Alzheimer disease-associated peptide, amyloid β40, inhibits vascular regeneration with induction of endothelial autophagy

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 29, Issue 11, 2009, Pages 1909-1915

  Hayashi, Shin Ichiro ^a,d   Sato, Naoyuki ^b   Yamamoto, Akitsugu ^c   Ikegame, Yuka ^a   Nakashima, Shigeru ^b   Ogihara, Toshio ^d   Morishita, Ryuichi ^b  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Amyloid; Autophagy; Cerebrovascular disorders; Endothelium

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ALZHEIMER DISEASE; ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN SLICE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HIPPOCAMPUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; AUTOPHAGY; BLOOD VESSELS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; HIPPOCAMPUS; HUMANS; MALE; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; PEPTIDE FRAGMENTS; PROBABILITY; REGENERATION; TRANSFECTION;

EID: 73949133110     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.109.188516     Document Type: Article

References (29)

1. Alzheimer A. Uber eine eigenartig Erkrankung der Hirnrinde. Allg Z. Psychiatrie Psych Ger Med. 1907;62:146-148.
2. Roth M. The natural history of mental disorder in old age. J Mental Sci. 1995;101:281-301.
3. Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron. 1991;6:487-498.
4. Harman D. Alzheimer's disease pathogenesis: role of aging. Ann N Y Acad Sci. 2006;1067:454-460.
5. Golde TE, Eckman CB, Younkin SG. Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochem Biophys Acta. 2000;1502:172-187.
6. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995;1:27-31.
7. Risau W. Mechanism of angiogenesis. Nature. 1997;386:671-674.
8. De la Torre JC. Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol. 2004;3:184-190.
9. Kabeya Y, Mizushima N, Ueno T, Yamomoto A, Kirisaka T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000;19:5720-5728.
10. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell. 2004;15:1101-1111.
11. Johnson KA, Albert MS. Albert. Perfusion abnormalities in prodromal Alzheimer's disease. Neurobiol Aging. 2000;21:289-292.
12. Asahara T, Isner JM. Endothelial progenitor cells for vascular regeneration. J Hematother Stem Cell Res. 2000;11:171-178.
13. Zhang ZG, Zhang L, Jiang Q, Chopp M. Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ Res. 2002;90:284-288.
14. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008;451:1069-1075.
15. Levine B, Yuan J. Autophagy in cell death: an incorrect convict? J ClinInvest. 2005;115:2679-2688.
16. Brazil DP, Hemmings BA. Ten years of protein kinase B signaling: a hard Akt to follow. Trends Biochem Sci. 2001;26:657-664.
17. Degtyarev M, De Maziere A, Orr C, Lin J, Lee BB, Tien JY, Prior WW, van Dijk S, Wu H, Gray DC, Davis DP, Stern HM, Murray LJ, Hoeflich KP, Klumperman J, Friedman LS, Lin K. Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotrophic agents. J Cell Biol. 2008;183:101-116.
18. Arico S, Petiot A, Bauvy C, Dubbelhuisn PF, Meijer AJ, Codogno P, Ogier-Denis E. The tumor suppressor PTEN positively regulates macro-autophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem. 2001;276:35243-35246.
19. Siojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res. 2002;90:1243-1250. (Pubitemid 34787405)
20. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher A. Activation of nitric oxide synthase in endothelial cells by Akt dependent phosphorylation. Nature. 1999;399:601-605.
21. Fulton D, Gratton J-P, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC. Regulation of endothelial derived nitric oxide production by the protein kinase Akt. Nature. 1999;399: 597-601.
22. Criton M. Strategies for disease modification in Alzheimer's disease. Nature Rev Neurosci. 2004;5:677-685.
23. Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, Fox NC, Eisner L, Kirby L, Rovira MB, Forette F, Orgogozo JM. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology. 2005;64:1553-1562.
24. Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 1998;95:23-39.
25. Vazquez E, Ramaswamy S, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol. 2000;20:5010-5018.
26. Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee J-H, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Naslund J, Mathews PM, Cataldo AM, Nixon RA. Macroautophagy-a novel /3-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol. 2005;171:87-98.
27. Patel NS, Quadros A, Brem S, Wotoczek-Obadia M, Mathura VS, Laporte V, Mullan M, Paris D. Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptides. Amyloid. 2008;15:5-19.
28. Carmeliet P, Tessier-Lavigne M. Common mechanisms of nerve and blood vessel wiring. Nature. 2005;436:193-200.
29. Giri R, Shen Y, Stins M, Yan SD, Schmidt AM, Stern D, Kim K, Zlokovic B, Kakra VK. /3-Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am J Physiol. 2000;279:C1772-C1781.