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Volumn 2011, Issue , 2011, Pages

Antigen-based immune therapeutics for type 1 diabetes: Magic bullets or ordinary blanks?

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; B25ASP INSULIN; BHT 3021; CYCLOSPORIN A; DENDRITIC CELL VACCINE; DIAMYD; FREUND ADJUVANT; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE ANTIBODY; HEAT SHOCK PROTEIN 60; INSULIN; INSULIN BETA CHAIN; INSULIN BETA CHAIN 9 23; INSULIN GLARGINE; INSULIN ZINC SUSPENSION; ISLET GLUCOSE 6 PHOSPHATASE CATALYTIC SUBUNIT RELATED PROTEIN; METFORMIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NBI 6024; PIG INSULIN; PLASMID DNA; PLASMID DNA PROINSULIN; PREPROINSULIN; PROINSULIN; PROINSULIN PEPTIDE C19 A3; RECOMBINANT GLUTAMATE DECARBOXYLASE VACCINE; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ANTIGEN; BIOLOGICAL MARKER;

EID: 79959207833     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2011/286248     Document Type: Review
Times cited : (29)

References (123)
  • 1
    • 1342303482 scopus 로고    scopus 로고
    • Of Mice and Not Men: Differences between Mouse and Human Immunology
    • Mestas J., Hughes C. C. W., Of mice and not men: differences between mouse and human immunology Journal of Immunology 2004 172 5 2731 2738 (Pubitemid 38263654)
    • (2004) Journal of Immunology , vol.172 , Issue.5 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.W.2
  • 2
    • 0032910989 scopus 로고    scopus 로고
    • Increased -cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse
    • DOI 10.2337/diabetes.48.5.989
    • Sreenan S., Pick A. J., Levisetti M., Baldwin A. C., Pugh W., Polonsky K. S., Increased -cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse Diabetes 1999 48 5 989 996 (Pubitemid 29226344)
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 989-996
    • Sreenan, S.1    Pick, A.J.2    Levisetti, M.3    Baldwin, A.C.4    Pugh, W.5    Polonsky, K.S.6
  • 3
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • Gepts W., Pathologic anatomy of the pancreas in juvenile diabetes mellitus Diabetes 1965 14 10 619 633
    • (1965) Diabetes , vol.14 , Issue.10 , pp. 619-633
    • Gepts, W.1
  • 4
    • 0023181004 scopus 로고
    • Aberrant expression of Class II major histocompatibility complex molecules by B cells and hyperexpression of Class I major histocompatibility complex molecules by insulin containing islets in Type 1 (insulin-dependent) diabetes mellitus
    • DOI 10.1007/BF00299027
    • Foulis A. K., Farquharson M. A., Hardman R., Aberrant expression of Class II major histocompatibility complex molecules by B cells and hyperexpression of Class I major histocompatibility complex molecules by insulin containing islets in Type 1 (insulin-dependent) diabetes mellitus Diabetologia 1987 30 5 333 343 (Pubitemid 17083703)
    • (1987) Diabetologia , vol.30 , Issue.5 , pp. 333-343
    • Foulis, A.K.1    Farquharson, M.A.2    Hardman, R.3
  • 5
    • 0022475906 scopus 로고
    • The histopathology of the pancreas in Type I (insulin-dependent) diabetes mellitus: A 25-year review of deaths in patients under 20 years of age in the United Kingdom
    • Foulis A. K., Liddle C. N., Farquharson M. A., The histopathology of the pancreas in Type I (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom Diabetologia 1986 29 5 267 274 (Pubitemid 16080921)
    • (1986) Diabetologia , vol.29 , Issue.5 , pp. 267-274
    • Foulis, A.K.1    Liddle, C.N.2    Farquharson, M.A.3
  • 6
    • 38949113134 scopus 로고    scopus 로고
    • Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus
    • Klinke D. J., Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus PLoS ONE 2008 3 1
    • (2008) PLoS ONE , vol.3 , Issue.1
    • Klinke, D.J.1
  • 7
    • 31844443691 scopus 로고    scopus 로고
    • Natural history of -cell function in type 1 diabetes
    • supplement 2
    • Sherry N. A., Tsai E. B., Herold K. C., Natural history of -cell function in type 1 diabetes Diabetes 2005 54 supplement 2 S32 S39
    • (2005) Diabetes , vol.54
    • Sherry, N.A.1    Tsai, E.B.2    Herold, K.C.3
  • 8
    • 58149348476 scopus 로고    scopus 로고
    • Cell mass and type 1 diabetes: Going, going, gone?
