Long-term prevention of diabetes and marked suppression of insulin autoantibodies and insulitis in mice lacking native insulin B9-23 sequence

Annals of the New York Academy of Sciences

Volumn 1079, Issue , 2006, Pages 122-129

  Nakayama, M ^b   Babaya, N ^b   Miao, D ^b   Gianani, R ^b   Liu, E ^b   Elliott, J F ^b   Eisenbarth, G S ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b NONE

Author keywords

Insulin autoantibodies; Insulin B9 23 peptide; Insulin knockout; NOD mouse

Indexed keywords

AUTOANTIBODY; INSULIN ANTIBODY; INSULIN B [9-23]; INSULIN DERIVATIVE; PEPTIDE DERIVATIVE; PREPROINSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GEMELLA; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; IMMUNOASSAY; INSULIN GENE; INSULITIS; KNOCKOUT GENE; LYMPHOCYTE TRANSFER; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; REGULATORY T LYMPHOCYTE; SCID MOUSE; SPLEEN CELL; TH2 CELL; TRANSGENE; WILD TYPE;

EID: 33845684328     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1375.018     Document Type: Conference Paper

References (15)

1. WEGMANN, D.R., M. NORBURY-GLASER & D. DANIEL. 1994. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur. J. Immunol. 24: 1853-1857.
2. PUGLIESE, A., M. ZELLER, A. FERNANDEZ JR., et al. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat. Genet. 15: 293-297.
3. JAECKEL, E., M.A. LIPES & H. VON BOEHMER 2005. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat. Immunol. 5: 1028-1035.
4. KENT, S.C., Y. CHEN, L. BREGOLI, et al. 2005. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 435: 224-228.
5. DANIEL, D., R.G. GILL, N. SCHLOOT & D. WEGMANN. 1995. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur.J. Immunol. 25: 1056-1062.
6. CHEN, W., I. BERGEROT, J.F. ELLIOTT, et al. 2001. Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes. J. Immunol. 167: 4926-4935.
7. ABIRU, N., D. WEGMANN, E. KAWASAKI, et al. 2000. Dual overlapping peptides recognized by insulin peptide B:9-23 T cell receptor AV13S3 T cell clones of the NOD mouse. J. Autoimmun. 14: 231-237.
8. WONG, F.S., J. KARTTUNEN, C. DUMONT, et al. 1999. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat. Med. 5: 1026-1031.
9. MORIYAMA, H., N. ABIRU, J. PARONEN, et al. 2003. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc. Natl. Acad. Sci. USA 100: 10376-10381.
10. THÉBAULT-BAUMONT, K., D. DUBOIS-LAFORGUE, P. KRIEF, et al. 2003. Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. J. Clin. Invest. 111: 851-857.
11. NAKAYAMA, M., N. ABIRU, H. MORIYAMA, et al. 2005. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435: 220-223.
12. ALLEVA, D.G., A. GAUR, L. JIN, et al. 2002. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes 51: 2126-2134.
13. NAKAYAMA, M., H. MORIYAMA, N. ABIRU, et al. 2004. Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene. Ann. N. Y. Acad. Sci. 1037: 193-198.
14. YU, L., D.T. ROBLES, N. ABIRU, et al. 2000. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc. Natl. Acad. Sci. USA 97: 1701-1706.
15. NAKAYAMA, M., N. BABAYA, D. MIAO, et al. 2005. Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout. J. Autoimmun. 25: 193-198.