메뉴 건너뛰기




Volumn 119, Issue 17, 2012, Pages 3951-3961

P85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; FLUOROURACIL; INTERLEUKIN 3; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; STEM CELL FACTOR RECEPTOR;

EID: 84860328809     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-05-355602     Document Type: Article
Times cited : (11)

References (47)
  • 1
    • 0017767169 scopus 로고
    • Development of mast cells from grafted bone marrow cells in irradiated mice
    • Kitamura Y, Shimada M, Hatanaka K, Miyano Y. Development of mast cells from grafted bone marrow cells in irradiated mice. Nature. 1977; 268(5619):442-443.
    • (1977) Nature , vol.268 , Issue.5619 , pp. 442-443
    • Kitamura, Y.1    Shimada, M.2    Hatanaka, K.3    Miyano, Y.4
  • 2
    • 0030024349 scopus 로고    scopus 로고
    • Identification of a committed precursor for the mast cell lineage
    • Rodewald HR, Dessing M, Dvorak AM, Galli SJ. Identification of a committed precursor for the mast cell lineage. Science. 1996;271(5250):818-822. (Pubitemid 26058936)
    • (1996) Science , vol.271 , Issue.5250 , pp. 818-822
    • Rodewald, H.-R.1    Dessing, M.2    Dvorak, A.M.3    Galli, S.J.4
  • 3
    • 44349101991 scopus 로고    scopus 로고
    • Immunomodulatory mast cells: Negative, as well as positive, regulators of immunity
    • DOI 10.1038/nri2327, PII NRI2327
    • Galli SJ, Grimbaldeston M, Tsai M. Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol. 2008;8(6):478-486. (Pubitemid 351733419)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.6 , pp. 478-486
    • Galli, S.J.1    Grimbaldeston, M.2    Tsai, M.3
  • 5
    • 49449109223 scopus 로고    scopus 로고
    • Pharmacological targeting of the KIT growth factor receptor: A therapeutic consideration for mast cell disorders
    • Jensen BM, Akin C, Gilfillan AM. Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders. Br J Pharmacol. 2008;154(8):1572-1582.
    • (2008) Br J Pharmacol , vol.154 , Issue.8 , pp. 1572-1582
    • Jensen, B.M.1    Akin, C.2    Gilfillan, A.M.3
  • 6
    • 0025884259 scopus 로고
    • The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo: Analysis by anatomical distribution, histochemistry, and protease phenotype
    • Tsai M, Shih LS, Newlands GF, et al. The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo: analysis by anatomical distribution, histochemistry, and protease phenotype. J Exp Med. 1991;174(1):125-131.
    • (1991) J Exp Med , vol.174 , Issue.1 , pp. 125-131
    • Tsai, M.1    Shih, L.S.2    Newlands, G.F.3
  • 8
    • 0025160956 scopus 로고
    • Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors
    • Nocka K, Buck J, Levi E, Besmer P. Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. EMBO J. 1990;9(10):3287-3294.
    • (1990) EMBO J , vol.9 , Issue.10 , pp. 3287-3294
    • Nocka, K.1    Buck, J.2    Levi, E.3    Besmer, P.4
  • 9
    • 0028238763 scopus 로고
    • The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis
    • Lemura A, Tsai M, Ando A, Wershil BK, Galli SJ. The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis. Am J Pathol. 1994;144(2):321-328. (Pubitemid 24165953)
    • (1994) American Journal of Pathology , vol.144 , Issue.2 , pp. 321-328
    • Iemura, A.1    Tsai, M.2    Ando, A.3    Wershil, B.K.4    Galli, S.J.5
  • 10
    • 0028895383 scopus 로고
    • Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells
    • Serve H, Yee NS, Stella G, Sepp-Lorenzino L, Tan JC, Besmer P. Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J. 1995;14(3):473-483.
