-
1
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta- peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard, F., Cannon, C., Barbour, R., Burke, R.L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Lieberburg, I., Motter, R., Nguyen, M., Soriano, F., Vasquez, N., Weiss, K., Welch, B., Seubert, P., Schenk, D. & Yednock, T. (2000) Peripherally administered antibodies against amyloid beta- peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med., 6, 916-919.
-
(2000)
Nat. Med.
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, M.13
Lieberburg, I.14
Motter, R.15
Nguyen, M.16
Soriano, F.17
Vasquez, N.18
Weiss, K.19
Welch, B.20
Seubert, P.21
Schenk, D.22
Yednock, T.23
more..
-
2
-
-
84865529158
-
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
-
for the Dom antly Inherited Alzheimer Network.
-
Bateman, R.J., Xiong, C., Benzinger, T.L.S., Fagan, A.M., Goate, A., Fox, N.C., Marcus, D.S., Cairns, N.J., Xie, X., Blazey, T.M., Holtzman, D.M., Santacruz, A., Buckles, V., Oliver, A., Moulder, K., Aisen, P.S., Ghetti, B., Klunk, W.E., McDade, E., Martins, R.N., Masters, C.L., Mayeux, R., Ringman, J.M., Rossor, M.N., Schofield, P.R., Sperling, R.A., Salloway, S., Morris, J.C. & for the Dominantly Inherited Alzheimer Network. (2012) Clinical and biomarker changes in dominantly inherited Alzheimer's disease. New Engl. J. Med., 367, 795-804.
-
(2012)
New Engl. J. Med.
, vol.367
, pp. 795-804
-
-
Bateman, R.J.1
Xiong, C.2
Benzinger, T.L.S.3
Fagan, A.M.4
Goate, A.5
Fox, N.C.6
Marcus, D.S.7
Cairns, N.J.8
Xie, X.9
Blazey, T.M.10
Holtzman, D.M.11
Santacruz, A.12
Buckles, V.13
Oliver, A.14
Moulder, K.15
Aisen, P.S.16
Ghetti, B.17
Klunk, W.E.18
McDade, E.19
Martins, R.N.20
Masters, C.L.21
Mayeux, R.22
Ringman, J.M.23
Rossor, M.N.24
Schofield, P.R.25
Sperling, R.A.26
Salloway, S.27
Morris, J.C.28
more..
-
3
-
-
0141457931
-
Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease
-
Beckmann, N., Schuler, A., Mueggler, T., Meyer, E.P., Wiederhold, K.-H., Staufenbiel, M. & Krucker, T. (2003) Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease. J. Neurosci., 23, 8453-8459.
-
(2003)
J. Neurosci.
, vol.23
, pp. 8453-8459
-
-
Beckmann, N.1
Schuler, A.2
Mueggler, T.3
Meyer, E.P.4
Wiederhold, K.-H.5
Staufenbiel, M.6
Krucker, T.7
-
4
-
-
84855304100
-
Cerebrospinal fluid levels of β-amyloid 1-42, but not Tau are fully changed already 5 to 10 years before the onset of Alzheimer dementia
-
Buchhave, P., Minthon, L., Zetterberg, H., Wallin, A.K., Blennow, K. & Hansson, O. (2012) Cerebrospinal fluid levels of β-amyloid 1-42, but not Tau are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Arch. Gen. Psychiat., 69, 98-106.
-
(2012)
Arch. Gen. Psychiat.
, vol.69
, pp. 98-106
-
-
Buchhave, P.1
Minthon, L.2
Zetterberg, H.3
Wallin, A.K.4
Blennow, K.5
Hansson, O.6
-
5
-
-
13044265226
-
Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
-
Calhoun, M.E., Burgermeister, P., Phinney, A.L., Stalder, M.M., Tolnay, M., Wiederhold, K.-H., Abramowski, D., Sturchler-Pierrat, C., Sommer, B., Staufenbiel, M. & Jucker, M. (1999) Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. Proc. Natl. Acad. Sci. USA, 96, 14088-14093.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14088-14093
-
-
Calhoun, M.E.1
Burgermeister, P.2
Phinney, A.L.3
Stalder, M.M.4
Tolnay, M.5
Wiederhold, K.-H.6
Abramowski, D.7
Sturchler-Pierrat, C.8
Sommer, B.9
Staufenbiel, M.10
Jucker, M.11
-
6
-
-
84867463345
-
Alzheimer's drugs take a new tack
-
Callaway, E. (2012) Alzheimer's drugs take a new tack. Nature, 489, 13-14.
-
(2012)
Nature
, vol.489
, pp. 13-14
-
-
Callaway, E.1
-
7
-
-
0035877756
-
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
-
Chishti, M.A., Yang, D., Janus, C., Phinney, A.L., Horne, P., Pearson, J., Strome, R., Zuker, N., Loukides, J., French, J., Turner, S., Lozza, G., Grilli, M., Kunicki, S., Morissette, C., Paquette, J., Gervais, F., Bergeron, C., Fraser, P.E., Carlson, G.A., St George-Hyslop, P. & Westaway, D. (2001) Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J. Biol. Chem., 276, 21562-21570.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21562-21570
-
-
Chishti, M.A.1
Yang, D.2
Janus, C.3
Phinney, A.L.4
Horne, P.5
Pearson, J.6
Strome, R.7
Zuker, N.8
Loukides, J.9
French, J.10
Turner, S.11
Lozza, G.12
Grilli, M.13
Kunicki, S.14
Morissette, C.15
Paquette, J.16
Gervais, F.17
Bergeron, C.18
Fraser, P.E.19
Carlson, G.A.20
St George-Hyslop, P.21
Westaway, D.22
more..
-
8
-
-
0035099136
-
Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy
-
Christie, R., Yamada, M., Moskowitz, M. & Hyman, B. (2001) Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy. Am. J. Pathol., 158, 1065-1071.
-
(2001)
Am. J. Pathol.
, vol.158
, pp. 1065-1071
-
-
Christie, R.1
Yamada, M.2
Moskowitz, M.3
Hyman, B.4
-
9
-
-
79551713201
-
Brain microbleeds and Alzheimer's disease: innocent observation or key player?
-
Cordonnier, C. & van der Flier, W.M. (2011) Brain microbleeds and Alzheimer's disease: innocent observation or key player? Brain, 134, 335-344.
