast Saccharomyces. Life Cycle and Inheritance vol. 1 (1981), Cold Spring Harbor Laboratory Press, Cold Spring Harbor 505-635
15. King M.P., and Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 246 (1989) 500-503
16. Inoue K., Ito S., Takai D., Soejima A., Shisa H., LePecq J.B., SegalBendirdjian E., Kagawa Y., and Hayashi J.I. Isolation of mitochondrial DNA-less mouse cell lines and their application for trapping mouse synaptosomal mitochondrial DNA with deletion mutations. J. Biol. Chem. 272 24 (1997) 15510-15515
17. Larsson N.G., Wang J., Wilhelmsson H., Oldfors A., Rustin P., Lewandoski M., Barsh G.S., and Clayton D.A. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat. Genet. 18 (1998) 231-236
18. Kaukonen J., Juselius J.K., Tiranti V., Kyttala A., Zeviani M., Comi G.P., Keranen S., Peltonen L., and Suomalainen A. Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science 289 (2000) 782-785
19. Spelbrink J.N., Li F.Y., Tiranti V., Nikali K., Yuan Q.P., Tariq M., Wanrooij S., Garrido N., Comi G., Morandi L., Santoro L., Toscano A., Fabrizi G.M., Somer H., Croxen R., Beeson D., Poulton J., Suomalainen A., Jacobs H.T., Zeviani M., and Larsson C. Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat. Genet. 28 (2001) 223-231
20. Van Goethem G., Dermaut B., Lofgren A., Martin J.J., and Van Broeckhoven C. Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions. Nat. Genet. 28 (2001) 211-212
21. Mandel H., Szargel R., Labay V., Elpeleg O., Saada A., Shalata A., Anbinder Y., Berkowitz D., Hartman C., Barak M., Eriksson S., and Cohen N. The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA. Nat. Genet. 29 (2001) 337-341
22. Saada A., Shaag A., Mandel H., Nevo Y., Eriksson S., and Elpeleg O. Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. Nat. Genet. 29 (2001) 342-344
23. Yaffe M.P. The machinery of mitochondrial inheritance and behavior. Science 283 (1999) 1493-1497
24. Brown W.M., George Jr. M., and Wilson A.C. Rapid evolution of animal mitochondrial DNA. Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 1967-1971
25. Hauswirth W.W., and Laipis P.J. Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows. Proc. Natl. Acad. Sci. U. S. A. 79 (1982) 4686-4690
26. Wallace D.C. Mitochondrial diseases in man and mouse. Science 283 (1999) 1482-1488
27. Fayet G., Jansson M., Sternberg D., Moslemi A.R., Blondy P., Lombes A., Fardeau M., and Oldfors A. Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function. Neuromuscul. Disord. 12 (2002) 484-493
28. Chinnery P.F., Thorburn D.R., Samuels D.C., White S.L., Dahl H.M., Turnbull D.M., Lightowlers R.N., and Howell N. The inheritance of mitochondrial DNA heteroplasmy: random drift, selection or both?. Trends Genet. 16 (2000) 500-505
29. Hauswirth W.W., and Laipis P.J. Transmission genetics of mammalian mitochondria: a molecular model and experimental evidence. In: Quagliariello E. (Ed). Achievements and Perspectives of Mitochondrial Research (1985), Elsevier, Amsterdam 49-59
30. Jenuth J.P., Peterson A.C., Fu K., and Shoubridge E.A. Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA. Nat. Genet. 14 (1996) 146-151
31. Brown D.T., Samuels D.C., Michael E.M., Turnbull D.M., and Chinnery P.F. Random genetic drift determines the level of mutant mtDNA in human primary oocytes. Am. J. Hum. Genet. 68 (2001) 533-536
32. Piko L., and Taylor K.D. Amounts of mitochondrial DNA and abundance of some mitochondrial gene transcripts in early mouse embryos. Dev. Biol. 123 (1987) 364-374
33. Macmillan C., Lach B., and Shoubridge E.A. Variable distribution of mutant mitochondrial DNAs (tRNA(Leu[3243])) in tissues of symptomatic relatives with MELAS: the role of mitotic segregation. Neurology 43 (1993) 1586-1590
