Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 3, 2013, Pages 356-364

  Ortega, Francisco J ^a,b   Jolkkonen, Jukka ^b   Mahy, Nicole ^a   Rodríguez, Manuel J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

angiogenesis; brain ischemia; microglia; neural stem cells; neuroprotection; regeneration and recovery

Indexed keywords

BROXURIDINE; CASPASE 3; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; SULFONYLUREA RECEPTOR 1;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN CORTEX; BRAIN INFARCTION SIZE; CELL MIGRATION; COGNITION; CONTROLLED STUDY; DRUG BINDING; FOLLOW UP; FUNCTIONAL STATUS; HIPPOCAMPUS; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LONG TERM CARE; LOW DRUG DOSE; MALE; MAZE TEST; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORIMOTOR FUNCTION; TASK PERFORMANCE; TRANSIENT ISCHEMIC ATTACK; TREATMENT OUTCOME;

ANIMALS; ANTIGENS, NUCLEAR; ATP-BINDING CASSETTE TRANSPORTERS; BRAIN ISCHEMIA; CELL MOVEMENT; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYBURIDE; HIPPOCAMPUS; HYPOGLYCEMIC AGENTS; MALE; MAZE LEARNING; MICROGLIA; MICROTUBULE-ASSOCIATED PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE TISSUE PROTEINS; NEUROGENESIS; NEUROPEPTIDES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, WISTAR; RECEPTORS, DRUG; RECOVERY OF FUNCTION; TIME FACTORS;

EID: 84874655480     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.166     Document Type: Article

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