-
(2011)
Brain
, vol.134
, pp. 335-344
-
-
Cordonnier, C.1
van der Flier, W.M.2
-
10
-
-
84862777666
-
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
-
Cramer, P.E., Cirrito, J.R., Wesson, D.W., Lee, C.Y.D., Karlo, J.C., Zinn, A.E., Casali, B.T., Restivo, J.L., Goebel, W.D., James, M.J., Brunden, K.R., Wilson, D.A. & Landreth, G.E. (2012) ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science, 335, 1503-1506.
-
(2012)
Science
, vol.335
, pp. 1503-1506
-
-
Cramer, P.E.1
Cirrito, J.R.2
Wesson, D.W.3
Lee, C.Y.D.4
Karlo, J.C.5
Zinn, A.E.6
Casali, B.T.7
Restivo, J.L.8
Goebel, W.D.9
James, M.J.10
Brunden, K.R.11
Wilson, D.A.12
Landreth, G.E.13
-
11
-
-
62649162907
-
Mild cognitive impairment and Alzheimer disease: patterns of altered cerebral blood flow at MR imaging
-
Dai, W., Lopez, O., Carmichael, O., Becker, J., Kuller, L. & Gach, H. (2009) Mild cognitive impairment and Alzheimer disease: patterns of altered cerebral blood flow at MR imaging. Radiology, 250, 856-866.
-
(2009)
Radiology
, vol.250
, pp. 856-866
-
-
Dai, W.1
Lopez, O.2
Carmichael, O.3
Becker, J.4
Kuller, L.5
Gach, H.6
-
12
-
-
77952342062
-
Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease
-
Danielyan, L., Klein, R., Hanson, L.R., Buadze, M., Schwab, M., Gleiter, C.H. & Frey, W.H. II (2010) Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease. Rejuv. Res., 13, 195-201.
-
(2010)
Rejuv. Res.
, vol.13
, pp. 195-201
-
-
Danielyan, L.1
Klein, R.2
Hanson, L.R.3
Buadze, M.4
Schwab, M.5
Gleiter, C.H.6
Frey, W.H.7
-
13
-
-
2442594971
-
Early-onset and robust cerebral microvascular accumulation of amyloid β-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid β-protein precursor
-
Davis, J., Xu, F., Deane, R., Romanov, G., Previti, M.L., Zeigler, K., Zlokovic, B.V. & Van Nostrand, W.E. (2004) Early-onset and robust cerebral microvascular accumulation of amyloid β-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid β-protein precursor. J. Biol. Chem., 279, 20296-20306.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20296-20306
-
-
Davis, J.1
Xu, F.2
Deane, R.3
Romanov, G.4
Previti, M.L.5
Zeigler, K.6
Zlokovic, B.V.7
Van Nostrand, W.E.8
-
14
-
-
0033049396
-
Perfusion magnetic resonance imaging with continuous arterial spin labeling: methods and clinical applications in the central nervous system
-
Detre, J. & Alsop, D. (1999) Perfusion magnetic resonance imaging with continuous arterial spin labeling: methods and clinical applications in the central nervous system. Eur. J. Radiol., 30, 115-124.
-
(1999)
Eur. J. Radiol.
, vol.30
, pp. 115-124
-
-
Detre, J.1
Alsop, D.2
-
15
-
-
84867722515
-
Amyloid-ß-dependent compromise of microvascular structure and function in a model of Alzheimer's disease
-
Dorr, A., Sahota, B., Chinta, L.V., Brown, M.E., Lai, A.Y., Ma, K., Hawkes, C.A., McLaurin, J. & Stefanovic, B. (2012) Amyloid-ß-dependent compromise of microvascular structure and function in a model of Alzheimer's disease. Brain, 135, 3039-3050.
-
(2012)
Brain
, vol.135
, pp. 3039-3050
-
-
Dorr, A.1
Sahota, B.2
Chinta, L.V.3
Brown, M.E.4
Lai, A.Y.5
Ma, K.6
Hawkes, C.A.7
McLaurin, J.8
Stefanovic, B.9
-
16
-
-
0025291802
-
Altered angioarchitecture in selected areas of brains with Alzheimer's disease
-
Fischer, V.W., Siddiqi, A. & Yusufaly, Y. (1990) Altered angioarchitecture in selected areas of brains with Alzheimer's disease. Acta Neuropathol., 79, 672-679.
-
(1990)
Acta Neuropathol.
, vol.79
, pp. 672-679
-
-
Fischer, V.W.1
Siddiqi, A.2
Yusufaly, Y.3
-
17
-
-
80054966360
-
Therapeutic modulation of cerebral microhemorrhage in a mouse model of cerebral amyloid angiopathy
-
Fisher, M., Vasilevko, V., Passos, G.F., Ventura, C., Quiring, D. & Cribbs, D.H. (2011) Therapeutic modulation of cerebral microhemorrhage in a mouse model of cerebral amyloid angiopathy. Stroke, 42, 3300-3303.
-
(2011)
Stroke
, vol.42
, pp. 3300-3303
-
-
Fisher, M.1
Vasilevko, V.2
Passos, G.F.3
Ventura, C.4
Quiring, D.5
Cribbs, D.H.6
-
18
-
-
84869116509
-
Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross sectional study
-
Fleisher, A.S., Chen, K., Quiroz, Y.T., Jakimovich, L.J., Gutierrez-Gomez, M., Langoi, C.M., Langbaum, J.B.S., Ayutyanont, N., Roontiva, A., Thiyyagura, P., Lee, W., Mo, H., Lopez, L., Moreno, S., Acosta-Baena, N., Giraldo, M., Garcia, G., Reiman, R.A., Huentelman, M.J., Kosik, K.S., Tariot, P.N., Lopera, F. & Reiman, E.M. (2012) Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross sectional study. Lancet Neurol., 11, 1057-1065.
-
(2012)
Lancet Neurol.
, vol.11
, pp. 1057-1065
-
-
Fleisher, A.S.1
Chen, K.2
Quiroz, Y.T.3
Jakimovich, L.J.4
Gutierrez-Gomez, M.5
Langoi, C.M.6
Langbaum, J.B.S.7
Ayutyanont, N.8
Roontiva, A.9
Thiyyagura, P.10
Lee, W.11
Mo, H.12
Lopez, L.13
Moreno, S.14
Acosta-Baena, N.15
Giraldo, M.16
Garcia, G.17
Reiman, R.A.18
Huentelman, M.J.19
Kosik, K.S.20
Tariot, P.N.21
Lopera, F.22
Reiman, E.M.23
more..