    • (1995) EMBO J , vol.14 , Issue.3 , pp. 473-483
    • Serve, H.1    Yee, N.S.2    Stella, G.3    Sepp-Lorenzino, L.4    Tan, J.C.5    Besmer, P.6
  • 11
    • 0020606416 scopus 로고
    • Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, P cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity
    • Ihle JN, Keller J, Oroszlan S, et al. Biologic properties of homogeneous interleukin 3: I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity. J Immunol. 1983;131(1):282-287. (Pubitemid 13067894)
    • (1983) Journal of Immunology , vol.131 , Issue.1 , pp. 282-287
    • Ihle, J.N.1    Keller, J.2    Oroszlan, S.3
  • 12
    • 0026555097 scopus 로고
    • Interleukin-3 and hematopoiesis
    • Ihle JN. Interleukin-3 and hematopoiesis. Chem Immunol. 1992;51:65-106.
    • (1992) Chem Immunol. , vol.51 , pp. 65-106
    • Ihle, J.N.1
  • 13
    • 0023694835 scopus 로고
    • The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
    • Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature. 1988; 335(6185):88-89.
    • (1988) Nature , vol.335 , Issue.6185 , pp. 88-89
    • Chabot, B.1    Stephenson, D.A.2    Chapman, V.M.3    Besmer, P.4    Bernstein, A.5
  • 14
    • 0018096538 scopus 로고
    • Decrease of mast cells in W/W(V) mice and their increase by bone marrow transplantation
    • Kitamura Y, Go S, Hatanaka K. Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation. Blood. 1978;52(2):447-452. (Pubitemid 8395558)
    • (1978) Blood , vol.52 , Issue.2 , pp. 447-452
    • Kitamura, Y.1    Go, S.2    Hatanaka, K.3
  • 18
    • 70349331057 scopus 로고    scopus 로고
    • AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2
    • Jiao B, Wu CF, Liang Y, et al. AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2. Leukemia. 2009; 23(9):1598-1604.
    • (2009) Leukemia , vol.23 , Issue.9 , pp. 1598-1604
    • Jiao, B.1    Wu, C.F.2    Liang, Y.3
  • 19
    • 38349157811 scopus 로고    scopus 로고
    • Hematopoietic cytokines
    • Metcalf D. Hematopoietic cytokines. Blood. 2008; 111(2):485-491.
    • (2008) Blood , vol.111 , Issue.2 , pp. 485-491
    • Metcalf, D.1
  • 23
    • 0026660653 scopus 로고
    • Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation
    • Backer JM, Myers MG Jr, Shoelson SE, et al. Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBOJ. 1992;11(9):3469-3479.
    • (1992) EMBOJ , vol.11 , Issue.9 , pp. 3469-3479
    • Backer, J.M.1    Myers Jr., M.G.2    Shoelson, S.E.3
  • 25
    • 0025727594 scopus 로고
    • CDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor
    • Escobedo JA, Navankasattusas S, Kavanaugh WM, Milfay D, Fried VA, Williams LT. cDNA-cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. Cell. 1991;65(1):75-82. (Pubitemid 121001215)
    • (1991) Cell , vol.65 , Issue.1 , pp. 75-82
    • Escobedo, J.A.1    Navankasattusas, S.2    Michael Kavanaugh, W.3    Milfay, D.4    Fried, V.A.5    Williams, L.T.6
  • 26
    • 0030271565 scopus 로고    scopus 로고
    • Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85α gene
    • DOI 10.1006/geno.1996.0527
    • Fruman DA, Cantley LC, Carpenter CL. Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Genomics. 1996;37(1):113-121. (Pubitemid 26341841)
    • (1996) Genomics , vol.37 , Issue.1 , pp. 113-121
    • Fruman, D.A.1    Cantley, L.C.2    Carpenter, C.L.3
  • 27
    • 0028982198 scopus 로고
    • The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase
    • Pons S, Asano T, Glasheen E, et al. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol. 1995;15(8):4453-4465.