34. Chinnery P.F., Zwijnenburg P.J., Walker M., Howell N., Taylor R.W., Lightowlers R.N., Bindoff L., and Turnbull D.M. Nonrandom tissue distribution of mutant mtDNA. Am. J. Med. Genet. 85 (1999) 498-501
35. Jenuth J.P., Peterson A.C., and Shoubridge E.A. Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice. Nat. Genet. 16 (1997) 93-95
36. Battersby B.J., Loredo-Osti J.C., and Shoubridge E.A. Nuclear genetic control of mitochondrial DNA segregation. Nat. Genet. 33 (2003) 183-186
37. Battersby B.J., and Shoubridge E.A. Selection of a mtDNA sequence variant in hepatocytes of heteroplasmic mice is not due to differences in respiratory chain function or efficiency of replication. Hum. Mol. Genet. 10 (2001) 2469-2479
38. Battersby B.J., Redpath M.E., and Shoubridge E.A. Mitochondrial DNA segregation in hematopoietic lineages does not depend on MHC presentation of mitochondrially encoded peptides. Hum. Mol. Genet. 14 (2005) 2587-2594
39. Chinnery P.F., Howell N., Lightowlers R.N., and Turnbull D.M. MELAS and MERRF. The relationship between maternal mutation load and the frequency of clinically affected offspring. Brain 121 (1998) 1889-1894
40. Chinnery P.F., DiMauro S., Shanske S., Schon E.A., Zeviani M., Mariotti C., Carrara F., Lombes A., Laforet P., Ogier H., Jaksch M., Lochmuller H., Horvath R., Deschauer M., Thorburn D.R., Bindoff L.A., Poulton J., Taylor R.W., Matthews J.N., and Turnbull D.M. Risk of developing a mitochondrial DNA deletion disorder. Lancet 364 (2004) 592-596
41. Leonard J.V., and Schapira A.H. Mitochondrial respiratory chain disorders I: mitochondrial DNA defects. Lancet 355 (2000) 299-304
42. Poulton J., and Marchington D.R. Segregation of mitochondrial DNA (mtDNA) in human oocytes and in animal models of mtDNA disease: clinical implications. Reproduction 123 (2002) 751-755
43. Birky Jr. C.W. The inheritance of genes in mitochondria and chloroplasts: laws, mechanisms, and models. Annu. Rev. Genet. 35 (2001) 125-148
44. Jacobs H.T., Lehtinen S.K., and Spelbrink J.N. No sex please, we're mitochondria: a hypothesis on the somatic unit of inheritance of mammalian mtDNA. BioEssays 22 (2000) 564-572
45. Nass S., and Nass M.M. Intramitochondrial fibers with DNA characteristics. II. Enzymatic and other hydrolytic treatments. J. Cell Biol. 19 (1963) 613-629
46. Nass M.M., and Nass S. Intramitochondrial fibers with DNA characteristics. I. Fixation and electron staining reactions. J. Cell Biol. 19 (1963) 593-611
47. Nass M.M., Nass S., and Afzelius B.A. The general occurrence of mitochondrial DNA. Exp. Cell Res. 37 (1965) 516-539
48. Nass M.M. The circularity of mitochondrial DNA. Proc. Natl. Acad. Sci. U. S. A. 56 (1966) 1215-1222
49. Albring M., Griffith J., and Attardi G. Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication. Proc. Natl. Acad. Sci. U. S. A. 74 (1977) 1348-1352
50. Nass M.M. Mitochondrial DNA. I. Intramitochondrial distribution and structural relations of single- and double-length circular DNA. J. Mol. Biol. 42 (1969) 521-528
51. Iborra F.J., Kimura H., and Cook P.R. The functional organization of mitochondrial genomes in human cells. BMC Biol. 2 (2004) 9
52. Cavelier L., Johannisson A., and Gyllensten U. Analysis of mtDNA copy number and composition of single mitochondrial particles using flow cytometry and PCR. Exp. Cell Res. 259 (2000) 79-85
53. Satoh M., and Kuroiwa T. Organization of multiple nucleoids and DNA molecules in mitochondria of a human cell. Exp. Cell Res. 196 (1991) 137-140
54. Legros F., Malka F., Frachon P., Lombès A., and Rojo M. Organization and dynamics of human mitochondrial DNA. J. Cell Sci. 117 (2004) 2653-2662