-
19
-
-
84883841879
-
Object recognition memory and BDNF expression are reduced in young TgCRND8 mice
-
Francis, B.M., Kim, J., Barakat, M.E., Fraenkl, S., Yucel, Y.H., Peng, S., Michalski, B., Fahnestock, M., McLaurin, J. & Mount, H.T.J. (2012) Object recognition memory and BDNF expression are reduced in young TgCRND8 mice. Neurobiol. Aging, 33, 555-563.
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 555-563
-
-
Francis, B.M.1
Kim, J.2
Barakat, M.E.3
Fraenkl, S.4
Yucel, Y.H.5
Peng, S.6
Michalski, B.7
Fahnestock, M.8
McLaurin, J.9
Mount, H.T.J.10
-
20
-
-
33644649803
-
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
-
Girouard, H. & Iadecola, C. (2006) Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J. Appl. Physiol., 100, 328-335.
-
(2006)
J. Appl. Physiol.
, vol.100
, pp. 328-335
-
-
Girouard, H.1
Iadecola, C.2
-
21
-
-
80052400687
-
Vascular contributions to cognitive impairment and dementia. A statement for healthcare professionals from the American Heart Association/American Stroke Association
-
Gorelick, P.B., Scuteri, A., Black, S.E., DeCarli, C., Greenberg, S.M., Iadecola, C., Launer, L.J., Laurent, S., Lopez, O.L., Nyenhuis, D., Petersen, R.C., Schneider, J.A., Tzourio, C., Arnett, D.K., Bennett, D.A., Chui, H.C., Higashida, R.T., Lindquist, R., Nilsson, P.M., Roman, G.C., Sellke, F.W. & Seshadri, S. (2011) Vascular contributions to cognitive impairment and dementia. A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 42, 2672-2713.
-
(2011)
Stroke
, vol.42
, pp. 2672-2713
-
-
Gorelick, P.B.1
Scuteri, A.2
Black, S.E.3
DeCarli, C.4
Greenberg, S.M.5
Iadecola, C.6
Launer, L.J.7
Laurent, S.8
Lopez, O.L.9
Nyenhuis, D.10
Petersen, R.C.11
Schneider, J.A.12
Tzourio, C.13
Arnett, D.K.14
Bennett, D.A.15
Chui, H.C.16
Higashida, R.T.17
Lindquist, R.18
Nilsson, P.M.19
Roman, G.C.20
Sellke, F.W.21
Seshadri, S.22
more..
-
22
-
-
0036130319
-
Cerebral amyloid angiopathy and vessel dysfunction
-
Greenberg, S.M. (2002) Cerebral amyloid angiopathy and vessel dysfunction. Cerebrovasc. Dis., 13(Suppl. 2), 42-47.
-
(2002)
Cerebrovasc. Dis.
, vol.13
, Issue.SUPPL. 2
, pp. 42-47
-
-
Greenberg, S.M.1
-
23
-
-
33747153860
-
Deposition of mouse amyloid β in human APP/PS1 double and single AD model transgenic mice
-
van Groen, T., Kiliaan, A.J. & Kadish, I. (2006) Deposition of mouse amyloid β in human APP/PS1 double and single AD model transgenic mice. Neurobiol. Dis., 23, 653-662.
-
(2006)
Neurobiol. Dis.
, vol.23
, pp. 653-662
-
-
van Groen, T.1
Kiliaan, A.J.2
Kadish, I.3
-
24
-
-
84871195370
-
Impact of angiotensin receptor blockers on Alzheimer's disease pathology in a large brain autopsy series
-
Hajjar, I., Brown, L., Mack, W.J. & Chui, H. (2012) Impact of angiotensin receptor blockers on Alzheimer's disease pathology in a large brain autopsy series. Arch. Neurol., 69, 1632-1638.
-
(2012)
Arch. Neurol.
, vol.69
, pp. 1632-1638
-
-
Hajjar, I.1
Brown, L.2
Mack, W.J.3
Chui, H.4
-
25
-
-
58149373440
-
Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: Contribution of soluble and insoluble amyloid-ß peptide, partial restoration via γ-secretase inhibition
-
Han, B.H., Zhou, M.-L., Abousaleh, F., Brendza, R.P., Dietrich, H.H., Koenigsknecht-Talboo, J., Cirrito, J.R., Milner, E., Holtzman, D.M. & Zipfel, G.J. (2008) Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: Contribution of soluble and insoluble amyloid-ß peptide, partial restoration via γ-secretase inhibition. J. Neurosci., 28, 13542-13550.
-
(2008)
J. Neurosci.
, vol.28
, pp. 13542-13550
-
-
Han, B.H.1
Zhou, M.-L.2
Abousaleh, F.3
Brendza, R.P.4
Dietrich, H.H.5
Koenigsknecht-Talboo, J.6
Cirrito, J.R.7
Milner, E.8
Holtzman, D.M.9
Zipfel, G.J.10
-
26
-
-
59049104731
-
Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebralamyloid angiopathy
-
Hawkes, C.A. & McLaurin, J. (2009) Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebralamyloid angiopathy. Proc. Natl. Acad. Sci. USA, 106, 1261-1266.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 1261-1266
-
-
Hawkes, C.A.1
McLaurin, J.2
-
27
-
-
79954623282
-
Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy
-
Hawkes, C.A., Härtig, W., Kacza, J., Schliebs, R., Weller, R.O., Nicoll, J.A. & Carare, R.O. (2011) Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy. Acta Neuropathol., 121, 431-443.
-
(2011)
Acta Neuropathol.
, vol.121
, pp. 431-443
-
-
Hawkes, C.A.1
Härtig, W.2
Kacza, J.3
Schliebs, R.4
Weller, R.O.5
Nicoll, J.A.6
Carare, R.O.7
-
28
-
-
73949133110
-
Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy
-
Hayashi, S., Sato, N., Yamamoto, A., Ikegame, Y., Nakashima, S., Ogihara, T. & Morishita, R. (2009) Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy. Arterioscl. Throm. Vas., 29, 1909-1915.
-
(2009)
Arterioscl. Throm. Vas.
