-
1
-
-
43649106996
-
Extreme genetic risk for type 1A diabetes in the post-genome era
-
E.E. Baschal, and G.S. Eisenbarth Extreme genetic risk for type 1A diabetes in the post-genome era J Autoimmun 31 1 2008 1 6
-
(2008)
J Autoimmun
, vol.31
, Issue.1
, pp. 1-6
-
-
Baschal, E.E.1
Eisenbarth, G.S.2
-
2
-
-
36448978896
-
Type 1 diabetes as a relapsing-remitting disease?
-
M. von Herrath, S. Sanda, and K. Herold Type 1 diabetes as a relapsing-remitting disease? Nat Rev Immunol 7 12 2007 988 994
-
(2007)
Nat Rev Immunol
, vol.7
, Issue.12
, pp. 988-994
-
-
Von Herrath, M.1
Sanda, S.2
Herold, K.3
-
3
-
-
67650999438
-
Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice
-
C.M. Filippi Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice J Clin Invest 119 6 2009 1515 1523
-
(2009)
J Clin Invest
, vol.119
, Issue.6
, pp. 1515-1523
-
-
Filippi, C.M.1
-
4
-
-
58149337282
-
Viral trigger for type 1 diabetes: Pros and cons
-
C.M. Filippi, and M.G. von Herrath Viral trigger for type 1 diabetes: pros and cons Diabetes 57 11 2008 2863 2871
-
(2008)
Diabetes
, vol.57
, Issue.11
, pp. 2863-2871
-
-
Filippi, C.M.1
Von Herrath, M.G.2
-
5
-
-
70349673424
-
Immunotherapy for the prevention and treatment of type 1 diabetes: Human trials and a look into the future
-
M. Rewers, and P. Gottlieb Immunotherapy for the prevention and treatment of type 1 diabetes: human trials and a look into the future Diab Care 32 10 2009 1769 1782
-
(2009)
Diab Care
, vol.32
, Issue.10
, pp. 1769-1782
-
-
Rewers, M.1
Gottlieb, P.2
-
6
-
-
70349705744
-
Immunotherapy for the prevention and treatment of type 1 diabetes: Optimizing the path from bench to bedside
-
D. Bresson, and M. von Herrath Immunotherapy for the prevention and treatment of type 1 diabetes: optimizing the path from bench to bedside Diab Care 32 10 2009 1753 1768
-
(2009)
Diab Care
, vol.32
, Issue.10
, pp. 1753-1768
-
-
Bresson, D.1
Von Herrath, M.2
-
7
-
-
34848887156
-
Recovery from diabetes in mice by beta cell regeneration
-
T. Nir, D.A. Melton, and Y. Dor Recovery from diabetes in mice by beta cell regeneration J Clin Invest 117 9 2007 2553 2561
-
(2007)
J Clin Invest
, vol.117
, Issue.9
, pp. 2553-2561
-
-
Nir, T.1
Melton, D.A.2
Dor, Y.3
-
8
-
-
0029826977
-
B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: Analysis of a new "speed congenic" stock of NOD.Ig mu null mice
-
D.V. Serreze B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice J Exp Med 184 5 1996 2049 2053
-
(1996)
J Exp Med
, vol.184
, Issue.5
, pp. 2049-2053
-
-
Serreze, D.V.1
-
9
-
-
70449480577
-
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function
-
M.D. Pescovitz Rituximab, B-lymphocyte depletion, and preservation of beta-cell function N Engl J Med 361 22 2009 2143 2152
-
(2009)
N Engl J Med
, vol.361
, Issue.22
, pp. 2143-2152
-
-
Pescovitz, M.D.1
-
10
-
-
0027958044
-
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
-
L. Chatenoud Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice Proc Natl Acad Sci USA 91 1 1994 123 127
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.1
, pp. 123-127
-
-
Chatenoud, L.1
-
11
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
K.C. Herold Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus N Engl J Med 346 22 2002 1692 1698
-
(2002)
N Engl J Med
, vol.346
, Issue.22
, pp. 1692-1698
-
-
Herold, K.C.1
-
12
-
-
20044375937
-
A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
-
K.C. Herold A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes Diabetes 54 6 2005 1763 1769
-
(2005)
Diabetes
, vol.54
, Issue.6
, pp. 1763-1769
-
-
Herold, K.C.1
-
13
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
DOI 10.1056/NEJMoa043980
-
B. Keymeulen Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes N Engl J Med 352 25 2005 2598 2608 (Pubitemid 41007846)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.25
, pp. 2598-2608
-
-
Keymeulen, B.1
Vandemeulebroucke, E.2
Ziegler, A.G.3
Mathieu, C.4
Kaufman, L.5
Hale, G.6
Gorus, F.7
Goldman, M.8
Walter, M.9
Candon, S.10
Schandene, L.11
Crenier, L.12
De Block, C.13
Seigneurin, J.-M.14
De Pauw, P.15
Pierard, D.16
Weets, I.17
Rebello, P.18
Bird, P.19
Berrie, E.20
Frewin, M.21
Waldmann, H.22
Bach, J.-F.23
Pipeleers, D.24
Chatenoud, L.25
more..
