Drug abuse, brain calcification and glutamate-induced neurodegeneration

Current Drug Abuse Reviews

Volumn 2, Issue 1, 2009, Pages 99-112

  Rodríguez, Manuel J ^a   Pugliese, Marco ^a   Mahy, Nicole ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Addiction; Calcium precipitation; Central nervous system; Drug abuse; Excitotoxicity; Glutamate; Neurodegeneration

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMPA RECEPTOR; CALCIUM ION; GLUTAMATE RECEPTOR; GLUTAMIC ACID; MEMANTINE; PROTEINASE; CALCIUM;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN CALCIFICATION; CALCIUM BINDING; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CATECHOLAMINERGIC SYSTEM; CELL ENERGY; CELL INTERACTION; CELL LOSS; CENTRAL NERVOUS SYSTEM; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG ABUSE; DRUG DEPENDENCE; DRUG TARGETING; EMOTIONALITY; ENZYME ACTIVATION; EXCITOTOXICITY; GABAERGIC TRANSMISSION; GLIA; HUMAN; NERVE CELL LESION; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEUROMODULATION; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PATHOPHYSIOLOGY; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; REGULATORY MECHANISM; SYNAPTOGENESIS; WITHDRAWAL SYNDROME; ADAPTATION; ADDICTION; ANIMAL; BRAIN; CALCINOSIS; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; METABOLISM; REINFORCEMENT; REVIEW;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BRAIN; CALCINOSIS; CALCIUM; GLUTAMIC ACID; HUMANS; NERVE DEGENERATION; RECEPTORS, GLUTAMATE; REINFORCEMENT (PSYCHOLOGY); SUBSTANCE-RELATED DISORDERS;

EID: 70349784065     PISSN: 18744737     EISSN: None     Source Type: Journal    
DOI: 10.2174/1874473710902010099     Document Type: Article

References (137)

1. Cami J, Farre M. Drug addiction. N Engl J Med 2003; 349: 975-86.
2. Balster RL. Drug abuse potential evaluation in animals. Br J Addict 1991; 86: 1549-58.
3. Shin EH, Bian S, Shim YB, et al. Cocaine increases endoplasmic reticulum stress protein expression in striatal neurons. Neuroscience 2007; 145: 621-30.
4. Liechti ME, Vollenweider FX. Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies. Hum Psychopharmacol 2001; 16: 589-98.
5. Robinson TE. Neuroscience. Addicted rats. Science 2004; 305: 951-3.
6. Kieffer BL, Gaveriaux-Ruff C. Exploring the opioid system by gene knockout. Prog Neurobiol 2002; 66: 285-306.
7. Mantamadiotis T, Lemberger T, Bleckmann SC, et al. Disruption of CREB function in brain leads to neurodegeneration. Nat Genet 2002; 31: 47-54.
8. Spanagel R. Alcohol addiction research: from animal models to clinics. Best Pract Res Clin Gastroenterol 2003; 17: 507-18.
9. Groenewegen HJ, Wright CI, Beijer AV, Voorn P. Convergence and segregation of ventral striatal inputs and outputs. Ann N Y Acad Sci 1999; 877: 49-63.
10. D'Ascenzo M, Fellin T, Terunuma M, et al. mGluR5 stimulates gliotransmission in the nucleus accumbens. Proc Natl Acad Sci USA 2007; 104: 1995-2000.
11. Reid MS, Berger SP. Evidence for sensitization of cocaine-induced nucleus accumbens glutamate release. NeuroReport 1996; 7: 1325-9.
12. Bellone C, Luscher C. Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression. Nat Neurosci 2006; 9: 636-41.
13. Schilstrom B, Yaka R, Argilli E, et al. Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. J Neurosci 2006; 26: 8549-58.
14. Fitzgerald LW, Ortiz J, Hamedani AG, Nestler EJ. Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents. J Neurosci 1996; 16: 274-82.
15. Loftis JM, Janowsky A. Cocaine treatment- and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit. Psychopharmacology (Berl) 2002; 164: 349-59.