, vol.29
, pp. 1909-1915
-
-
Hayashi, S.1
Sato, N.2
Yamamoto, A.3
Ikegame, Y.4
Nakashima, S.5
Ogihara, T.6
Morishita, R.7
-
29
-
-
4344648449
-
Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
-
Herzig, M.C., Winkler, D.T., Burgermeister, P., Pfeifer, M., Kohler, E., Schmidt, S.D., Danner, S., Abramowski, D., Stürchler-Pierrat, C., Bürki, K., van Duinen, S.G., Maat-Schieman, M.L.C., Staufenbiel, M., Mathews, P.M. & Jucker, M. (2004) Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat. Neurosci., 7, 954-960.
-
(2004)
Nat. Neurosci.
, vol.7
, pp. 954-960
-
-
Herzig, M.C.1
Winkler, D.T.2
Burgermeister, P.3
Pfeifer, M.4
Kohler, E.5
Schmidt, S.D.6
Danner, S.7
Abramowski, D.8
Stürchler-Pierrat, C.9
Bürki, K.10
van Duinen, S.G.11
Maat-Schieman, M.L.C.12
Staufenbiel, M.13
Mathews, P.M.14
Jucker, M.15
-
30
-
-
41149127354
-
Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging
-
Holland, C.M., Smith, E.E., Csapo, I., Gurol, M.E., Brylka, D.A., Killiany, R.J., Blacker, D., Albert, M.S., Guttmann, C.R. & Greenberg, S.M. (2008) Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging. Stroke, 39, 1127-1133.
-
(2008)
Stroke
, vol.39
, pp. 1127-1133
-
-
Holland, C.M.1
Smith, E.E.2
Csapo, I.3
Gurol, M.E.4
Brylka, D.A.5
Killiany, R.J.6
Blacker, D.7
Albert, M.S.8
Guttmann, C.R.9
Greenberg, S.M.10
-
31
-
-
84867956994
-
Alzheimer's disease, cerebrovascular disease, and the β-amyloid cascade
-
Honjo, K., Black, S.E. & Verhoeff, N.P. (2012) Alzheimer's disease, cerebrovascular disease, and the β-amyloid cascade. Can. J. Neurol., 39, 712-728.
-
(2012)
Can. J. Neurol.
, vol.39
, pp. 712-728
-
-
Honjo, K.1
Black, S.E.2
Verhoeff, N.P.3
-
32
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F. & Cole, G. (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science, 274, 99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
33
-
-
84862908271
-
Effects of age and amyloid deposition on Ab dynamics in the human central nervous system
-
Huang, Y., Potter, R., Sigurdson, W., Santacruz, A., Shih, S., Ju, Y.-E., Kasten, T., Morris, J.C., Minun, M., Duntley, S. & Bateman, R.J. (2012) Effects of age and amyloid deposition on Ab dynamics in the human central nervous system. Arch. Neurol., 69, 51-58.
-
(2012)
Arch. Neurol.
, vol.69
, pp. 51-58
-
-
Huang, Y.1
Potter, R.2
Sigurdson, W.3
Santacruz, A.4
Shih, S.5
Ju, Y.-E.6
Kasten, T.7
Morris, J.C.8
Minun, M.9
Duntley, S.10
Bateman, R.J.11
-
34
-
-
84861218392
-
Morphological and pathological evolution of the brain microcirculation in aging and Alzheimer's disease
-
Hunter, J.M., Kwan, J., Malek-Ahmadi, M., Maarouf, C.L., Kokjohn, T.A., Belden, C., Sabbagh, M.N., Beach, T.G. & Roher, A.E. (2012) Morphological and pathological evolution of the brain microcirculation in aging and Alzheimer's disease. PLoS ONE, 7, e36893.
-
(2012)
PLoS ONE
, vol.7
-
-
Hunter, J.M.1
Kwan, J.2
Malek-Ahmadi, M.3
Maarouf, C.L.4
Kokjohn, T.A.5
Belden, C.6
Sabbagh, M.N.7
Beach, T.G.8
Roher, A.E.9
-
35
-
-
72049130805
-
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
-
Jack, C.R., Knopman, D.S., Jagust, W.J., Shaw, L.M., Aisen, P.S., Weiner, M.W., Petersen, R.C. & Trojanowski, J.Q. (2010) Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol., 9, 119-128.
-
(2010)
Lancet Neurol.
, vol.9
, pp. 119-128
-
-
Jack, C.R.1
Knopman, D.S.2
Jagust, W.J.3
Shaw, L.M.4
Aisen, P.S.5
Weiner, M.W.6
Petersen, R.C.7
Trojanowski, J.Q.8
-
36
-
-
84871001204
-
Apolipoprotein E, not fibrillary β-amyloid, reduces cerebral glucose metabolism in normal aging
-
for the Alzheimer's Disease Neuroimag g Initiative.
-
Jagust, W.J., Landau, S.M. & for the Alzheimer's Disease Neuroimaging Initiative. (2012) Apolipoprotein E, not fibrillary β-amyloid, reduces cerebral glucose metabolism in normal aging. J. Neurosci., 32, 18227-18233.
-
(2012)
J. Neurosci.
, vol.32
, pp. 18227-18233
-
-
Jagust, W.J.1
Landau, S.M.2
-
37
-
-
13844298168
-
Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience
-
Johnson, N.A., Jahng, G.H., Weiner, M.W., Miller, B.L., Chui, H.C., Jagust, W.J., Gorno-Tempini, M.L. & Schuff, N. (2005) Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience. Radiology, 234, 851-859.
-
(2005)
Radiology
, vol.234
, pp. 851-859
-
-
Johnson, N.A.1
Jahng, G.H.2
Weiner, M.W.3
Miller, B.L.4
Chui, H.C.5
Jagust, W.J.6
Gorno-Tempini, M.L.7
Schuff, N.8
-
38
-
-
0030452414
-
Cerebral vessels in ageing and Alzheimer's disease
-
Kalaria, R.N. (1996) Cerebral vessels in ageing and Alzheimer's disease. Pharmacol. Therapeut., 72, 193-214.
-
(1996)
Pharmacol. Therapeut.
, vol.72
, pp. 193-214
-
-
Kalaria, R.N.1
-
39
-
-
0036130159
-
Small vessel disease and Alzheimer's dementia: pathological considerations
-
Kalaria, R.N. (2002) Small vessel disease and Alzheimer's dementia: pathological considerations. Cerebrovasc. Dis., 13(Suppl. 2), 48-52..
-
(2002)
Cerebrovasc. Dis.
