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Volumn 5, Issue 2, 2013, Pages 53-66

Antigen-based vs. Systemic immunomodulation in type 1 diabetes: The pros and cons

Author keywords

Ag specific; Clinical trial; Combination therapy; Patient; Systemic; Therapy; Type 1 diabetes

Indexed keywords

ABATACEPT; ANTIGEN; CYCLOSPORIN A; INSULIN; OTELIXIZUMAB; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RITUXIMAB; TEPLIZUMAB; VITAMIN D;

EID: 84879332708     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.24785     Document Type: Review
Times cited : (11)

References (149)
  • 1
    • 67049159857 scopus 로고    scopus 로고
    • Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study
    • EURODIAB Study Group PMID:19481249; http://dx.doi.org/10.1016/S0140- 6736(09)60568-7
    • Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G; EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009; 373:2027-33; PMID:19481249; http://dx.doi.org/10.1016/S0140-6736(09)60568-7
    • (2009) Lancet , vol.373 , pp. 2027-2033
    • Patterson, C.C.1    Dahlquist, G.G.2    Gyürüs, E.3    Green, A.4    Soltész, G.5
  • 2
    • 77954128990 scopus 로고    scopus 로고
    • Immune cell crosstalk in type 1 diabetes
    • PMID:20577267; http://dx.doi.org/10.1038/nri2787
    • Lehuen A, Diana J, Zaccone P, Cooke A. Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol 2010; 10:501-13; PMID:20577267; http://dx.doi.org/10. 1038/nri2787
    • (2010) Nat Rev Immunol , vol.10 , pp. 501-513
    • Lehuen, A.1    Diana, J.2    Zaccone, P.3    Cooke, A.4
  • 3
    • 0023709376 scopus 로고
    • Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion
    • The Canadian-European Randomized Control Trial Group PMID:2903105; http://dx.doi.org/10.2337/diabetes.37.11.1574
    • The Canadian-European Randomized Control Trial Group. Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. Diabetes 1988; 37:1574-82; PMID:2903105; http://dx.doi.org/10.2337/diabetes.37.11.1574
    • (1988) Diabetes , vol.37 , pp. 1574-1582
  • 4
    • 0022619110 scopus 로고
    • Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial
    • PMID:2873396; http://dx.doi.org/10.1016/S0140-6736(86)91943-4
    • Feutren G, Papoz L, Assan R, Vialettes B, Karsenty G, Vexiau P, et al. Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet 1986; 2:119-24; PMID:2873396; http://dx.doi.org/10.1016/S0140-6736(86)91943-4
    • (1986) Lancet , vol.2 , pp. 119-124
    • Feutren, G.1    Papoz, L.2    Assan, R.3    Vialettes, B.4    Karsenty, G.5    Vexiau, P.6
  • 6
    • 20044375937 scopus 로고    scopus 로고
    • A single course of anti-CD3 monoclonal antibody hOKT3γ1(ala-ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
    • DOI 10.2337/diabetes.54.6.1763
    • Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, et al. A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005; 54:1763-9; PMID:15919798; http://dx.doi.org/10.2337/diabe-tes.54.6.1763 (Pubitemid 40770766)
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1763-1769
    • Herold, K.C.1    Gitelman, S.E.2    Masharani, U.3    Hagopian, W.4    Bisikirska, B.5    Donaldson, D.6    Rother, K.7    Diamond, B.8    Harlan, D.M.9    Bluestone, J.A.10
  • 8
    • 80051471700 scopus 로고    scopus 로고
    • Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial
    • Protégé Trial Investigators PMID:21719095; http://dx.doi.org/10.1016/S0140-6736(11)60931-8
    • Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry RJ Jr., et al.; Protégé Trial Investigators. Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial. Lancet 2011; 378:487-97; PMID:21719095; http://dx.doi.org/10.1016/S0140-6736(11)60931-8
    • (2011) Lancet , vol.378 , pp. 487-497
    • Sherry, N.1    Hagopian, W.2    Ludvigsson, J.3    Jain, S.M.4    Wahlen, J.5    Ferry Jr., R.J.6
  • 9
    • 68949106914 scopus 로고    scopus 로고
    • The anti-inter-leukin-1 in type 1 diabetes action trial - Background and rationale
    • PMID:19405081; http://dx.doi.org/10.1002/dmrr.960
    • Pickersgill LM, Mandrup-Poulsen TR. The anti-inter-leukin-1 in type 1 diabetes action trial - background and rationale. Diabetes Metab Res Rev 2009; 25:321-4; PMID:19405081; http://dx.doi.org/10.1002/dmrr.960
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 321-324
    • Pickersgill, L.M.1    Mandrup-Poulsen, T.R.2
  • 10
    • 79960912796 scopus 로고    scopus 로고
    • Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: A randomised, double-blind, placebo-controlled trial
    • Type 1 Diabetes TrialNet Abatacept Study Group PMID:21719096; http://dx.doi.org/10.1016/S0140-6736(11)60886-6
    • Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, et al.; Type 1 Diabetes TrialNet Abatacept Study Group. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet 2011; 378:412-9; PMID:21719096; http://dx.doi.org/10.1016/S0140-6736(11)60886-6
    • (2011) Lancet , vol.378 , pp. 412-419
    • Orban, T.1    Bundy, B.2    Becker, D.J.3    DiMeglio, L.A.4    Gitelman, S.E.5    Goland, R.6
  • 11
    • 70449480577 scopus 로고    scopus 로고
    • Rituximab, B-lymphocyte depletion, and preservation of beta-cell function
    • Type 1 Diabetes TrialNet Anti-CD20 Study Group PMID:19940299; http://dx.doi.org/10.1056/NEJMoa0904452
    • Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H, Becker DJ, Gitelman SE, Goland R, et al.; Type 1 Diabetes TrialNet Anti-CD20 Study Group. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med 2009; 361:2143-52; PMID:19940299; http://dx.doi.org/10.1056/NEJMoa0904452
    • (2009) N Engl J Med , vol.361 , pp. 2143-2152
    • Pescovitz, M.D.1    Greenbaum, C.J.2    Krause-Steinrauf, H.3    Becker, D.J.4    Gitelman, S.E.5    Goland, R.6
  • 12
    • 77956263961 scopus 로고    scopus 로고
    • No effect of the 1alpha,25-dihydroxyvi-tamin D3 on beta-cell residual function and insulin requirement in adults with new-onset type 1 diabetes
    • PMID:20357369; http://dx.doi.org/10.2337/dc09-2297
    • Walter M, Kaupper T, Adler K, Foersch J, Bonifacio E, Ziegler AG. No effect of the 1alpha,25-dihydroxyvi-tamin D3 on beta-cell residual function and insulin requirement in adults with new-onset type 1 diabetes. Diabetes Care 2010; 33:1443-8; PMID:20357369; http://dx.doi.org/10.2337/dc09-2297
    • (2010) Diabetes Care , vol.33 , pp. 1443-1448
    • Walter, M.1    Kaupper, T.2    Adler, K.3    Foersch, J.4    Bonifacio, E.5    Ziegler, A.G.6
  • 14
    • 70350680951 scopus 로고    scopus 로고
    • Protective effects of 1-alpha-hydroxyvitamin D3 on residual beta-cell function in patients with adult-onset latent autoimmune diabetes (LADA)
    • PMID:19488999; http://dx.doi.org/10.1002/dmrr.977
    • Li X, Liao L, Yan X, Huang G, Lin J, Lei M, et al. Protective effects of 1-alpha-hydroxyvitamin D3 on residual beta-cell function in patients with adult-onset latent autoimmune diabetes (LADA). Diabetes Metab Res Rev 2009; 25:411-6; PMID:19488999; http://dx.doi.org/10.1002/dmrr.977
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 411-416
    • Li, X.1    Liao, L.2    Yan, X.3    Huang, G.4    Lin, J.5    Lei, M.6
  • 15
    • 80855124111 scopus 로고    scopus 로고
    • The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: A randomized controlled trial
    • PMID:22069289; http://dx.doi.org/10.1002/dmrr.1276
    • Bock G, Prietl B, Mader JK, Höller E, Wolf M, Pilz S, et al. The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: a randomized controlled trial. Diabetes Metab Res Rev 2011; 27:942-5; PMID:22069289; http://dx.doi.org/10.1002/dmrr.1276
    • (2011) Diabetes Metab Res Rev , vol.27 , pp. 942-945
    • Bock, G.1    Prietl, B.2    Mader, J.K.3    Höller, E.4    Wolf, M.5    Pilz, S.6
  • 16
    • 84864745214 scopus 로고    scopus 로고
    • Cyclosporine: A review