-
14
-
-
34547230077
-
CD3-specific antibodies: A portal to the treatment of autoimmunity
-
L. Chatenoud, and J.A. Bluestone CD3-specific antibodies: a portal to the treatment of autoimmunity Nat Rev Immunol 7 8 2007 622 632
-
(2007)
Nat Rev Immunol
, vol.7
, Issue.8
, pp. 622-632
-
-
Chatenoud, L.1
Bluestone, J.A.2
-
15
-
-
85056050903
-
Polyclonal anti-T-cell therapy for type 1 diabetes mellitus of recent onset
-
F. Saudek Polyclonal anti-T-cell therapy for type 1 diabetes mellitus of recent onset Rev Diabet Stud 1 2 2004 80 88
-
(2004)
Rev Diabet Stud
, vol.1
, Issue.2
, pp. 80-88
-
-
Saudek, F.1
-
16
-
-
0028331371
-
Effect of adjuvant therapy on development of diabetes in mouse and man
-
N. Shehadeh Effect of adjuvant therapy on development of diabetes in mouse and man Lancet 343 8899 1994 706 707
-
(1994)
Lancet
, vol.343
, Issue.8899
, pp. 706-707
-
-
Shehadeh, N.1
-
17
-
-
51649084550
-
Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism
-
L. Ban Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism Proc Natl Acad Sci USA 105 36 2008 13644 13649
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.36
, pp. 13644-13649
-
-
Ban, L.1
-
18
-
-
67650079482
-
Etanercept treatment in children with new-onset type 1 diabetes: Pilot randomized, placebo-controlled, double-blind study
-
L. Mastrandrea Etanercept treatment in children with new-onset type 1 diabetes: pilot randomized, placebo-controlled, double-blind study Diab Care 32 7 2009 1244 1249
-
(2009)
Diab Care
, vol.32
, Issue.7
, pp. 1244-1249
-
-
Mastrandrea, L.1
-
19
-
-
0032146564
-
IL-1 produced and released endogenously within human islets inhibits beta cell function
-
M. Arnush IL-1 produced and released endogenously within human islets inhibits beta cell function J Clin Invest 102 3 1998 516 526
-
(1998)
J Clin Invest
, vol.102
, Issue.3
, pp. 516-526
-
-
Arnush, M.1
-
20
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
C.M. Larsen Interleukin-1-receptor antagonist in type 2 diabetes mellitus N Engl J Med 356 15 2007 1517 1526
-
(2007)
N Engl J Med
, vol.356
, Issue.15
, pp. 1517-1526
-
-
Larsen, C.M.1
-
21
-
-
78650033950
-
T.128. Short-term administration of anakinra does not appear to affect stimulated C-peptide responses acutely in patients with type 1 diabetes
-
S. Sanda T.128. Short-term administration of anakinra does not appear to affect stimulated C-peptide responses acutely in patients with type 1 diabetes Clin Immunol 131 Supplement 1 2009 S89
-
(2009)
Clin Immunol
, vol.131
, Issue.SUPPL. 1
, pp. 89
-
-
Sanda, S.1
-
22
-
-
58849117178
-
Improved efficacy of a tolerizing DNA vaccine for reversal of hyperglycemia through enhancement of gene expression and localization to intracellular sites
-
N. Solvason Improved efficacy of a tolerizing DNA vaccine for reversal of hyperglycemia through enhancement of gene expression and localization to intracellular sites J Immunol 181 12 2008 8298 8307
-
(2008)
J Immunol
, vol.181
, Issue.12
, pp. 8298-8307
-
-
Solvason, N.1
-
23
-
-
0031985550
-
Protection against autoimmune diabetes with oral insulin is associated with the presence of IL-4 type 2 T-cells in the pancreas and pancreatic lymph nodes
-
C. Ploix Protection against autoimmune diabetes with oral insulin is associated with the presence of IL-4 type 2 T-cells in the pancreas and pancreatic lymph nodes Diabetes 47 1 1998 39 44
-
(1998)
Diabetes
, vol.47
, Issue.1
, pp. 39-44
-
-
Ploix, C.1
-
24
-
-
0030754787
-
Metabolically inactive insulin analog prevents type i diabetes in prediabetic NOD mice
-
D.G. Karounos, J.S. Bryson, and D.A. Cohen Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice J Clin Invest 100 6 1997 1344 1348
-
(1997)
J Clin Invest
, vol.100
, Issue.6
, pp. 1344-1348
-
-
Karounos, D.G.1
Bryson, J.S.2
Cohen, D.A.3
-
25
-
-
33644856659
-
Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope
-
D.G. Alleva Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope Scand J Immunol 63 1 2006 59 69
-
(2006)
Scand J Immunol
, vol.63
, Issue.1
, pp. 59-69
-
-