, vol.13
, Issue.SUPPL. 2
, pp. 48-52
-
-
Kalaria, R.N.1
-
40
-
-
84865575181
-
Cerebrovascular disease and mechanisms of cognitive impairment. Evidence from clinicopathological studies in humans
-
Kalaria, R.N. (2012) Cerebrovascular disease and mechanisms of cognitive impairment. Evidence from clinicopathological studies in humans. Stroke, 43, 2526-2534.
-
(2012)
Stroke
, vol.43
, pp. 2526-2534
-
-
Kalaria, R.N.1
-
41
-
-
82555164994
-
Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis
-
Klohs, J., Deistung, A., Schweser, F., Grandjea, J., Dominietto, M., Waschkies, C., Nitsch, R.M., Knuese, I., Reichenbach, J.R. & Rudin, M. (2011) Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis. J. Cerebr. Blood F. Met., 31, 2282-2292.
-
(2011)
J. Cerebr. Blood F. Met.
, vol.31
, pp. 2282-2292
-
-
Klohs, J.1
Deistung, A.2
Schweser, F.3
Grandjea, J.4
Dominietto, M.5
Waschkies, C.6
Nitsch, R.M.7
Knuese, I.8
Reichenbach, J.R.9
Rudin, M.10
-
42
-
-
84856667645
-
Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice
-
Klohs, J., Baltes, C., Princz-Kranz, F., Ratering, D., Nitsch, R.M., Knuesel, I. & Rudin, M. (2012) Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice. J. Neurosci., 32, 1705-1713.
-
(2012)
J. Neurosci.
, vol.32
, pp. 1705-1713
-
-
Klohs, J.1
Baltes, C.2
Princz-Kranz, F.3
Ratering, D.4
Nitsch, R.M.5
Knuesel, I.6
Rudin, M.7
-
43
-
-
34447564164
-
Intracellular Aβ and cognitive deficits precede β-amyloid deposition in transgenic arcAβ mice
-
Knobloch, M., Konietzko, U., Krebs, D.C. & Nitsch, R.M. (2007) Intracellular Aβ and cognitive deficits precede β-amyloid deposition in transgenic arcAβ mice. Neurobiol. Aging, 28, 1297-1306.
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1297-1306
-
-
Knobloch, M.1
Konietzko, U.2
Krebs, D.C.3
Nitsch, R.M.4
-
44
-
-
20344371724
-
Stereological analysis of microvascular parameters in a double transgenic model of Alzheimer's disease
-
Lee, G.D., Aruna, J.H., Barrett, P.M., Lei, D.L., Ingram, D.K. & Mouton, P.R. (2005) Stereological analysis of microvascular parameters in a double transgenic model of Alzheimer's disease. Brain Res. Bull., 65, 317-322.
-
(2005)
Brain Res. Bull.
, vol.65
, pp. 317-322
-
-
Lee, G.D.1
Aruna, J.H.2
Barrett, P.M.3
Lei, D.L.4
Ingram, D.K.5
Mouton, P.R.6
-
45
-
-
74949131237
-
Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis
-
Li, N.-C., Lee, A., Whitmer, R.A., Kivipelto, M., Lawler, E., Kazis, L.E. & Wolozin, B. (2010) Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ, 340, b5465.
-
(2010)
BMJ
, vol.340
-
-
Li, N.-C.1
Lee, A.2
Whitmer, R.A.3
Kivipelto, M.4
Lawler, E.5
Kazis, L.E.6
Wolozin, B.7
-
46
-
-
0034674785
-
Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid β peptide and inhibit Aβ-induced toxicity
-
McLaurin, J., Golomb, R., Jurewiczi, A., Anteli, J.P. & Fraser, P.E. (2000) Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid β peptide and inhibit Aβ-induced toxicity. J. Biol. Chem., 275, 18495-18502.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18495-18502
-
-
McLaurin, J.1
Golomb, R.2
Jurewiczi, A.3
Anteli, J.P.4
Fraser, P.E.5
-
47
-
-
33745922350
-
Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model
-
McLaurin, J., Kierstead, M.E., Brown, M.E., Hawkes, C.A., Lambermon, M.H., Phinney, A.L., Darabie, A.A., Cousins, J.E., French, J.E., Lan, M.F., Chen, F., Wong, S.S., Mount, H.T., Fraser, P.E., Westaway, D. & St George-Hyslop, P. (2006) Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nat. Med., 12, 801-808.
-
(2006)
Nat. Med.
, vol.12
, pp. 801-808
-
-
McLaurin, J.1
Kierstead, M.E.2
Brown, M.E.3
Hawkes, C.A.4
Lambermon, M.H.5
Phinney, A.L.6
Darabie, A.A.7
Cousins, J.E.8
French, J.E.9
Lan, M.F.10
Chen, F.11
Wong, S.S.12
Mount, H.T.13
Fraser, P.E.14
Westaway, D.15
St George-Hyslop, P.16
-
48
-
-
80054711185
-
Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice
-
Merlini, M. & Meyer, E.P. (2011) Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice. Acta Neuropathol., 122, 293-311.
-
(2011)
Acta Neuropathol.
, vol.122
, pp. 293-311
-
-
Merlini, M.1
Meyer, E.P.2
-
49
-
-
25144486849
-
Cerebral microvascular amyloid β protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid β precursor protein
-
Miao, J., Feng Xu, F., Davis, J., Otte-Höller, I., Verbeek, M.M. & Van Nostrand, W.E. (2005) Cerebral microvascular amyloid β protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid β precursor protein. Am. J. Pathol., 167, 505-515.
-
(2005)
Am. J. Pathol.
, vol.167
, pp. 505-515
-
-
Miao, J.1
Feng Xu, F.2
Davis, J.3
Otte-Höller, I.4
Verbeek, M.M.5
Van Nostrand, W.E.6
-
50
-
-
0037104754
-
Compromised hemodynamic response in amyloid precursor protein transgenic mice
-
Mueggler, T., Sturchler-Pierrat, C., Baumann, D., Rausch, M., Staufenbiel, M. & Rudin, M. (2002) Compromised hemodynamic response in amyloid precursor protein transgenic mice. J. Neurosci., 22, 7218-7224.