    • (1995) Mol Cell Biol , vol.15 , Issue.8 , pp. 4453-4465
    • Pons, S.1    Asano, T.2    Glasheen, E.3
  • 30
    • 80052576659 scopus 로고    scopus 로고
    • Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL
    • Mali RS, Ramdas B, Ma P, et al. Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. Cancer Cell. 2011;20(3):357-369.
    • (2011) Cancer Cell , vol.20 , Issue.3 , pp. 357-369
    • Mali, R.S.1    Ramdas, B.2    Ma, P.3
  • 31
    • 0031092657 scopus 로고    scopus 로고
    • 2+ Mobilization, but Not Degranulation, in Lyn-Deficient Bone Marrow-Derived Mast Cells
    • Nishizumi H, Yamamoto T. Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells. J Immunol. 1997;158(5):2350-2355. (Pubitemid 127470021)
    • (1997) Journal of Immunology , vol.158 , Issue.5 , pp. 2350-2355
    • Nishizumi, H.1    Yamamoto, T.2
  • 32
    • 0026039464 scopus 로고
    • Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis
    • Blume-Jensen P, Claesson-Welsh L, Siegbahn A, Zsebo KM, Westermark B, Heldin CH. Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. EMBOJ. 1991;10(13):4121-4128. (Pubitemid 21905443)
    • (1991) EMBO Journal , vol.10 , Issue.13 , pp. 4121-4128
    • Blume-Jensen, P.1    Claesson-Welsh, L.2    Siegbahn, A.3    Zsebo, K.M.4    Westermark, B.5    Heldin, C.-H.6
  • 33
    • 0033568568 scopus 로고    scopus 로고
    • Signaling via Src family kinases is required for normal internalization of the receptor c-Kit
    • Broudy VC, Lin NL, Liles WC, et al. Signaling via Src family kinases is required for normal internalization of the receptor c-Kit. Blood. 1999;94(6): 1979-1986. (Pubitemid 29430414)
    • (1999) Blood , vol.94 , Issue.6 , pp. 1979-1986
    • Broudy, V.C.1    Lin, N.L.2    Liles, W.C.3    Corey, S.J.4    O'Laughlin, B.5    Mou, S.6    Linnekin, D.7
  • 34
    • 0029740513 scopus 로고    scopus 로고
    • C-kit ligand stimulates tyrosine phosphorylation of the c-Cbl protein in human hematopoietic cells
    • Wisniewski D, Strife A, Clarkson B. c-kit ligand stimulates tyrosine phosphorylation of the c-Cbl protein in human hematopoietic cells. Leukemia. 1996;10(9):1436-1442. (Pubitemid 26290322)
    • (1996) Leukemia , vol.10 , Issue.9 , pp. 1436-1442
    • Wisniewski, D.1    Strife, A.2    Clarkson, B.3
  • 35
    • 11144244315 scopus 로고    scopus 로고
    • Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl)
    • DOI 10.1182/blood-2004-05-1768
    • Zeng S, Xu Z, Lipkowitz S, Longley JB. Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl). Blood. 2005;105(1): 226-232. (Pubitemid 40053087)
    • (2005) Blood , vol.105 , Issue.1 , pp. 226-232
    • Zeng, S.1    Xu, Z.2    Lipkowitz, S.3    Longley, J.B.4
  • 36
    • 34548856481 scopus 로고    scopus 로고
    • Genetic and pharmacologic evidence implicating the p85α, but not p85β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis
    • DOI 10.1182/blood-2006-10-053058
    • Munugalavadla V, Sims EC, Borneo J, Chan RJ, Kapur R. Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis. Blood. 2007;110(5):1612-1620. (Pubitemid 47443979)
    • (2007) Blood , vol.110 , Issue.5 , pp. 1612-1620
    • Munugalavadla, V.1    Sims, E.C.2    Borneo, J.3    Chan, R.J.4    Kapur, R.5
  • 37
    • 0033757592 scopus 로고    scopus 로고
    • Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha
    • Fruman DA, Mauvais-Jarvis F, Pollard DA, et al. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nat Genet. 2000;26(3): 379-382.