55. Stevens B. Mitochondrial structure. In: Strathern J.N., Jones E.W., and Broach J.R. (Eds). The Molecular Biology of the Yeast Saccharomyces. Life Cycle and Inheritance vol. 1 (1981), Cold Spring Harbor Laboratory Press, Cold Spring Harbor 471-504
56. Hayashi J., Takemitsu M., Goto Y., and Nonaka I. Human mitochondria and mitochondrial genome function as a single dynamic cellular unit. J. Cell Biol. 125 (1994) 43-50
57. Coppey-Moisan M., Brunet A.C., Morais R., and Coppey J. Dynamical change of mitochondrial DNA induced in the living cell by perturbing the electrochemical gradient. Biophys. J. 71 (1996) 2319-2328
58. Dellinger M., and Geze M. Detection of mitochondrial DNA in living animal cells with fluorescence microscopy. J. Microsc. 204 (2001) 196-202
59. Margineantu D.H., Gregory Cox W., Sundell L., Sherwood S.W., Beechem J.M., and Capaldi R.A. Cell cycle dependent morphology changes and associated mitochondrial DNA redistribution in mitochondria of human cell lines. Mitochondrion 1 (2002) 425-435
60. Ashley N., Harris D., and Poulton J. Detection of mitochondrial DNA depletion in living human cells using PicoGreen staining. Exp. Cell Res. 303 (2005) 432-446
61. Magnusson J., Orth M., Lestienne P., and Taanman J.W. Replication of mitochondrial DNA occurs throughout the mitochondria of cultured human cells. Exp. Cell Res. 289 (2003) 133-142
62. Garrido N., Griparic L., Jokitalo E., Wartiovaara J., Van Der Bliek A.M., and Spelbrink J.N. Composition and dynamics of human mitochondrial nucleoids. Mol. Biol. Cell 14 (2003) 1583-1596
63. Shmookler Reis R.J., and Goldstein S. Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation. J. Biol. Chem. 258 (1983) 9078-9085
64. Moraes C.T. What regulates mitochondrial DNA copy number in animal cells?. Trends Genet. 17 (2001) 199-205
65. Mita S., Schmidt B., Schon E.A., DiMauro S., and Bonilla E. Detection of "deleted" mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 9509-9513
66. Shoubridge E.A., Karpati G., and Hastings K.E. Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease. Cell 62 (1990) 43-49
67. Lehtinen S.K., Hance N., El Meziane A., Juhola M.K., Juhola K.M., Karhu R., Spelbrink J.N., Holt I.J., and Jacobs H.T. Genotypic stability, segregation and selection in heteroplasmic human cell lines containing np 3243 mutant mtDNA. Genetics 154 (2000) 363-380
68. Korhonen J.A., Pham X.H., Pellegrini M., and Falkenberg M. Reconstitution of a minimal mtDNA replisome in vitro. EMBO J. 23 (2004) 2423-2429
69. Gaspari M., Larsson N.G., and Gustafsson C.M. The transcription machinery in mammalian mitochondria. Biochim. Biophys. Acta 1659 (2004) 148-152
70. Stuart J.A., Mayard S., Hashiguchi K., Souza-Pinto N.C., and Bohr V.A. Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction. Nucleic Acids Res. 33 (2005) 3722-3732
71. D'Aurelio M., Gajewski C.D., Lin M.T., Mauck W.M., Shao L.Z., Lenaz G., Moraes C.T., and Manfredi G. Heterologous mitochondrial DNA recombination in human cells. Hum. Mol. Genet. 13 (2004) 3171-3179
72. Tsaousis A.D., Martin D.P., Ladoukakis E.D., Posada D., and Zouros E. Widespread recombination in published animal mtDNA sequences. Mol. Biol. Evol. 22 (2005) 925-933
73. Diffley J.F., and Stillman B. A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 7864-7868
74. Caron F., Jacq C., and Rouviere-Yaniv J. Characterization of a histone-like protein extracted from yeast mitochondria. Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 4265-4269
75. Newman S.M., Zelenaya-Troitskaya O., Perlman P.S., and Butow R.A. Analysis of mitochondrial DNA nucleoids in wild-type and a mutant strain of Saccharomyces cerevisiae that lacks the mitochondrial HMG box protein Abf2p. Nucleic Acids Res. 24 (1996) 386-393
