메뉴 건너뛰기




Volumn 32, Issue 50, 2012, Pages 18227-18233

Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; FLORBETAPIR F 18; FLUORODEOXYGLUCOSE F 18;

EID: 84871001204     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3266-12.2012     Document Type: Article
Times cited : (142)

References (71)
  • 1
    • 0034784359 scopus 로고    scopus 로고
    • An energy budget for signaling in the grey matter of the brain
    • CrossRef Medline
    • Attwell D, Laughlin SB (2001) An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 21:1133-1145. CrossRef Medline
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 1133-1145
    • Attwell, D.1    Laughlin, S.B.2
  • 5
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • CrossRef Medline
    • Braak H, Braak E (1997) Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 18:351-357. CrossRef Medline
    • (1997) Neurobiol Aging , vol.18 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 8
  • 20
    • 64249122538 scopus 로고    scopus 로고
    • Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila
    • CrossRef Medline
    • Gilestro GF, Tononi G, Cirelli C (2009) Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila. Science 324:109-112. CrossRef Medline
    • (2009) Science , vol.324 , pp. 109-112
    • Gilestro, G.F.1    Tononi, G.2    Cirelli, C.3
  • 21
    • 1842427969 scopus 로고    scopus 로고
    • Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
    • CrossRef Medline
    • Greicius MD, Srivastava G, Reiss AL, Menon V (2004) Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A 101:4637-4642. CrossRef Medline
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4637-4642
    • Greicius, M.D.1    Srivastava, G.2    Reiss, A.L.3    Menon, V.4
  • 22
    • 70349876480 scopus 로고    scopus 로고
    • Disruption of functional connectivity in clinically normal older adults harboring amyloid burden
    • CrossRef Medline
    • Hedden T, Van Dijk KR, Becker JA, Mehta A, Sperling RA, Johnson KA, Buckner RL (2009) Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. J Neurosci 29:12686-12694. CrossRef Medline
    • (2009) J Neurosci , vol.29 , pp. 12686-12694
    • Hedden, T.1    van Dijk, K.R.2    Becker, J.A.3    Mehta, A.4    Sperling, R.A.5    Johnson, K.A.6    Buckner, R.L.7
  • 25
    • 82455175189 scopus 로고    scopus 로고
    • Lifespan brain activity, beta-amyloid, and Alzheimer's disease
    • CrossRef Medline
    • Jagust WJ, Mormino EC (2011) Lifespan brain activity, beta-amyloid, and Alzheimer's disease. Trends Cogn Sci 15:520-526. CrossRef Medline
    • (2011) Trends Cogn Sci , vol.15 , pp. 520-526
    • Jagust, W.J.1    Mormino, E.C.2
  • 28
    • 0242403213 scopus 로고    scopus 로고
    • Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients
    • CrossRef Medline
    • Ji Y, Gong Y, Gan W, Beach T, Holtzman DM, Wisniewski T (2003) Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience 122:305-315. CrossRef Medline
    • (2003) Neuroscience , vol.122 , pp. 305-315
    • Ji, Y.1    Gong, Y.2    Gan, W.3    Beach, T.4    Holtzman, D.M.5    Wisniewski, T.6
  • 32
    • 68249134074 scopus 로고    scopus 로고
    • The role of apolipoprotein E in Alzheimer's disease
    • CrossRef Medline
    • Kim J, Basak JM, Holtzman DM (2009) The role of apolipoprotein E in Alzheimer's disease. Neuron 63:287-303. CrossRef Medline
    • (2009) Neuron , vol.63 , pp. 287-303
    • Kim, J.1    Basak, J.M.2    Holtzman, D.M.3
  • 35
    • 67650094927 scopus 로고    scopus 로고
    • Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age
    • CrossRef Medline
    • Kok E, Haikonen S, Luoto T, Huhtala H, Goebeler S, Haapasalo H, Karhunen PJ (2009) Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age. Ann Neurol 65:650-657. CrossRef Medline
    • (2009) Ann Neurol , vol.65 , pp. 650-657
    • Kok, E.1    Haikonen, S.2    Luoto, T.3    Huhtala, H.4    Goebeler, S.5    Haapasalo, H.6    Karhunen, P.J.7
  • 37
    • 33846633336 scopus 로고    scopus 로고
    • Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    • CrossRef Medline
    • Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL (2007) Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27:796-807. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 796-807
    • Lacor, P.N.1    Buniel, M.C.2    Furlow, P.W.3    Clemente, A.S.4    Velasco, P.T.5    Wood, M.6    Viola, K.L.7    Klein, W.L.8
  • 41
    • 0042093508 scopus 로고    scopus 로고
    • ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory
    • CrossRef Medline
    • Levi O, Jongen-Relo AL, Feldon J, Roses AD, Michaelson DM (2003) ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory. Neurobiol Dis 13:273-282. CrossRef Medline
    • (2003) Neurobiol Dis , vol.13 , pp. 273-282
    • Levi, O.1    Jongen-Relo, A.L.2    Feldon, J.3    Roses, A.D.4    Michaelson, D.M.5
  • 44
    • 0028173205 scopus 로고
    • Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
    • CrossRef Medline
    • Ma J, Yee A, Brewer HB Jr, Das S, Potter H (1994) Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature 372:92-94. CrossRef Medline
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer Jr., H.B.3    Das, S.4    Potter, H.5
  • 46
    • 0027425211 scopus 로고
    • The clinical dementia rating (CDR): Current version and scoring rules
    • CrossRef Medline
    • Morris JC (1993) The clinical dementia rating (CDR): current version and scoring rules. Neurology 43:2412-2414. CrossRef Medline