Alleva, D.G.1
-
26
-
-
58149302798
-
Proinsulin peptide immunotherapy in type 1 diabetes: Report of a first-in-man phase i safety study
-
S.L. Thrower Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man phase I safety study Clin Exp Immunol 155 2 2009 156 165
-
(2009)
Clin Exp Immunol
, vol.155
, Issue.2
, pp. 156-165
-
-
Thrower, S.L.1
-
27
-
-
55249110198
-
GAD treatment and insulin secretion in recent-onset type 1 diabetes
-
J. Ludvigsson GAD treatment and insulin secretion in recent-onset type 1 diabetes N Engl J Med 359 18 2008 1909 1920
-
(2008)
N Engl J Med
, vol.359
, Issue.18
, pp. 1909-1920
-
-
Ludvigsson, J.1
-
28
-
-
25444455671
-
Regulation of pancreatic beta-cell mass
-
L. Bouwens, and I. Rooman Regulation of pancreatic beta-cell mass Physiol Rev 85 4 2005 1255 1270
-
(2005)
Physiol Rev
, vol.85
, Issue.4
, pp. 1255-1270
-
-
Bouwens, L.1
Rooman, I.2
-
29
-
-
35448986170
-
The replication of beta cells in normal physiology, in disease and for therapy
-
P.C. Butler The replication of beta cells in normal physiology, in disease and for therapy Nat Clin Pract Endocrinol Metab 3 11 2007 758 768
-
(2007)
Nat Clin Pract Endocrinol Metab
, vol.3
, Issue.11
, pp. 758-768
-
-
Butler, P.C.1
-
30
-
-
0033513455
-
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
-
G. Xu Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats Diabetes 48 12 1999 2270 2276
-
(1999)
Diabetes
, vol.48
, Issue.12
, pp. 2270-2276
-
-
Xu, G.1
-
31
-
-
0038497464
-
Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes
-
O.G. Kolterman Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes J Clin Endocrinol Metab 88 7 2003 3082 3089
-
(2003)
J Clin Endocrinol Metab
, vol.88
, Issue.7
, pp. 3082-3089
-
-
Kolterman, O.G.1
-
32
-
-
70349645780
-
Current advances and travails in islet transplantation
-
D.M. Harlan Current advances and travails in islet transplantation Diabetes 58 10 2009 2175 2184
-
(2009)
Diabetes
, vol.58
, Issue.10
, pp. 2175-2184
-
-
Harlan, D.M.1
-
33
-
-
65549128625
-
Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: Implications for diabetes cell therapies
-
S.H. Lee Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies Transplantation 87 7 2009 983 991
-
(2009)
Transplantation
, vol.87
, Issue.7
, pp. 983-991
-
-
Lee, S.H.1
-
34
-
-
67651064939
-
Real-time bioluminescence imaging of macroencapsulated fibroblasts reveals allograft protection in rhesus monkeys (Macaca mulatta)
-
A.F. Tarantal, C.C. Lee, and P. Itkin-Ansari Real-time bioluminescence imaging of macroencapsulated fibroblasts reveals allograft protection in rhesus monkeys (Macaca mulatta) Transplantation 88 1 2009 38 41
-
(2009)
Transplantation
, vol.88
, Issue.1
, pp. 38-41
-
-
Tarantal, A.F.1
Lee, C.C.2
Itkin-Ansari, P.3
-
35
-
-
22844439662
-
Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
-
B.K. Kleinschmidt-DeMasters, and K.L. Tyler Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis N Engl J Med 353 4 2005 369 374
-
(2005)
N Engl J Med
, vol.353
, Issue.4
, pp. 369-374
-
-
Kleinschmidt-Demasters, B.K.1
Tyler, K.L.2
-
36
-
-
72249103423
-
Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes
-
K.I. Rother Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes Diab Care 32 12 2009 2251 2257
-
(2009)
Diab Care
, vol.32
, Issue.12
, pp. 2251-2257
-
-
Rother, K.I.1
-
37
-
-
77950651774
-
Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes
-
D. Bresson Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes Mol Ther 2009
-
(2009)
Mol Ther
-
-
Bresson, D.1
-
38
-
-
33646392755
-
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
-
D. Bresson Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs J Clin Invest 116 5 2006 1371 1381
-
(2006)
J Clin Invest
, vol.116
, Issue.5
, pp. 1371-1381
-
-
Bresson, D.1
-
39
-
-
35548999311
-
Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells
-
N.A. Sherry Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells Endocrinology 148 11 2007 5136 5144
-
(2007)
Endocrinology
, vol.148
, Issue.11
, pp. 5136-5144
-
-
Sherry, N.A.1
|