76. Bianchi M.E. Prokaryotic HU and eukaryotic HMG1: a linked relationship. Mol. Microbiol. 14 (1994) 1-5
77. Oberto J., Drlica K., and Rouviere-Yaniv J. Histones, HMG, HU, IHF: Meme combat. Biochimie 76 (1994) 901-908
78. Parisi M.A., and Clayton D.A. Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science 252 (1991) 965-969
79. Antoshechkin I., and Bogenhagen D.F. Distinct roles for two purified factors in transcription of Xenopus mitochondrial DNA. Mol. Cell Biol. 15 (1995) 7032-7042
80. Takata K., Yoshida H., Hirose F., Yamaguchi M., Kai M., Oshige M., Sakimoto I., Koiwai O., and Sakaguchi K. Drosophila mitochondrial transcription factor A: characterization of its cDNA and expression pattern during development. Biochem. Biophys. Res. Commun. 287 (2001) 474-483
81. Sasaki N., Kuroiwa H., Nishitani C., Takano H., Higashiyama T., Kobayashi T., Shirai Y., Sakai A., Kawano S., Murakami-Murofushi K., and Kuroiwa T. Glom is a novel mitochondrial DNA packaging protein in Physarum polycephalum and causes intense chromatin condensation without suppressing DNA functions. Mol. Biol. Cell 14 (2003) 4758-4769
82. Alam T.I., Kanki T., Muta T., Ukaji K., Abe Y., Nakayama H., Takio K., Hamasaki N., and Kang D. Human mitochondrial DNA is packaged with TFAM. Nucleic Acids Res. 31 (2003) 1640-1645
83. Parisi M.A., Xu B., and Clayton D.A. A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro. Mol. Cell. Biol. 13 (1993) 1951-1961
84. Megraw T.L., and Chae C.B. Functional complementarity between the HMG1-like yeast mitochondrial histone HM and the bacterial histone-like protein HU. J. Biol. Chem. 268 (1993) 12758-12763
85. Xu C.W., Hines J.C., Engel M.L., Russell D.G., and Ray D.S. Nucleus-encoded histone H1-like proteins are associated with kinetoplast DNA in the trypanosomatid Crithidia fasciculata. Mol. Cell. Biol. 16 (1996) 564-576
86. Takamatsu C., Umeda S., Ohsato T., Ohno T., Abe Y., Fukuoh A., Shinagawa H., Hamasaki N., and Kang D. Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein. EMBO Rep. 3 (2002) 451-456
87. Van Tuyle G.C., and Pavco P.A. The rat liver mitochondrial DNA-protein complex: displaced single strands of replicative intermediates are protein coated. J. Cell Biol. 100 (1985) 251-257
88. Van Dyck E., Foury F., Stillman B., and Brill S.J. A single-stranded DNA binding protein required for mitochondrial DNA replication in S. cerevisiae is homologous to E. coli SSB. EMBO J. 11 (1992) 3421-3430
89. Mikhailov V.S., and Bogenhagen D.F. Effects of Xenopus laevis mitochondrial single-stranded DNA-binding protein on primer-template binding and 3′ → 5′ exonuclease activity of DNA polymerase gamma. J. Biol. Chem. 271 (1996) 18939-18946
90. Yang C., Curth U., Urbanke C., and Kang C. Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution. Nat. Struct. Biol. 4 (1997) 153-157
91. Farr C.L., Matsushima Y., Lagina III A.T., Luo N., and Kaguni L.S. Physiological and biochemical defects in functional interactions of mitochondrial DNA polymerase and DNA-binding mutants of single-stranded DNA-binding protein. J. Biol. Chem. 279 (2004) 17047-17053
92. Maier D., Farr C.L., Poeck B., Alahari A., Vogel M., Fischer S., Kaguni L.S., and Schneuwly S. Mitochondrial single-stranded DNA-binding protein is required for mitochondrial DNA replication and development in Drosophila melanogaster. Mol. Biol. Cell 12 (2001) 821-830
93. Fu G.K., and Markovitz D.M. The human LON protease binds to mitochondrial promoters in a single-stranded, site-specific, strand-specific manner. Biochemistry 37 (1998) 1905-1909
94. Liu T., Lu B., Lee I., Ondrovicova G., Kutejova E., and Suzuki C.K. DNA and RNA binding by the mitochondrial lon protease is regulated by nucleotide and protein substrate. J. Biol. Chem. 279 (2004) 13902-13910
