Adenosine and inosine increase cutaneous vasopermeability by activating A3 receptors on mast cells

Journal of Clinical Investigation

Volumn 105, Issue 3, 2000, Pages 361-367

  Tilley, Stephen L ^a   Wagoner, Victoria A ^a   Salvatore, Christopher A ^b   Jacobson, Marlene A ^b   Koller, Beverly H ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A3 RECEPTOR; BLOOD GROUP M ANTIGEN; IMMUNOGLOBULIN E RECEPTOR; INOSINE; UNCLASSIFIED DRUG;

ADOLESCENT; AGED; ANAPHYLAXIS; ANIMAL CELL; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; CYTOLOGY; EDEMA; INFLAMMATION; MAST CELL; MAST CELL DEGRANULATION; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; SKIN BLOOD VESSEL;

EID: 0033965558     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8253     Document Type: Article

References (46)

1. Mentzer, R.M., Rubio, R., and Berne, R.M. 1975. Release of adenosine by hypoxic canine lung tissue and its possible role in pulmonary circulation. Am. J. Physiol. 229:1625-1631.
2. Marquardt, D.L., Gruber, H.E., and Wasserman, S.I. 1984. Adenosine release from stimulated mast cells. Proc. Natl. Acad. Sci. USA. 81:6192-6196.
3. Schrader, J., and Gerlach, E. 1976. Compartmentation of cardiac adenine nucleotides and formation of adenosine. Pflugers Arch. 367:129-135.
4. Rubio, R., Berne, R.M., Bockman, E.L., and Curnish, R.R. 1975. Relationship between adenosine concentration and oxygen supply in rat brain. Am. J. Pyhsiol. 228:1896-1902.
5. 3adenosine receptors and stimulates mast cell degranulation. J. Clin. Invest. 100:2849-2857.
6. Ralevic, V., and Burnstock, G. 1998. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:413-492.
7. Mills, G.C., Schmalstieg, F.C., Trimmer, K.B., Goldman, A.S., and Goldblum, R.M. 1976. Purine metabolism in adenosine deaminase deficiency. Proc. Natl. Acad. Sci. USA. 73:2867-2871.
8. Collis, M.G. 1989. The vasodilator role of adenosine. Pharmacol. Ther. 41:143-162.
9. Gawlowski, D.M., and Duran, W.N. 1986. Dose-related effects of adenosine and bradykinin on microvascular permselectivity to macromolecules in the hamster cheek pouch. Circ. Res: 58:348-355.
10. Overholser, K.A., and Harris, T. R. 1984. Effect of exogenous adenosine on resistance, capillary permeability-surface area and flow in ischemic canine myocardium. J. Pharmacol. Exp. Ther. 229:148-152.
11. Sollevi, A., and Fredholm, B. 1981. Role of adenosine in adipose tissue circulation. Acta Physiol. Scand. 112:293-298.
12. 2 receptor-mediated relaxation in isolated rabbit aorta. Eur. J. Pharmacol. 238:65-74.
13. 2 receptor agonist, in the isolated rat femoral artery and vein. Eur. J. Pharmacol. 281:9-15.
14. Haynes, J., Jr., Obiako, B., Thompson, W.J., and Downey, J. 1995. Adenosine-induced vasodilation: receptor characterization in pulmonary circulation. Am. J. Physiol 268:H1862-H1868.
15. Elliott, J., and Brady, F.E. 1998. Characterization of vasodilatory adenosine receptors in equine digital veins. J. Vet. Pharmacol. Ther. 21:74-81.
16. Haselton, F.R., Alexander, J.S., and Mueller, S.N. 1993. Adenosine decreases permeability of in vitro endothelial monolayers. J. Appl. Physiol. 74:1581-1590.
17. 2-adenosine receptor stimulation increases macromolecule permeability of coronary endothehal cells. Am. J. Physiol. 262:H1174-H1181.
18. Galli, S.J. 1990. New insights into "the riddle of the mast cells": microenvironmental regulation of mast cell development and phenotypic heterogeneity. Lab. Invest. 62:5-33.
19. Rakusan, K., Sarkar, K., Turek, Z., and Wicker, P. 1990. Mast cells in the rat heart during normal growth and in cardiac hypertrophy. Circ. Res. 66:511-516.