    • (1993) Neurology , vol.43 , pp. 2412-2414
    • Morris, J.C.1
  • 47
    • 77649314191 scopus 로고    scopus 로고
    • APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
    • CrossRef Medline
    • Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA (2010) APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol 67:122-131. CrossRef Medline
    • (2010) Ann Neurol , vol.67 , pp. 122-131
    • Morris, J.C.1    Roe, C.M.2    Xiong, C.3    Fagan, A.M.4    Goate, A.M.5    Holtzman, D.M.6    Mintun, M.A.7
  • 49
    • 0027209083 scopus 로고
    • Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices
    • CrossRef Medline
    • Nitsch RM, Farber SA, Growdon JH, Wurtman RJ (1993) Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices. Proc Natl Acad Sci U S A 90:5191-5193. CrossRef Medline
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5191-5193
    • Nitsch, R.M.1    Farber, S.A.2    Growdon, J.H.3    Wurtman, R.J.4
  • 51
    • 0027374047 scopus 로고
    • Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
    • CrossRef Medline
    • Rebeck GW, Reiter JS, Strickland DK, Hyman BT (1993) Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 11:575-580. CrossRef Medline
    • (1993) Neuron , vol.11 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hyman, B.T.4
  • 52
    • 0029970342 scopus 로고    scopus 로고
    • Preclinical evidence of Alzheimer's disease in persons homozygous for the e4 allele for apolipoprotein E
    • CrossRef Medline
    • Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D (1996) Preclinical evidence of Alzheimer's disease in persons homozygous for the e4 allele for apolipoprotein E. N Engl J Med 334:752-758. CrossRef Medline
    • (1996) N Engl J Med , vol.334 , pp. 752-758
    • Reiman, E.M.1    Caselli, R.J.2    Yun, L.S.3    Chen, K.4    Bandy, D.5    Minoshima, S.6    Thibodeau, S.N.7    Osborne, D.8
  • 55
    • 0344552488 scopus 로고    scopus 로고
    • Resting-state brain glucose utilization as measured by PET is directly related to regional synaptophysin levels: A study in baboons
    • CrossRef Medline
    • Rocher AB, Chapon F, Blaizot X, Baron JC, Chavoix C (2003) Resting-state brain glucose utilization as measured by PET is directly related to regional synaptophysin levels: a study in baboons. Neuroimage 20:1894-1898. CrossRef Medline
    • (2003) Neuroimage , vol.20 , pp. 1894-1898
    • Rocher, A.B.1    Chapon, F.2    Blaizot, X.3    Baron, J.C.4    Chavoix, C.5
  • 57
    • 0029073383 scopus 로고
    • Genetic dissection of Alzheimer disease, a heterogeneous disorder
    • CrossRef Medline
    • Schellenberg GD (1995) Genetic dissection of Alzheimer disease, a heterogeneous disorder. Proc Natl Acad Sci U S A 92:8552-8559. CrossRef Medline
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 8552-8559
    • Schellenberg, G.D.1
  • 59
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • CrossRef Medline
    • Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL (2007) Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27:2866-2875. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 63
    • 0141867844 scopus 로고    scopus 로고
    • New roles for astrocytes: Regulation of CNS synaptogenesis
    • CrossRef Medline
    • Slezak M, Pfrieger FW (2003) New roles for astrocytes: regulation of CNS synaptogenesis. Trends Neurosci 26:531-535. CrossRef Medline
    • (2003) Trends Neurosci , vol.26 , pp. 531-535
    • Slezak, M.1    Pfrieger, F.W.2
  • 65
    • 82755195583 scopus 로고    scopus 로고
    • The effects of APOEepsilon4 on the BOLD response
    • CrossRef Medline
    • Trachtenberg AJ, Filippini N, Mackay CE (2012) The effects of APOEepsilon4 on the BOLD response. Neurobiol Aging 33:323-334. CrossRef Medline
    • (2012) Neurobiol Aging , vol.33 , pp. 323-334
    • Trachtenberg, A.J.1    Filippini, N.2    Mackay, C.E.3
  • 68
    • 78650639655 scopus 로고    scopus 로고
    • Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE epsilon4 allele, the major late-onset Alzheimer's susceptibility gene
    • CrossRef Medline
    • Valla J, Yaari R, Wolf AB, Kusne Y, Beach TG, Roher AE, Corneveaux JJ, Huentelman MJ, Caselli RJ, Reiman EM (2010) Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE epsilon4 allele, the major late-onset Alzheimer's susceptibility gene. J Alzheimers Dis 22:307-313. CrossRef Medline
    • (2010) J Alzheimers Dis , vol.22 , pp. 307-313
    • Valla, J.1    Yaari, R.2    Wolf, A.B.3    Kusne, Y.4    Beach, T.G.5    Roher, A.E.6    Corneveaux, J.J.7    Huentelman, M.J.8    Caselli, R.J.9    Reiman, E.M.10
  • 70
    • 34248190279 scopus 로고    scopus 로고
    • A beta oligomers-a decade of discovery
    • CrossRef Medline
    • Walsh DM, Selkoe DJ (2007) A beta oligomers-a decade of discovery. J Neurochem 101:1172-1184. CrossRef Medline
    • (2007) J Neurochem , vol.101 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 71
    • 15944410978 scopus 로고    scopus 로고
    • Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology
    • CrossRef Medline
    • Wang C, Wilson WA, Moore SD, Mace BE, Maeda N, Schmechel DE, Sullivan PM (2005) Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiol Dis 18:390-398. CrossRef Medline
    • (2005) Neurobiol Dis , vol.18 , pp. 390-398
    • Wang, C.1    Wilson, W.A.2    Moore, S.D.3    Mace, B.E.4    Maeda, N.5    Schmechel, D.E.6    Sullivan, P.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.