-
(2002)
J. Neurosci.
, vol.22
, pp. 7218-7224
-
-
Mueggler, T.1
Sturchler-Pierrat, C.2
Baumann, D.3
Rausch, M.4
Staufenbiel, M.5
Rudin, M.6
-
51
-
-
0034662501
-
Aβ1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation
-
Niwa, K., Younkin, L., Ebeling, C., Turner, S.K., Westaway, D., Younkin, S., Ashe, K.H., Carlson, G.A. & Iadecola, C. (2000) Aβ1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc. Natl. Acad. Sci. USA, 97, 9735-9740.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9735-9740
-
-
Niwa, K.1
Younkin, L.2
Ebeling, C.3
Turner, S.K.4
Westaway, D.5
Younkin, S.6
Ashe, K.H.7
Carlson, G.A.8
Iadecola, C.9
-
52
-
-
0035665509
-
Aβ-peptides enhance vasoconstriction in cerebral circulation
-
Niwa, K., Porter, V.A., Kazama, K., Cornfield, D., Carlson, G.A. & Iadecola, C. (2001) Aβ-peptides enhance vasoconstriction in cerebral circulation. Am. J. Physiol.-Heart C., 281, H2417-H2424.
-
(2001)
Am. J. Physiol.-Heart C.
, vol.281
-
-
Niwa, K.1
Porter, V.A.2
Kazama, K.3
Cornfield, D.4
Carlson, G.A.5
Iadecola, C.6
-
53
-
-
3242667174
-
Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis
-
Paris, D., Patel, N., DelleDonne, A., Quadros, A., Smeed, R. & Mullan, M. (2004a) Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis. Neurosci. Lett., 366, 80-85.
-
(2004)
Neurosci. Lett.
, vol.366
, pp. 80-85
-
-
Paris, D.1
Patel, N.2
DelleDonne, A.3
Quadros, A.4
Smeed, R.5
Mullan, M.6
-
54
-
-
14044258771
-
NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid β peptide
-
Park, L., Anrather, J., Zhou, P., Frys, K., Pitstick, R., Younkin, S., Carlson, G.A. & Iadecola, C. (2005) NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid β peptide. J. Neurosci., 25, 1769-1777.
-
(2005)
J. Neurosci.
, vol.25
, pp. 1769-1777
-
-
Park, L.1
Anrather, J.2
Zhou, P.3
Frys, K.4
Pitstick, R.5
Younkin, S.6
Carlson, G.A.7
Iadecola, C.8
-
55
-
-
39549106246
-
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein
-
Park, L., Zhou, P., Pitstick, R., Capone, C., Anrather, J., Norris, E.H., Younkin, L., Younkin, S., Carlson, G., McEwen, B.S. & Iadecola, C. (2008) Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc. Natl. Acad. Sci. USA, 105, 1347-1352.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 1347-1352
-
-
Park, L.1
Zhou, P.2
Pitstick, R.3
Capone, C.4
Anrather, J.5
Norris, E.H.6
Younkin, L.7
Younkin, S.8
Carlson, G.9
McEwen, B.S.10
Iadecola, C.11
-
56
-
-
34547791784
-
Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
-
Paul, J., Strickland, S. & Melchor, P.J. (2007) Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J. Exp. Med., 204, 1999-2008.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1999-2008
-
-
Paul, J.1
Strickland, S.2
Melchor, P.J.3
-
57
-
-
0028491538
-
Microvascular pathology and vascular basement membrane components in Alzheimer's disease
-
Perlmutter, L.S. (1994) Microvascular pathology and vascular basement membrane components in Alzheimer's disease. Mol. Neurobiol., 9, 33-40.
-
(1994)
Mol. Neurobiol.
, vol.9
, pp. 33-40
-
-
Perlmutter, L.S.1
-
58
-
-
0037112201
-
Cerebral hemorrhage after passive anti-Aβ immunotherapy
-
Pfeifer, M., Boncristiano, S., Bondolfi, L., Stalder, A., Deller, T., Staufenbiel, M., Mathews, P.M. & Jucker, M. (2002) Cerebral hemorrhage after passive anti-Aβ immunotherapy. Science, 298, 1379.
-
(2002)
Science
, vol.298
, pp. 1379
-
-
Pfeifer, M.1
Boncristiano, S.2
Bondolfi, L.3
Stalder, A.4
Deller, T.5
Staufenbiel, M.6
Mathews, P.M.7
Jucker, M.8
-
59
-
-
84862700955
-
The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease
-
Pimentel-Coelho, P.M. & Rivest, S. (2012) The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease. Eur. J. Neurosci., 35, 1917-1937.
-
(2012)
Eur. J. Neurosci.
, vol.35
, pp. 1917-1937
-
-
Pimentel-Coelho, P.M.1
Rivest, S.2
-
60
-
-
33847185849
-
Antibody-mediated clearance of amyloid-β peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging
-
Prada, C.M., Garcia-Alloza, M., Betensky, R.A., Zhang-Nunes, S.X., Greenberg, S.M., Bacskai, B.J. & Frosch, M.P. (2007) Antibody-mediated clearance of amyloid-β peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J. Neurosci., 27, 1973-1980.
-
(2007)
J. Neurosci.
, vol.27
, pp. 1973-1980
-
-
Prada, C.M.1
Garcia-Alloza, M.2
Betensky, R.A.3
Zhang-Nunes, S.X.4
Greenberg, S.M.5
Bacskai, B.J.6
Frosch, M.P.7
-
61
-
-
77955844123
-
Vascular response to acetazolamide decreases as a function of age in the arcAβ mouse model of cerebral amyloidosis
-
Princz-Kranz, F.L., Mueggler, T., Knobloch, M., Nitsch, R.M. & Rudin, M. (2010) Vascular response to acetazolamide decreases as a function of age in the arcAβ mouse model of cerebral amyloidosis. Neurobiol. Dis., 40, 284-292.
-
(2010)
Neurobiol. Dis.
, vol.40
, pp. 284-292
-
-
Princz-Kranz, F.L.1
Mueggler, T.2
Knobloch, M.3
Nitsch, R.M.4
Rudin, M.5
-
62
-
-
84874912869
-
Posterior cingulated glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal late-middle aged persons at 3 levels of genetic risk for Alzheimer disease
-
doi:10.1001/2013.jamaneurol.286. [Epub ahead of pr t].
-
Protas, H.D., Chen, K., Langbaum, J.B.S., Fleisher, A.S., Alexander, G.E., Lee, W., Bandy, D., deLeon, M.J., Mosconi, L., Buckley, S., Truran-Sacrey, D., Schuff, N., Weiner, M.W., Caselli, R.J. & Reiman, E.M. (2012) Posterior cingulated glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal late-middle aged persons at 3 levels of genetic risk for Alzheimer disease. Arch. Neurol., doi:10.1001/2013.jamaneurol.286. [Epub ahead of print].