16. Lu W, Monteggia LM, Wolf ME. Repeated administration of amphetamine or cocaine does not alter AMPA receptor subunit expression in the rat midbrain. Neuropsychopharmacology 2002; 26: 1-13.
17. Hemby SE, Horman B, Tang W. Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration. Brain Res 2005; 1064: 75-82.
18. Zhang XF, Hu XT, White FJ, Wolf ME. Increased responsiveness of ventral tegmental area dopamine neurons to glutamate after repeated administration of cocaine or amphetamine is transient and selectively involves AMPA receptors. J Pharmacol Exp Ther 1997; 281: 699-706.
19. Boudreau AC, Wolf ME. Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens. J Neurosci 2005; 25: 9144-51.
20. Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL. Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science 2001; 292: 1175-8.
21. Harris GC, Aston-Jones G. Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment. Neuropsychopharmacology 2003; 28: 73-6.
22. Szumlinski KK, Dehoff MH, Kang SH, et al. Homer proteins regulate sensitivity to cocaine. Neuron 2004; 43: 401-13.
23. Lominac KD, Oleson EB, Pava M, et al. Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function. J Neurosci 2005; 25: 11586-94.
24. Wolf ME, Xue CJ, Li Y, Wavak D. Amphetamine increases glutamate efflux in the rat ventral tegmental area by a mechanism involving glutamate transporters and reactive oxygen species. J Neurochem 2000; 75: 1634-44.
25. Raudensky J, Yamamoto BK. Effects of chronic unpredictable stress on monoamine transporter immunoreactivity and methamphetamine-induced dopamine release in the nucleus accumbens shell. Synapse 2007; 61: 353-5.
26. Wang JQ, Daunais JB, McGinty JF. NMDA receptors mediate amphetamine-induced upregulation of zif/268 and preprodynorphin mRNA expression in rat striatum. Synapse 1994; 18: 343-53.
27. Ferguson SM, Norton CS, Watson SJ, Akil H, Robinson TE. Amphetamine-evoked c-fos mRNA expression in the caudateputamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context. J Neurochem 2003; 86: 33-44.
28. Saal D, Dong Y, Bonci A, Malenka RC. Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 2003; 37: 577-82.
29. Labarca R, Gajardo MI, Seguel M, et al. Effects of D-amphetamine administration on the release of endogenous excitatory amino acids in the rat nucleus accumbens. Prog Neuropsychopharmacol Biol Psychiatry 1995; 19: 467-73.
30. Lu W, Chen H, Xue CJ, Wolf ME. Repeated amphetamine administration alters the expression of mRNA for AMPA receptor subunits in rat nucleus accumbens and prefrontal cortex. Synapse 1997; 26: 269-80.
31. Peterson JD, Wolf ME, White FJ. Altered responsiveness of medial prefrontal cortex neurons to glutamate and dopamine after withdrawal from repeated amphetamine treatment. Synapse 2000; 36: 342-4.
32. Mao L, Wang JQ. Differentially altered mGluR1 and mGluR5 mRNA expression in rat caudate nucleus and nucleus accumbens in the development and expression of behavioral sensitization to repeated amphetamine administration. Synapse 2001; 41: 230-40.
33. Trevisan L, Fitzgerald LW, Brose N, et al. Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J Neurochem 1994; 62: 1635-8.
34. Henniger MS, Wotjak CT, Holter SM. Long-term voluntary ethanol drinking increases expression of NMDA receptor 2B subunits in rat frontal cortex. Eur J Pharmacol 2003; 470: 33-6.
35. Marutha Ravindran CR, Ticku MK. Changes in methylation pattern of NMDA receptor NR2B gene in cortical neurons after chronic ethanol treatment in mice. Brain Res Mol Brain Res 2004; 121: 19-27.
36. Blevins T, Mirshahi T, Woodward JJ. Increased agonist and antagonist sensitivity of N-methyl-D-aspartate stimulated calcium flux in cultured neurons following chronic ethanol exposure. Neurosci Lett 1995; 200: 214-8.
37. Ortiz J, Fitzgerald LW, Charlton M, et al. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 1995; 21: 289-98.
38. Floyd DW, Jung KY, McCool BA. Chronic ethanol ingestion facilitates N-methyl-D-aspartate receptor function and expression in rat lateral/basolateral amygdala neurons. J Pharmacol Exp Ther 2003; 307: 1020-9.