95. Bogenhagen D.F., Wang Y., Shen E.L., and Kobayashi R. Protein components of mitochondrial DNA nucleoids in higher eukaryotes. Mol. Cell. Proteomics 2 (2003) 1205-1216
96. Xu C., and Ray D.S. Isolation of proteins associated with kinetoplast DNA networks in vivo. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 1786-1789
97. Suzuki T., Kawano S., and Kuroiwa T. Structure of three-dimensionally rod-shaped mitochondrial nucleoids isolated from the slime mould Physarum polycephalum. J.Cell Sci. 58 (1982) 241-261
98. Miyakawa I., Sando N., Kawano S., Nakamura S., and Kuroiwa T. Isolation of morphologically intact mitochondrial nucleoids from the yeast, Saccharomyces cerevisiae. J. Cell Sci. 88 (1987) 431-439
99. Barat M., Rickwood D., Dufresne C., and Mounolou J.C. Characterization of DNA-protein complexes from the mitochondria of Xenopus laevis oocytes. Exp. Cell Res. 157 (1985) 207-217
100. Kaufman B.A., Newman S.M., Hallberg R.L., Slaughter C.A., Perlman P.S., and Butow R.A. In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 7772-7777
101. Hillar M., Rangayya V., Jafar B.B., Chambers D., Vitzu M., and Wyborny L.E. Membrane-bound mitochondrial DNA: isolation, transcription and protein composition. Arch. Int. Physiol. Biochim. 87 (1979) 29-49
102. Van Tuyle G.C., and McPherson M.L. A compact form of rat liver mitochondrial DNA stabilized by bound proteins. J. Biol. Chem. 254 (1979) 6044-6053
103. Miyakawa I., Fumoto S., Kuroiwa T., and Sando N. Characterization of DNA-binding proteins involved in the assembly of mitochondrial nucleoids in the yeast Saccharomyces cerevisiae. Plant Cell Physiol. 36 (1995) 1179-1188
104. Van Tuyle G.C., and Pavco P.A. Characterization of a rat liver mitochondrial DNA-protein complex. Replicative intermediates are protected against branch migrational loss. J. Biol. Chem. 256 (1981) 12772-12779
105. Chen X.J., Wang X., Kaufman B.A., and Butow R.A. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science 307 (2005) 714-717
106. Burgess S.M., Delannoy M., and Jensen R.E. MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J. Cell Biol. 126 (1994) 1375-1391
107. Sogo L.F., and Yaffe M.P. Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J. Cell Biol. 126 (1994) 1361-1373
108. Berger K.H., Sogo L.F., and Yaffe M.P. Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J. Cell Biol. 136 (1997) 545-553
109. Boldogh I.R., Nowakowski D.W., Yang H.C., Chung H., Karmon S., Royes P., and Pon L.A. A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery. Mol. Biol. Cell 14 (2003) 4618-4627
110. Hobbs A.E., Srinivasan M., McCaffery J.M., and Jensen R.E. Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability. J. Cell Biol. 152 (2001) 401-410
111. Meeusen S., and Nunnari J. Evidence for a two membrane-spanning autonomous mitochondrial DNA replisome. J. Cell Biol. 163 (2003) 503-510
112. Youngman M.J., Hobbs A.E., Burgess S.M., Srinivasan M., and Jensen R.E. Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids. J. Cell Biol. 164 (2004) 677-688
113. Dimmer K.S., Jakobs S., Vogel F., Altmann K., and Westermann B. Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast. J. Cell Biol. 168 (2005) 103-115
114. Kondo-Okamoto N., Shaw J.M., and Okamoto K. Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation. J. Biol. Chem. 278 (2003) 48997-49005
115. Oliver N.A., and Wallace D.C. Assignment of two mitochondrially synthesized polypeptides to human mitochondrial DNA and their use in the study of intracellular mitochondrial interaction. Mol. Cell. Biol. 2 (1982) 30X-41X
116. Hayashi J., Ohta S., Kikuchi A., Takemitsu M., Goto Y., and Nonaka I. Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 10614-10618