    • Akirav E., Kushner J. A., Herold K. C., cell mass and type 1 diabetes: going, going, gone? Diabetes 2008 57 11 2883 2888
    • (2008) Diabetes , vol.57 , Issue.11 , pp. 2883-2888
    • Akirav, E.1    Kushner, J.A.2    Herold, K.C.3
  • 10
    • 11144298970 scopus 로고    scopus 로고
    • Insulin resistance is a risk factor for progression to Type 1 diabetes
    • DOI 10.1007/s00125-004-1507-3
    • Fourlanos S., Narendran P., Byrnes G. B., Colman P. G., Harrison L. C., Insulin resistance is a risk factor for progression to Type 1 diabetes Diabetologia 2004 47 10 1661 1667 (Pubitemid 40022398)
    • (2004) Diabetologia , vol.47 , Issue.10 , pp. 1661-1667
    • Fourlanos, S.1    Narendran, P.2    Byrnes, G.B.3    Colman, P.G.4    Harrison, L.C.5
  • 11
    • 0020585332 scopus 로고
    • Metformin reduces insulin requirement in Type 1 (insulin-dependent) diabetes
    • Pagano G., Tagliaferro V., Carta Q., Metformin reduces insulin requirement in Type 1 (insulin-dependent) diabetes Diabetologia 1983 24 5 351 354 (Pubitemid 13092221)
    • (1983) Diabetologia , vol.24 , Issue.5 , pp. 351-354
    • Pagano, G.1    Tagliaferro, V.2    Carta, Q.3
  • 12
    • 0037768213 scopus 로고    scopus 로고
    • Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance: A randomized controlled trial
    • DOI 10.2337/diacare.26.1.138
    • Hamilton J., Cummings E., Zdravkovic V., Finegood D., Daneman D., Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance: a randomized controlled trial Diabetes Care 2003 26 1 138 143 (Pubitemid 36929006)
    • (2003) Diabetes Care , vol.26 , Issue.1 , pp. 138-143
    • Hamilton, J.1    Cummings, E.2    Zdravkovic, V.3    Finegood, D.4    Daneman, D.5
  • 14
    • 0021359025 scopus 로고
    • Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset
    • Stiller C. R., Dupre J., Gent M., Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset Science 1984 223 4643 1362 1367 (Pubitemid 14161003)
    • (1984) Science , vol.223 , Issue.4643 , pp. 1362-1367
    • Stiller, C.R.1    Dupre, J.2    Gent, M.3
  • 16
    • 77951776390 scopus 로고    scopus 로고
    • Genetics, pathogenesis and clinical interventions in type 1 diabetes
    • Bluestone J. A., Herold K., Eisenbarth G., Genetics, pathogenesis and clinical interventions in type 1 diabetes Nature 2010 464 7293 1293 1300
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1293-1300
    • Bluestone, J.A.1    Herold, K.2    Eisenbarth, G.3
  • 17
    • 0242364727 scopus 로고    scopus 로고
    • A comprehensive guide to antibody and T-cell responses in type 1 diabetes
    • DOI 10.1034/j.1399-0039.2003.00152.x
    • Lieberman S. M., DiLorenzo T. P., A comprehensive guide to antibody and T-cell responses in type 1 diabetes Tissue Antigens 2003 62 5 359 377 (Pubitemid 37338877)
    • (2003) Tissue Antigens , vol.62 , Issue.5 , pp. 359-377
    • Lieberman, S.M.1    DiLorenzo, T.P.2
  • 24
    • 0028914351 scopus 로고
    • Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice
    • Daniel D., Gill R. G., Schloot N., Wegmann D., Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice European Journal of Immunology 1995 25 4 1056 1062
    • (1995) European Journal of Immunology , vol.25 , Issue.4 , pp. 1056-1062
    • Daniel, D.1    Gill, R.G.2    Schloot, N.3    Wegmann, D.4
  • 25
    • 0032823399 scopus 로고    scopus 로고
    • Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library
    • DOI 10.1038/12465
    • Wong F. S., Karttunen J., Dumont C., Wen LI., Visintin I., Pilip I. M., Shastri N., Pamer E. G., Janeway C. A., Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library Nature Medicine 1999 5 9 1026 1031 (Pubitemid 29439573)
    • (1999) Nature Medicine , vol.5 , Issue.9 , pp. 1026-1031
    • Wong, F.S.1    Karttunen, J.2    Dumont, C.3    Wen, L.4    Visintin, I.5    Pilip, I.M.6    Shastri, N.7    Pamer, E.G.8    Janeway Jr., C.A.9
  • 28
    • 0034680105 scopus 로고    scopus 로고
    • Progression of autoimmune diabetes driven by avidity maturation of a T- cell population
    • Amranl A., Verdaguer J., Serra P., Tafuro S., Tan R., Santamaria P., Progression of autoimmune diabetes driven by avidity maturation of a T- cell population Nature 2000 406 6797 739 742
