Low doses of anti-CD3, ciclosporin A and the vitamin D analogue, TX527, synergise to delay recurrence of autoimmune diabetes in an islet-transplanted NOD mouse model of diabetes

Diabetologia

Volumn 55, Issue 10, 2012, Pages 2723-2732

  Baeke, F ^a   Van Belle, T L ^a   Takiishi, T ^a   Ding, L ^a   Korf, H ^a   Laureys, J ^a   Gysemans, C ^a   Mathieu, C ^a  

^a Division of Experimental Medicine and Endocrinology   (Belgium)

Author keywords

Autoimmunity; Combination therapy; Regulatory T cells; T cells; T helper skewing; Type 1 diabetes

Indexed keywords

19 NOR 14,20 BISEPI 23 YNE 1,25 DIHYDROXYVITAMIN D3; CALCIUM; CD8 ANTIGEN; CYCLOSPORIN A; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; TX 527; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DIABETES; AUTOIMMUNE DISEASE; BODY WEIGHT; BONE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERABILITY; FLOW CYTOMETRY; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPHENOTYPING; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; LYMPHOCYTIC INFILTRATION; MONOTHERAPY; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RECURRENT DISEASE; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT RESPONSE;

ALKYNES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; CELL PROLIFERATION; CHOLECALCIFEROL; CYCLOSPORINE; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED NOD; RECURRENCE; T-LYMPHOCYTES; VITAMIN D;

EID: 84866104188     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2630-1     Document Type: Article

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