117. Takai D., Isobe K., and Hayashi J. Transcomplementation between different types of respiration-deficient mitochondria with different pathogenic mutant mitochondrial DNAs. J. Biol. Chem. 274 (1999) 11199-11202
118. Takai D., Inoue K., Yi G., Nonaka I., and Hayashi J.I. The interorganellar interaction between distinct human mitochondria with deletion mutant mtDNA from a patient with mitochondrial disease and with HeLa mtDNA. J. Biol. Chem. 272 (1997) 6028-6033
119. Ono T., Isobe K., Nakada K., and Hayashi J.I. Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria. Nat. Genet. 28 (2001) 272-275
120. Yoneda M., Miyatake T., and Attardi G. Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles. Mol. Cell Biol. 14 (1994) 2699X-2712X
121. Enriquez J.A., Cabezas-Herrera J., Bayona-Bafaluy M.P., and Attardi G. Very rare complementation between mitochondria carrying different mitochondrial DNA mutations points to intrinsic genetic autonomy of the organelles in cultured human cells. J. Biol. Chem. 275 (2000) 11207-11215
122. Attardi G., Enriquez J.A., and Cabezas-Herrera J. Inter-mitochondrial complementation of mtDNA mutations and nuclear context. Nat. Genet. 30 (2002) 360
123. Nakada K., Inoue K., Ono T., Isobe K., Ogura A., Goto Y.I., Nonaka I., and Hayashi J.I. Inter-mitochondrial complementation: mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. Nat. Med. 7 (2001) 934-940
124. Legros F., Lombes A., Frachon P., and Rojo M. Mitochondrial fusion in human cells is efficient, requires the inner membrane potential and is mediated by mitofusins. Mol. Biol. Cell 13 (2002) 4343-4354
125. Mattenberger Y., James D.I., and Martinou J.C. Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin. FEBS Lett. 538 (2003) 53-59
126. Ishihara N., Jofuku A., Eura Y., and Mihara K. Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells. Biochem. Biophys. Res. Commun. 301 (2003) 891-898
127. Nunnari J., Marshall W.F., Straight A., Murray A., Sedat J.W., and Walter P. Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mol. Biol. Cell 8 (1997) 1233-1242
128. Okamoto K., Perlman P.S., and Butow R.A. The sorting of mitochondrial DNA and mitochondrial proteins in zygotes: preferential transmission of mitochondrial DNA to the medial bud. J. Cell Biol. 142 (1998) 613-623
129. Ball E.H., and Singer S.J. Mitochondria are associated with microtubules and not with intermediate filaments in cultured fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 79 (1982) 123-126
130. Tanaka Y., Kanai Y., Okada Y., Nonaka S., Takeda S., Harada A., and Hirokawa N. Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. [In Process Citation]. Cell 93 (1998) 1147-1158
131. Boldogh I.R., Yang H.C., and Pon L.A. Mitochondrial inheritance in budding yeast. Traffic 2 (2001) 368-374
132. Yaffe M.P., Stuurman N., and Vale R.D. Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 11424-11428
133. Waterman-Storer C.M., Sanger J.W., and Sanger J.M. Dynamics of organelles in the mitotic spindles of living cells: membrane and microtubule interactions. Cell Motil. Cytoskeleton 26 (1993) 19-39
134. Warren G., and Wickner W. Organelle inheritance. Cell 84 (1996) 395-400
135. Falkenberg M., Gaspari M., Rantanen A., Trifunovic A., Larsson N.G., and Gustafsson C.M. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat. Genet. 31 (2002) 289-294
136. Davis A.F., Jeong-Yu S., and Clayton D.A. Distribution of RNase MRP RNA during Xenopus laevis oogenesis. Mol. Reprod. Dev. 42 (1995) 359-368
137. Coene E.D., Hollinshead M.S., Waeytens A.A., Schelfhout V.R., Eechaute W.P., Shaw M.K., Van Oostveldt P.M., and Vaux D.J. Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria. Mol. Biol. Cell. 16 (2005) 997-1010