    • (2000) Nature , vol.406 , Issue.6797 , pp. 739-742
    • Amranl, A.1    Verdaguer, J.2    Serra, P.3    Tafuro, S.4    Tan, R.5    Santamaria, P.6
  • 29
    • 9144271119 scopus 로고    scopus 로고
    • + T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase
    • Lieberman S. M., Takaki T., Han B., Santamaria P., Serreze D. V., DiLorenzo T. P., Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase Journal of Immunology 2004 173 11 6727 6734 (Pubitemid 39541058)
    • (2004) Journal of Immunology , vol.173 , Issue.11 , pp. 6727-6734
    • Lieberman, S.M.1    Takaki, T.2    Han, B.3    Santamaria, P.4    Serreze, D.V.5    DiLorenzo, T.P.6
  • 30
    • 3042704212 scopus 로고    scopus 로고
    • Targeted disruption of the IA-2 gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice
    • DOI 10.2337/diabetes.53.7.1684
    • Kubosaki A., Gross S., Miura J., Saeki K., Zhu M., Nakamura S., Hendriks W., Notkins A. L., Targeted disruption of the IA-2 gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice Diabetes 2004 53 7 1684 1691 (Pubitemid 38857025)
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1684-1691
    • Kubosaki, A.1    Gross, S.2    Miura, J.3    Saeki, K.4    Zhu, M.5    Nakamura, S.6    Hendriks, W.7    Notkins, A.L.8
  • 31
    • 0038204841 scopus 로고    scopus 로고
    • Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase
    • DOI 10.1084/jem.20030215
    • Jaeckel E., Klein L., Martin-Orozco N., Von Boehmer H., Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase Journal of Experimental Medicine 2003 197 12 1635 1644 (Pubitemid 36745339)
    • (2003) Journal of Experimental Medicine , vol.197 , Issue.12 , pp. 1635-1644
    • Jaeckel, E.1    Klein, L.2    Martin-Orozco, N.3    Von Boehmer, H.4
  • 35
    • 0025472820 scopus 로고
    • Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy
    • Atkinson M. A., Maclaren N. K., Luchetta R., Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy Diabetes 1990 39 8 933 937
    • (1990) Diabetes , vol.39 , Issue.8 , pp. 933-937
    • Atkinson, M.A.1    MacLaren, N.K.2    Luchetta, R.3
  • 36
    • 0029128019 scopus 로고
    • The prevention of IDDM: Injecting insulin into the cytokine network
    • Gladstone P., Nepom G. T., The prevention of IDDM: injecting insulin into the cytokine network Diabetes 1995 44 7 859 862
    • (1995) Diabetes , vol.44 , Issue.7 , pp. 859-862
    • Gladstone, P.1    Nepom, G.T.2
  • 37
    • 0029068841 scopus 로고
    • Isohormonal therapy of endocrine autoimmunity
    • Schloot N., Eisenbarth G. S., Isohormonal therapy of endocrine autoimmunity Immunology Today 1995 16 6 289 294
    • (1995) Immunology Today , vol.16 , Issue.6 , pp. 289-294
    • Schloot, N.1    Eisenbarth, G.S.2
  • 38
    • 0024504171 scopus 로고
    • A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus
    • Shah S. C., Malone J. I., Simpson N. E., A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus The New England Journal of Medicine 1989 320 9 550 554 (Pubitemid 19070538)
    • (1989) New England Journal of Medicine , vol.320 , Issue.9 , pp. 550-554
    • Shah, S.C.1    Malone, J.I.2    Simpson, N.E.3
  • 39
    • 0027480065 scopus 로고
    • Insulin prophylaxis in individuals at high risk of type I diabetes
    • DOI 10.1016/0140-6736(93)91215-8
    • Keller R. J., Eisenbarth G. S., Jackson R. A., Insulin prophylaxis in individuals at high risk of type I diabetes The Lancet 1993 341 8850 927 928 (Pubitemid 23109113)
    • (1993) Lancet , vol.341 , Issue.8850 , pp. 927-928
    • Keller, R.J.1    Eisenbarth, G.S.2    Jackson, R.A.3
  • 40
    • 0031976734 scopus 로고    scopus 로고
    • Delay of Type I diabetes in high risk, first degree relatives by parenteral antigen administration: The Schwabing insulin Prophylaxis Pilot Trial
    • DOI 10.1007/s001250050943
    • Fchtenbusch M., Rabl W., Grassl B., Bachmann W., Standl E., Ziegler A. G., Delay of Type I diabetes in high risk, first degree relatives by parenteral antigen administration: the Schwabing insulin Prophylaxis Pilot Trial Diabetologia 1998 41 5 536 541 (Pubitemid 28206823)