    • (2000) Nat Genet , vol.26 , Issue.3 , pp. 379-382
    • Fruman, D.A.1    Mauvais-Jarvis, F.2    Pollard, D.A.3
  • 39
    • 0035895375 scopus 로고    scopus 로고
    • New responsibilities for the PI3K regulatory subunit p85 alpha
    • Okkenhaug K, Vanhaesebroeck B. New responsibilities for the PI3K regulatory subunit p85 alpha. Sci STKE. 2001;2001(65): pe1.
    • (2001) Sci STKE , vol.2001 , Issue.65
    • Okkenhaug, K.1    Vanhaesebroeck, B.2
  • 40
    • 2442719040 scopus 로고    scopus 로고
    • Enhanced T cell proliferation in mice lacking the p85β subunit of phosphoinositide 3-kinase
    • Deane JA, Trifilo MJ, Yballe CM, Choi S, Lane TE, Fruman DA. Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase. J Immunol. 2004;172(11):6615-6625. (Pubitemid 38669096)
    • (2004) Journal of Immunology , vol.172 , Issue.11 , pp. 6615-6625
    • Deane, J.A.1    Trifilo, M.J.2    Yballe, C.M.3    Choi, S.4    Lane, T.E.5    Fruman, D.A.6
  • 41
    • 0028158499 scopus 로고
    • Ligand-dependent polyubiquitination of c-kit gene product: A possible mechanism of receptor down modulation in M07e cells
    • Miyazawa K, Toyama K, Gotoh A, Hendrie PC, Mantel C, Broxmeyer HE. Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells. Blood. 1994;83(1):137-145. (Pubitemid 24016525)
    • (1994) Blood , vol.83 , Issue.1 , pp. 137-145
    • Miyazawa, K.1    Toyama, K.2    Gotoh, A.3    Hendrie, P.C.4    Mantel, C.5    Broxmeyer, H.E.6
  • 43
    • 77950529536 scopus 로고    scopus 로고
    • E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease
    • Bandi SR, Brandts C, Rensinghoff M, et al. E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease. Blood. 2009;114(19):4197-4208.
    • (2009) Blood , vol.114 , Issue.19 , pp. 4197-4208
    • Bandi, S.R.1    Brandts, C.2    Rensinghoff, M.3
  • 44
    • 33749390318 scopus 로고    scopus 로고
    • 936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation
    • DOI 10.1042/BJ20060464
    • Masson K, Heiss E, Band H, Ronnstrand L. Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Biochem J. 2006;399(1):59-67. (Pubitemid 44505407)
    • (2006) Biochemical Journal , vol.399 , Issue.1 , pp. 59-67
    • Masson, K.1    Heiss, E.2    Band, H.3    Ronnstrand, L.4
  • 45
    • 67149106146 scopus 로고    scopus 로고
    • Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia
    • Sulahian R, Cleaver O, Huang LJ. Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia. Blood. 2009;113(21):5287-5297.
    • (2009) Blood , vol.113 , Issue.21 , pp. 5287-5297
    • Sulahian, R.1    Cleaver, O.2    Huang, L.J.3
  • 46
    • 4444289580 scopus 로고    scopus 로고
    • Roles of MITF for development of mast cells in mice: Effects on both precursors and tissue environments
    • DOI 10.1182/blood-2004-01-0247
    • Morii E, Oboki K, Ishihara K, Jippo T, Hirano T, Kitamura Y. Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments. Blood. 2004;104(6):1656-1661. (Pubitemid 39202271)
    • (2004) Blood , vol.104 , Issue.6 , pp. 1656-1661
    • Morii, E.1    Oboki, K.2    Ishihara, K.3    Jippo, T.4    Hirano, T.5    Kitamura, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.