Excitotoxicity in neurological disorders - The glutamate paradox

International Journal of Developmental Neuroscience

Volumn 18, Issue 2-3, 2000, Pages 281-287

  Obrenovitch, T P ^a   Urenjak, J ^a   Zilkha, E ^a   Jay, T M ^b  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; DOMOIC ACID; EXCITOTOXIN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; ION CHANNEL; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; QUINOLINIC ACID; TETRODOTOXIN;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; MICRODIALYSIS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

ANIMALS; CELL DEATH; GLUTAMIC ACID; NERVOUS SYSTEM DISEASES; NEURONS; NEUROTOXINS;

EID: 0034012860     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-5748(99)00096-9     Document Type: Conference Paper

References (60)

1. Ames A. III. Energy requirements of CNS cells as related to their function and to their vulnerability to ischemia: a commentary based on studies on retina. Can. J. Physiol. Pharmacol. 70:(Suppl.):1992;S158-S164.
2. Ames A. III, Maynard K.I., Kaplan S. Protection against CNS ischemia by temporary interruption of function-related processes of neurons. J. Cereb. Blood Flow Metab. 15:1995;433-439.
3. Bacher A., Kwon J.Y., Zornow M.H. Effects of temperature on cerebral tissue oxygen tension, carbon dioxide tension, and pH during transient global ischemia in rabbits. Anesthesiology. 88:1998;403-409.
4. Bliss T.V.P., Collingridge G.L. A synaptic model of memory: Long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
5. Bradford H.F. Glutamate, GABA and epilepsy. Prog. Neurobiol. 47:1995;656-659.
6. Bullock R., Zauner A., Woodward J.J., Myseros J., Choi S.C., Ward J.D., Marmarou A., Young H.F. Factors affecting excitatory amino acid release following severe human head injury. J. Neurosurg. 89:1998;507-518.
7. Busch E., Gyngel M.L., Eis M., Hoehn-Berlage M., Hossmann K.A. Potassium-induced cortical spreading depressions during focal cerebral ischemia in rats: contribution to lesion growth assessed by diffusion-weighted NMR and biochemical imaging. J. Cereb. Blood Flow Metab. 16:1996;1090-1099.
8. Clements J.D., Lester R.A., Tong G., Jahr C.E., Westbrook G.L. The time course of glutamate in the synaptic cleft. Science. 258:1992;1498-1501.
9. Dawson L.A., Routledge C. Differential effects of potassium channel blockers on extracellular concentrations of dopamine and 5-HT in the striatum of conscious rats. Br. J. Pharmacol. 116:1995;3260-3264.
10. Doriat J.F., Cortey A., Daval J.L. Selective alterations in binding kinetic parameters and allosteric regulation of N-methyl-D-aspartate receptors after prolonged seizures in the developing rat brain. Pediatr. Res. 43:1998;415-420.
11. Edwards F.A. Anatomy and electrophysiology of fast central synapses lead to a structural model for long-term potentiation. Physiol. Rev. 75:1995;759-787.
12. Eliasof S., Werblin F. Characterization of the glutamate transporter in retinal cones of the tiger salamander. J. Neurosci. 13:1993;402-411.
13. Glavinovic M.I., Rabie H.R. Monte Carlo simulation of spontaneous miniature excitatory postsynaptic currents in rat hippocampal synapse in the presence and absence of desensitization. Naunyn-Schmiedeberg's Arch. Pharmacol. 435:1998;193-202.
14. Hertz L. Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmitters. Prog. Neurobiol. 13:1979;277-323.
15. Hoffman W.E., Charbel F.T., Munoz L., Ausman J.I. Comparison of brain tissue metabolic changes during ischemia at 35 degrees and 18 degrees C. Surg. Neurol. 49:1998;85-88.
16. Jay T.M., Zilkha E., Obrenovitch T.P. Long-term potentiation in the dentate gyrus is not linked to increased extracellular glutamate concentration. J. Neurophysiol. 81:1999;1741-1748.