    • (1998) Diabetologia , vol.41 , Issue.5 , pp. 536-541
    • Fuchtenbusch, M.1    Rabl, W.2    Grassl, B.3    Bachmann, W.4    Standl, E.5    Ziegler, A.-G.6
  • 41
    • 0037198427 scopus 로고    scopus 로고
    • Effects of insulin in relatives of patients with type 1 diabetes mellitus
    • Diabetes Prevention Trial-Type 1 Diabetes Study G
    • Diabetes Prevention Trial-Type 1 Diabetes Study G, Effects of insulin in relatives of patients with type 1 diabetes mellitus The New England Journal of Medicine 2002 346 1685 1691
    • (2002) The New England Journal of Medicine , vol.346 , pp. 1685-1691
  • 43
    • 0030062937 scopus 로고    scopus 로고
    • Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and 2-microglobulin- deficient BALB/c mice
    • Gury J. C., Galbiati F., Smiroldo S., Adorini L., Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and 2-microglobulin-deficient BALB/c mice Journal of Experimental Medicine 1996 183 2 485 497
    • (1996) Journal of Experimental Medicine , vol.183 , Issue.2 , pp. 485-497
    • Gury, J.C.1    Galbiati, F.2    Smiroldo, S.3    Adorini, L.4
  • 45
    • 0030754787 scopus 로고    scopus 로고
    • Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice
    • Karounos D. G., Bryson J. S., Cohen D. A., Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice Journal of Clinical Investigation 1997 100 6 1344 1348 (Pubitemid 27425758)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.6 , pp. 1344-1348
    • Karounos, D.G.1    Bryson, J.S.2    Cohen, D.A.3
  • 49
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The diabetes prevention trial-type 1
    • DOI 10.2337/diacare.28.5.1068
    • Skyler J. S., Effects of oral insulin in relatives of patients with type 1 diabetes: the diabetes prevention trial-type 1 Diabetes Care 2005 28 5 1068 1076 (Pubitemid 40616615)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1068-1076
    • Skyler, J.S.1
  • 50
    • 4644230843 scopus 로고    scopus 로고
    • Pancreatic -cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
    • DOI 10.2337/diacare.27.10.2348
    • Harrison L. C., Honeyman M. C., Steele C. E., Stone N. L., Sarugeri E., Bonifacio E., Couper J. J., Colman P. G., Pancreatic -cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes Diabetes Care 2004 27 10 2348 2355 (Pubitemid 39281384)
    • (2004) Diabetes Care , vol.27 , Issue.10 , pp. 2348-2355
    • Harrison, L.C.1    Honeyman, M.C.2    Steele, C.E.3    Stone, N.L.4    Sarugeri, E.5    Bonifacio, E.6    Couper, J.J.7    Colman, P.G.8
  • 52
    • 79953220761 scopus 로고    scopus 로고
    • Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes
    • Fourlanos S., Perry C., Gellert S. A., Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes Diabetes 2011 60 4 1237 1245
    • (2011) Diabetes , vol.60 , Issue.4 , pp. 1237-1245
    • Fourlanos, S.1    Perry, C.2    Gellert, S.A.3
  • 56
    • 77956614531 scopus 로고    scopus 로고
    • GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD enzyme activity and humoral response
    • Chramy M., Skoglund C., Johansson I., Ludvigsson J., Hampe C. S., Casas R., GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD enzyme activity and humoral response Clinical Immunology 2010 137 31 40
    • (2010) Clinical Immunology , vol.137 , pp. 31-40
    • Chramy, M.1    Skoglund, C.2    Johansson, I.3    Ludvigsson, J.4    Hampe, C.S.5    Casas, R.6
  • 57
    • 0347990607 scopus 로고    scopus 로고
    • Transmission of Maternal Islet Antibodies and Risk of Autoimmune Diabetes in Offspring of Mothers with Type 1 Diabetes
    • DOI 10.2337/diabetes.53.1.1
    • Koczwara K., Bonifacio E., Ziegler A. G., Transmission of maternal islet antibodies and risk of autoimmune diabetes in offspring of mothers with type 1 diabetes Diabetes 2004 53 1 1 4 (Pubitemid 38044690)
    • (2004) Diabetes , vol.53 , Issue.1 , pp. 1-4
    • Koczwara, K.1    Bonifacio, E.2    Ziegler, A.-G.3
  • 58
    • 0035020056 scopus 로고    scopus 로고
    • Enzymatically mediated engineering of multivalent MHC class II-peptide chimeras