-
(2012)
Arch. Neurol.
-
-
Protas, H.D.1
Chen, K.2
Langbaum, J.B.S.3
Fleisher, A.S.4
Alexander, G.E.5
Lee, W.6
Bandy, D.7
deLeon, M.J.8
Mosconi, L.9
Buckley, S.10
Truran-Sacrey, D.11
Schuff, N.12
Weiner, M.W.13
Caselli, R.J.14
Reiman, E.M.15
-
63
-
-
84869126018
-
Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study
-
Reiman, E.M., Quiroz, Y.T., Fleisher, A.S., Chen, K., Velez-Pardo, C., Jimenez-Del-Rio, M., Fagan, A.M., Shah, A.R., Alvarez, S., Arbelaez, A., Giraldo, M., Acosta-Baena, N., Sperling, R.A., Dickerson, B., Stern, C.E., Tirado, V., Munoz, C., Reiman, R.A., Huentelman, M.J., Alexander, G.E., Langbaum, J.B.S., Kosik, K.S., Tariot, P.N. & Lopera, F. (2012) Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study. Lancet Neurol., 11, 1048-1056.
-
(2012)
Lancet Neurol.
, vol.11
, pp. 1048-1056
-
-
Reiman, E.M.1
Quiroz, Y.T.2
Fleisher, A.S.3
Chen, K.4
Velez-Pardo, C.5
Jimenez-Del-Rio, M.6
Fagan, A.M.7
Shah, A.R.8
Alvarez, S.9
Arbelaez, A.10
Giraldo, M.11
Acosta-Baena, N.12
Sperling, R.A.13
Dickerson, B.14
Stern, C.E.15
Tirado, V.16
Munoz, C.17
Reiman, R.A.18
Huentelman, M.J.19
Alexander, G.E.20
Langbaum, J.B.S.21
Kosik, K.S.22
Tariot, P.N.23
Lopera, F.24
more..
-
64
-
-
33845484383
-
Blocking the apolipoprotein E/amyloid-β interaction as a potential therapeutic approach for Alzheimer's disease
-
Sadowski, M.J., Pankiewicz, J., Scholtzova, H., Mehta, P.D., Prelli, F., Quartermain, D. & Wisniewski, T. (2006) Blocking the apolipoprotein E/amyloid-β interaction as a potential therapeutic approach for Alzheimer's disease. Proc. Natl. Acad. Sci. USA, 103, 18787-18792.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 18787-18792
-
-
Sadowski, M.J.1
Pankiewicz, J.2
Scholtzova, H.3
Mehta, P.D.4
Prelli, F.5
Quartermain, D.6
Wisniewski, T.7
-
65
-
-
33748980079
-
In vivo characterization of endothelial cell activation in a transgenic mouse model of Alzheimer's disease
-
Schultheiss, C., Blechert, B., Gaertner, F.C., Drecoll, E., Mueller, J., Weber, G.F., Drzezga, A. & Essler, M. (2006) In vivo characterization of endothelial cell activation in a transgenic mouse model of Alzheimer's disease. Angiogenesis, 9, 59-65.
-
(2006)
Angiogenesis
, vol.9
, pp. 59-65
-
-
Schultheiss, C.1
Blechert, B.2
Gaertner, F.C.3
Drecoll, E.4
Mueller, J.5
Weber, G.F.6
Drzezga, A.7
Essler, M.8
-
66
-
-
34548225478
-
Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy
-
Shin, H.K., Jones, P.B., Garcia-Alloza, M., Borrelli, L., Greenberg, S.M., Bacskai, B.J., Frosch, M.P., Hyman, B.T., Moskowitz1, M.A. & Ayata, C. (2007) Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain, 130, 2310-2319.
-
(2007)
Brain
, vol.130
, pp. 2310-2319
-
-
Shin, H.K.1
Jones, P.B.2
Garcia-Alloza, M.3
Borrelli, L.4
Greenberg, S.M.5
Bacskai, B.J.6
Frosch, M.P.7
Hyman, B.T.8
Moskowitz1, M.A.9
Ayata, C.10
-
67
-
-
79956098248
-
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute of Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
Sperling, R.A., Aisen, P.S., Beckett, L.A., Bennett, D.A., Craft, S., Fagan, A.M., Iwatsubo, T., Jack, C.R., Kaye, J., Montine, T.J., Park, D.C., Reiman, E.M., Rowe, C.C., Siemers, E., Stern, Y., Yaffe, K., Carrillo, M.C., Thies, B., Morrison-Bogorad, M., Wagster, M.V. & Phelps, C.H. (2011) Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute of Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement., 7, 280-292.
-
(2011)
Alzheimers Dement.
, vol.7
, pp. 280-292
-
-
Sperling, R.A.1
Aisen, P.S.2
Beckett, L.A.3
Bennett, D.A.4
Craft, S.5
Fagan, A.M.6
Iwatsubo, T.7
Jack, C.R.8
Kaye, J.9
Montine, T.J.10
Park, D.C.11
Reiman, E.M.12
Rowe, C.C.13
Siemers, E.14
Stern, Y.15
Yaffe, K.16
Carrillo, M.C.17
Thies, B.18
Morrison-Bogorad, M.19
Wagster, M.V.20
Phelps, C.H.21
more..
-
68
-
-
0036736218
-
Amyloid precursor protein, presenilins and a-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease
-
Suh, Y.-H. & Checler, F. (2002) Amyloid precursor protein, presenilins and a-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharmacol. Rev., 54, 469-525.
-
(2002)
Pharmacol. Rev.
, vol.54
, pp. 469-525
-
-
Suh, Y.-H.1
Checler, F.2
-
69
-
-
0032573452
-
Soluble Alzheimers beta-amyloid constricts the cerebral vasculature in vivo
-
Suo, Z., Humphrey, J., Kundtz, A., Sethi, F., Placzek, A., Crawford, F. & Mullan, M. (1998) Soluble Alzheimers beta-amyloid constricts the cerebral vasculature in vivo. Neurosci. Lett., 257, 77-80.
-
(1998)
Neurosci. Lett.