17. Kanner B.I., Bendahan A. Binding order of substrates to the sodium and potassium ion coupled L-glutamic acid transporter from rat brain. Biochemistry. 21:1982;6327-6330.
18. Kano T., Shimizu-Sasamata M., Huang P.L., Moskowitz M.A., Lo E.H. Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo. Neuroscience. 86:1998;695-699.
19. Korf J. Intracerebral trafficking of lactate in vivo during stress, exercise, electroconvulsive shock and ischemia as studied with microdialysis. Dev. Neurosci. 18:1996;405-414.
20. Lada M.W., Vickroy T.W., Kennedy R.T. Evidence for neuronal origin and metabotropic receptor-mediated regulation of extracellular glutamate and aspartate in rat striatum in vivo following electrical stimulation of the prefrontal cortex. J. Neurochem. 70:1998;617-625.
21. Lauritzen M. Pathophysiology of the migraine aura: The spreading depression theory. Brain. 117:1994;199-210.
22. Mangano R.M., Schwarcz R. Chronic infusion of endogenous excitatory amino acids into rat striatum and hippocampus. Brain Res. Bull. 10:1983;47-51.
23. Meldrum B., Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11:1994;54-62.
24. Marrannes R., Willems R., De Prins E., Wauquier A. Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat. Brain Res. 457:1988;226-240.
25. Miele M., Boutelle M.G., Fillenz M. The source of physiologically stimulated glutamate efflux from the striatum of conscious rats. J. Physiol. (Lond.). 497:1996;745-751.
26. Obrenovitch T.P. The ischaemic penumbra: Twenty years on. Cerebrovasc. Brain Metabol. Rev. 7:1995;297-323.
27. Obrenovitch T.P., Richards D.A., Sarna G.S., Symon L. Combined intracerebral microdialysis and electrophysiological recording: Methodology and applications. J. Neurosci. Meth. 47:1993;139-145.
28. Obrenovitch T.P., Urenjak J. Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy. Prog. Neurobiol. 51:1997;39-87.
29. Obrenovitch T.P., Urenjak J. Is high extracellular glutamate the key to excitotoxicity in traumatic brain injury? J. Neurotrauma. 14:1997;677-698.
30. Obrenovitch T.P., Urenjak J., Zilkha E. Intracerebral microdialysis combined with recording of extracellular field potential: a novel method for investigation of depolarizing drugs in vivo. Br. J. Pharmacol. 113:1994;1295-1302.
31. Obrenovitch T.P., Urenjak J., Zilkha E. Evidence disputing the link between seizure activity and high extracellular glutamate. J. Neurochem. 66:1996;2446-2454.
32. Obrenovitch T.P., Urenjak J., Zilkha E. Effects of increased extracellular glutamate levels on the local field potential in the brain of anaesthetized rats. Br. J. Pharmacol. 122:1997;372-378.
33. Obrenovitch T.P., Zilkha E. High extracellular potassium, and not extracellular glutamate, is required for the propagation of spreading depression. J. Neurophysiol. 73:1995;2107-2114.
34. Obrenovitch T.P., Zilkha E. Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-methyl-D-aspartate receptor complex. Br. J. Pharmacol. 117:1996;931-937.
35. Obrenovitch T.P., Zilkha E., Urenjak J. Intracerebral microdialysis: Electrophysiological evidence of a critical pitfall. J. Neurochem. 64:1995;1884-1888.
36. Obrenovitch T.P., Zilkha E., Urenjak J. Evidence against high extracellular glutamate promoting the elicitation of spreading depression by potassium. J. Cereb. Blood Flow Metab. 16:1996;923-931.
37. Obrenovitch T.P., Zilkha E., Urenjak J. Effect of pharmacological inhibition of glutamate-uptake on ischemia-induced glutamate efflux and anoxic depolarization latency. Naunyn-Schmiedeberg's Arch. Pharmacol. 357:1998;225-231.