    • Casares S., Bona C. A., Brumeanu T. D., Enzymatically mediated engineering of multivalent MHC class II-peptide chimeras Protein Engineering 2001 14 3 195 200 (Pubitemid 32487974)
    • (2001) Protein Engineering , vol.14 , Issue.3 , pp. 195-200
    • Casares, S.1    Bona, C.A.2    Brumeanu, T.-D.3
  • 60
    • 0037651223 scopus 로고    scopus 로고
    • Peptide-based treatment for autoimmune diseases: Learning how to handle a double-edged sword
    • DOI 10.1172/JCI200318395
    • Pugliese A., Peptide-based treatment for autoimmune diseases: learning how to handle a double-edged sword Journal of Clinical Investigation 2003 111 9 1280 1282 (Pubitemid 36554697)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.9 , pp. 1280-1282
    • Pugliese, A.1
  • 61
    • 1842475456 scopus 로고    scopus 로고
    • Differential Recognition and Activation Thresholds in Human Autoreactive GAD-Specific T-Cells
    • DOI 10.2337/diabetes.53.4.971
    • Mallone R., Kochik S. A., Laughlin E. M., Gersuk V. H., Reijonen H., Kwok W. W., Nepom G. T., Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells Diabetes 2004 53 4 971 977 (Pubitemid 38436609)
    • (2004) Diabetes , vol.53 , Issue.4 , pp. 971-977
    • Mallone, R.1    Kochik, S.A.2    Laughlin, E.M.3    Gersuk, V.H.4    Reijonen, H.5    Kwok, W.W.6    Nepom, G.T.7
  • 63
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 8399) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B., Goodwin B., Richert N., Cortese I., Kondo T., Afshar G., Gran B., Eaton J., Antel J., Frank J. A., McFarland H. F., Martin R., Encephalitogenic potential of the myelin basic protein peptide (amino acids 8399) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand Nature Medicine 2000 6 10 1167 1175
    • (2000) Nature Medicine , vol.6 , Issue.10 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6    Gran, B.7    Eaton, J.8    Antel, J.9    Frank, J.A.10    McFarland, H.F.11    Martin, R.12
  • 65
    • 0033786591 scopus 로고    scopus 로고
    • Specific immunotherapy: One size does not fit all
    • Genain C. P., Zamvil S. S., Specific immunotherapy: one size does not fit all Nature Medicine 2000 6 10 1098 1100
    • (2000) Nature Medicine , vol.6 , Issue.10 , pp. 1098-1100
    • Genain, C.P.1    Zamvil, S.S.2
  • 68
    • 85047690395 scopus 로고    scopus 로고
    • Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
    • DOI 10.1172/JCI200419585
    • Arif S., Tree T. I., Astill T. P., Tremble J. M., Bishop A. J., Dayan C. M., Roep B. O., Peakman M., Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health Journal of Clinical Investigation 2004 113 3 451 463 (Pubitemid 38544189)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.3 , pp. 451-463
    • Arif, S.1    Tree, T.I.2    Astill, T.P.3    Tremble, J.M.4    Bishop, A.J.5    Dayan, C.M.6    Roep, B.O.7    Peakman, M.8
  • 69
    • 0035944844 scopus 로고    scopus 로고
    • -cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • DOI 10.1016/S0140-6736(01)06801-5
    • Raz I., Elias D., Avron A., Tamir M., Metzger M., Cohen I. R., -cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial The Lancet 2001 358 9295 1749 1753 (Pubitemid 33152998)
    • (2001) Lancet , vol.358 , Issue.9295 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3    Tamir, M.4    Metzger, M.5    Cohen, I.R.6
  • 70
    • 34249812097 scopus 로고    scopus 로고
    • Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: Extension of a randomized, double-blind, phase II trial
    • DOI 10.1002/dmrr.712
    • Raz I., Avron A., Tamir M., Metzger M., Symer L., Eldor R., Cohen I. R., Elias D., Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial Diabetes/Metabolism Research and Reviews 2007 23 4 292 298 (Pubitemid 46851470)
    • (2007) Diabetes/Metabolism Research and Reviews , vol.23 , Issue.4 , pp. 292-298
    • Raz, I.1    Avron, A.2    Tamir, M.3    Metzger, M.4    Symer, L.5    Eldor, R.6    Cohen, I.R.7    Elias, D.8
  • 71
    • 0043205830 scopus 로고    scopus 로고
    • T cells respond to heat shock protein 60 via TLR2: Activation of adhesion and inhibition of chemokine receptors
    • Zanin-Zhorov A., Nussbaum G., Franitza S., Cohen I. R., Lider O., T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors The FASEB Journal 2003 17 11 1567 1569