    • PMID:22263104; http://dx.doi.org/10.1155/2012/230-386
    • Tedesco D, Haragsim L. Cyclosporine: a review. J Transplant 2012; 2012:230-386; PMID:22263104; http://dx.doi.org/10.1155/2012/230-386
    • (2012) J Transplant , vol.2012 , pp. 230-386
    • Tedesco, D.1    Haragsim, L.2
  • 17
    • 0020658241 scopus 로고
    • Cyclosporin prevents diabetes in BB Wistar rats
    • Laupacis A, Stiller CR, Gardell C, Keown P, Dupre J, Wallace AC, et al. Cyclosporin prevents diabetes in BB Wistar rats. Lancet 1983; 1:10-2; PMID:6129365; http://dx.doi.org/10.1016/S0140-6736(83)91558-1 (Pubitemid 13211278)
    • (1983) Lancet , vol.1 , Issue.8314 , pp. 10-12
    • Laupacis, A.1    Gardell, C.2    Stiller, C.R.3
  • 18
    • 0021359025 scopus 로고
    • Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset
    • Stiller CR, Dupré J, Gent M, Jenner MR, Keown PA, Laupacis A, et al. Effects of cyclosporine immunosup-pression in insulin-dependent diabetes mellitus of recent onset. Science 1984; 223:1362-7; PMID:6367043; http://dx.doi.org/10.1126/science.6367043 (Pubitemid 14161003)
    • (1984) Science , vol.223 , Issue.4643 , pp. 1362-1367
    • Stiller, C.R.1    Dupre, J.2    Gent, M.3
  • 19
    • 0023914913 scopus 로고
    • Effects of immuno-suppression with cyclosporine in insulin-dependent diabetes mellitus of recent onset: The Canadian open study at 44 months
    • PMID:3289204
    • Dupré J, Stiller CR, Gent M, Donner A, von Graffenreid B, Murphy G, et al. Effects of immuno-suppression with cyclosporine in insulin-dependent diabetes mellitus of recent onset: the Canadian open study at 44 months. Transplant Proc 1988; 20(Suppl 4):184-92; PMID:3289204
    • (1988) Transplant Proc , vol.20 , Issue.SUPPL. 4 , pp. 184-192
    • Dupré, J.1    Stiller, C.R.2    Gent, M.3    Donner, A.4    Von Graffenreid, B.5    Murphy, G.6
  • 20
    • 0025909735 scopus 로고
    • Follow-up of cyclosporin A treatment in type 1 (insulin-dependent) diabetes mellitus: Lack of long-term effects
    • PMID:1884902; http://dx.doi.org/10.1007/BF00403182
    • Martin S, Schernthaner G, Nerup J, Gries FA, Koivisto VA, Dupré J, et al. Follow-up of cyclosporin A treatment in type 1 (insulin-dependent) diabetes mellitus: lack of long-term effects. Diabetologia 1991; 34:429-34; PMID:1884902; http://dx.doi.org/10.1007/BF00403182
    • (1991) Diabetologia , vol.34 , pp. 429-434
    • Martin, S.1    Schernthaner, G.2    Nerup, J.3    Gries, F.A.4    Koivisto, V.A.5    Dupré, J.6
  • 21
    • 0025049497 scopus 로고
    • Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin
    • Bougnères P F, Landais P, Boisson C, Carel JC, Frament N, Boitard C, et al. Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin. Diabetes 1990; 39:1264-72; PMID:2210078; http://dx.doi.org/10.2337/diabetes.39.10.1264 (Pubitemid 20327064)
    • (1990) Diabetes , vol.39 , Issue.10 , pp. 1264-1272
    • Bougneres, P.-F.1    Landais, P.2    Boisson, C.3    Carel, J.-C.4    Frament, N.5    Boitard, C.6    Chaussain, J.-L.7    Bach, J.-F.8
  • 22
    • 0033009588 scopus 로고    scopus 로고
    • Cyclosporine nephrotoxicity in type 1 diabetic patients: A 7-year follow-up study
    • Parving HH, Tarnow L, Nielsen FS, Rossing P, Mandrup-Poulsen T, Osterby R, et al. Cyclosporine nephrotoxicity in type 1 diabetic patients. A 7-year follow-up study. Diabetes Care 1999; 22:478-83; PMID:10097932; http://dx.doi.org/10.2337/dia-care.22.3.478 (Pubitemid 29106908)
    • (1999) Diabetes Care , vol.22 , Issue.3 , pp. 478-483
    • Parving, H.-H.1    Tarnow, L.2    Nielsen, F.S.3    Rossing, P.4    Mandrup-Poulsen, T.5    Osterby, R.6    Nerup, J.7
  • 24
    • 0019851727 scopus 로고
    • Treatment of acute renal allograft rejection with OKT3 monoclonal antibody
    • Cosimi AB, Burton RC, Colvin RB, Goldstein G, Delmonico FL, LaQuaglia M P, et al. Treatment of acute renal allograft rejection with OKT3 monoclonal antibody. Transplantation 1981; 32:535-9; PMID:7041358; http://dx.doi.org/10. 1097/00007890-198112000-00018 (Pubitemid 12204717)
    • (1981) Transplantation , vol.32 , Issue.6 , pp. 535-539
    • Cosimi, A.B.1    Burton, R.C.2    Colvin, R.B.3
  • 25
    • 0029102761 scopus 로고
    • An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity
    • PMID:7636216
    • Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, et al. An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity. J Immunol 1995; 155:1544-55; PMID:7636216
    • (1995) J Immunol , vol.155 , pp. 1544-1555
    • Alegre, M.L.1    Tso, J.Y.2    Sattar, H.A.3    Smith, J.4    Desalle, F.5    Cole, M.6
  • 27
    • 0029059420 scopus 로고
    • Fc receptor binding of anti-CD3 monoclonal antibodies is not essential for immunosuppression, but triggers cytokine-related side effects
    • PMID:7614975; http://dx.doi.org/10.1002/eji.1830250603
    • Vossen AC, Tibbe GJ, Kroos MJ, van de Winkel JG, Benner R, Savelkoul H F. Fc receptor binding of anti-CD3 monoclonal antibodies is not essential for immunosuppression, but triggers cytokine-related side effects. Eur J Immunol 1995; 25:1492-6; PMID:7614975; http://dx.doi.org/10.1002/eji.1830250603
    • (1995) Eur J Immunol , vol.25 , pp. 1492-1496
    • Vossen, A.C.1    Tibbe, G.J.2    Kroos, M.J.3    Van De Winkel, J.G.4    Benner, R.5    Savelkoul, H.F.6
  • 29
    • 0027458717 scopus 로고
    • The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties
    • Bolt S, Routledge E, Lloyd I, Chatenoud L, Pope H, Gorman SD, et al. The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties. Eur J Immunol 1993; 23:403-11; PMID:8436176; http://dx.doi.org/10.1002/eji.1830230216 (Pubitemid 23075070)
    • (1993) European Journal of Immunology , vol.23 , Issue.2 , pp. 403-411
    • Bolt, S.1    Routledge, E.2    Lloyd, I.3    Chatenoud, L.4    Pope, H.5    Gorman, S.D.6    Clark, M.7    Waldmann, H.8
  • 30
    • 0031569177 scopus 로고    scopus 로고
    • CD3 antibody-induced dominant self tolerance in overtly diabetic nod mice
    • Chatenoud L, Primo J, Bach J F. CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immunol 1997; 158:2947-54; PMID:9058834 (Pubitemid 127470558)
    • (1997) Journal of Immunology , vol.158 , Issue.6 , pp. 2947-2954
    • Chatenoud, L.1    Primo, J.2    Bach, J.-F.3
  • 32
    • 80051931752 scopus 로고    scopus 로고
    • Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells
    • PMID:21742976; http://dx.doi.org/10.4049/jimmunol.1100713
    • Penaranda C, Tang Q, Bluestone JA. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol 2011; 187:2015-22; PMID:21742976; http://dx.doi.org/10.4049/jimmunol. 1100713
    • (2011) J Immunol , vol.187 , pp. 2015-2022
    • Penaranda, C.1    Tang, Q.2    Bluestone, J.A.3
  • 33
    • 34547230077 scopus 로고    scopus 로고
    • CD3-specific antibodies: A portal to the treatment of autoimmunity
    • DOI 10.1038/nri2134, PII NRI2134
    • Chatenoud L, Bluestone JA. CD3-specific antibodies: a portal to the treatment of autoimmunity. Nat Rev Immunol 2007; 7:622-32; PMID:17641665; http://dx.doi.org/10.1038/nri2134 (Pubitemid 47123550)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.8 , pp. 622-632
    • Chatenoud, L.1    Bluestone, J.A.2
  • 34
    • 0020361983 scopus 로고
    • Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody
    • DOI 10.1002/eji.1830121116
    • Chatenoud L, Baudrihaye M F, Kreis H, Goldstein G, Schindler J, Bach J F. Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody. Eur J Immunol 1982; 12:979-82; PMID:6759145; http://dx.doi.org/10. 1002/eji.1830121116 (Pubitemid 13203591)
    • (1982) European Journal of Immunology , vol.12 , Issue.11 , pp. 979-982
    • Chatenoud, L.1    Baudrihaye, M.F.2    Kreis, H.3
  • 35
    • 77956254994 scopus 로고    scopus 로고
    • Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints
    • PMID:20679403; http://dx.doi.org/10.1084/jem.20100205
    • Nishio J, Feuerer M, Wong J, Mathis D, Benoist C. Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. J Exp Med 2010; 207:1879-89; PMID:20679403; http://dx.doi.org/10.1084/jem.20100205
    • (2010) J Exp Med , vol.207 , pp. 1879-1889
    • Nishio, J.1    Feuerer, M.2    Wong, J.3    Mathis, D.4    Benoist, C.5
  • 36
    • 0141796312 scopus 로고    scopus 로고
    • TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    • DOI 10.1038/nm924
    • Belghith M, Bluestone JA, Barriot S, Mégret J, Bach J F, Chatenoud L. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 2003; 9:1202-8; PMID:12937416; http://dx.doi.org/10.1038/nm924 (Pubitemid 37173706)
    • (2003) Nature Medicine , vol.9 , Issue.9 , pp. 1202-1208
    • Belghith, M.1    Bluestone, J.A.2    Barriot, S.3    Megret, J.4    Bach, J.-F.5    Chatenoud, L.6
  • 38
    • 84856274206 scopus 로고    scopus 로고
    • Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients
    • PMID:22277969; http://dx.doi.org/10.1126/scitrans-lmed.3003401
    • Waldron-Lynch F, Henegariu O, Deng S, Preston-Hurlburt P, Tooley J, Flavell R, et al. Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients. Sci Transl Med 2012; 4:18ra12; PMID:22277969; http://dx.doi.org/10.1126/scitrans-lmed.3003401
    • (2012) Sci Transl Med , vol.4
    • Waldron-Lynch, F.1    Henegariu, O.2    Deng, S.3    Preston-Hurlburt, P.4    Tooley, J.5    Flavell, R.6
  • 39
    • 79551715405 scopus 로고    scopus 로고
    • Human CD3 transgenic mice: Preclinical testing of antibodies promoting immune tolerance
    • PMID:21289272; http://dx.doi.org/10.1126/scitranslmed.3001830
    • Kuhn C, You S, Valette F, Hale G, van Endert P, Bach J F, et al. Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance. Sci Transl Med 2011; 3:68ra10; PMID:21289272; http://dx.doi.org/10. 1126/scitranslmed.3001830
    • (2011) Sci Transl Med , vol.3
    • Kuhn, C.1    You, S.2    Valette, F.3    Hale, G.4    Van Endert, P.5    Bach, J.F.6
  • 41
    • 67649933375 scopus 로고    scopus 로고
    • Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years
    • Immune Tolerance Network ITN007AI Study Group PMID:19443276; http://dx.doi.org/10.1016/j.clim.2009.04.007
    • Herold KC, Gitelman S, Greenbaum C, Puck J, Hagopian W, Gottlieb P, et al.; Immune Tolerance Network ITN007AI Study Group. Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years. Clin Immunol 2009; 132:166-73; PMID:19443276; http://dx.doi.org/10.1016/j.clim.2009.04.007
    • (2009) Clin Immunol , vol.132 , pp. 166-173
    • Herold, K.C.1    Gitelman, S.2    Greenbaum, C.3    Puck, J.4    Hagopian, W.5    Gottlieb, P.6
  • 42
    • 77949266510 scopus 로고    scopus 로고
    • Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
    • PMID:20225393; http://dx.doi.org/10.1007/s00125-009-1644-9
    • Keymeulen B, Walter M, Mathieu C, Kaufman L, Gorus F, Hilbrands R, et al. Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia 2010; 53:614-23; PMID:20225393; http://dx.doi.org/10.1007/s00125-009-1644-9
    • (2010) Diabetologia , vol.53 , pp. 614-623
    • Keymeulen, B.1    Walter, M.2    Mathieu, C.3    Kaufman, L.4    Gorus, F.5    Hilbrands, R.6
  • 43
    • 77949513969 scopus 로고    scopus 로고
    • Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients
    • PMID:20007541; http://dx.doi.org/10.1182/blood-2009-02-204875
    • Keymeulen B, Candon S, Fafi-Kremer S, Ziegler A, Leruez-Ville M, Mathieu C, et al. Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients. Blood 2010; 115:1145-55; PMID:20007541; http://dx.doi.org/10.1182/blood-2009-02-204875
    • (2010) Blood , vol.115 , pp. 1145-1155
    • Keymeulen, B.1    Candon, S.2    Fafi-Kremer, S.3    Ziegler, A.4    Leruez-Ville, M.5    Mathieu, C.6
  • 44
    • 80855124117 scopus 로고    scopus 로고
    • Preservation of recall immunity in anti-CD3-treated recent onset type 1 diabetes patients
    • PMID:22069286; http://dx.doi.org/10.1002/dmrr.1273
    • Alkemade GM, Hilbrands R, Vandemeulebroucke E, Pipeleers D, Waldmann H, Mathieu C, et al. Preservation of recall immunity in anti-CD3-treated recent onset type 1 diabetes patients. Diabetes Metab Res Rev 2011; 27:925-7; PMID:22069286; http://dx.doi.org/10.1002/dmrr.1273
    • (2011) Diabetes Metab Res Rev , vol.27 , pp. 925-927
    • Alkemade, G.M.1    Hilbrands, R.2    Vandemeulebroucke, E.3    Pipeleers, D.4    Waldmann, H.5    Mathieu, C.6
  • 45
    • 0022596377 scopus 로고
    • Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans
    • DOI 10.1007/BF02427283
    • Mandrup-Poulsen T, Bendtzen K, Nerup J, Dinarello CA, Svenson M, Nielsen JH. Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. Diabetologia 1986; 29:63-7; PMID:3514344; http://dx.doi.org/10.1007/ BF02427283 (Pubitemid 16162744)
    • (1986) Diabetologia , vol.29 , Issue.1 , pp. 63-67
    • Mandrup-Poulsen, T.1    Bendtzen, K.2    Nerup, J.3
  • 46
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death - The signal-transduction of immune-mediated beta-cell apoptosis
    • DOI 10.1007/s001250100021
    • Eizirik DL, Mandrup-Poulsen T. A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001; 44:2115-33; PMID:11793013; http://dx.doi.org/10.1007/s001250100021 (Pubitemid 34015464)
    • (2001) Diabetologia , vol.44 , Issue.12 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 47
    • 69549105888 scopus 로고    scopus 로고
    • Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes
    • PMID:19542207; http://dx.doi.org/10.2337/dc09-0533
    • Larsen CM, Faulenbach M, Vaag A, Ehses JA, Donath MY, Mandrup-Poulsen T. Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes Care 2009; 32:1663-8; PMID:19542207; http://dx.doi.org/10. 2337/dc09-0533
    • (2009) Diabetes Care , vol.32 , pp. 1663-1668
    • Larsen, C.M.1    Faulenbach, M.2    Vaag, A.3    Ehses, J.A.4    Donath, M.Y.5    Mandrup-Poulsen, T.6
  • 48
    • 0036845130 scopus 로고    scopus 로고
    • Long-term safety and maintenance of clinical improvement following treatment with anakinra (Recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: Extension phase of a randomized, double-blind, placebo-controlled trial
    • DOI 10.1002/art.10578
    • Nuki G, Bresnihan B, Bear MB, McCabe D; European Group Of Clinical Investigators. Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2002; 46:2838-46; PMID:12428223; http://dx.doi.org/10.1002/art.10578 (Pubitemid 35315874)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.11 , pp. 2838-2846
    • Nuki, G.1    Bresnihan, B.2    Bear, M.B.3    McCabe, D.4
  • 49
    • 84878300647 scopus 로고    scopus 로고
    • Interleukin-1 antagonism in type 1 diabetes of recent onset: Two multicentre, randomised, double-blind, placebo-controlled trials
    • for the Type 1 Diabetes TrialNet Canakinumab Study Group; for the AIDA Study Group PMID:23562090; http://dx.doi.org/10.1016/S0140-6736(13)60023-9
    • Moran A, Bundy B, Becker DJ, Dimeglio LA, Gitelman SE, Goland R, et al.; for the Type 1 Diabetes TrialNet Canakinumab Study Group; for the AIDA Study Group. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet 2013; 381:1905-15;PMID:23562090; http://dx.doi.org/10.1016/S0140-6736(13)60023-9
    • (2013) Lancet , vol.381 , pp. 1905-1915
    • Moran, A.1    Bundy, B.2    Becker, D.J.3    Dimeglio, L.A.4    Gitelman, S.E.5    Goland, R.6
  • 50
    • 65349119978 scopus 로고    scopus 로고
    • CD28 and CTLA-4 coreceptor expression and signal transduction
    • PMID:19426212; http://dx.doi.org/ 10.1111/j.1600-065X.2009.00770.x.
    • Rudd CE, Taylor A, Schneider H. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 2009; 229:12-26; PMID:19426212; http://dx.doi.org/10.1111/j.1600-065X.2009.00770.x.
