Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85α Src homology-2 domains

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 34, 2011, Pages 14157-14162

  Lee, Jennifer Y ^a,b   Chiu, Yu Hsin ^a,b   Asara, John ^a,b   Cantley, Lewis C ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ASPARTIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PHORBOL ESTER; PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE D; PROTEIN P85; PROTEIN P85ALPHA; PROTEIN TYROSINE PHOSPHATASE SHP 2; SERINE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL STIMULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; MOLECULAR INTERACTION; MOUSE; MUTATION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; ENZYME ACTIVATION; ENZYME ACTIVATORS; HEK293 CELLS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

EID: 80052180666     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1107747108     Document Type: Article

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