    • (2003) The FASEB Journal , vol.17 , Issue.11 , pp. 1567-1569
    • Zanin-Zhorov, A.1    Nussbaum, G.2    Franitza, S.3    Cohen, I.R.4    Lider, O.5
  • 72
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • DOI 10.1146/annurev.immunol.14.1.1
    • Sloan-Lancaster J., Allen P. M., Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology Annual Review of Immunology 1996 14 1 27 (Pubitemid 26130175)
    • (1996) Annual Review of Immunology , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 73
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • DOI 10.1073/pnas.93.2.956
    • Daniel D., Wegmann D. R., Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23) Proceedings of the National Academy of Sciences of the United States of America 1996 93 2 956 960 (Pubitemid 26041202)
    • (1996) Proceedings of the National Academy of Sciences of the United States of America , vol.93 , Issue.2 , pp. 956-960
    • Daniel, D.1    Wegmann, D.R.2
  • 75
    • 0036300542 scopus 로고    scopus 로고
    • Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide
    • Alleva D. G., Gaur A., Jin L., Wegmann D., Gottlieb P. A., Pahuja A., Johnson E. B., Motheral T., Putnam A., Crowe P. D., Ling N., Boehme S. A., Conlon P. J., Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide Diabetes 2002 51 7 2126 2134 (Pubitemid 34729017)
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2126-2134
    • Alleva, D.G.1    Gaur, A.2    Jin, L.3    Wegmann, D.4    Gottlieb, P.A.5    Pahuja, A.6    Johnson, E.B.7    Motheral, T.8    Putnam, A.9    Crowe, P.D.10    Ling, N.11    Boehme, S.A.12    Conlon, P.J.13
  • 77
    • 70449412682 scopus 로고    scopus 로고
    • No effect of the altered peptide ligand NBI-6024 on -cell residual function and insulin needs in new-onset type 1 diabetes
    • Walter M., Philotheou A., Bonnici F., Ziegler A. G., Jimenez R., No effect of the altered peptide ligand NBI-6024 on -cell residual function and insulin needs in new-onset type 1 diabetes Diabetes Care 2009 32 11 2036 2040
    • (2009) Diabetes Care , vol.32 , Issue.11 , pp. 2036-2040
    • Walter, M.1    Philotheou, A.2    Bonnici, F.3    Ziegler, A.G.4    Jimenez, R.5
  • 79
    • 0037122011 scopus 로고    scopus 로고
    • + T cell tolerance
    • DOI 10.1084/jem.20021598
    • Bonifaz L., Bonnyay D., Mahnke K., Rivera M., Nussenzweig M. C., Steinman R. M., Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance Journal of Experimental Medicine 2002 196 12 1627 1638 (Pubitemid 36026474)
    • (2002) Journal of Experimental Medicine , vol.196 , Issue.12 , pp. 1627-1638
    • Bonifaz, L.1    Bonnyay, D.2    Mahnke, K.3    Rivera, M.4    Nussenzweig, M.C.5    Steinman, R.M.6
  • 83
    • 77954630153 scopus 로고    scopus 로고
    • The immunotherapeutic potential of dendritic cells in type 1 diabetes
    • Mukherjee G., Dilorenzo T. P., The immunotherapeutic potential of dendritic cells in type 1 diabetes Clinical and Experimental Immunology 2010 161 2 197 207
    • (2010) Clinical and Experimental Immunology , vol.161 , Issue.2 , pp. 197-207
    • Mukherjee, G.1    Dilorenzo, T.P.2
  • 84
    • 0018414685 scopus 로고
    • The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells
    • Miller S. D., Wetzig R. P., Claman H. N., The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells Journal of Experimental Medicine 1979 149 3 758 773 (Pubitemid 9137687)
    • (1979) Journal of Experimental Medicine , vol.149 , Issue.3 , pp. 758-773
    • Miller, S.D.1    Wetzig, R.P.2    Claman, H.N.3
  • 85
    • 34548204279 scopus 로고    scopus 로고
    • Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease
    • DOI 10.1038/nri2153, PII NRI2153
    • Miller S. D., Turley D. M., Podojil J. R., Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease Nature Reviews Immunology 2007 7 9 665 677 (Pubitemid 47327394)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.9 , pp. 665-677
    • Miller, S.D.1    Turley, D.M.2    Podojil, J.R.3
  • 86
    • 77951901513 scopus 로고    scopus 로고
    • Immunotherapy of type 1 diabetes: Where are we and where should we be going?