39. Moghaddam B, Bolinao ML. Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens. Neurosci Lett 1994; 178: 99-102.
40. Smith A, Watson CJ, Frantz KJ, et al. Differential increase in taurine levels by low-dose ethanol in the dorsal and ventral striatum revealed by microdialysis with on-line capillary electrophoresis. Alcohol Clin Exp Res 2004; 28: 1028-38.
41. Smith TL. Regulation of glutamate uptake in astrocytes continuously exposed to ethanol. Life Sci 1997; 61: 2499-505.
42. Tsai G. Glutamatergic neurotransmission in alcoholism. J Biomed Sci 1998; 5: 309-20.
43. Bienkowski P, Krzascik P, Koros E, et al. Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat. Eur J Pharmacol 2001; 413: 81-9.
44. Regan TJ. Alcohol and the cardiovascular system. JAMA 1990; 264: 377-81.
45. Favalli L, Rozza A, Frattini P, et al. Ischemia-induced glutamate release in rat frontoparietal cortex after chronic alcohol and withdrawal. Neurosci Lett 2002; 326: 183-6.
46. Olney JW, Tenkova T, Dikranian K, et al. Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain. Brain Res Dev Brain Res 2002; 133: 115-26.
47. Farber NB, Olney JW. Drugs of abuse that cause developing neurons to commit suicide. Brain Res Dev Brain Res 2003; 147: 37-45.
48. Olney JW, Ho OL, Rhee V. Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system. Exp Brain Res 1971; 14: 61-76.
49. Obrenovitch TP, Urenjak J, Zilkha E, Jay TM. Excitotoxicity in neurological disorders--the glutamate paradox. Int J Dev Neurosci 2000; 18: 281-7.
50. Arundine M, Tymianski M. Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci 2004; 61: 657-68.
51. Katayama Y, Maeda T, Koshinaga M, Kawamata T, Tsubokawa T. Role of excitatory amino acid-mediated ionic fluxes in traumatic brain injury. Brain Pathol 1995; 5: 427-35.
52. Mahy N, Bendahan G, Boatell ML, et al. Differential brain area vulnerability to long-term subcortical excitotoxic lesions. Neuroscience 1995; 65: 15-25.
53. Nitsch C, Scotti A. Ibotenic acid-induced calcium deposits in rat substantia nigra. Ultrastructure of their time-dependent formation. Acta Neuropathol 1992; 85: 55-70.
54. Robledo P, Ursu G, Mahy N. Effects of adenosine and gamma-aminobutyric acid A receptor antagonists on N-methyl-D-aspartate induced neurotoxicity in the rat hippocampus. Hippocampus 1999; 9: 527-33.
55. Liévens JC, Bernal F, Forni C, Mahy N, Kerkerian-LeGoff L. Characterization of striatal lesions produced by glutamate uptake alteration: cell death, reactive gliosis and changes in GLT1 and GADD45 mRNA expression. Glia 2000; 29: 222-32.
56. Obrenovitch TP, Urenjak J. Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy. Prog Neurobiol 1997; 51: 39-87.
57. Nugent FS, Penick EC, Kauer JA. Opioids block long-term potentiation of inhibitory synapses. Nature 2007; 446: 1086-90.
58. Mark KA, Quinton MS, Russek SJ, Yamamoto BK. Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release. J Neurosci 2007; 27: 6823-31.
59. Stephans SE, Yamamoto BK. Methamphetamine-induced neurotoxicity: roles for glutamate and dopamine efflux. Synapse 1994; 17: 203-9.
60. Choi D. Calcium-mediated neurotoxicity: relationship to specific channels types and role in ischemic damage. Trends Neurosci 1988; 11: 465-9.
61. Garthwaite G, Garthwaite J. Amino acid neurotoxicity: intracellular sites of calcium accumulation associated with the onset of irreversible damage to rat cerebellar neurones in vitro. Neurosci Lett 1986; 71: 53-8.