    • (2009) Immunol Rev , vol.229 , pp. 12-26
    • Rudd, C.E.1    Taylor, A.2    Schneider, H.3
  • 51
    • 65349185047 scopus 로고    scopus 로고
    • The clinical utility of inhibiting CD28-mediated costimulation
    • PMID:19426230; http://dx.doi.org/10.1111/j.1600-065X.2009.00780.x
    • Linsley PS, Nadler SG. The clinical utility of inhibiting CD28-mediated costimulation. Immunol Rev 2009; 229:307-21; PMID:19426230; http://dx.doi.org/ 10.1111/j.1600-065X.2009.00780.x
    • (2009) Immunol Rev , vol.229 , pp. 307-321
    • Linsley, P.S.1    Nadler, S.G.2
  • 54
    • 0028900297 scopus 로고
    • Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
    • PMID:7532678; http://dx.doi.org/10.1084/jem.181.3.1145
    • Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, et al. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med 1995; 181:1145-55; PMID:7532678; http://dx.doi.org/10.1084/jem.181.3.1145
    • (1995) J Exp Med , vol.181 , pp. 1145-1155
    • Lenschow, D.J.1    Ho, S.C.2    Sattar, H.3    Rhee, L.4    Gray, G.5    Nabavi, N.6
  • 56
    • 0035807589 scopus 로고    scopus 로고
    • Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency
    • PMID:11586956; http://dx.doi.org/10.1056/NEJMoa010465
    • Martin S, Wolf-Eichbaum D, Duinkerken G, Scherbaum WA, Kolb H, Noordzij JG, et al. Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency. N Engl J Med 2001; 345:1036-40; PMID:11586956; http://dx.doi.org/ 10.1056/NEJMoa010465
    • (2001) N Engl J Med , vol.345 , pp. 1036-1040
    • Martin, S.1    Wolf-Eichbaum, D.2    Duinkerken, G.3    Scherbaum, W.A.4    Kolb, H.5    Noordzij, J.G.6
  • 58
    • 23044436849 scopus 로고    scopus 로고
    • Vitamin D and type 1 diabetes mellitus: State of the art
    • DOI 10.1016/j.tem.2005.06.004, PII S1043276005001268
    • Mathieu C, Badenhoop K. Vitamin D and type 1 diabetes mellitus: state of the art. Trends Endocrinol Metab 2005; 16:261-6; PMID:15996876; http://dx.doi.org/10.1016/j.tem.2005.06.004 (Pubitemid 41058757)
    • (2005) Trends in Endocrinology and Metabolism , vol.16 , Issue.6 , pp. 261-266
    • Mathieu, C.1    Badenhoop, K.2
  • 59
    • 0028357305 scopus 로고
    • 3
    • Mathieu C, Waer M, Laureys J, Rutgeerts O, Bouillon R. Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia 1994; 37:552-8; PMID:7926338; http://dx.doi.org/10.1007/BF00403372 (Pubitemid 24162425)
    • (1994) Diabetologia , vol.37 , Issue.6 , pp. 552-558
    • Mathieu, C.1    Waer, M.2    Laureys, J.3    Rutgeerts, O.4    Bouillon, R.5
  • 60
    • 0036020679 scopus 로고    scopus 로고
    • 3 analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice
    • Gregori S, Giarratana N, Smiroldo S, Uskokovic M, Adorini L. A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 2002; 51:1367-74; PMID:11978632; http://dx.doi.org/10.2337/diabe-tes.51.5.1367 (Pubitemid 34826601)
    • (2002) Diabetes , vol.51 , Issue.5 , pp. 1367-1374
    • Gregori, S.1    Giarratana, N.2    Smiroldo, S.3    Uskokovic, M.4    Adorini, L.5
  • 61
    • 0043063940 scopus 로고    scopus 로고
    • 3 completely protects NOD mice from insulin-dependent diabetes mellitus
    • DOI 10.1016/S0003-9861(03)00338-2
    • Zella JB, McCary LC, DeLuca H F. Oral administration of 1,25-dihydroxyvitamin D3 completely protects NOD mice from insulin-dependent diabetes mellitus. Arch Biochem Biophys 2003; 417:77-80; PMID:12921782; http://dx.doi.org/10.1016/S0003-9861(03)00338-2 (Pubitemid 36960051)
    • (2003) Archives of Biochemistry and Biophysics , vol.417 , Issue.1 , pp. 77-80
    • Zella, J.B.1    McCary, L.C.2    DeLuca, H.F.3
  • 62
    • 0035802695 scopus 로고    scopus 로고
    • Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study
    • DOI 10.1016/S0140-6736(01)06580-1
    • Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001; 358:1500-3; PMID:11705562; http://dx.doi.org/10.1016/S0140- 6736(01)06580-1 (Pubitemid 33055701)
    • (2001) Lancet , vol.358 , Issue.9292 , pp. 1500-1503
    • Hypponen, E.1    Laara, E.2    Reunanen, A.3    Jarvelin, M.-R.4    Virtanen, S.M.5
  • 63
    • 0032939358 scopus 로고    scopus 로고
    • Vitamin D supplement in early childhood and risk for Type I (insulin- dependent) diabetes mellitus
    • DOI 10.1007/s001250051112
    • Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group. Diabetologia 1999; 42:51-4; PMID:10027578; http://dx.doi.org/10.1007/ s001250051112 (Pubitemid 29039737)
    • (1999) Diabetologia , vol.42 , Issue.1 , pp. 51-54
    • Dahlquist, G.1
  • 64
    • 19444384955 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established
    • DOI 10.1016/j.exphem.2005.03.008, PII S0301472X05001323
    • Kang EM, Zickler P P, Burns S, Langemeijer SM, Brenner S, Phang OA, et al. Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established. Exp Hematol 2005; 33:699-705; PMID:15911094; http://dx.doi.org/10. 1016/j.exphem.2005.03.008 (Pubitemid 40725836)
    • (2005) Experimental Hematology , vol.33 , Issue.6 , pp. 699-705
    • Kang, E.M.1    Zickler, P.P.2    Burns, S.3    Langemeijer, S.M.4    Brenner, S.5    Phang, O.A.6    Patterson, N.7    Harlan, D.8    Tisdale, J.F.9
  • 66
    • 64749084427 scopus 로고    scopus 로고
    • C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
    • PMID:19366777; http://dx.doi.org/10.1001/jama.2009.470
    • Couri CE, Oliveira MC, Stracieri AB, Moraes DA, Pieroni F, Barros GM, et al. C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 2009; 301:1573-9; PMID:19366777; http://dx.doi.org/ 10.1001/jama.2009.470
    • (2009) JAMA , vol.301 , pp. 1573-1579
    • Couri, C.E.1    Oliveira, M.C.2    Stracieri, A.B.3    Moraes, D.A.4    Pieroni, F.5    Barros, G.M.6
  • 67
    • 0028997320 scopus 로고
    • Self and non-self antigen in diabetic autoimmunity: Molecules and mechanisms
    • PMID:7658921; http://dx.doi.org/10.1016/0098-2997(95)00001-W
    • Karges WJ, Ilonen J, Robinson BH, Dosch HM. Self and non-self antigen in diabetic autoimmunity: molecules and mechanisms. Mol Aspects Med 1995; 16:79-213; PMID:7658921; http://dx.doi.org/10.1016/0098-2997(95)00001-W
    • (1995) Mol Aspects Med , vol.16 , pp. 79-213
    • Karges, W.J.1    Ilonen, J.2    Robinson, B.H.3    Dosch, H.M.4
  • 68
    • 0034323073 scopus 로고    scopus 로고
    • High-throughput radioassays for autoantibodies to recombinant autoantigens
    • PMID:11056082; http://dx.doi.org/10.2741/kawasaki
    • Kawasaki E, Eisenbarth GS. High-throughput radioassays for autoantibodies to recombinant autoantigens. Front Biosci 2000; 5:E181-90; PMID:11056082; http://dx.doi.org/10.2741/kawasaki
    • (2000) Front Biosci , vol.5
    • Kawasaki, E.1    Eisenbarth, G.S.2
  • 69
    • 84856775181 scopus 로고    scopus 로고
    • The role of autoantibodies to zinc transporter 8 in prediction of type 1 diabetes in relatives: Lessons from the European Nicotinamide Diabetes Intervention Trial (ENDIT) cohort
    • PMID:22162482
    • Long AE, Gooneratne AT, Rokni S, Williams AJ, Bingley PJ. The role of autoantibodies to zinc transporter 8 in prediction of type 1 diabetes in relatives: lessons from the European Nicotinamide Diabetes Intervention Trial (ENDIT) cohort. J Clin Endocrinol Metab 2012; 97:632-7; PMID:22162482
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 632-637
    • Long, A.E.1    Gooneratne, A.T.2    Rokni, S.3    Williams, A.J.4    Bingley, P.J.5
  • 70
    • 77951776390 scopus 로고    scopus 로고
    • Genetics, pathogenesis and clinical interventions in type 1 diabetes
    • PMID:20432533; http://dx.doi.org/10.1038/nature08933
    • Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010; 464:1293-300; PMID:20432533; http://dx.doi.org/10.1038/nature08933
    • (2010) Nature , vol.464 , pp. 1293-1300
    • Bluestone, J.A.1    Herold, K.2    Eisenbarth, G.3
  • 71
    • 50949092228 scopus 로고    scopus 로고
    • Autoimmune mechanisms in type 1 diabetes
    • PMID:18625444; http://dx.doi.org/10.1016/j.autrev.2008.04.008