20. Rhodin, J.A.G., and Fujita, H. 1989. Capillary growth in the mesentery of normal young rats. Intraviral video and electron microscope analyses. J. Submicrosc. Cytol. Pathol. 21:1-34.
21. Metcalfe, D.D., Baram, D., and Mekori, Y.A. 1997. Mast cells. Physiol. Rev. 77:1033-1079.
22. Marquardt, D.L., Parker, C.W., and Sullivan, T.J. 1978. Potentiation of mast cell mediator release by adenosine. J. Immunol. 120:871-878.
23. Doyle, M.P., Linden, J., and Duling, B.R. 1994. Nucleoside-induced arteriolar constriction: a mast cell-dependent response. Am. J. Physiol. 266:H2042-H2050.
24. 3 receptor-mediated hypotension in the rat. Br. J. Pharmacol. 115:945-952.
25. Marquardt, D.L., Walker, L.L., and Heinemann, S.F. 1994. Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. J. Immunol. 150:4508-4515.
26. 2b receptors evoke interleukin-8 secretion in human mast cells. J. Clin. Invest. 96:1979-1986.
27. 2b receptor. Mol. Pharmacol. 52:846-860.
28. 3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J. Biol. Chem. 268 16887-16890.
29. 3 receptor activation in rats. Eur. J. Pharmacol. 298:293-297.
30. 3 receptors promote degranulation of rat mast cells both in vitro and in vivo. Inflamm. Res. 46:180-184.
31. Shepherd, R.K., Linden, J., and Duling, B.R. 1996. Adenosine-induced mast vasoconstriction in vivo. Circ. Res. 78:627-634.
32. 3 adenosine receptor gene in mice and its effect on stimulated inflammatory cells. J. Biol. Chem. In press.
33. Dombrowicz, D., et al. 1998. Allergy-associated FcRβ is a molecular amplifier of IgE- and IgG-mediated in vivo responses. Immunity. 8:517-529.
34. FRI-bearing cells in interleukin-3-dependent mouse bone marrow cultures: correlation with histamine content and mast cell maturation. Blood. 79:972-980.
35. Jancso-Gabor, A., Szolcsanyi, J., and Jancso, N. 1967. A simple method for measuring the amount of azovan blue exuded into the skin in response to an inflammatory stimulus. J. Pharm. Pharmacol. 19:486-487.
36. Takai, T., Li, M., Sylvestre, D., Clynes, R., and Ravetch, J.V. 1994. FcRγchain deletion results in pleiotrophic effector cell defects. Cell. 76:519-529.
37. Dombrowicz, D., Flamand, V., Brigman, K.K., Koller, B.H., and Kinet, J.P. 1993. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene. Cell 75:969-976.
38. Yamawaki, I., Tamaoki, J., Takeda, Y., and Nagai, A. 1998. Effect of adenosine and its analogues on miocrovascular leakage in the rat trachea. Nihon Kokyuki Gakkai Zasshi. 36:231-235.
39. Marquardt, D.L., and Walker, L.L. 1988. Alteration of mast cell responsiveness to adenosine by pertussis toxin. Biochem. Pharmacol. 37:4019-4025.
40. Ali, H., Cunha-Melo, J.R., Saul, W.F., and Beaven, M.A. 1990. Activation of phospholipase c via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. J. Biol. Chem. 265:745-753.
41. q in human embryonic kidney 293 cells and HMC-I mast cells. Mol. Pharmacol. 56:705-713.
42. 3 adenosine receptor. J. Biol. Chem. 270:16895-16902.
43. Silverman, E.S., Gerritsen, M.E., and Collins, T. 1997. Metabolic functions of the pulmonary endothelium. In The lung: scientific foundations. R.G. Crystal, J.B. West, E.R. Weibel, and P.J. Barnes, editors. Lippincott-Raven. Philadelphia, PA. 629-651.
44. Hellewell, P.G., and Pearson, J.D. 1983. Metabolism of circulating adenosine by the porcine isolated perfused lung. Circ. Res. 53:1-7.
45. Jones, C.E., Thomas, J.X., Devous, M.D., Norris, C.P., and Smith, E.E. 1977. Positive motropic response to inosine in the in situ canine heart. Am. J. Physiol. 233:H438-H443.
46. Church, M.K., Hughes, P.J., and Vardey, C.J. 1986. Studies on the receptor mediating cyclic AMP-independent enhancement by adenosine of IgE-dependent mediator release from rat mast cells. Br. J. Pharmacol. 87:233-242.