    • Luo X., Herold K. C., Miller S. D., Immunotherapy of type 1 diabetes: where are we and where should we be going? Immunity 2010 32 4 488 499
    • (2010) Immunity , vol.32 , Issue.4 , pp. 488-499
    • Luo, X.1    Herold, K.C.2    Miller, S.D.3
  • 87
    • 0025174370 scopus 로고
    • Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides
    • Kennedy M. K., Tan L. J., Dal Canto M. C., Tuohy V. K., Lu Z., Trotter J. L., Miller S. D., Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides Journal of Immunology 1990 144 3 909 915 (Pubitemid 20065030)
    • (1990) Journal of Immunology , vol.144 , Issue.3 , pp. 909-915
    • Kennedy, M.K.1    Tan, L.J.2    Dal Canto, M.C.3    Tuohy, V.K.4    Lu, Z.5    Trotter, J.L.6    Miller, S.D.7
  • 90
    • 23244456102 scopus 로고    scopus 로고
    • DNA vaccines: Progress and challenges
    • Donnelly J. J., Wahren B., Liu M. A., DNA vaccines: progress and challenges Journal of Immunology 2005 175 2 633 639 (Pubitemid 41094942)
    • (2005) Journal of Immunology , vol.175 , Issue.2 , pp. 633-639
    • Donnelly, J.J.1    Wahren, B.2    Liu, M.A.3
  • 93
    • 34547150491 scopus 로고    scopus 로고
    • What does the future hold for cell-based tolerogenic therapy?
    • DOI 10.1038/nri2137, PII NRI2137
    • Bluestone J. A., Thomson A. W., Shevach E. M., Weiner H. L., What does the future hold for cell-based tolerogenic therapy? Nature Reviews Immunology 2007 7 8 650 654 (Pubitemid 47123553)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.8 , pp. 650-654
    • Bluestone, J.A.1    Thomson, A.W.2    Shevach, E.M.3    Weiner, H.L.4
  • 95
    • 2942692039 scopus 로고    scopus 로고
    • + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • DOI 10.1084/jem.20040180
    • Tarbell K. V., Yamazaki S., Olson K., Toy P., Steinman R. M., CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes Journal of Experimental Medicine 2004 199 11 1467 1477 (Pubitemid 38780402)
    • (2004) Journal of Experimental Medicine , vol.199 , Issue.11 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 96
    • 33845379986 scopus 로고    scopus 로고
    • + regulatory T cells of both healthy subjects and type 1 diabetic patients
    • Battaglia M., Stabilini A., Migliavacca B., Horejs-Hoeck J., Kaupper T., Roncarolo M. G., Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients Journal of Immunology 2006 177 12 8338 8347 (Pubitemid 44893795)
    • (2006) Journal of Immunology , vol.177 , Issue.12 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    Migliavacca, B.3    Horejs-Hoeck, J.4    Kaupper, T.5    Roncarolo, M.-G.6
  • 99
    • 79151474882 scopus 로고    scopus 로고
    • Generation and expansion of regulatory human CD4(+) T-cell clones specific for pancreatic islet autoantigens
    • Dromey J. A., Lee B. H., Yu H., Generation and expansion of regulatory human CD4(+) T-cell clones specific for pancreatic islet autoantigens Journal of Autoimmunity 2010 36 47 55
    • (2010) Journal of Autoimmunity , vol.36 , pp. 47-55
    • Dromey, J.A.1    Lee, B.H.2    Yu, H.3
  • 101
    • 0036659913 scopus 로고    scopus 로고
    • + regulatory T cells in vivo in humans
    • DOI 10.1182/blood.V100.1.174
    • Dhodapkar M. V., Steinman R. M., Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans Blood 2002 100 1 174 177 (Pubitemid 35177444)
    • (2002) Blood , vol.100 , Issue.1 , pp. 174-177
    • Dhodapkar, M.V.1    Steinman, R.M.2
  • 102
    • 0035425422 scopus 로고    scopus 로고
    • Designer dendritic cells for tolerance induction: Guided not misguided missiles
    • DOI 10.1016/S1471-4906(01)01959-7, PII S1471490601019597
    • Hackstein H., Morelli A. E., Thomson A. W., Designer dendritic cells for tolerance induction: guided not misguided missiles Trends in Immunology 2001 22 8 437 442 (Pubitemid 32709978)
    • (2001) Trends in Immunology , vol.22 , Issue.8 , pp. 437-442
    • Hackstein, H.1    Morelli, A.E.2    Thomson, A.W.3
  • 103
    • 4644297765 scopus 로고    scopus 로고
    • Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells
    • Machen J., Harnaha JO., Lakomy R., Styche A., Trucco M., Giannoukakis N., Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells Journal of Immunology 2004 173 7 4331 4341 (Pubitemid 39280661)