    • Knip M, Siljander H. Autoimmune mechanisms in type 1 diabetes. Autoimmun Rev 2008; 7:550-7; PMID:18625444; http://dx.doi.org/10.1016/j.autrev.2008.04.008
    • (2008) Autoimmun Rev , vol.7 , pp. 550-557
    • Knip, M.1    Siljander, H.2
  • 72
    • 72249122333 scopus 로고    scopus 로고
    • Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1
    • Diabetes Prevention Trial-Type 1 Study Group PMID:19741189; http://dx.doi.org/10.2337/dc09-0934
    • Orban T, Sosenko JM, Cuthbertson D, Krischer J P, Skyler JS, Jackson R, et al.; Diabetes Prevention Trial-Type 1 Study Group. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009; 32:2269-74; PMID:19741189; http://dx.doi.org/10.2337/dc09-0934
    • (2009) Diabetes Care , vol.32 , pp. 2269-2274
    • Orban, T.1    Sosenko, J.M.2    Cuthbertson, D.3    Krischer, J.P.4    Skyler, J.S.5    Jackson, R.6
  • 73
    • 33847629171 scopus 로고    scopus 로고
    • Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes
    • DOI 10.1111/j.1365-2249.2006.03244.x
    • Di Lorenzo T P, Peakman M, Roep BO. Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol 2007; 148:1-16; PMID:17349009; http://dx.doi.org/10.1111/j. 1365-2249.2006.03244.x (Pubitemid 46364983)
    • (2007) Clinical and Experimental Immunology , vol.148 , Issue.1 , pp. 1-16
    • Di Lorenzo, T.P.1    Peakman, M.2    Roep, B.O.3
  • 74
    • 76949098835 scopus 로고    scopus 로고
    • Chromogranin A is an autoantigen in type 1 diabetes
    • PMID:20139986; http://dx.doi.org/10.1038/ni.1844
    • Stadinski BD, Delong T, Reisdorph N, Reisdorph R, Powell RL, Armstrong M, et al. Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol 2010; 11:225-31; PMID:20139986; http://dx.doi.org/10.1038/ni.1844
    • (2010) Nat Immunol , vol.11 , pp. 225-231
    • Stadinski, B.D.1    Delong, T.2    Reisdorph, N.3    Reisdorph, R.4    Powell, R.L.5    Armstrong, M.6
  • 76
    • 73349090874 scopus 로고    scopus 로고
    • Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes
    • PMID:19901909; http://dx.doi.org/10.1038/labinvest.2009.116
    • Li SW, Koya V, Li Y, Donelan W, Lin P, Reeves WH, et al. Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes. Lab Invest 2010; 90:31-9; PMID:19901909; http://dx.doi.org/10.1038/ labinvest.2009.116
    • (2010) Lab Invest , vol.90 , pp. 31-39
    • Li, S.W.1    Koya, V.2    Li, Y.3    Donelan, W.4    Lin, P.5    Reeves, W.H.6
  • 77
    • 80052880827 scopus 로고    scopus 로고
    • Islet amyloid polypeptide is a target antigen for diabetogenic CD4+ T cells
    • PMID:21734016; http://dx.doi.org/10.2337/db11-0288
    • Delong T, Baker RL, Reisdorph N, Reisdorph R, Powell RL, Armstrong M, et al. Islet amyloid polypeptide is a target antigen for diabetogenic CD4+ T cells. Diabetes 2011; 60:2325-30; PMID:21734016; http://dx.doi.org/10.2337/db11-0288
    • (2011) Diabetes , vol.60 , pp. 2325-2330
    • Delong, T.1    Baker, R.L.2    Reisdorph, N.3    Reisdorph, R.4    Powell, R.L.5    Armstrong, M.6
  • 78
    • 80855138461 scopus 로고    scopus 로고
    • Insulin as a key autoantigen in the development of type 1 diabetes
    • PMID:22069258; http://dx.doi.org/10.1002/dmrr.1250
    • Nakayama M. Insulin as a key autoantigen in the development of type 1 diabetes. Diabetes Metab Res Rev 2011; 27:773-7; PMID:22069258; http://dx.doi.org/10.1002/dmrr.1250
    • (2011) Diabetes Metab Res Rev , vol.27 , pp. 773-777
    • Nakayama, M.1
  • 80
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • DOI 10.1073/pnas.93.2.956
    • Daniel D, Wegmann DR. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci U S A 1996; 93:956-60; PMID:8570667; http://dx.doi.org/10.1073/ pnas.93.2.956 (Pubitemid 26041202)
    • (1996) Proceedings of the National Academy of Sciences of the United States of America , vol.93 , Issue.2 , pp. 956-960
    • Daniel, D.1    Wegmann, D.R.2
  • 83
    • 0038204841 scopus 로고    scopus 로고
    • Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase
    • DOI 10.1084/jem.20030215
    • Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H. Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med 2003; 197:1635-44; PMID:12796471; http://dx.doi.org/10.1084/jem.20030215 (Pubitemid 36745339)
    • (2003) Journal of Experimental Medicine , vol.197 , Issue.12 , pp. 1635-1644
    • Jaeckel, E.1    Klein, L.2    Martin-Orozco, N.3    Von Boehmer, H.4
  • 84
    • 0033065979 scopus 로고    scopus 로고
    • Glutamate decarboxylase and GABA in pancreatic islets: Lessons from knock-out mice
    • Kash S F, Condie BG, Baekkeskov S. Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice. Horm Metab Res 1999; 31:340-4; PMID:10422732; http://dx.doi.org/10.1055/s-2007-978750 (Pubitemid 29299617)
    • (1999) Hormone and Metabolic Research , vol.31 , Issue.5 , pp. 340-344
    • Kash, S.F.1    Condie, B.G.2    Baekkeskov, S.3
  • 85
    • 0942290492 scopus 로고    scopus 로고
    • IA-2 is not required for the development of diabetes in NOD mice [7]
    • DOI 10.1007/s00125-003-1252-z
    • Kubosaki A, Miura J, Notkins AL. IA-2 is not required for the development of diabetes in NOD mice. Diabetologia 2004; 47:149-50; PMID:14614561; http://dx.doi.org/10.1007/s00125-003-1252-z (Pubitemid 38141956)
    • (2004) Diabetologia , vol.47 , Issue.1 , pp. 149-150
    • Kubosaki, A.1    Miura, J.2    Notkins, A.L.3
  • 86
    • 0033553645 scopus 로고    scopus 로고
    • Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells
    • DOI 10.1126/science.284.5417.1183
    • Yoon JW, Yoon CS, Lim HW, Huang QQ, Kang Y, Pyun KH, et al. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells. Science 1999; 284:1183-7; PMID:10325232; http://dx.doi.org/10.1126/science.284. 5417.1183 (Pubitemid 29288411)
    • (1999) Science , vol.284 , Issue.5417 , pp. 1183-1187
    • Yoon, J.-W.1    Yoon, C.-S.2    Lim, H.-W.3    Huang, Q.Q.4    Kang, Y.5    Pyun, K.H.6    Hirasawa, K.7    Sherwin, R.S.8    Jun, H.-S.9
  • 87
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • DOI 10.1038/366072a0
    • Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 1993; 366:72-5; PMID:8232539; http://dx.doi.org/10.1038/ 366072a0 (Pubitemid 23345239)
    • (1993) Nature , vol.366 , Issue.6450 , pp. 72-75
    • Tisch, R.1    Yang, X.-D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 89
    • 0030175880 scopus 로고    scopus 로고
    • Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes
    • DOI 10.1006/jaut.1996.0051
    • Verge C F, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Chase H P, et al. Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes. J Autoimmun 1996; 9:379-83; PMID:8816974; http://dx.doi.org/10.1006/jaut.1996.0051 (Pubitemid 26226598)
    • (1996) Journal of Autoimmunity , vol.9 , Issue.3 , pp. 379-383
    • Verge, C.F.1    Gianani, R.2    Kawasaki, E.3    Yu, L.4    Pietropaolo, M.5    Chase, H.P.6    Eisenbarth, G.S.7
  • 92
    • 33845337973 scopus 로고    scopus 로고
    • Proinsulin: A unique autoantigen triggering autoimmune diabetes
    • DOI 10.1172/JCI30760
    • You S, Chatenoud L. Proinsulin: a unique autoantigen triggering autoimmune diabetes. J Clin Invest 2006; 116:3108-10; PMID:17143326; http://dx.doi.org/10.1172/JCI30760 (Pubitemid 44878624)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.12 , pp. 3108-3110
    • You, S.1    Chatenoud, L.2
  • 93
    • 33845662118 scopus 로고    scopus 로고
    • Oral tolerance: Therapeutic implications for autoimmune diseases
    • DOI 10.1080/17402520600876804, PII U608745454W48W74
    • Faria AM, Weiner HL. Oral tolerance: therapeutic implications for autoimmune diseases. Clin Dev Immunol 2006; 13:143-57; PMID:17162357; http://dx.doi.org/10.1080/17402520600876804 (Pubitemid 44950033)
    • (2006) Clinical and Developmental Immunology , vol.13 , Issue.2-4 , pp. 143-157
    • Faria, A.M.C.1    Weiner, H.L.2
  • 94
    • 0028146261 scopus 로고