62. Tymianski M, Tator CH. Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury. Neurosurgery 1996; 38: 1176-95.
63. Petegnief V, Saura J, Dewar D, et al. Long-term effects of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate and 6-nitro-7-sulphamoylbenzo(f)quinoxaline-2,3-dione in the rat basal ganglia: calcification, changes in glutamate receptors and glial reactions. Neuroscience 1999; 94: 105-15.
64. Mattson MP. Mitochondrial regulation of neuronal plasticity. Neurochem Res 2007; (DOI 10.1007/s11064-006-9170-3).
65. 2+ release. J Biol Chem 2005; 131: 1315-26.
66. Pérez-García MJ, Cena V, de Pablo Y, et al. Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway. J Biol Chem 2004; 279: 6132-42.
67. Rose CR, Konnerth A. Stores not just for storage. Intracellular calcium release and synaptic plasticity. Neuron 2001; 31: 519-22.
68. Chalmers S, Nicholls DG. The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria. J Biol Chem 2003; 278: 19062-70.
69. Nicholls DG, Vesce S, Kirk L, Chalmers S. Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells. Cell Calcium 2003; 34: 407-24.
70. Ramonet D, De Yebra L, Fredriksson K, et al. Similar calcification process in acute and chronic human brain pathologies. J Neurosci Res 2006; 83: 147-56.
71. Rodríguez MJ, Bernal F, Andrés N, Malpesa Y, Mahy N. Excitatory amino acids and neurodegeneration: a hypothetical role of calcium precipitation. Int J Dev Neurosci 2000; 18: 299-307.
72. Kalivas PW. Glutamate systems in cocaine addiction. Curr Opin Pharmacol 2004; 4: 23-9.
73. Saura J, Boatell ML, Bendahan G, Mahy N. Calcium deposits formation and glial reaction in rat brain after ibotenic acid-induced basal forebrain lesions. Eur J Neurosci 1995; 7: 1569-78.
74. Bernal F, Saura J, Ojuel J, Mahy N. Differential vulnerability of hippocampus, basal ganglia and prefrontal cortex to long-term NMDA excitotoxicity. Exp Neurol 2000; 161: 686-95.
75. Mahy N, Prats A, Riveros A, Andrés N, Bernal F. Basal ganglia calcification induced by excitotoxicity: an experimental model characterised by electron microscopy and X-ray microanalysis. Acta Neuropathol 1999; 98: 217-25.
76. Kim KM. Apoptosis and calcification. Scanning Microsc 1995; 9: 1137-78.
77. Honda E, Aoki M, Brunno M, Ito A. Light and electron microscopic study on surface and internal structure of human brain stones with reference to some natural minerals. Bulletin de l'Institut Oceanographique (Monaco) 1994; Spec. Iss. 14: 115-20.
78. Kodaka T, Mori R, Debari K, Yamada M. Scanning electron microscopy and electron probe microanalysis studies of human pineal concretions. J Electron Microsc 1994; 43: 307-17.
79. Yu ZF, Bruce-Keller J, Goodman Y, Mattson MP. Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo. J Neurosci Res 1998; 53: 613-25.
80. Boatell ML, Bendahan G, Mahy N. Time-related cortical amino acid changes after basal forebrain lesion: a microdialysis study. J Neurochem 1995; 64: 285-91.
81. Rodríguez MJ, Robledo P, Andrade C, Mahy N. In vivo coordinated interactions between inhibitory systems to control glutamate-mediated hippocampal excitability. J Neurochem 2005; 95: 651-61.
82. Ballarín M, Reiriz J, Ambrosio S, et al. Acute effects of MPP+ on purine metabolism in rat striatum studied in vivo using the microdialysis technique. Brain Res 1989; 483: 184-7.
83. Petersen OH, Gerasimenko OV, Gerasimenko JV, Mogami H, Tepikin AV. The calcium store in the nuclear envelope. Cell Calcium 1998; 23: 87-90.
84. Andre-Frei V, Chevallay B, Orly I, et al. Acellular mineral deposition in collagen-based biomaterials incubated in cell culture media. Calci Tissue Int 2000; 66: 204-11.