    • (2004) Journal of Immunology , vol.173 , Issue.7 , pp. 4331-4341
    • Machen, J.1    Harnaha, J.2    Lakomy, R.3    Styche, A.4    Trucco, M.5    Giannoukakis, N.6
  • 105
    • 1642536454 scopus 로고    scopus 로고
    • + T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species
    • Kusmartsev S., Nefedova Y., Yoder D., Gabrilovich D. I., Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species Journal of Immunology 2004 172 2 989 999 (Pubitemid 38113758)
    • (2004) Journal of Immunology , vol.172 , Issue.2 , pp. 989-999
    • Kusmartsev, S.1    Nefedova, Y.2    Yoder, D.3    Gabrilovich, D.I.4
  • 107
    • 31544446571 scopus 로고    scopus 로고
    • + immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    • DOI 10.1158/0008-5472.CAN-05-1299
    • Huang BO., Pan P. Y., Li Q., Sato A. I., Levy D. E., Bromberg J., Divino C. M., Chen S. H., Gr-1CD115 immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host Cancer Research 2006 66 2 1123 1131 (Pubitemid 43165981)
    • (2006) Cancer Research , vol.66 , Issue.2 , pp. 1123-1131
    • Huang, B.1    Pan, P.-Y.2    Li, Q.3    Sato, A.I.4    Levy, D.E.5    Bromberg, J.6    Divino, C.M.7    Chen, S.-H.8
  • 112
    • 78649740257 scopus 로고    scopus 로고
    • Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: Position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society
    • Mallone R., Mannering S. I., Brooks-Worrell B. M., Durinovic-Bell I., Cilio C. M., Wong F. S., Schloot N. C., Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society Clinical and Experimental Immunology 2011 163 1 33 49
    • (2011) Clinical and Experimental Immunology , vol.163 , Issue.1 , pp. 33-49
    • Mallone, R.1    Mannering, S.I.2    Brooks-Worrell, B.M.3    Durinovic-Bell, I.4    Cilio, C.M.5    Wong, F.S.6    Schloot, N.C.7
  • 115
  • 116
    • 33947726341 scopus 로고    scopus 로고
    • Moving towards efficient therapies in type 1 diabetes: To combine or not to combine?
    • DOI 10.1016/j.autrev.2006.09.013, PII S1568997206001625
    • Bresson D., von Herrath M., Moving towards efficient therapies in type 1 diabetes: to combine or not to combine? Autoimmunity Reviews 2007 6 5 315 322 (Pubitemid 46507996)
    • (2007) Autoimmunity Reviews , vol.6 , Issue.5 , pp. 315-322
    • Bresson, D.1    Von Herrath, M.2
  • 117
    • 77950649733 scopus 로고    scopus 로고
    • Developing combination immunotherapies for type 1 diabetes: Recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group
    • Matthews J. B., Staeva T. P., Bernstein P. L., Peakman M., Von Herrath M., Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group Clinical and Experimental Immunology 2010 160 2 176 184
    • (2010) Clinical and Experimental Immunology , vol.160 , Issue.2 , pp. 176-184
    • Matthews, J.B.1    Staeva, T.P.2    Bernstein, P.L.3    Peakman, M.4    Von Herrath, M.5
  • 118
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • DOI 10.1056/NEJM200007273430401
    • Shapiro A. M. J., Lakey J. R. T., Ryan E. A., Korbutt G. S., Toth E., Warnock G. L., Kneteman N. M., Rajotte R. V., Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen The New England Journal of Medicine 2000 343 4 230 238 (Pubitemid 30490390)
    • (2000) New England Journal of Medicine , vol.343 , Issue.4 , pp. 230-238
    • Shapiro, A.M.J.1    Lakey, J.R.T.2    Ryan, E.A.3    Korbutt, G.S.4    Toth, E.5    Warnock, G.L.6    Kneteman, N.M.7    Rajotte, R.V.8
  • 122
    • 34047180982 scopus 로고    scopus 로고
    • Update on the current status of peptide immunotherapy
    • Larch M., Update on the current status of peptide immunotherapy Journal of Allergy and Clinical Immunology 2007 119 4 906 909
    • (2007) Journal of Allergy and Clinical Immunology , vol.119 , Issue.4 , pp. 906-909
    • Larch, M.1
  • 123
    • 44849138907 scopus 로고    scopus 로고
    • Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization
    • Achenbach P., Barker J., Bonifacio E., Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization Current Diabetes Reports 2008 8 2 87 93
    • (2008) Current Diabetes Reports , vol.8 , Issue.2 , pp. 87-93
    • Achenbach, P.1    Barker, J.2    Bonifacio, E.3


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