    • Antigen-driven tissue-specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse
    • PMID:7522160; http://dx.doi.org/10.1002/eji.1830240926
    • al-Sabbagh A, Miller A, Santos LM, Weiner HL. Antigen-driven tissue-specific suppression following oral tolerance: orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur J Immunol 1994; 24:2104-9; PMID:7522160; http://dx.doi.org/10.1002/eji.1830240926
    • (1994) Eur J Immunol , vol.24 , pp. 2104-2109
    • Al-Sabbagh, A.1    Miller, A.2    Santos, L.M.3    Weiner, H.L.4
  • 95
    • 79954511312 scopus 로고    scopus 로고
    • Oral tolerance
    • PMID:21488901; http://dx.doi.org/10.1111/j.1600-065X.2011.01017.x
    • Weiner HL, da Cunha A P, Quintana F, Wu H. Oral tolerance. Immunol Rev 2011; 241:241-59; PMID:21488901; http://dx.doi.org/10.1111/j.1600-065X.2011. 01017.x
    • (2011) Immunol Rev , vol.241 , pp. 241-259
    • Weiner, H.L.1    Da Cunha, A.P.2    Quintana, F.3    Wu, H.4
  • 96
    • 0031452948 scopus 로고    scopus 로고
    • Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens
    • DOI 10.1084/jem.186.12.2039
    • Tian J, Lehmann PV, Kaufman DL. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. J Exp Med 1997; 186:2039-43; PMID:9396773; http://dx.doi.org/10.1084/jem.186.12.2039 (Pubitemid 28013688)
    • (1997) Journal of Experimental Medicine , vol.186 , Issue.12 , pp. 2039-2043
    • Tian, J.1    Lehmann, P.V.2    Kaufman, D.L.3
  • 98
    • 70349257206 scopus 로고    scopus 로고
    • Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients
    • Belgian Diabetes Registry PMID:19647467; http://dx.doi.org/10.1016/j. diabet.2009.02.005
    • Vandemeulebroucke E, Gorus FK, Decochez K, Weets I, Keymeulen B, De Block C, et al.; Belgian Diabetes Registry. Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients. Diabetes Metab 2009; 35:319-27; PMID:19647467; http://dx.doi.org/10.1016/j.diabet.2009.02.005
    • (2009) Diabetes Metab , vol.35 , pp. 319-327
    • Vandemeulebroucke, E.1    Gorus, F.K.2    Decochez, K.3    Weets, I.4    Keymeulen, B.5    De Block, C.6
  • 99
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The diabetes prevention trial-type 1
    • DOI 10.2337/diacare.28.5.1068
    • Skyler JS, Krischer J P, Wolfsdorf J, Cowie C, Palmer J P, Greenbaum C, et al. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial - Type 1. Diabetes Care 2005; 28:1068-76; PMID:15855569; http://dx.doi.org/10.2337/diacare.28.5.1068 (Pubitemid 40616615)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1068-1076
    • Skyler, J.S.1
  • 100
    • 0037015552 scopus 로고    scopus 로고
    • Therapy to prevent type 1 diabetes mellitus
    • PMID:12362017; http://dx.doi.org/10.1056/NEJM200210033471415
    • Carel JC, Landais P, Bougnères P. Therapy to prevent type 1 diabetes mellitus. N Engl J Med 2002; 347:1115-6; PMID:12362017; http://dx.doi.org/10.1056/NEJM200210033471415
    • (2002) N Engl J Med , vol.347 , pp. 1115-1116
    • Carel, J.C.1    Landais, P.2    Bougnères, P.3
  • 104
    • 55749104546 scopus 로고    scopus 로고
    • Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A double-blind, randomised controlled trial
    • PMID:18814906; http://dx.doi.org/10.1016/S0140-6736(08)61309-4
    • Näntö-Salonen K, Kupila A, Simell S, Siljander H, Salonsaari T, Hekkala A, et al. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial. Lancet 2008; 372:1746-55; PMID:18814906; http://dx.doi.org/10.1016/S0140-6736(08)61309-4
    • (2008) Lancet , vol.372 , pp. 1746-1755
    • Näntö-Salonen, K.1    Kupila, A.2    Simell, S.3    Siljander, H.4    Salonsaari, T.5    Hekkala, A.6
  • 105
    • 79953220761 scopus 로고    scopus 로고
    • Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes
    • PMID:21307076; http://dx.doi.org/10.2337/db10-1360
    • Fourlanos S, Perry C, Gellert SA, Martinuzzi E, Mallone R, Butler J, et al. Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes. Diabetes 2011; 60:1237-45; PMID:21307076; http://dx.doi.org/10.2337/db10-1360
    • (2011) Diabetes , vol.60 , pp. 1237-1245
    • Fourlanos, S.1    Perry, C.2    Gellert, S.A.3    Martinuzzi, E.4    Mallone, R.5    Butler, J.6
  • 107
    • 55249110198 scopus 로고    scopus 로고
    • GAD treatment and insulin secretion in recent-onset type 1 diabetes
    • PMID:18843118; http://dx.doi.org/10.1056/NEJMoa0804328
    • Ludvigsson J, Faresjö M, Hjorth M, Axelsson S, Chéramy M, Pihl M, et al. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N Engl J Med 2008; 359:1909-20; PMID:18843118; http://dx.doi.org/10. 1056/NEJMoa0804328
    • (2008) N Engl J Med , vol.359 , pp. 1909-1920
    • Ludvigsson, J.1    Faresjö, M.2    Hjorth, M.3    Axelsson, S.4    Chéramy, M.5    Pihl, M.6
  • 108
    • 79960743608 scopus 로고    scopus 로고
    • Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: A randomised double-blind trial
    • Type 1 Diabetes TrialNet GAD Study Group PMID:21714999; http://dx.doi.org/10.1016/S0140-6736(11)60895-7
    • Wherrett DK, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, et al.; Type 1 Diabetes TrialNet GAD Study Group. Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet 2011; 378:319-27; PMID:21714999; http://dx.doi.org/10.1016/S0140-6736(11)60895-7.
    • (2011) Lancet , vol.378 , pp. 319-327
    • Wherrett, D.K.1    Bundy, B.2    Becker, D.J.3    DiMeglio, L.A.4    Gitelman, S.E.5    Goland, R.6
  • 109
    • 84856564903 scopus 로고    scopus 로고
    • GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
    • PMID:22296077; http://dx.doi.org/10.1056/NEJMoa1107096
    • Ludvigsson J, Krisky D, Casas R, Battelino T, Castaño L, Greening J, et al. GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. N Engl J Med 2012; 366:433-42; PMID:22296077; http://dx.doi.org/10.1056/ NEJMoa1107096.
    • (2012) N Engl J Med , vol.366 , pp. 433-442
    • Ludvigsson, J.1    Krisky, D.2    Casas, R.3    Battelino, T.4    Castaño, L.5    Greening, J.6
  • 110
    • 0035113503 scopus 로고    scopus 로고
    • Oral administration of insulin to neonates suppresses spontaneous and cyclophosphamide induced diabetes in the NOD mouse
    • DOI 10.1006/jaut.2000.0471
    • Maron R, Guerau-de-Arellano M, Zhang X, Weiner HL. Oral administration of insulin to neonates suppresses spontaneous and cyclophosphamide induced diabetes in the NOD mouse. J Autoimmun 2001; 16:21-8; PMID:11221993; http://dx.doi.org/10.1006/jaut.2000.0471 (Pubitemid 32174171)
    • (2001) Journal of Autoimmunity , vol.16 , Issue.1 , pp. 21-28
    • Maron, R.1    Guerau-De-Arellano, M.2    Zhang, X.3    Weiner, H.L.4
  • 112
    • 84869869418 scopus 로고    scopus 로고
    • Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading
    • PMID:22647732; http://dx.doi.org/10.1016/j.jaut.2012.04.005
    • Prasad S, Kohm A P, McMahon JS, Luo X, Miller SD. Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading. J Autoimmun 2012; 39:347-53; PMID:22647732; http://dx.doi.org/10.1016/j.jaut.2012.04.005
    • (2012) J Autoimmun , vol.39 , pp. 347-353
    • Prasad, S.1    Kohm, A.P.2    McMahon, J.S.3    Luo, X.4    Miller, S.D.5
  • 113
    • 0030456670 scopus 로고    scopus 로고
    • Aerosol insulin induces regulatory CD8 γ T cells that prevent murine insulin-dependent diabetes
    • DOI 10.1084/jem.184.6.2167
    • Harrison LC, Dempsey-Collier M, Kramer DR, Takahashi K. Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes. J Exp Med 1996; 184:2167-74; PMID:8976172; http://dx.doi.org/10.1084/ jem.184.6.2167 (Pubitemid 27023717)
    • (1996) Journal of Experimental Medicine , vol.184 , Issue.6 , pp. 2167-2174
    • Harrison, L.C.1    Dempsey-Collier, M.2    Kramer, D.R.3    Takahashi, K.4
  • 114
    • 33645788313 scopus 로고    scopus 로고
    • Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes
    • PMID:16585551
    • Every AL, Kramer DR, Mannering SI, Lew AM, Harrison LC. Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes. J Immunol 2006; 176:4608-15; PMID:16585551.
