Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy

Journal of Allergy and Clinical Immunology

Volumn 132, Issue 4, 2013, Pages 959-968

  Collmann, Emilie ^a   Bohnacker, Thomas ^a   Marone, Romina ^a   Dawson, Janet ^b   Rehberg, Markus ^c   Stringer, Rowan ^d   Krombach, Fritz ^c   Burkhart, Christoph ^b   Hirsch, Emilio ^e   Hollingworth, Gregory J ^d   Thomas, Matthew ^d   Wymann, Matthias P ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^e UNIVERSITY OF TURIN   (Italy)

Author keywords

allergy; anaphylaxis; inflammation; Mast cells; migration; phosphoinositide 3 kinase; recruitment

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; IMMUNOGLOBULIN E; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADHESION; ALLERGIC REACTION; ALLERGY; ANAPHYLAXIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL ACTIVATION; CHEMOTAXIS; CREMASTER MUSCLE; CYTOKINE RELEASE; DEGRANULATION; ENDOTHELIUM CELL; GENE; IN VIVO STUDY; MAST CELL; MAST CELL DEGRANULATION; MICROSCOPY; MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; SKIN;

2,4,6-TRINITROPHENOL; 2,4-DINITROPHENOL; ALLERGY; ANAPHYLAXIS; BMMC; BONE MARROW-DERIVED MAST CELL; DNP; FACS; FLUORESCENCE-ACTIVATED CELL SORTING; G PROTEIN-COUPLED RECEPTOR; GPCR; HALF-MAXIMAL INHIBITORY CONCENTRATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELL; HUVEC; IC(50); IMDM; INFLAMMATION; ISCOVE MODIFIED DULBECCO MEDIUM; MAPK; MAST CELLS; MIGRATION; MITOGEN-ACTIVATED PROTEIN KINASE; PASSIVE CUTANEOUS ANAPHYLAXIS; PCA; PHOSPHATIDYLINOSITOL; PHOSPHOINOSITIDE 3-KINASE; PHOSPHORYLATED PKB; PI3K; PKB/AKT; PPKB; PROTEIN KINASE B; PTDINS; RECRUITMENT; SCF; SDF-1Α; STEM CELL FACTOR; STROMAL CELL-DERIVED FACTOR 1Α; TNP; VASCULAR CELL ADHESION MOLECULE 1; VCAM-1; VERY LATE ANTIGEN; VLA;

ANAPHYLAXIS; ANIMALS; ANTI-ALLERGIC AGENTS; CELL DEGRANULATION; CELL MOVEMENT; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; ENDOTHELIAL CELLS; ENZYME INHIBITORS; HUMANS; HYPERSENSITIVITY; MAST CELLS; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 3-KINASES;

EID: 84884910533     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.03.008     Document Type: Article

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