, vol.257
, pp. 77-80
-
-
Suo, Z.1
Humphrey, J.2
Kundtz, A.3
Sethi, F.4
Placzek, A.5
Crawford, F.6
Mullan, M.7
-
71
-
-
63149148789
-
Intracerebroventricular amyloid-β antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice
-
Thakker, D.R., Weatherspoon, M.R., Harrison, J., Keene, T.E., Lane, D.S., Kaemmerer, W.F., Stewart, G.R. & Shafer, L.L. (2009) Intracerebroventricular amyloid-β antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc. Natl. Acad. Sci. USA, 106, 4501-4506.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 4501-4506
-
-
Thakker, D.R.1
Weatherspoon, M.R.2
Harrison, J.3
Keene, T.E.4
Lane, D.S.5
Kaemmerer, W.F.6
Stewart, G.R.7
Shafer, L.L.8
-
72
-
-
70349847734
-
Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances
-
Thal, D.R., Capetillo-Zarate, E., Larionov, S., Staufenbiel, M., Zurbruegg, S. & Beckmann, N. (2009) Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances. Neurobiol. Aging, 30, 1936-1948.
-
(2009)
Neurobiol. Aging
, vol.30
, pp. 1936-1948
-
-
Thal, D.R.1
Capetillo-Zarate, E.2
Larionov, S.3
Staufenbiel, M.4
Zurbruegg, S.5
Beckmann, N.6
-
73
-
-
84859316471
-
Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits
-
Tong, X.-K., Lecrux, C. & Hamel, E. (2012) Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits. J. Neurosci., 32, 4705-4715.
-
(2012)
J. Neurosci.
, vol.32
, pp. 4705-4715
-
-
Tong, X.-K.1
Lecrux, C.2
Hamel, E.3
-
74
-
-
0037266894
-
Age-dependent cognitive decline in the APP23 model precedes amyloid deposition
-
Van Dam, D., D'Hooge, R., Staufenbiel, M., Van Ginneken, C., Van Meir, F. & De Deyn, P.P. (2003) Age-dependent cognitive decline in the APP23 model precedes amyloid deposition. Eur. J. Neurosci., 17, 388-396.
-
(2003)
Eur. J. Neurosci.
, vol.17
, pp. 388-396
-
-
Van Dam, D.1
D'Hooge, R.2
Staufenbiel, M.3
Van Ginneken, C.4
Van Meir, F.5
De Deyn, P.P.6
-
75
-
-
36049002393
-
Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease
-
Wang, J., Ho, L., Chen, L., Zhao, Z., Zhao, W., Qian, X., Humala, N., Seror, I., Bartholomew, S., Rosendorff, C. & Pasinetti, G.M. (2007) Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J. Clin. Invest., 117, 3393-3402.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3393-3402
-
-
Wang, J.1
Ho, L.2
Chen, L.3
Zhao, Z.4
Zhao, W.5
Qian, X.6
Humala, N.7
Seror, I.8
Bartholomew, S.9
Rosendorff, C.10
Pasinetti, G.M.11
-
76
-
-
14244255355
-
Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
-
Wilcock, D.M., Rojiani, A., Rosenthal, A., Subbarao, S., Freeman, M.J., Gordon, M.N. & Morgan, D. (2004) Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. J. Neuroinflamm., 1, 24.
-
(2004)
J. Neuroinflamm.
, vol.1
, pp. 24
-
-
Wilcock, D.M.1
Rojiani, A.2
Rosenthal, A.3
Subbarao, S.4
Freeman, M.J.5
Gordon, M.N.6
Morgan, D.7
-
77
-
-
0035282982
-
Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy
-
Winkler, D.T., Bondolfi, L., Herzig, M.C., Jann, L., Calhoun, M.E., Wiederhold, K.-H., Tolnay, M., Staufenbiel, M. & Jucker, M. (2001) Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy. J. Neurosci., 21, 1619-1627.
-
(2001)
J. Neurosci.
, vol.21
, pp. 1619-1627
-
-
Winkler, D.T.1
Bondolfi, L.2
Herzig, M.C.3
Jann, L.4
Calhoun, M.E.5
Wiederhold, K.-H.6
Tolnay, M.7
Staufenbiel, M.8
Jucker, M.9
-
78
-
-
33947525706
-
Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice
-
Xu, F., Grande, A.M., Robinson, J.K., Previti, M.L., Vasek, M., Davis, J. & Van Nostrand, W.E. (2007) Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice. Neuroscience, 146, 98-107.
-
(2007)
Neuroscience
, vol.146
, pp. 98-107
-
-
Xu, F.1
Grande, A.M.2
Robinson, J.K.3
Previti, M.L.4
Vasek, M.5
Davis, J.6
Van Nostrand, W.E.7
-
79
-
-
79955585471
-
Blocking the Apolipoprotein E/Amyloid-β interaction reduces fibrillar vascular amyloid deposition and cerebral microhemorrhages in TgSwDI mice
-
Yang, J., Jia, Y., Mehtab, P., Batesa, K.A., Suna, Y. & Wisniewskia, T. (2011) Blocking the Apolipoprotein E/Amyloid-β interaction reduces fibrillar vascular amyloid deposition and cerebral microhemorrhages in TgSwDI mice. J. Alzheimers Dis., 24, 269-285.
-
(2011)
J. Alzheimers Dis.
, vol.24
, pp. 269-285
-
-
Yang, J.1
Jia, Y.2
Mehtab, P.3
Batesa, K.A.4
Suna, Y.5
Wisniewskia, T.6
-
80
-
-
68549111123
-
Simultaneous measurement of arterial transit time, arterial blood volume, and cerebral blood flow using arterial spin-labeling in patients with Alzheimer disease
-
Yoshiura, T., Hiwatashi, A., Yamashita, K., Ohyagi, Y., Monji, A., Takayama, Y., Nagao, E., Kamano, H., Noguchi, T. & Honda, H. (2009) Simultaneous measurement of arterial transit time, arterial blood volume, and cerebral blood flow using arterial spin-labeling in patients with Alzheimer disease. Am. J. Neuroradiol., 30, 1388-1393.
-
(2009)
Am. J. Neuroradiol.
, vol.30
, pp. 1388-1393
-
-
Yoshiura, T.1
Hiwatashi, A.2
Yamashita, K.3
Ohyagi, Y.4
Monji, A.5
Takayama, Y.6
Nagao, E.7
Kamano, H.8
Noguchi, T.9
Honda, H.10
-
81
-
-
81555200043
-
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
-
Zlokovic, B.V. (2011) Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat. Rev. Neurosci., 12, 723-738.
-
(2011)
Nat. Rev. Neurosci.
, vol.12
, pp. 723-738
-
-
Zlokovic, B.V.1
|