    • (2006) J Immunol , vol.176 , pp. 4608-4615
    • Every, A.L.1    Kramer, D.R.2    Mannering, S.I.3    Lew, A.M.4    Harrison, L.C.5
  • 116
    • 33845684328 scopus 로고    scopus 로고
    • Long-term prevention of diabetes and marked suppression of insulin autoantibodies and insulitis in mice lacking native insulin B9-23 sequence
    • DOI 10.1196/annals.1375.018, Immunology of Diabetes IV: Progress in Our Understanding
    • Nakayama M, Babaya N, Miao D, Gianani R, Liu E, Elliott J F, et al. Long-term prevention of diabetes and marked suppression of insulin autoantibodies and insulitis in mice lacking native insulin B9-23 sequence. Ann N Y Acad Sci 2006; 1079:122-9; PMID:17130542; http://dx.doi.org/10.1196/annals. 1375.018 (Pubitemid 44968711)
    • (2006) Annals of the New York Academy of Sciences , vol.1079 , pp. 122-129
    • Nakayama, M.1    Babaya, N.2    Miao, D.3    Gianani, R.4    Liu, E.5    Elliott, J.F.6    Eisenbarth, G.S.7
  • 117
    • 80054692681 scopus 로고    scopus 로고
    • Long-term outcome of individuals treated with oral insulin: Diabetes prevention trial-type 1 (DPT-1) oral insulin trial
    • DPT-1 and TrialNet Study Groups PMID:21610124; http://dx.doi.org/10.2337/ dc11-0523
    • Vehik K, Cuthbertson D, Ruhlig H, Schatz DA, Peakman M, Krischer JP; DPT-1 and TrialNet Study Groups. Long-term outcome of individuals treated with oral insulin: diabetes prevention trial-type 1 (DPT-1) oral insulin trial. Diabetes Care 2011; 34:1585-90; PMID:21610124; http://dx.doi.org/10.2337/dc11- 0523
    • (2011) Diabetes Care , vol.34 , pp. 1585-1590
    • Vehik, K.1    Cuthbertson, D.2    Ruhlig, H.3    Schatz, D.A.4    Peakman, M.5    Krischer, J.P.6
  • 118
    • 80051967777 scopus 로고    scopus 로고
    • Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes
    • PMID:21515841; http://dx.doi.org/10.2337/dc10-1449
    • Ryhänen SJ, Härkönen T, Siljander H, Näntö- Salonen K, Simell T, Hyöty H, et al. Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes. Diabetes Care 2011; 34:1383-8; PMID:21515841; http://dx.doi.org/10.2337/dc10-1449
    • (2011) Diabetes Care , vol.34 , pp. 1383-1388
    • Ryhänen, S.J.1    Härkönen, T.2    Siljander, H.3    Näntö- Salonen, K.4    Simell, T.5    Hyöty, H.6
  • 119
    • 77952243765 scopus 로고    scopus 로고
    • Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy
    • PMID:19931408; http://dx.doi.org/10.1016/j.jaut.2009.10.005
    • Orban T, Farkas K, Jalahej H, Kis J, Treszl A, Falk B, et al. Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy. J Autoimmun 2010; 34:408-15; PMID:19931408; http://dx.doi.org/10.1016/j.jaut.2009.10.005
    • (2010) J Autoimmun , vol.34 , pp. 408-415
    • Orban, T.1    Farkas, K.2    Jalahej, H.3    Kis, J.4    Treszl, A.5    Falk, B.6
  • 120
    • 0036867545 scopus 로고    scopus 로고
    • Role of glutamic acid decarboxylase in the pathogenesis of type 1 diabetes
    • DOI 10.1007/PL00012512
    • Jun HS, Khil LY, Yoon JW. Role of glutamic acid decar-boxylase in the pathogenesis of type 1 diabetes. Cell Mol Life Sci 2002; 59:1892-901; PMID:12530520; http://dx.doi.org/10.1007/PL00012512 (Pubitemid 36015862)
    • (2002) Cellular and Molecular Life Sciences , vol.59 , Issue.11 , pp. 1892-1901
    • Jun, H.S.1    Khil, L.Y.2    Yoon, J.W.3
  • 122
    • 67650360252 scopus 로고    scopus 로고
    • Therapy with GAD in diabetes
    • PMID:19267332; http://dx.doi.org/10.1002/dmrr.941
    • Ludvigsson J. Therapy with GAD in diabetes. Diabetes Metab Res Rev 2009; 25:307-15; PMID:19267332; http://dx.doi.org/10.1002/dmrr.941
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 307-315
    • Ludvigsson, J.1
  • 123
    • 0033601230 scopus 로고    scopus 로고
    • The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65
    • DOI 10.1074/jbc.274.52.37200
    • Kanaani J, Lissin D, Kash S F, Baekkeskov S. The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65. J Biol Chem 1999; 274:37200-9; PMID:10601283; http://dx.doi.org/10.1074/ jbc.274.52.37200 (Pubitemid 30016797)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.52 , pp. 37200-37209
    • Kanaani, J.1    Lissin, D.2    Kash, S.F.3    Baekkeskov, S.4
  • 124
    • 0029146498 scopus 로고
    • Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65)
    • PMID:7606872; http://dx.doi.org/10.1006/clin.1995.1092
    • Pleau JM, Fernandez-Saravia F, Esling A, Homo-Delarche F, Dardenne M. Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65). Clin Immunol Immunopathol 1995; 76:90-5; PMID:7606872; http://dx.doi.org/10.1006/clin.1995.1092
    • (1995) Clin Immunol Immunopathol , vol.76 , pp. 90-95
    • Pleau, J.M.1    Fernandez-Saravia, F.2    Esling, A.3    Homo-Delarche, F.4    Dardenne, M.5
  • 125
    • 0035253510 scopus 로고    scopus 로고
    • Antigen-specific mediated suppression of β cell autoimmunity by plasmid DNA vaccination
    • Tisch R, Wang B, Weaver DJ, Liu B, Bui T, Arthos J, et al. Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination. J Immunol 2001; 166:2122-32; PMID:11160264 (Pubitemid 32114703)
    • (2001) Journal of Immunology , vol.166 , Issue.3 , pp. 2122-2132
    • Tisch, R.1    Wang, B.2    Weaver, D.J.3    Liu, B.4    Bui, T.5    Arthos, J.6    Serreze, D.V.7
  • 126
    • 0029923430 scopus 로고    scopus 로고
    • Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
    • DOI 10.1084/jem.183.4.1561
    • Tian J, Atkinson MA, Clare-Salzler M, Herschenfeld A, Forsthuber T, Lehmann P V, et al. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 1996; 183:1561-7; PMID:8666914; http://dx.doi.org/10.1084/jem.183.4. 1561 (Pubitemid 26134299)
    • (1996) Journal of Experimental Medicine , vol.183 , Issue.4 , pp. 1561-1567
    • Tian, J.1    Atkinson, M.A.2    Clare-Salzler, M.3    Herschenfeld, A.4    Forsthuber, T.5    Lehmann, P.V.6    Kaufman, D.L.7
  • 127
    • 0031831753 scopus 로고    scopus 로고
    • Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice
    • DOI 10.2337/diabetes.47.6.894
    • Tisch R, Liblau RS, Yang XD, Liblau P, McDevitt HO. Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice. Diabetes 1998; 47:894-9; PMID:9604865; http://dx.doi.org/10.2337/diabetes.47.6.894 (Pubitemid 28255662)
    • (1998) Diabetes , vol.47 , Issue.6 , pp. 894-899
    • Tisch, R.1    Liblau, R.S.2    Yang, X.-D.3    Liblau, P.4    McDevitt, H.O.5
  • 128
    • 67349116493 scopus 로고    scopus 로고
    • GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes
    • PMID:19404608; http://dx.doi.org/10.1007/s00125-009-1371-2
    • Agardh CD, Lynch KF, Palmér M, Link K, Lernmark A. GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes. Diabetologia 2009; 52:1363-8; PMID:19404608; http://dx.doi.org/10.1007/s00125-009-1371-2
    • (2009) Diabetologia , vol.52 , pp. 1363-1368
    • Agardh, C.D.1    Lynch, K.F.2    Palmér, M.3    Link, K.4    Lernmark, A.5
  • 129
    • 79953756466 scopus 로고    scopus 로고
    • Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: A randomised controlled trial
    • PMID:21116604; http://dx.doi.org/10.1007/s00125-010-1988-1
    • Ludvigsson J, Hjorth M, Chéramy M, Axelsson S, Pihl M, Forsander G, et al. Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: a randomised controlled trial. Diabetologia 2011; 54:634-40; PMID:21116604; http://dx.doi.org/10.1007/s00125-010-1988-1
    • (2011) Diabetologia , vol.54 , pp. 634-640
    • Ludvigsson, J.1    Hjorth, M.2    Chéramy, M.3    Axelsson, S.4    Pihl, M.5    Forsander, G.6
  • 130
    • 69249212422 scopus 로고    scopus 로고
    • Immune modulation in type 1 diabetes mellitus using DiaPep277: A short review and update of recent clinical trial results
    • PMID:19267355; http://dx.doi.org/10.1002/dmrr.942
    • Eldor R, Kassem S, Raz I. Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results. Diabetes Metab Res Rev 2009; 25:316-20; PMID:19267355; http://dx.doi.org/10. 1002/dmrr.942
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 316-320
    • Eldor, R.1    Kassem, S.2    Raz, I.3
  • 132
    • 0030960632 scopus 로고    scopus 로고
    • Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens
    • Elias D, Meilin A, Ablamunits V, Birk OS, Carmi P, Könen-Waisman S, et al. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens. Diabetes 1997; 46:758-64; PMID:9133541; http://dx.doi.org/10.2337/diabetes.46.5.758 (Pubitemid 27188251)
    • (1997) Diabetes , vol.46 , Issue.5 , pp. 758-764
    • Elias, D.1    Meilin, A.2    Ablamunits, V.3    Birk, O.S.4    Carmi, P.5    Konen-Waisman, S.6    Cohen, I.R.7
  • 133
    • 0031913650 scopus 로고    scopus 로고
    • Islet T cells secreting IFN-γ in NOD mouse diabetes: Arrest by p277 peptide treatment
    • DOI 10.1006/jaut.1997.0177
    • Ablamunits V, Elias D, Reshef T, Cohen IR. Islet T cells secreting IFN-gamma in NOD mouse diabetes: arrest by p277 peptide treatment. J Autoimmun 1998; 11:73-81; PMID:9480725; http://dx.doi.org/10.1006/jaut.1997.0177 (Pubitemid 28080730)
    • (1998) Journal of Autoimmunity , vol.11 , Issue.1 , pp. 73-81
    • Ablamunits, V.1    Elias, D.2    Reshef, T.3    Cohen, I.R.4
  • 134
    • 0033106415 scopus 로고    scopus 로고
    • T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides
    • DOI 10.1006/jaut.1998.0262
    • Abulafia-Lapid R, Elias D, Raz I, Keren-Zur Y, Atlan H, Cohen IR. T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides. J Autoimmun 1999; 12:121-9; PMID:10047432; http://dx.doi.org/10.1006/jaut.1998.0262 (Pubitemid 29130589)
    • (1999) Journal of Autoimmunity , vol.12 , Issue.2 , pp. 121-129
    • Abulafia-Lapid, R.1    Elias, D.2    Raz, I.3    Keren-Zur, Y.4    Atlan, H.5    Cohen, I.R.6
  • 135
    • 0035944844 scopus 로고    scopus 로고
    • β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • DOI 10.1016/S0140-6736(01)06801-5
    • Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 2001; 358:1749-53; PMID:11734230; http://dx.doi.org/10.1016/S0140-6736(01)06801-5 (Pubitemid 33152998)
    • (2001) Lancet , vol.358 , Issue.9295 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3    Tamir, M.4    Metzger, M.5    Cohen, I.R.6
  • 136
    • 34249812097 scopus 로고    scopus 로고
    • Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: Extension of a randomized, double-blind, phase II trial
    • DOI 10.1002/dmrr.712
    • Raz I, Avron A, Tamir M, Metzger M, Symer L, Eldor R, et al. Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial. Diabetes Metab Res Rev 2007; 23:292-8; PMID:17124720; http://dx.doi.org/10.1002/dmrr.712 (Pubitemid 46851470)
    • (2007) Diabetes/Metabolism Research and Reviews , vol.23 , Issue.4 , pp. 292-298
    • Raz, I.1    Avron, A.2    Tamir, M.3    Metzger, M.4    Symer, L.5    Eldor, R.6    Cohen, I.R.7    Elias, D.8
  • 137
    • 10244255039 scopus 로고    scopus 로고
    • Satisfaction (not) guaranteed: Re-evaluating the use of animal models of type 1 diabetes
    • DOI 10.1038/nri1502
    • Roep BO, Atkinson M, von Herrath M. Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes. Nat Rev Immunol 2004; 4:989-97; PMID:15573133; http://dx.doi.org/10.1038/nri1502 (Pubitemid 39620073)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.12 , pp. 989-997
    • Roep, B.O.1    Atkinson, M.2    Von Herrath, M.3
  • 138
    • 79959207833 scopus 로고    scopus 로고
    • Antigen-based immune therapeutics for type 1 diabetes: Magic bullets or ordinary blanks?