38. Olney J.W. Kainic acid and other excitotoxins: a comparative analysis. Adv. Biochem. Psychopharmacol. 27:1981;375-384.
39. Olney J.W., De Gubareff T. Glutamate neurotoxicity and Huntington's chorea. Nature. 271:1978;557-559.
40. Olney J.W., Ho O.L. Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature. 227:1970;609-611.
41. Pei Q., Leslie R.A., Graham-Smith D.G., Zetterström T.S.C. 5-HT efflux from rat hippocampus in vivo produced by 4-aminopyridine is increased by chronic lithium administration. Neuroreport. 6:1995;716-720.
42. 2+-permeable AMPA receptors in neurological disorders. Trends Neurosci. 20:1997;464-470.
43. Peng Y.G., Taylor T.B., Finch R.E., Switzer R.C., Ramsdell J.S. Neuroexcitatory and neurotoxic actions of the amnesic shellfish poison, domoic acid. Neuroreport. 5:1994;981-985.
44. Rossetti Z.L., Marcangione C., Wise R.A. Increase of extracellular glutamate and expression of Fos-like immunoreactivity in the ventral tegmental area in response to electrical stimulation of the prefrontal cortex. J. Neurochem. 70:1998;1503-1512.
45. Rusakov D.A., Harrison E., Stewart M.G. Synapses in hippocampus occupy only 1-2% of cell membranes and are spaced less than half-micron apart: a quantitative ultrastructure analysis with discussion of physiological implications. Neuropharmacology. 37:1998;513-521.
46. Sanchez-Prieto J., Herrero I., Miras-Portuga M.T., Mora F. Unchanged exocytotic release of glutamic acid in cortex and neostriatum of the rat during aging. Brain Res. Bull. 33:1994;357-359.
47. Schwarcz R., Scholz D., Coyle J.T. Structure-activity relations for the neurotoxicity of kainic acid derivatives and glutamate analogues. Neuropharmacology. 17:1978;145-151.
48. Segovia G., Porras A., Mora F. Effects of 4-aminopyridine on extracellular concentrations of glutamate in striatum of the freely moving rat. Neurochem. Res. 22:1997;1491-1497.
49. Shimizu-Sasamata M., Bosque-Hamilton P., Huang P.L., Moskowitz M.A., Lo E.H. Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene. J. Neurosci. 18:1998;9564-9571.
50. Sokoloff L. Sites and mechanisms of function-related changes in energy metabolism in the nervous system. Dev. Neurosci. 15:1993;194-206.
51. Stone T.W. Neuropharmacology of quinolinic and kynurenic acids. Pharmacol. Rev. 45:1993;309-379.
52. +-induced depolarisation in the rat striatum. J. Neurochem. 62:1994;2368-2374.
53. +-channel inhibitors: An analysis of plasma membrane ion fluxes. J. Neurochem. 67:1996;389-397.
54. Timmerman W., Westerink B.H.C. Brain microdialysis of GABA and glutamate: What does it signify? Synapse. 27:1997;242-261.
55. Toth E., Lajtha A. Motor effects of intracaudate injection of excitatory amino acids. Pharmacol. Biochem. Behav. 33:1989;175-179.
56. + channels: A rational and effective strategy against ischemic brain damage. Pharmacol. Rev. 48:1996;21-67.
57. Wahl F., Obrenovitch T.P., Hardy A.M., Plotkine M., Boulu R., Symon L. Extracellular glutamate during focal cerebral ischaemia in rats: Time course and calcium-dependency. J. Neurochem. 63:1994;1003-1011.
58. Westergaard N., Sonnewald U., Schousboe A. Metabolic trafficking between neurons and astrocytes: the glutamate/glutamine cycle revisited. Dev. Neurosci. 17:1995;203-211.
59. You Z.-B., Tzschentke T.M., Brodin E., Wise R.A. Electrical stimulation of the prefrontal cortex increases cholecystokinin, glutamate, and dopamine release in the nucleus accumbens: an in vivo microdialysis study in freely moving rats. J. Neurosci. 18:1998;6492-6500.
60. Zilkha E., Obrenovitch T.P., Koshy A., Kusakabe H., Bennetto H.P. Extracellular glutamate: on-line monitoring using microdialysis coupled to enzyme-amperometric analysis. J. Neurosci. Meth. 60:1995;1-9.