85. Verkhratsky A, Toescu EC. Calcium and neuronal ageing. Trends Neurosci 1998; 21: 2-7.
86. Magistretti PJ, Pellerin L, Rothman DL, Shulman RG. Energy on demand. Science 1999; 283: 496-7.
87. Ramonet D, Pugliese M, Rodríguez MJ, et al. Calcium precipitation in acute and chronic brain diseases. Journal of Physiology-Paris 2002; 96: 307-12.
88. Rodríguez MJ, Ursu G, Bernal F, Cusí V, Mahy N. Perinatal human hypoxia-ischemia vulnerability correlates with brain calcification. Neurobiol Dis 2001; 8: 59-68.
89. Ansari MQ, Chincanchan CA, Armstrong DL. Brain calcification in hypoxic-ischemic lesions: an autopsy review. Pediatr Neurol 1990; 6: 94-101.
90. 2+ Accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J Neurosci 1993; 13: 1993-2000.
91. Sibson NR, Dhankhar A, Mason GF, et al. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci USA 1998; 95: 316-21.
92. Acikgoz O, Gonenc S, Gezer S, et al. Methamphetamine causes depletion of glutathione and an increase in oxidized glutathione in the rat striatum and prefrontal cortex. Neurotoxiciol Res 2001; 3: 277-80.
93. Tata DA, Yamamoto BK. Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction. Addiction 2007; 102 (Suppl 1): 49-60.
94. Mattson MP, Mark RJ. Excitotoxicity and excitoprotection in vitro. Adv Neurol 1996; 71: 1-35.
95. Wang KKW. Calpain and caspase: can you tell the difference? Trends Neurosci 2000; 23: 20-6.
96. Chan SL, Mattson MP. Caspase and calpain substrates: roles in synaptic plasticity and cell death. J Neurosci Res 1999; 58: 167-90.
97. Nicotera P, Leist M, Manzo L. Neuronal cell death: a demise with different shapes. Trends Pharmacol Sci 1999; 20: 46-51.
98. Roy M, Sapolsky R. Neuronal apoptosis in acute necrotic insults: why is this subject such a mess. Trends Neurosci 1999; 22: 419-22.
99. Sapolsky RM. Cellular defenses against excitotoxic insults. J Neurochem 2001; 76: 1601-11.
100. + channels. Ann N Y Acad Sci 1999; 868: 233-85.
101. + channels: Molecular determinants and function of the SK family. Nat Rev Neurosci 2004; 5: 758-70.
102. + current in hippocampal pyramidal neurons. Proc Natl Acad Sci USA 1999; 96: 4662-7.
103. Yamada K, Ji JJ, Yuan H, et al. Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science 2001; 292: 1543-6.
104. Saransaari P, Oja SS. Enhanced GABA release in cell-damaging conditions in the adult and developing mouse hippocampus. Int J Dev Neurosci 1997; 15: 163-74.
105. Saransaari P, Oja SS. Charateristics of taurine release induced by free radicals in mouse hippocampal slices. Amino Acids 2004; 26: 91-8.
106. Pearson T, Frenguelli BG. Adrenoceptor subtype-specific acceleration of the hypoxic deppression of excitatory synaptic transmission in area CA1 of the rat hippocampus. Eur J Neurosci 2004; 20: 1555-65.
107. Danbolt NC. The high affinity uptake system for excitatory amino acids in the brain. Prog Neurobiol 1994; 44: 377-96.
108. Gegelashvili G, Schousboe A. Cellular distribution and kinetic properties of high-affinity glutamate transporters. Brain Res Bull 1998; 45: 233-8.
109. Hertz L, Dringen R, Schousboe A, Robinson SR. Astrocytes: glutamate producers for neurons. J Neurosci Res 1999; 57: 417-28.
110. García O, Massieu L. Glutamate uptake inhibitor L-transpyrrolidine 2,4-dicarboxylate becomes neurotoxic in the presence of subthreshold concentrations of mitocondrial toxin 3-nitropropionate: involvement of mitocondrial reducing activity and ATP production. J Neurosci Res 2003; 74: 956-66.
111. Massieu L, Haces ML, Montiel T, Hernández-Fonseca K. Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition. Neuroscience 2003; 120: 356-87.