    • PMID:21647401; http://dx.doi.org/10.1155/2011/286-248
    • Culina S, Boitard C, Mallone R. Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks? Clin Dev Immunol 2011; 2011:286-248; PMID:21647401; http://dx.doi.org/10.1155/2011/286-248
    • (2011) Clin Dev Immunol , vol.2011 , pp. 286-248
    • Culina, S.1    Boitard, C.2    Mallone, R.3
  • 139
    • 44849138907 scopus 로고    scopus 로고
    • Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization
    • Pre-POINT Study Group PMID:18445349; http://dx.doi.org/10.1007/s11892- 008-0017-y
    • Achenbach P, Barker J, Bonifacio E; Pre-POINT Study Group. Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization. Curr Diab Rep 2008; 8:87-93; PMID:18445349; http://dx.doi.org/10.1007/s11892-008-0017-y
    • (2008) Curr Diab Rep , vol.8 , pp. 87-93
    • Achenbach, P.1    Barker, J.2    Bonifacio, E.3
  • 140
    • 45749111446 scopus 로고    scopus 로고
    • Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    • DOI 10.1038/nature06939, PII NATURE06939
    • Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 2008; 453:1122-6; PMID:18496530; http://dx.doi.org/10.1038/nature06939 (Pubitemid 351871731)
    • (2008) Nature , vol.453 , Issue.7198 , pp. 1122-1126
    • Eisenbarth, S.C.1    Colegio, O.R.2    O'Connor Jr., W.3    Sutterwala, F.S.4    Flavell, R.A.5
  • 141
    • 76349093141 scopus 로고    scopus 로고
    • Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes
    • PMID:19690518; http://dx.doi.org/10.1038/mt.2009.197
    • Bresson D, Fradkin M, Manenkova Y, Rottembourg D, von Herrath M. Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes. Mol Ther 2010; 18:307-16; PMID:19690518; http://dx.doi.org/10.1038/mt.2009.197
    • (2010) Mol Ther , vol.18 , pp. 307-316
    • Bresson, D.1    Fradkin, M.2    Manenkova, Y.3    Rottembourg, D.4    Von Herrath, M.5
  • 142
    • 33646392755 scopus 로고    scopus 로고
    • Anti-CD3 and nasal proinsulin combination therapy enhances remission from recentonset autoimmune diabetes by inducing Tregs
    • PMID:16628253; http://dx.doi.org/10.1172/JCI27191
    • Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, et al. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recentonset autoimmune diabetes by inducing Tregs. J Clin Invest 2006; 116:1371-81; PMID:16628253; http://dx.doi.org/10.1172/JCI27191
    • (2006) J Clin Invest , vol.116 , pp. 1371-1381
    • Bresson, D.1    Togher, L.2    Rodrigo, E.3    Chen, Y.4    Bluestone, J.A.5    Herold, K.C.6
  • 143
    • 84866104188 scopus 로고    scopus 로고
    • Low doses of anti-CD3, ciclosporin A and the vitamin D analogue, TX527, synergise to delay recurrence of autoimmune diabetes in an islet-transplanted NOD mouse model of diabetes
    • PMID:22752077; http://dx.doi.org/10.1007/s00125-012-2630-1
    • Baeke F, Van Belle TL, Takiishi T, Ding L, Korf H, Laureys J, et al. Low doses of anti-CD3, ciclosporin A and the vitamin D analogue, TX527, synergise to delay recurrence of autoimmune diabetes in an islet-transplanted NOD mouse model of diabetes. Diabetologia 2012; 55:2723-32; PMID:22752077; http://dx.doi.org/10.1007/s00125-012-2630-1
    • (2012) Diabetologia , vol.55 , pp. 2723-2732
    • Baeke, F.1    Van Belle, T.L.2    Takiishi, T.3    Ding, L.4    Korf, H.5    Laureys, J.6
  • 144
    • 84555188737 scopus 로고    scopus 로고
    • Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: Evidence of improved immune regulation
    • PMID:22043003; http://dx.doi.org/10.2337/db11-1033
    • Ablamunits V, Henegariu O, Hansen JB, Opare-Addo L, Preston-Hurlburt P, Santamaria P, et al. Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation. Diabetes 2012; 61:145-54; PMID:22043003; http://dx.doi.org/10.2337/db11-1033
    • (2012) Diabetes , vol.61 , pp. 145-154
    • Ablamunits, V.1    Henegariu, O.2    Hansen, J.B.3    Opare-Addo, L.4    Preston-Hurlburt, P.5    Santamaria, P.6
  • 145
    • 0036314243 scopus 로고    scopus 로고
    • Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice
    • Rabinovitch A, Suarez-Pinzon WL, Shapiro AM, Rajotte RV, Power R. Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice. Diabetes 2002; 51:638-45; PMID:11872661; http://dx.doi.org/10.2337/diabetes.51.3.638 (Pubitemid 34760170)
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 638-645
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    James Shapiro, A.M.3    Rajotte, R.V.4    Power, R.5
  • 146
    • 84865478468 scopus 로고    scopus 로고
    • Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
    • Diabetes TrialNet and the Immune Tolerance Network PMID:22721971; http://dx.doi.org/10.2337/db12-0049
    • Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, et al.; Diabetes TrialNet and the Immune Tolerance Network. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes 2012; 61:2340-8; PMID:22721971; http://dx.doi.org/10.2337/db12-0049
    • (2012) Diabetes , vol.61 , pp. 2340-2348
    • Long, S.A.1    Rieck, M.2    Sanda, S.3    Bollyky, J.B.4    Samuels, P.L.5    Goland, R.6
  • 148
    • 78649983200 scopus 로고    scopus 로고
    • Immunotherapy of type 1 diabetes - How to rationally prioritize combination therapies in T1D
    • PMID:20667487; http://dx.doi.org/10.1016/j.intimp.2010.07.008
    • Boettler T, von Herrath M. Immunotherapy of type 1 diabetes - how to rationally prioritize combination therapies in T1D. Int Immunopharmacol 2010; 10:1491-5; PMID:20667487; http://dx.doi.org/10.1016/j.intimp.2010.07.008
    • (2010) Int Immunopharmacol , vol.10 , pp. 1491-1495
    • Boettler, T.1    Von Herrath, M.2
  • 149
    • 84860228482 scopus 로고    scopus 로고
    • Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice
    • PMID:22484814; http://dx.doi.org/10.1172/JCI60530
    • Takiishi T, Korf H, Van Belle TL, Robert S, Grieco FA, Caluwaerts S, et al. Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice. J Clin Invest 2012; 122:1717-25; PMID:22484814; http://dx.doi.org/10.1172/JCI60530 Programme Programme
    • (2012) J Clin Invest , vol.122 , pp. 1717-1725
    • Takiishi, T.1    Korf, H.2    Van Belle, T.L.3    Robert, S.4    Grieco, F.A.5    Caluwaerts, S.6


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