112. Ramonet D, Rodríguez MJ, Fredriksson K, Bernal F, Mahy N. In vivo neuroprotective adaptation of the glutamate/glutamine cycle to neuronal death. Hippocampus 2004; 14: 586-94.
113. Louzada PR, Lima ACP, Mendonça-Silva D, et al. Taurine prevents the neurotoxicity of β-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders. FASEB J 2004; 18: 511-8.
114. Mori M, Gähwiler BH, Gerber U. β-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro. J Physiol 2002; 539: 191-200.
115. Miller RJ. Mitochondria -the Kraken wakes! Trends Neurosci 1998; 21: 95-7.
116. Berridge MJ. Neuronal calcium signaling. Neuron 1998; 21: 13-26.
117. Schinder AF, Olson EC, Spitzer NC, Montal M. Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J Neurosci 1996; 16: 6125-33.
118. Stout AK, Raphael HM, Kanterewicz BI, Klann E, Reynolds IJ. Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat Neurosci 1998; 1: 366-73.
119. Chen Q, Moulder K, Tenkova T, et al. Excitotoxic cell death dependent on inhibitory receptor activation. Exp Neurol 1999; 160: 215-25.
120. Makinen S, van Groen T, Clarke J, et al. Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 2008; 28: 263-8.
121. Lebon V, Petersen KF, Cline GW, et al. Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci 2002; 22: 1523-31.
122. Back T, Hoehn M, Mies G, et al. Penumbral tissue alkalosis in focal cerebral ischemia: relationship to energy metabolism, blood flow, and steady potential. Ann Neurol 2000; 47: 485-92.
123. Sibson NR, Dhankhar A, Mason GF, et al. In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamineácycling. Proc Natl Acad Sci USA 1997; 94: 2699-704.
124. McAlonan GM, Dawson GR, Wilkinson LO, Robbins TW, Everitt BJ. The effects of AMPA-induced lesions of the medial septum and vertical limb nucleus of the diagonal band of Broca on spatial delayet non-matching to sample and spatial learning in the water maze. Eur J Neurosci 1995; 7: 1034-49.
125. Venero J, Hefti F. Regional specific induction of BDNF and truncated trkB.T1 receptors in the hippocampal formation after intraseptal injection of kainic acid. Brain Res 1998; 790: 270-7.
126. Matés J, Pérez-Gómez C, Nuñez de Castro I, Asenjo M, Márquez J. Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death. Int J Biochem Cell Biol 2002; 34: 439-58.
127. Miele VJ, Bailes JE, Cantu RC, Rabb CH. Subdural hematomas in boxing: the spectrum of consequences. Neurosurg Focus 2006; 21: E10.
128. Yoshiyama Y, Uryu K, Higuchi M, et al. Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in transgenic tauopathy mouse model. J Neurotrauma 2005; 22: 1134-41.
129. Tomkins O, Friedman O, Ivens S, et al. Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex. Neurobiol Dis 2007; 25: 367-77.
130. Koistinaho M, Koistinaho J. Interactions between Alzheimer's disease and cerebral ischemia-focus on inflammation. Brain Res Brain Res Rev 2005; 48: 240-50.
131. Pluta R. Alzheimer lesions after ischemia-reperfusion brain injury. Folia Neuropathol 2004; 42: 181-6.
132. Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurode-generation. Trends Neurosci 2005; 28: 202-8.
133. Heidbreder C. Novel pharmacotherapeutic targets for the management of drug addiction. Eur J Pharmacol 2005; 526: 101-12.
134. Nagy J. Renaissance of NMDA receptor antagonists: do they have a role in the pharmacotherapy for alcoholism? IDrugs 2004; 7: 339-50.
135. Backstrom P, Hyytia P. Ionotropic glutamate receptor antagonists modulate cue-induced reinstatement of ethanol-seeking behavior. Alcohol Clin Exp Res 2004; 28: 558-65.
136. Kenny PJ, Boutrel B, Gasparini F, Koob GF, Markou A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology (Berl) 2005; 179: 247-54.
137. Schroeder JP, Overstreet DH, Hodge CW. The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology (Berl) 2005; 179: 262-70.